(Q51750916)

English

Predicting the expression of recombinant monoclonal antibodies in Chinese hamster ovary cells based on sequence features of the CDR3 domain.

scientific article published on 6 December 2013

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

11 April 2018

http://europepmc.org/abstract/MED/24311306

Predicting the expression of recombinant monoclonal antibodies in Chinese hamster ovary cells based on sequence features of the CDR3 domain. (English)

1 reference

Europe PubMed Central

PubMed publication ID

11 April 2018

http://europepmc.org/abstract/MED/24311306

author name string

Leon P Pybus

1

1 reference

Europe PubMed Central

PubMed publication ID

11 April 2018

http://europepmc.org/abstract/MED/24311306

David C James

2

1 reference

Europe PubMed Central

PubMed publication ID

11 April 2018

http://europepmc.org/abstract/MED/24311306

Greg Dean

3

1 reference

Europe PubMed Central

PubMed publication ID

11 April 2018

http://europepmc.org/abstract/MED/24311306

Tim Slidel

4

1 reference

Europe PubMed Central

PubMed publication ID

11 April 2018

http://europepmc.org/abstract/MED/24311306

Colin Hardman

5

1 reference

Europe PubMed Central

PubMed publication ID

11 April 2018

http://europepmc.org/abstract/MED/24311306

Andrew Smith

6

1 reference

Europe PubMed Central

PubMed publication ID

11 April 2018

http://europepmc.org/abstract/MED/24311306

Olalekan Daramola

7

1 reference

Europe PubMed Central

PubMed publication ID

11 April 2018

http://europepmc.org/abstract/MED/24311306

Ray Field

8

1 reference

Europe PubMed Central

PubMed publication ID

11 April 2018

http://europepmc.org/abstract/MED/24311306

publication date

6 December 2013

1 reference

Europe PubMed Central

PubMed publication ID

11 April 2018

http://europepmc.org/abstract/MED/24311306

Biotechnology Progress

1 reference

Europe PubMed Central

PubMed publication ID

11 April 2018

http://europepmc.org/abstract/MED/24311306

30

1 reference

Europe PubMed Central

PubMed publication ID

11 April 2018

http://europepmc.org/abstract/MED/24311306

1

1 reference

Europe PubMed Central

PubMed publication ID

11 April 2018

http://europepmc.org/abstract/MED/24311306

188-197

1 reference

Europe PubMed Central

PubMed publication ID

11 April 2018

http://europepmc.org/abstract/MED/24311306

Industrialization of mAb production technology: the bioprocessing industry at a crossroads

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Codon engineering for improved antibody expression in mammalian cells

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The structural dependence of amino acid hydrophobicity parameters

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Effects of rare codon clusters on high-level expression of heterologous proteins in Escherichia coli

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Mfold web server for nucleic acid folding and hybridization prediction

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Affinity panning of a library of peptides displayed on bacteriophages reveals the binding specificity of BiP.

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Detection of discriminative sequence patterns in the neighborhood of proline cis peptide bonds and their functional annotation.

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Analysis and prediction of the metabolic stability of proteins based on their sequential features, subcellular locations and interaction networks

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Analysis and prediction of translation rate based on sequence and functional features of the mRNA.

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Conformational parameters for amino acids in helical, beta-sheet, and random coil regions calculated from proteins

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Toward predicting protein topology: an approach to identifying beta hairpins.

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High accuracy prediction of beta-turns and their types using propensities and multiple alignments.

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A neural network method for prediction of beta-turn types in proteins using evolutionary information.

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Strand-loop-strand motifs: prediction of hairpins and diverging turns in proteins

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21 January 2018

Prediction of chain turns in globular proteins on a hydrophobic basis

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21 January 2018

Prediction of the location and type of beta-turns in proteins using neural networks.

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21 January 2018

Impact of gene vector design on the control of recombinant monoclonal antibody production by Chinese hamster ovary cells

1 reference

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Regulation of recombinant monoclonal antibody production in chinese hamster ovary cells: a comparative study of gene copy number, mRNA level, and protein expression.

1 reference

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21 January 2018

A clone screening method using mRNA levels to determine specific productivity and product quality for monoclonal antibodies

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On the optimal ratio of heavy to light chain genes for efficient recombinant antibody production by CHO cells.

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Control of IgG LC:HC ratio in stably transfected CHO cells and study of the impact on expression, aggregation, glycosylation and conformational stability

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Assembly of immunoglobulin light chains as a prerequisite for secretion. A model for oligomerization-dependent subunit folding

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BiP and immunoglobulin light chain cooperate to control the folding of heavy chain and ensure the fidelity of immunoglobulin assembly

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Unassembled Ig heavy chains do not cycle from BiP in vivo but require light chains to trigger their release

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Heterologous protein expression is enhanced by harmonizing the codon usage frequencies of the target gene with those of the expression host.

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Biophysical properties of human antibody variable domains

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Design of therapeutic proteins with enhanced stability.

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Aggregation-prone motifs in human immunoglobulin G.

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Potential aggregation prone regions in biotherapeutics: A survey of commercial monoclonal antibodies.

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Conformations of immunoglobulin hypervariable regions

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Common features of the conformations of antigen-binding loops in immunoglobulins and application to modeling loop conformations

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Reduction of interchain disulfide bonds precedes the dislocation of Ig-mu chains from the endoplasmic reticulum to the cytosol for proteasomal degradation

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Functional heterogeneity and heritability in CHO cell populations

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Identifiers

10.1002/BTPR.1839

1 reference

Europe PubMed Central

PubMed publication ID

11 April 2018

http://europepmc.org/abstract/MED/24311306

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

11 April 2018

http://europepmc.org/abstract/MED/24311306

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