(Q57652670)

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Insights into the programmed ketoreduction of partially reducing polyketide synthases: stereo- and substrate-specificity of the ketoreductase domain

scientific article published on 01 November 2014

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16 February 2020

Insights into the programmed ketoreduction of partially reducing polyketide synthases: stereo- and substrate-specificity of the ketoreductase domain (English)

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16 February 2020

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16 February 2020

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Ishin Soehano

1

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16 February 2020

Lifeng Yang

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16 February 2020

Xuewei Liu

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16 February 2020

publication date

1 November 2014

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16 February 2020

Organic and Biomolecular Chemistry

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16 February 2020

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16 February 2020

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16 February 2020

8542-8549

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16 February 2020

The biosynthesis, molecular genetics and enzymology of the polyketide-derived metabolites

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6-MSAS-like polyketide synthase genes occur in lichenized ascomycetes

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The neocarzinostatin biosynthetic gene cluster from Streptomyces carzinostaticus ATCC 15944 involving two iterative type I polyketide synthases

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Neocarzinostatin naphthoate synthase: an unique iterative type I PKS from neocarzinostatin producer Streptomyces carzinostaticus.

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Characterization of the azinomycin B biosynthetic gene cluster revealing a different iterative type I polyketide synthase for naphthoate biosynthesis

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21 January 2018

Synthesis of (R)-Mellein by a Partially Reducing Iterative Polyketide Synthase

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21 January 2018

Polyketide chain length control by chain length factor

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21 January 2018

Understanding substrate specificity of polyketide synthase modules by generating hybrid multimodular synthases.

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21 January 2018

Structural basis for biosynthetic programming of fungal aromatic polyketide cyclization

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21 January 2018

Purification and properties of 6-methylsalicylic acid synthase from Penicillium patulum

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21 January 2018

Structural similarities between 6-methylsalicylic acid synthase from Penicillium patulum and vertebrate type I fatty acid synthase: evidence from thiol modification studies

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21 January 2018

Hidden function of catalytic domain in 6-methylsalicylic acid synthase for product release

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21 January 2018

Stereochemistry of catalysis by the ketoreductase activity in the first extension module of the erythromycin polyketide synthase

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21 January 2018

The crystal structure of the actIII actinorhodin polyketide reductase: proposed mechanism for ACP and polyketide binding

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21 January 2018

Broad substrate specificity of ketoreductases derived from modular polyketide synthases.

1 reference

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21 January 2018

Stereospecificity of ketoreductase domains of the 6-deoxyerythronolide B synthase

1 reference

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21 January 2018

A tylosin ketoreductase reveals how chirality is determined in polyketides

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21 January 2018

The crystal structure of a mammalian fatty acid synthase

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21 January 2018

The biochemical basis for stereochemical control in polyketide biosynthesis

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21 January 2018

Insights into the stereospecificity of ketoreduction in a modular polyketide synthase

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21 January 2018

Structural and functional analysis of C2-type ketoreductases from modular polyketide synthases

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21 January 2018

Structural Studies of an A2-Type Modular Polyketide Synthase Ketoreductase Reveal Features Controlling α-Substituent Stereochemistry

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21 January 2018

Structural and functional analysis of A-type ketoreductases from the amphotericin modular polyketide synthase

1 reference

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21 January 2018

Structural and Biochemical Studies of the Hedamycin Type II Polyketide Ketoreductase ( Hed KR): Molecular Basis of Stereo- and Regiospecificities

1 reference

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21 January 2018

Structural and Biochemical Analyses of Regio- and Stereospecificities Observed in a Type II Polyketide Ketoreductase

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21 January 2018

Divergence of multimodular polyketide synthases revealed by a didomain structure

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21 January 2018

Substrate-dependent stereospecificity of Tyl-KR1: an isolated polyketide synthase ketoreductase domain from Streptomyces fradiae.

1 reference

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21 January 2018

Coupled methyl group epimerization and reduction by polyketide synthase ketoreductase domains. Ketoreductase-catalyzed equilibrium isotope exchange

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21 January 2018

The structures of type I polyketide synthases

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21 January 2018

The structure of a ketoreductase determines the organization of the beta-carbon processing enzymes of modular polyketide synthases.

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21 January 2018

Structural and functional studies of atrans-acyltransferase polyketide assembly line enzyme that catalyzes stereoselective α- and β-ketoreduction

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21 January 2018

The type I fatty acid and polyketide synthases: a tale of two megasynthases

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21 January 2018

A fungal ketoreductase domain that displays substrate-dependent stereospecificity

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Emergence of diverse biochemical activities in evolutionarily conserved structural scaffolds of proteins

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Probing the selectivity and protein·protein interactions of a nonreducing fungal polyketide synthase using mechanism-based crosslinkers.

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21 January 2018

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Identifiers

10.1039/C4OB01777C

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25238086%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25238086%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

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