(Q50858344)

24 March 2018

review article

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title

New roles for cyclin-dependent kinases in T cell biology: linking cell division and differentiation. (English)

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24 March 2018

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Andrew D Wells

1

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24 March 2018

Peter A Morawski

series ordinal

2

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24 March 2018

publication date

7 March 2014

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24 March 2018

Nature Reviews Immunology

published in

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24 March 2018

volume

14

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24 March 2018

issue

4

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24 March 2018

page(s)

261-270

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24 March 2018

Massive expansion of antigen-specific CD8+ T cells during an acute virus infection

cites work

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Conserved T cell receptor repertoire in primary and memory CD8 T cell responses to an acute viral infection

31 March 2020

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The role of naive T cell precursor frequency and recruitment in dictating immune response magnitude

31 March 2020

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Determination of lymphocyte division by flow cytometry

31 March 2020

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Following the fate of individual T cells throughout activation and clonal expansion. Signals from T cell receptor and CD28 differentially regulate the induction and duration of a proliferative response

31 March 2020

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Class I-restricted cross-presentation of exogenous self-antigens leads to deletion of autoreactive CD8(+) T cells

31 March 2020

1 reference

Cdks, cyclins and CKIs: roles beyond cell cycle regulation

31 March 2020

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Distinct roles for cyclin-dependent kinases in cell cycle control

31 March 2020

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Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

31 March 2020

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Cyclin-dependent kinase 1 (Cdk1) is essential for cell division and suppression of DNA re-replication but not for liver regeneration.

31 March 2020

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Cdk1 is sufficient to drive the mammalian cell cycle

31 March 2020

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Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice.

31 March 2020

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Cdk2 knockout mice are viable

31 March 2020

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Targeted disruption of CDK4 delays cell cycle entry with enhanced p27(Kip1) activity

31 March 2020

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Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia

31 March 2020

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Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6

31 March 2020

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Requirement for cyclin D3 in lymphocyte development and T cell leukemias

31 March 2020

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A requirement for cyclin-dependent kinase 6 in thymocyte development and tumorigenesis

31 March 2020

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CDK6 kinase activity is required for thymocyte development

31 March 2020

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The role of cyclin-dependent kinases in T-cell development, proliferation, and function

31 March 2020

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Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis

31 March 2020

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Combined loss of Cdk2 and Cdk4 results in embryonic lethality and Rb hypophosphorylation

31 March 2020

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Mice thrive without Cdk4 and Cdk2.

31 March 2020

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Cell division regulates the T cell cytokine repertoire, revealing a mechanism underlying immune class regulation

31 March 2020

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A closer look at homeostatic proliferation of CD4+ T cells: costimulatory requirements and role in memory formation.

31 March 2020

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Helper T cell differentiation is controlled by the cell cycle

31 March 2020

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T cell effector function and anergy avoidance are quantitatively linked to cell division.

31 March 2020

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31 March 2020

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Antagonistic roles for CTLA-4 and the mammalian target of rapamycin in the regulation of clonal anergy: enhanced cell cycle progression promotes recall antigen responsiveness.

31 March 2020

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Induction of anergy in Th1 cells associated with increased levels of cyclin-dependent kinase inhibitors p21Cip1 and p27Kip1.

31 March 2020

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Cyclin-dependent kinases: molecular switches controlling anergy and potential therapeutic targets for tolerance

31 March 2020

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Transcriptional and epigenetic control of T helper cell specification: molecular mechanisms underlying commitment and plasticity.

31 March 2020

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New insights into the molecular basis of T cell anergy: anergy factors, avoidance sensors, and epigenetic imprinting

31 March 2020

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Asymmetric proteasome segregation as a mechanism for unequal partitioning of the transcription factor T-bet during T lymphocyte division

31 March 2020

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Asymmetric T lymphocyte division in the initiation of adaptive immune responses.

31 March 2020

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Cutting edge: Asymmetric memory T cell division in response to rechallenge

31 March 2020

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Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases

31 March 2020

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PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization

31 March 2020

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PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest

31 March 2020

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A novel function of adenovirus E1A is required to overcome growth arrest by the CDK2 inhibitor p27(Kip1).

