(Q52652923)

English

Exploring the dynamics and interaction of a full ErbB2 receptor and Trastuzumab-Fab antibody in a lipid bilayer model using Martini coarse-grained force field.

scientific article published on 17 August 2014

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

5 May 2018

http://europepmc.org/abstract/MED/25129484

Exploring the dynamics and interaction of a full ErbB2 receptor and Trastuzumab-Fab antibody in a lipid bilayer model using Martini coarse-grained force field. (English)

1 reference

Europe PubMed Central

PubMed publication ID

5 May 2018

http://europepmc.org/abstract/MED/25129484

0 references

Juan F Franco-Gonzalez

1

1 reference

Europe PubMed Central

PubMed publication ID

5 May 2018

http://europepmc.org/abstract/MED/25129484

2

1 reference

Europe PubMed Central

PubMed publication ID

5 May 2018

http://europepmc.org/abstract/MED/25129484

Javier Martínez-Salazar

4

1 reference

Europe PubMed Central

PubMed publication ID

5 May 2018

http://europepmc.org/abstract/MED/25129484

author name string

Victor L Cruz

3

1 reference

Europe PubMed Central

PubMed publication ID

5 May 2018

http://europepmc.org/abstract/MED/25129484

publication date

17 August 2014

1 reference

Europe PubMed Central

PubMed publication ID

5 May 2018

http://europepmc.org/abstract/MED/25129484

Journal of Computer - Aided Molecular Design

1 reference

Europe PubMed Central

PubMed publication ID

5 May 2018

http://europepmc.org/abstract/MED/25129484

28

1 reference

Europe PubMed Central

PubMed publication ID

5 May 2018

http://europepmc.org/abstract/MED/25129484

11

1 reference

Europe PubMed Central

PubMed publication ID

5 May 2018

http://europepmc.org/abstract/MED/25129484

1093-1107

1 reference

Europe PubMed Central

PubMed publication ID

5 May 2018

http://europepmc.org/abstract/MED/25129484

https://scigraph.springernature.com/pub.10.1007/s10822-014-9787-2

0 references

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Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene

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Humanization of an anti-p185HER2 antibody for human cancer therapy

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Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer

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Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab

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Conformational flexibility of the ErbB2 ectodomain and trastuzumab antibody complex as revealed by molecular dynamics and principal component analysis.

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Synergy between trastuzumab and pertuzumab for human epidermal growth factor 2 (Her2) from colocalization: an in silico based mechanism

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Molecular dynamics simulations of the transmembrane domain of the oncogenic ErbB2 receptor dimer in a DMPC bilayer.

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Spatial structure of the transmembrane domain heterodimer of ErbB1 and ErbB2 receptor tyrosine kinases

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Self-association of models of transmembrane domains of ErbB receptors in a lipid bilayer

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Design, synthesis and biological evaluation of thiazolidinone derivatives as potential EGFR and HER-2 kinase inhibitors

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Conformational regulation of the EGFR kinase core by the juxtamembrane and C-terminal tail: a molecular dynamics study.

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Conformational dynamics of the EGFR kinase domain reveals structural features involved in activation.

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Mechanism of activation and inhibition of the HER4/ErbB4 kinase

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Design, synthesis and biological evaluation of pyrazolyl-thiazolinone derivatives as potential EGFR and HER-2 kinase inhibitors

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ErbB3/HER3 intracellular domain is competent to bind ATP and catalyze autophosphorylation

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21 January 2018

Molecular dynamics analysis of conserved hydrophobic and hydrophilic bond-interaction networks in ErbB family kinases

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21 January 2018

Atomistic insights into regulatory mechanisms of the HER2 tyrosine kinase domain: a molecular dynamics study

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21 January 2018

A multiscale modeling approach to investigate molecular mechanisms of pseudokinase activation and drug resistance in the HER3/ErbB3 receptor tyrosine kinase signaling network

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21 January 2018

The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP

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An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor

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Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface

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Ectodomain orientation, conformational plasticity and oligomerization of ErbB1 receptors investigated by molecular dynamics.

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Human epidermal growth factor receptor (HER1) aligned on the plasma membrane adopts key features of Drosophila EGFR asymmetry

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1 reference

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Molecular dynamics simulation approach for the prediction of transmembrane helix-helix heterodimers assembly

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On the antibacterial action of cyclic peptides: insights from coarse-grained MD simulations

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Phase II study of weekly intravenous recombinant humanized anti-p185HER2 monoclonal antibody in patients with HER2/neu-overexpressing metastatic breast cancer

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Correlated motions and propagation of the effect of a local conformational change in the transmembrane helix of the c-erb B2 encoded protein and its V659E mutant, studied by molecular dynamics simulations

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Combining an Elastic Network With a Coarse-Grained Molecular Force Field: Structure, Dynamics, and Intermolecular Recognition

1 reference

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based on heuristic

inferred from PubMed ID database lookup

Insight into the recognition patterns of the ErbB receptor family transmembrane domains: heterodimerization models through molecular dynamics search

1 reference

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based on heuristic

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Dimeric structure of the transmembrane domain of glycophorin a in lipidic and detergent environments

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1 reference

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Identifiers

10.1007/S10822-014-9787-2

1 reference

Europe PubMed Central

PubMed publication ID

5 May 2018

http://europepmc.org/abstract/MED/25129484

DBLP publication ID

journals/jcamd/Franco-GonzalezRCM14

1 reference

DBLP Dataset 2021-01-02

28 January 2021

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

5 May 2018

http://europepmc.org/abstract/MED/25129484

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