(Q53707434)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29467300%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

title

High-throughput metabolomic analysis predicts mode of action of uncharacterized antimicrobial compounds (English)

1 reference

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17 March 2020

2

1 reference

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17 March 2020

Andrej Trauner

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29467300%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Balázs Papp

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29467300%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Mattia Zampieri

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29467300%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Maria Virginia Buchieri

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29467300%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Paola Picotti

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29467300%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Sébastien Gagneux

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29467300%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Joel Lelievre

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29467300%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Uwe Sauer

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29467300%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

author name string

Ilaria Piazza

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29467300%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Sonia Borrell

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29467300%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Brigitte Gicquel

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29467300%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

language of work or name

English

0 references

publication date

1 February 2018

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29467300%20AND%20SRC:MED&resulttype=core&format=json

Science Translational Medicine

17 March 2020

published in

1 reference

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17 March 2020

volume

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29467300%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

issue

429

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29467300%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

17 March 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6544516/fullTextXML

inferred from PubMed Central ID database lookup

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An antifungal agent inhibits an aminoacyl-tRNA synthetase by trapping tRNA in the editing site

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Activity motifs reveal principles of timing in transcriptional control of the yeast metabolic network

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Discovery of drug mode of action and drug repositioning from transcriptional responses

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Identification of small molecules enhancing autophagic function from drug network analysis

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Chemical probes of Escherichia coli uncovered through chemical-chemical interaction profiling with compounds of known biological activity

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High-throughput generation, optimization and analysis of genome-scale metabolic models

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A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy

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12 December 2020

Artificial gene amplification reveals an abundance of promiscuous resistance determinants in Escherichia coli

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12 December 2020

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12 December 2020

Reevaluation of moxifloxacin pharmacokinetics and their direct effect on the QT interval

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12 December 2020

High-throughput, accurate mass metabolome profiling of cellular extracts by flow injection-time-of-flight mass spectrometry.

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12 December 2020

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12 December 2020

Predicting the in vivo mechanism of action for drug leads using NMR metabolomics

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12 December 2020

MmpL3 is the cellular target of the antitubercular pyrrole derivative BM212

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12 December 2020

Metabolomic high-content nuclear magnetic resonance-based drug screening of a kinase inhibitor library

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12 December 2020

Chemical informatics and target identification in a zebrafish phenotypic screen.

1 reference

12 December 2020

SQ109 targets MmpL3, a membrane transporter of trehalose monomycolate involved in mycolic acid donation to the cell wall core of Mycobacterium tuberculosis

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12 December 2020

Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane

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12 December 2020

Fueling open-source drug discovery: 177 small-molecule leads against tuberculosis

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12 December 2020

Cell death from antibiotics without the involvement of reactive oxygen species

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12 December 2020

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Novel quinoline derivatives as inhibitors of bacterial DNA gyrase and topoisomerase IV.

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12 December 2020

Tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide and N-benzyl-6',7'-dihydrospiro[piperidine-4,4'-thieno[3,2-c]pyran] analogues with bactericidal efficacy against Mycobacterium tuberculosis targeting MmpL3

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12 December 2020

The Mycobacterium tuberculosis secreted protein Rv0203 transfers heme to membrane proteins MmpL3 and MmpL11.

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12 December 2020

para-Aminosalicylic acid is a prodrug targeting dihydrofolate reductase in Mycobacterium tuberculosis

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12 December 2020

Phenotypic screens as a renewed approach for drug discovery

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12 December 2020

Bacterial cytological profiling rapidly identifies the cellular pathways targeted by antibacterial molecules

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12 December 2020

Large-scale cytological profiling for functional analysis of bioactive compounds.

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12 December 2020

Target prediction for an open access set of compounds active against Mycobacterium tuberculosis

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12 December 2020

Metabolic suppression identifies new antibacterial inhibitors under nutrient limitation

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12 December 2020

Path2Models: large-scale generation of computational models from biochemical pathway maps

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12 December 2020

A screen for and validation of prodrug antimicrobials

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12 December 2020

Indoleamides are active against drug-resistant Mycobacterium tuberculosis

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12 December 2020

The antituberculosis antibiotic capreomycin inhibits protein synthesis by disrupting interaction between ribosomal proteins L12 and L10.

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12 December 2020

Deducing the mechanism of action of compounds identified in phenotypic screens by integrating their multiparametric profiles with a reference genetic screen

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12 December 2020

Opposing effects of target overexpression reveal drug mechanisms

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12 December 2020

Novel insights into the mechanism of inhibition of MmpL3, a target of multiple pharmacophores in Mycobacterium tuberculosis

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

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Elucidating Compound Mechanism of Action by Network Perturbation Analysis.

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A High-Throughput Screen to Identify LRRK2 Kinase Inhibitors for the Treatment of Parkinson's Disease Using RapidFire Mass Spectrometry

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12 December 2020

Bactericidal Antibiotics Induce Toxic Metabolic Perturbations that Lead to Cellular Damage

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

Therapeutic Potential of the Mycobacterium tuberculosis Mycolic Acid Transporter, MmpL3

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12 December 2020

THPP target assignment reveals EchA6 as an essential fatty acid shuttle in mycobacteria

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12 December 2020

Synergistic Interactions of MmpL3 Inhibitors with Antitubercular Compounds In Vitro

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12 December 2020

Metabolic constraints on the evolution of antibiotic resistance.

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12 December 2020

Nontargeted Metabolomics Reveals the Multilevel Response to Antibiotic Perturbations.

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12 December 2020

MmpL3 is the flippase for mycolic acids in mycobacteria

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12 December 2020

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12 December 2020

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24 October 2022

https://opencitations.net/index/coci/api/v1/citations/10.1016/J.CBPA.2016.12.006

Identifiers

DOI

10.1126/SCITRANSLMED.AAL3973

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29467300%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29467300%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

1 reference