31 March 2020

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Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation

31 March 2020

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CD28 costimulation mediates T cell expansion via IL-2-independent and IL-2-dependent regulation of cell cycle progression

31 March 2020

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p27kip1 functions as an anergy factor inhibiting interleukin 2 transcription and clonal expansion of alloreactive human and mouse helper T lymphocytes

31 March 2020

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The cyclin-dependent kinase inhibitor p27kip1 is required for transplantation tolerance induced by costimulatory blockade.

31 March 2020

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Opposing roles for the cyclin-dependent kinase inhibitor p27kip1 in the control of CD4+ T cell proliferation and effector function

31 March 2020

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A pathway regulated by cell cycle inhibitor p27Kip1 and checkpoint inhibitor Smad3 is involved in the induction of T cell tolerance.

31 March 2020

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p27Kip1 modulates cell migration through the regulation of RhoA activation.

31 March 2020

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Cyclin-dependent kinase 2 controls peripheral immune tolerance

31 March 2020

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31 March 2020

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Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death

31 March 2020

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Cyclin-dependent kinase 5 activity is required for T cell activation and induction of experimental autoimmune encephalomyelitis

31 March 2020

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Hematopoiesis and thymic apoptosis are not affected by the loss of Cdk2.

31 March 2020

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A cell culture model for T lymphocyte clonal anergy

31 March 2020

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p27(Kip1) negatively regulates the magnitude and persistence of CD4 T cell memory.

31 March 2020

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Regulation of memory CD8 T-cell differentiation by cyclin-dependent kinase inhibitor p27Kip1

31 March 2020

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Molecular mechanisms that control the expression and activity of Bcl-6 in TH1 cells to regulate flexibility with a TFH-like gene profile

31 March 2020

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p21CIP1/WAF1 controls proliferation of activated/memory T cells and affects homeostasis and memory T cell responses.

31 March 2020

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T-cell intrinsic and extrinsic mechanisms of p27Kip1 in the regulation of CD8 T-cell memory.

31 March 2020

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The transcription factor Foxo1 controls central-memory CD8+ T cell responses to infection

31 March 2020

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FoxO1 controls effector-to-memory transition and maintenance of functional CD8 T cell memory.

31 March 2020

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Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

31 March 2020

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Activation of FOXO1 by Cdk1 in cycling cells and postmitotic neurons

31 March 2020

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FOXO transcription factors throughout T cell biology

31 March 2020

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Deficiency of the cyclin kinase inhibitor p21(WAF-1/CIP-1) promotes apoptosis of activated/memory T cells and inhibits spontaneous systemic autoimmunity

31 March 2020

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The cell cycle inhibitor p21 controls T-cell proliferation and sex-linked lupus development.

31 March 2020

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Role of cyclin kinase inhibitor p21 in systemic autoimmunity.

31 March 2020

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p21(Cip1) up-regulated during histone deacetylase inhibitor-induced CD4(+) T-cell anergy selectively associates with mitogen-activated protein kinases

31 March 2020

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p27(Kip1) inhibits systemic autoimmunity through the control of Treg cell activity and differentiation

31 March 2020

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Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways

31 March 2020

2 references

31 March 2020

12 December 2020

Regulatory T cells: how do they suppress immune responses?

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A self-reactive TCR drives the development of Foxp3+ regulatory T cells that prevent autoimmune disease

31 March 2020

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Foxp3 protein stability is regulated by cyclin-dependent kinase 2

31 March 2020

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Akt-mediated phosphorylation of CDK2 regulates its dual role in cell cycle progression and apoptosis

31 March 2020

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Cutting edge: PHLPP regulates the development, function, and molecular signaling pathways of regulatory T cells

31 March 2020

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First insight into the kinome of human regulatory T cells

31 March 2020

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CD4+CD25+ regulatory T-cell lines from human cord blood have functional and molecular properties of T-cell anergy

31 March 2020

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Differential but direct abolishment of human regulatory T cell suppressive capacity by various TLR2 ligands

31 March 2020

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Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3

31 March 2020

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Cyclin-dependent kinase inhibitors as anticancer drugs.

