(Q51733786)

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20 March 2020

title

Apigenin, a dietary flavonoid, induces apoptosis, DNA damage, and oxidative stress in human breast cancer MCF-7 and MDA MB-231 cells (English)

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20 March 2020

8

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20 March 2020

Josip Madunić

2

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20 March 2020

Maja Antunović

3

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20 March 2020

author name string

Ivana Vrhovac Madunić

1

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20 March 2020

Mladen Paradžik

4

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20 March 2020

Vera Garaj-Vrhovac

5

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20 March 2020

Davorka Breljak

6

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20 March 2020

Inga Marijanović

7

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20 March 2020

publication date

14 March 2018

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Naunyn-Schmiedeberg's Archives of Pharmacology

20 March 2020

published in

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20 March 2020

volume

391

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20 March 2020

issue

5

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20 March 2020

page(s)

537-550

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https://scigraph.springernature.com/pub.10.1007/s00210-018-1486-4

20 March 2020

exact match

0 references

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Flavonoids apigenin and quercetin inhibit melanoma growth and metastatic potential

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Molecular portraits of human breast tumours

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Role of reactive oxygen species (ROS) in apoptosis induction

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Characterization of the necrotic cleavage of poly(ADP-ribose) polymerase (PARP-1): implication of lysosomal proteases

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Selective growth-inhibitory, cell-cycle deregulatory and apoptotic response of apigenin in normal versus human prostate carcinoma cells

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Apigenin acts on the tumor cell invasion process and regulates protease production

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Blocking telomerase by dietary polyphenols is a major mechanism for limiting the growth of human cancer cells in vitro and in vivo.

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Apoptosis as a novel target for cancer chemoprevention

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Apigenin drives the production of reactive oxygen species and initiates a mitochondrial mediated cell death pathway in prostate epithelial cells.

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Cytotoxicity of flavonoids toward cultured normal human cells

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Molecularly targeted agents: their promise as cancer chemopreventive interventions.

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Evaluation of apigenin using in vitro cytochalasin blocked micronucleus assay.

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Regulation of the p14ARF-Mdm2-p53 pathway: an overview in breast cancer

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A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes

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Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis

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Triple-negative breast cancer: therapeutic options

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From traditional Chinese medicine to rational cancer therapy.

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12 December 2020

Apigenin inhibits HGF-promoted invasive growth and metastasis involving blocking PI3K/Akt pathway and beta 4 integrin function in MDA-MB-231 breast cancer cells

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12 December 2020

Phytochemistry and pharmacogenomics of natural products derived from traditional Chinese medicine and Chinese materia medica with activity against tumor cells

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12 December 2020

Apigenin-induced prostate cancer cell death is initiated by reactive oxygen species and p53 activation

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12 December 2020

Cancer is a preventable disease that requires major lifestyle changes

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12 December 2020

Apigenin inhibits antiestrogen-resistant breast cancer cell growth through estrogen receptor-alpha-dependent and estrogen receptor-alpha-independent mechanisms

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12 December 2020

Apigenin causes G(2)/M arrest associated with the modulation of p21(Cip1) and Cdc2 and activates p53-dependent apoptosis pathway in human breast cancer SK-BR-3 cells

1 reference

12 December 2020

Evaluation of the cytogenetic status of human lymphocytes after exposure to a high concentration of bee venom in vitro

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12 December 2020

Biology, metastatic patterns, and treatment of patients with triple-negative breast cancer

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12 December 2020

5-Fluorouracil combined with apigenin enhances anticancer activity through induction of apoptosis in human breast cancer MDA-MB-453 cells

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12 December 2020

A selective eradication of human nonhereditary breast cancer cells by phenanthridine-derived polyADP-ribose polymerase inhibitors

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12 December 2020

Anticlastogenic effect of apigenin in human lymphocytes treated with ethinylestradiol

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12 December 2020

Apigenin: a promising molecule for cancer prevention

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12 December 2020

Apigenin induces caspase-dependent apoptosis in human lung cancer A549 cells through Bax- and Bcl-2-triggered mitochondrial pathway

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12 December 2020

Spectrophotometric analysis of flavonoid-DNA interactions and DNA damaging/protecting and cytotoxic potential of flavonoids in human peripheral blood lymphocytes

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12 December 2020

Protoapigenone, a natural derivative of apigenin, induces mitogen-activated protein kinase-dependent apoptosis in human breast cancer cells associated with induction of oxidative stress and inhibition of glutathione S-transferase π

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12 December 2020

Apigenin induces apoptosis in human lung cancer H460 cells through caspase- and mitochondria-dependent pathways

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12 December 2020

Triple-negative breast cancer

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12 December 2020

Triple-negative breast cancer: an unmet medical need

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12 December 2020

Apoptotic effects of genistein, biochanin-A and apigenin on LNCaP and PC-3 cells by p21 through transcriptional inhibition of polo-like kinase-1.

