(Q53421991)

14 May 2018

title

Calpastatin, an endogenous calpain-inhibitor protein, regulates the cleavage of the Cdk5 activator p35 to p25. (English)

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14 May 2018

author

Florian Plattner

4

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14 May 2018

Ko Sato

object named as

Ko Sato

1

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author name string

Seiji Minegishi

2

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14 May 2018

Jiro Takano

3

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14 May 2018

Taro Saito

5

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14 May 2018

Akiko Asada

6

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14 May 2018

Hiroyuki Kawahara

7

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14 May 2018

Nobuhisa Iwata

8

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14 May 2018

Takaomi C Saido

9

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14 May 2018

Shin-ichi Hisanaga

10

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14 May 2018

language of work or name

English

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publication date

15 March 2011

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14 May 2018

Journal of Neurochemistry

published in

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14 May 2018

volume

117

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14 May 2018

issue

3

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14 May 2018

page(s)

504-515

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14 May 2018

Neuronal calcium signaling

cites work

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07222.X

Mechanistic role of calpains in postischemic neurodegeneration

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Cdk5 deregulation in the pathogenesis of Alzheimer's disease

21 January 2018

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p25/cyclin-dependent kinase 5 induces production and intraneuronal accumulation of amyloid beta in vivo.

21 January 2018

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21 January 2018

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Protein degradation and protection against misfolded or damaged proteins

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21 January 2018

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Lack of phenotype for LTP and fear conditioning learning in calpain 1 knock-out mice

21 January 2018

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

21 January 2018

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Distinct mechanistic roles of calpain and caspase activation in neurodegeneration as revealed in mice overexpressing their specific inhibitors.

21 January 2018

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Understanding molecular mechanisms of proteolysis in Alzheimer's disease: progress toward therapeutic interventions

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Regulation and role of cyclin-dependent kinase activity in neuronal survival and death

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Enhanced activation of Ca2+/calmodulin-dependent protein kinase II upon downregulation of cyclin-dependent kinase 5-p35.

21 January 2018

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Recent advances in understanding the roles of Cdk5 in synaptic plasticity

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Neurotoxicity induces cleavage of p35 to p25 by calpain

21 January 2018

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Proteasome inhibitor PS-341 (bortezomib) induces calpain-dependent IkappaB(alpha) degradation

21 January 2018

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Calpain activation promotes BACE1 expression, amyloid precursor protein processing, and amyloid plaque formation in a transgenic mouse model of Alzheimer disease

21 January 2018

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Calpain in the CNS: from synaptic function to neurotoxicity

21 January 2018

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Membrane association facilitates degradation and cleavage of the cyclin-dependent kinase 5 activators p35 and p39.

21 January 2018

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A Ca(2+) switch aligns the active site of calpain

21 January 2018

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Comprehensive behavioral phenotyping of calpastatin-knockout mice

21 January 2018

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Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death

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Effects of the English (H6R) and Tottori (D7N) familial Alzheimer disease mutations on amyloid beta-protein assembly and toxicity

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Monoclonal antibody PHF-1 recognizes tau protein phosphorylated at serine residues 396 and 404.

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p35, the neuronal-specific activator of cyclin-dependent kinase 5 (Cdk5) is degraded by the ubiquitin-proteasome pathway.

21 January 2018

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Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

21 January 2018

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Calpains: attractive targets for the development of synthetic inhibitors

21 January 2018

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The roles of cyclin-dependent kinase 5 and glycogen synthase kinase 3 in tau hyperphosphorylation.

21 January 2018

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Marked calpastatin (CAST) depletion in Alzheimer's disease accelerates cytoskeleton disruption and neurodegeneration: neuroprotection by CAST overexpression

21 January 2018

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Regulation of membrane association and kinase activity of Cdk5-p35 by phosphorylation of p35.

21 January 2018

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The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium

21 January 2018

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21 January 2018

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Calpain mediates excitotoxic DNA fragmentation via mitochondrial pathways in adult brains: evidence from calpastatin mutant mice.

21 January 2018

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21 January 2018

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Calpain-mediated degradation of p35 to p25 in postmortem human and rat brains.

21 January 2018

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Differential neuroprotection by cyclosporin A and FK506 following ischemia corresponds with differing abilities to inhibit calcineurin and the mitochondrial permeability transition

21 January 2018

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Calpastatin levels affect calpain activation and calpain proteolytic activity in APP transgenic mouse model of Alzheimer's disease.

21 January 2018

1 reference

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Control of cyclin-dependent kinase 5 (Cdk5) activity by glutamatergic regulation of p35 stability

21 January 2018

1 reference

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Transcriptional regulation of beta-secretase by p25/cdk5 leads to enhanced amyloidogenic processing

21 January 2018

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Calpain-mediated mGluR1alpha truncation: a key step in excitotoxicity

21 January 2018

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A Cdk5 inhibitory peptide reduces tau hyperphosphorylation and apoptosis in neurons

21 January 2018

1 reference

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10.1111/J.1471-4159.2011.07222.X

21 January 2018

Identifiers

DOI

1 reference

14 May 2018

PubMed ID

21338355

1 reference

14 May 2018