31 March 2020

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CDK inhibitors suppress Th17 and promote iTreg differentiation, and ameliorate experimental autoimmune encephalomyelitis in mice

31 March 2020

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The cyclin dependent kinase inhibitor (R)-roscovitine prevents alloreactive T cell clonal expansion and protects against acute GvHD

31 March 2020

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Cyclin-dependent kinase inhibition limits glomerulonephritis and extends lifespan of mice with systemic lupus

31 March 2020

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Effect of seliciclib (CYC202, R-roscovitine) on lymphocyte alloreactivity and acute kidney allograft rejection in rat.

31 March 2020

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Selective cyclin-dependent kinase inhibitors discriminating between cell cycle and transcriptional kinases: future reality or utopia?

31 March 2020

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The cyclin-dependent kinase inhibitor seliciclib (R-roscovitine; CYC202) decreases the expression of mitotic control genes and prevents entry into mitosis

31 March 2020

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Pyrazolo[4,3-d]pyrimidine bioisostere of roscovitine: evaluation of a novel selective inhibitor of cyclin-dependent kinases with antiproliferative activity

31 March 2020

1 reference

The purines: potent and versatile small molecule inhibitors and modulators of key biological targets

31 March 2020

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TET enzymes, TDG and the dynamics of DNA demethylation.

31 March 2020

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The Dynamic Mobility of Histone H1 Is Regulated by Cyclin/CDK Phosphorylation

31 March 2020

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Cyclin-dependent kinases regulate epigenetic gene silencing through phosphorylation of EZH2

31 March 2020

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Phosphorylation of human DNMT1: implication of cyclin-dependent kinases

31 March 2020

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Asymmetric loading of Kar9 onto spindle poles and microtubules ensures proper spindle alignment

31 March 2020

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Cdk5: a multifaceted kinase in neurodegenerative diseases

31 March 2020

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Cyclin-dependent kinases regulate the antiproliferative function of Smads

31 March 2020

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CDK-mediated regulation of cell functions via c-Jun phosphorylation and AP-1 activation

31 March 2020

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Phosphorylation of Sp1 by cyclin-dependent kinase 2 modulates the role of Sp1 in CTP:phosphocholine cytidylyltransferase alpha regulation during the S phase of the cell cycle

31 March 2020

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Regulation of NF-kappaB by cyclin-dependent kinases associated with the p300 coactivator

31 March 2020

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Association of Cdk2/cyclin E and NF-kappa B complexes at G1/S phase

31 March 2020

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Phosphorylation of RUNX1 by cyclin-dependent kinase reduces direct interaction with HDAC1 and HDAC3.

31 March 2020

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Stats: transcriptional control and biological impact

31 March 2020

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CDK8 kinase phosphorylates transcription factor STAT1 to selectively regulate the interferon response

31 March 2020

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Foxo transcription factors control regulatory T cell development and function

31 March 2020

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Transcription factors Foxo3a and Foxo1 couple the E3 ligase Cbl-b to the induction of Foxp3 expression in induced regulatory T cells

31 March 2020

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FoxO transcription factors; Regulation by AKT and 14-3-3 proteins

31 March 2020

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CDK2-dependent phosphorylation of FOXO1 as an apoptotic response to DNA damage

31 March 2020

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AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

31 March 2020

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Dynamics and requirements of T cell clonal expansion in vivo at the single-cell level: effector function is linked to proliferative capacity.

31 March 2020

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12 December 2020

Cyclin-dependent kinase modulators and cancer therapy

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12 December 2020

Inhibition of cell cycle progression by rapamycin induces T cell clonal anergy even in the presence of costimulation

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12 December 2020

The restriction point of the cell cycle

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12 December 2020

Cell division number regulates IgG1 and IgE switching of B cells following stimulation by CD40 ligand and IL-4.

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12 December 2020

Identifiers

DOI

10.1038/NRI3625

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24 March 2018

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24 March 2018