(Q53215699)

12 May 2018

title

Apolipoprotein E, A beta-amyloid, and the molecular pathology of Alzheimer's disease. Therapeutic implications. (English)

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12 May 2018

author

Gunnar K. Gouras

2

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12 May 2018

Paul Greengard

6

object named as

Greengard P

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12 May 2018

Kaplitt M

1

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12 May 2018

Makimura H

3

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12 May 2018

Jovanovic J

4

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12 May 2018

Sweeney D

5

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12 May 2018

Relkin NR

7

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12 May 2018

Gandy S

8

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12 May 2018

language of work or name

English

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publication date

1 December 1996

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12 May 2018

Annals of the New York Academy of Sciences

published in

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12 May 2018

volume

802

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12 May 2018

page(s)

42-49

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12 May 2018

Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells

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Apolipoprotein E mRNA is abundant in the brain and adrenals, as well as in the liver, and is present in other peripheral tissues of rats and marmosets

21 January 2018

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Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

21 January 2018

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Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease.

21 January 2018

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Apolipoprotein E: a pathological chaperone protein in patients with cerebral and systemic amyloid

21 January 2018

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Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease

21 January 2018

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The apolipoprotein epsilon 4 allele in patients with Alzheimer's disease

21 January 2018

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Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

21 January 2018

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Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease

21 January 2018

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Apolipoprotein E allele epsilon 4 is linked to increased deposition of the amyloid beta-peptide (A-beta) in cases with or without Alzheimer's disease.

21 January 2018

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Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease

21 January 2018

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The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

21 January 2018

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A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors

21 January 2018

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A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid

21 January 2018

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Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

21 January 2018

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Release of excess amyloid beta protein from a mutant amyloid beta protein precursor.

21 January 2018

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Peptides homologous to the amyloid protein of Alzheimer's disease containing a glutamine for glutamic acid substitution have accelerated amyloid fibril formation.

21 January 2018

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An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

21 January 2018

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Differential expression of amyloid precursor protein mRNAs in cases of Alzheimer's disease and in aged nonhuman primates.

21 January 2018

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Amyloidogenesis in Alzheimer's disease: some possible therapeutic opportunities

21 January 2018

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APP processing, A beta-amyloidogenesis, and the pathogenesis of Alzheimer's disease

21 January 2018

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Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1749-6632.1996.TB32597.X

Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1996.TB32597.X

Cleavage of amyloid beta peptide during constitutive processing of its precursor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1996.TB32597.X

Processing of the Amyloid Protein Precursor to Potentially Amyloidogenic Derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1996.TB32597.X

Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1996.TB32597.X

Chloroquine inhibits intracellular degradation but not secretion of Alzheimer beta/A4 amyloid precursor protein

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1749-6632.1996.TB32597.X

Secretion of beta-amyloid precursor protein cleaved at the amino terminus of the beta-amyloid peptide

21 January 2018

1 reference

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Alzheimer beta/A4 amyloid precursor protein in human brain: aging-associated increases in holoprotein and in a proteolytic fragment

21 January 2018

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Alzheimer beta/A4-amyloid precursor protein: evidence for putative amyloidogenic fragment

21 January 2018

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Potentially Amyloidogenic, Carboxyl-Terminal Derivatives of the Amyloid Protein Precursor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1996.TB32597.X

Identification of a stable fragment of the Alzheimer amyloid precursor containing the beta-protein in brain microvessels

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1996.TB32597.X

Amyloid beta-peptide is produced by cultured cells during normal metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1996.TB32597.X

Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1996.TB32597.X

Production of the Alzheimer amyloid beta protein by normal proteolytic processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1996.TB32597.X

Alzheimer's disease and soluble A beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1996.TB32597.X

Expression of apolipoprotein E during nerve degeneration and regeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1996.TB32597.X

Hypothesis: microtubule instability and paired helical filament formation in the Alzheimer disease brain are related to apolipoprotein E genotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1996.TB32597.X

Genetic associations with human longevity at the APOE and ACE loci

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1996.TB32597.X

Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1996.TB32597.X

Protective effect of apoE epsilon 2 in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1996.TB32597.X

Protection against Alzheimer's disease with apoE epsilon 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1996.TB32597.X

Frequency of the apolipoprotein E epsilon 2 allele is diminished in sporadic Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1996.TB32597.X

Solvation Effects on the Conformational Behaviour of Gellan and Calcium Ion Binding to Gellan Double Helices

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1996.TB32597.X

Amyloid-associated proteins α1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1996.TB32597.X

Apolipoprotein E associates with beta amyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3

21 January 2018

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1111/J.1749-6632.1996.TB32597.X

Processing of Alzheimer A beta-amyloid precursor protein: cell biology, regulation, and role in Alzheimer disease

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1111/J.1749-6632.1996.TB32597.X

Isolation and characterization of apolipoprotein E

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1111/J.1749-6632.1996.TB32597.X

Apolipoprotein E in sporadic Alzheimer's disease: allelic variation and receptor interactions

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1111/J.1749-6632.1996.TB32597.X

Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1111/J.1749-6632.1996.TB32597.X

Apolipoprotein E, epsilon 4 allele as a major risk factor for sporadic early and late-onset forms of Alzheimer's disease: analysis of the 19q13.2 chromosomal region.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1111/J.1749-6632.1996.TB32597.X

Identifiers

DOI

10.1111/J.1749-6632.1996.TB32597.X

1 reference

12 May 2018

1 reference

12 May 2018