(Q54629048)

1 June 2018

title

Dynamic ligand binding dictates partial agonism at a G protein-coupled receptor. (English)

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1 June 2018

G protein-coupled receptor

main subject

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7

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Marco De Amici

11

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Ulrike Holzgrabe

12

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Andreas Bock

object named as

Andreas Bock

1

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author name string

Brian Chirinda

2

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1 June 2018

Fabian Krebs

3

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Regina Messerer

4

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1 June 2018

Julia Bätz

5

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Mathias Muth

6

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Dominika Klingenthal

8

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1 June 2018

Christian Tränkle

9

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Carsten Hoffmann

10

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Evi Kostenis

13

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1 June 2018

Klaus Mohr

14

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1 June 2018

publication date

10 November 2013

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1 June 2018

published in

Nature Chemical Biology

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1 June 2018

volume

10

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issue

1

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page(s)

18-20

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Seven-transmembrane receptors

cites work

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.1384

Molecular signatures of G-protein-coupled receptors

21 January 2018

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Efficacy at G-protein-coupled receptors

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Signalling bias in new drug discovery: detection, quantification and therapeutic impact.

21 January 2018

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The structure and function of G-protein-coupled receptors

21 January 2018

1 reference

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The structural basis for agonist and partial agonist action on a β(1)-adrenergic receptor

21 January 2018

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Probing the beta2 adrenoceptor binding site with catechol reveals differences in binding and activation by agonists and partial agonists

21 January 2018

1 reference

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Coupling ligand structure to specific conformational switches in the beta2-adrenoceptor

21 January 2018

1 reference

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Efficacy of the β₂-adrenergic receptor is determined by conformational equilibrium in the transmembrane region

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1384

Fluorescence resonance energy transfer analysis of alpha 2a-adrenergic receptor activation reveals distinct agonist-specific conformational changes.

21 January 2018

1 reference

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Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery

21 January 2018

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The dynamic process of β(2)-adrenergic receptor activation

21 January 2018

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Coupling of receptor conformation and ligand orientation determine graded activity

21 January 2018

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How many drug targets are there?

21 January 2018

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Dualsteric GPCR targeting: a novel route to binding and signaling pathway selectivity

21 January 2018

1 reference

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The allosteric vestibule of a seven transmembrane helical receptor controls G-protein coupling

21 January 2018

1 reference

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Deconvolution of complex G protein-coupled receptor signaling in live cells using dynamic mass redistribution measurements.

21 January 2018

1 reference

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Applying label-free dynamic mass redistribution technology to frame signaling of G protein-coupled receptors noninvasively in living cells.

21 January 2018

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Synthesis and functional characterization of novel derivatives related to oxotremorine and oxotremorine-M.

21 January 2018

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Design, synthesis, and action of oxotremorine-related hybrid-type allosteric modulators of muscarinic acetylcholine receptors

21 January 2018

1 reference

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Agonists with supraphysiological efficacy at the muscarinic M2 ACh receptor.

21 January 2018

1 reference

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A FlAsH-based FRET approach to determine G protein-coupled receptor activation in living cells

21 January 2018

1 reference

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Allosteric small molecules unveil a role of an extracellular E2/transmembrane helix 7 junction for G protein-coupled receptor activation

21 January 2018

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Allosteric Modulation of G Protein–Coupled Receptors

21 January 2018

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Estimation of agonist activity at G protein-coupled receptors: analysis of M2 muscarinic receptor signaling through Gi/o,Gs, and G15.

21 January 2018

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Convergent, short synthesis of the muscarinic superagonist iperoxo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1384

Allosteric interactions with muscarinic acetylcholine receptors: complex role of the conserved tryptophan M2422Trp in a critical cluster of amino acids for baseline affinity, subtype selectivity, and cooperativity

21 January 2018

1 reference

12 December 2020

Operational models of pharmacological agonism.

1 reference

12 December 2020

A simple method for estimation of agonist activity at receptor subtypes: comparison of native and cloned M3 muscarinic receptors in guinea pig ileum and transfected cells

1 reference

12 December 2020

Molecular basis of partial agonism at the neurotransmitter alpha2A-adrenergic receptor and Gi-protein heterotrimer

1 reference

12 December 2020

Estimation of the affinities of allosteric ligands using radioligand binding and pharmacological null methods.

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12 December 2020

Identifiers

DOI

10.1038/NCHEMBIO.1384

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1 June 2018

Dimensions Publication ID

1018530891

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1 June 2018