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12 December 2020

Apigenin induces apoptosis in human leukemia cells and exhibits anti-leukemic activity in vivo

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12 December 2020

Flavonoids: A versatile source of anticancer drugs

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12 December 2020

Evidence for activation of mutated p53 by apigenin in human pancreatic cancer

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12 December 2020

Acridine Orange/Ethidium Bromide (AO/EB) Staining to Detect Apoptosis

1 reference

12 December 2020

Apigenin ameliorates gamma radiation-induced cytogenetic alterations in cultured human blood lymphocytes.

1 reference

12 December 2020

Flavonoids and cancer prevention: a review of the evidence

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12 December 2020

Apigenin induces DNA damage through the PKCδ-dependent activation of ATM and H2AX causing down-regulation of genes involved in cell cycle control and DNA repair.

1 reference

12 December 2020

A prooxidant mechanism for the anticancer and chemopreventive properties of plant polyphenols

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12 December 2020

Apigenin shows synergistic anticancer activity with curcumin by binding at different sites of tubulin

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12 December 2020

Autophagy inhibition enhances apigenin-induced apoptosis in human breast cancer cells

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12 December 2020

Cruciferous vegetables: dietary phytochemicals for cancer prevention

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12 December 2020

Molecular basis for the action of a dietary flavonoid revealed by the comprehensive identification of apigenin human targets.

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12 December 2020

Modulation of radiation-induced and mitomycin C-induced chromosome damage by apigenin in human lymphocytes in vitro

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12 December 2020

Patterns of Recurrence and outcome according to breast cancer subtypes in lymph node-negative disease: results from international breast cancer study group trials VIII and IX.

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12 December 2020

Herbacetin, a constituent of ephedrae herba, suppresses the HGF-induced motility of human breast cancer MDA-MB-231 cells by inhibiting c-Met and Akt phosphorylation

1 reference

12 December 2020

Effects of dietary apigenin on tumor latency, incidence and multiplicity in a medroxyprogesterone acetate-accelerated 7,12-dimethylbenz(a)anthracene-induced breast cancer model

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12 December 2020

Flavonoids as prospective compounds for anti-cancer therapy.

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12 December 2020

Physico-chemical characterization and the in vitro genotoxicity of medical implants metal alloy (TiAlV and CoCrMo) and polyethylene particles in human lymphocytes.

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12 December 2020

Apigenin induces the apoptosis and regulates MAPK signaling pathways in mouse macrophage ANA-1 cells

1 reference

12 December 2020

Exposure of breast cancer cells to a subcytotoxic dose of apigenin causes growth inhibition, oxidative stress, and hypophosphorylation of Akt.

1 reference

12 December 2020

Cytotoxicity of dietary flavonoids on different human cancer types

1 reference

12 December 2020

Difference between Luminal A and Luminal B Subtypes According to Ki-67, Tumor Size, and Progesterone Receptor Negativity Providing Prognostic Information

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12 December 2020

Breast cancer statistics and markers

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12 December 2020

Apigenin induced MCF-7 cell apoptosis-associated reactive oxygen species

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12 December 2020

Quantification of malondialdehyde by HPLC-FL - application to various biological samples

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12 December 2020

The differential susceptibilities of MCF-7 and MDA-MB-231 cells to the cytotoxic effects of curcumin are associated with the PI3K/Akt-SKP2-Cip/Kips pathway.

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12 December 2020

Apigenin and Breast Cancers: From Chemistry to Medicine

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12 December 2020

Apigenin induces caspase-dependent apoptosis by inhibiting signal transducer and activator of transcription 3 signaling in HER2-overexpressing SKBR3 breast cancer cells

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12 December 2020

Lifestyle, nutrition and breast cancer: facts and presumptions for consideration

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12 December 2020

Apigenin induced apoptosis in esophageal carcinoma cells by destruction membrane structures

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12 December 2020

Apigenin Inhibits Growth of Breast Cancer Cells: The Role of ERα and HER2/neu

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12 December 2020

Induction of caspase-dependent extrinsic apoptosis by apigenin through inhibition of signal transducer and activator of transcription 3 (STAT3) signalling in HER2-overexpressing BT-474 breast cancer cells.

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12 December 2020

Flavones inhibit breast cancer proliferation through the Akt/FOXO3a signaling pathway

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12 December 2020

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12 December 2020

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12 December 2020

Natural Polyphenols for Prevention and Treatment of Cancer

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12 December 2020

The Anti-Cancer Effect of Polyphenols against Breast Cancer and Cancer Stem Cells: Molecular Mechanisms

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12 December 2020

Apigenin potentiates TRAIL therapy of non-small cell lung cancer via upregulating DR4/DR5 expression in a p53-dependent manner

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12 December 2020

Lead Phytochemicals for Anticancer Drug Development

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12 December 2020

Role of Apigenin in Cancer Prevention via the Induction of Apoptosis and Autophagy

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12 December 2020

Apigenin inhibits proliferation and invasion, and induces apoptosis and cell cycle arrest in human melanoma cells

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12 December 2020

Cytochrome P450 CYP1 metabolism of hydroxylated flavones and flavonols: Selective bioactivation of luteolin in breast cancer cells.

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12 December 2020

Apigenin: A dietary flavonoid with diverse anticancer properties

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12 December 2020

10.1007/S00210-018-1486-4

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29541820%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

1 reference