(Q59341026)

CD8-positive T-lymphocytes

18 October 2019

1 reference

8 April 2021

Marie Larsson

9

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Alireza Saeidi

1

object named as

Alireza Saeidi

0 references

Keivan Zandi

2

object named as

Keivan Zandi

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author name string

Yi Ying Cheok

3

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Hamidreza Saeidi

4

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Won Fen Wong

5

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Chalystha Yie Qin Lee

6

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Heng Choon Cheong

7

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Yean Kong Yong

8

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Esaki Muthu Shankar

Creative Commons Attribution 4.0 International

10

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language of work or name

English

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publication date

2018

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9 November 2018

3 references

12 October 2019

18 October 2019

8 April 2021

Frontiers in Immunology

3 references

12 October 2019

18 October 2019

8 April 2021

9

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page(s)

2569

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copyright license

3 references

Europe PubMed Central

12 October 2019

Europe PubMed Central

18 October 2019

Europe PubMed Central

Metabolic alterations associated with proliferation of mitogen-activated lymphocytes and of lymphoblastoid cell lines: evaluation of glucose and glutamine metabolism

8 April 2021

cites work

1 reference

12 December 2020

Lymphocyte responses and cytokines

1 reference

12 December 2020

Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells

1 reference

12 December 2020

Induction and exhaustion of lymphocytic choriomeningitis virus-specific cytotoxic T lymphocytes visualized using soluble tetrameric major histocompatibility complex class I-peptide complexes.

1 reference

12 December 2020

Viral immune evasion due to persistence of activated T cells without effector function

1 reference

12 December 2020

Assessing CD8 T cell number and dysfunction in the presence of antigen

1 reference

12 December 2020

PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine

1 reference

12 December 2020

PD-1:PD-L inhibitory pathway affects both CD4(+) and CD8(+) T cells and is overcome by IL-2

1 reference

12 December 2020

Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells

1 reference

12 December 2020

Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment

1 reference

12 December 2020

Viral targeting of hematopoietic progenitors and inhibition of DC maturation as a dual strategy for immune subversion

1 reference

12 December 2020

Differential tissue-specific regulation of antiviral CD8+ T-cell immune responses during chronic viral infection

1 reference

12 December 2020

Maintenance, loss, and resurgence of T cell responses during acute, protracted, and chronic viral infections

1 reference

12 December 2020

Memory CD8 T-cell differentiation during viral infection

1 reference

12 December 2020

SHP-1 and SHP-2 associate with immunoreceptor tyrosine-based switch motif of programmed death 1 upon primary human T cell stimulation, but only receptor ligation prevents T cell activation

1 reference

12 December 2020

PD-1 inhibits T-cell receptor induced phosphorylation of the ZAP70/CD3zeta signalosome and downstream signaling to PKCtheta

1 reference

12 December 2020

CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms

1 reference

12 December 2020

Restoring function in exhausted CD8 T cells during chronic viral infection

1 reference

12 December 2020

Formation of elongated giant mitochondria in DFO-induced cellular senescence: involvement of enhanced fusion process through modulation of Fis1

1 reference

12 December 2020

Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction

1 reference

12 December 2020

PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression

1 reference

12 December 2020

PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection

1 reference

12 December 2020

PD-1 Expression in Acute Hepatitis C Virus (HCV) Infection Is Associated with HCV-Specific CD8 Exhaustion

1 reference

12 December 2020

Resolution of a chronic viral infection after interleukin-10 receptor blockade

1 reference

12 December 2020

Increased mitochondrial mass characterizes the survival defect of HIV-specific CD8(+) T cells

1 reference

12 December 2020

Effector and memory CTL differentiation

1 reference

12 December 2020

Liver-Infiltrating Lymphocytes in Chronic Human Hepatitis C Virus Infection Display an Exhausted Phenotype with High Levels of PD-1 and Low Levels of CD127 Expression

1 reference

12 December 2020

Characterization of hepatitis B virus (HBV)-specific T-cell dysfunction in chronic HBV infection

1 reference

12 December 2020

IL-10, T cell exhaustion and viral persistence

1 reference

12 December 2020

Impaired NFAT nuclear translocation results in split exhaustion of virus-specific CD8+ T cell functions during chronic viral infection.

1 reference

12 December 2020

Identification of a human CD8+ regulatory T cell subset that mediates suppression through the chemokine CC chemokine ligand 4.

1 reference

12 December 2020

Upregulation of PD-1 Expression on Circulating and Intrahepatic Hepatitis C Virus-Specific CD8+ T Cells Associated with Reversible Immune Dysfunction

1 reference

12 December 2020

Requirement for T-bet in the aberrant differentiation of unhelped memory CD8+ T cells.

1 reference

12 December 2020

Viral targeting of fibroblastic reticular cells contributes to immunosuppression and persistence during chronic infection

1 reference

12 December 2020

Molecular signature of CD8+ T cell exhaustion during chronic viral infection.

1 reference

12 December 2020

Functional Restoration of HCV-Specific CD8 T Cells by PD-1 Blockade Is Defined by PD-1 Expression and Compartmentalization

1 reference

12 December 2020

Selective expansion of a subset of exhausted CD8 T cells by alphaPD-L1 blockade

1 reference

12 December 2020

The role of secondary lymphatic tissue in immune deficiency of HIV infection.

1 reference

12 December 2020

Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection.

1 reference

12 December 2020

IL-10 and PD-L1 operate through distinct pathways to suppress T-cell activity during persistent viral infection

1 reference

12 December 2020

Enhancing SIV-specific immunity in vivo by PD-1 blockade

1 reference

12 December 2020

IL-10 is up-regulated in multiple cell types during viremic HIV infection and reversibly inhibits virus-specific T cells

1 reference

12 December 2020

PD-1 and CTLA-4 inhibitory cosignaling pathways in HIV infection and the potential for therapeutic intervention

1 reference

12 December 2020

IL-21 is required to control chronic viral infection

1 reference

12 December 2020

PD-1 signaling in primary T cells

1 reference

12 December 2020

IL-21R on T cells is critical for sustained functionality and control of chronic viral infection

1 reference

12 December 2020

Enhancing CD8 T-cell memory by modulating fatty acid metabolism

1 reference

12 December 2020

A role for the transcriptional repressor Blimp-1 in CD8(+) T cell exhaustion during chronic viral infection.

1 reference

12 December 2020

The mTOR kinase determines effector versus memory CD8+ T cell fate by regulating the expression of transcription factors T-bet and Eomesodermin

1 reference

12 December 2020

T-cell exhaustion: characteristics, causes and conversion

1 reference

12 December 2020

Repetitive antigen stimulation induces stepwise transcriptome diversification but preserves a core signature of memory CD8(+) T cell differentiation

1 reference

12 December 2020

Pronounced virus-dependent activation drives exhaustion but sustains IFN-γ transcript levels

1 reference

12 December 2020

Differentiation and persistence of memory CD8(+) T cells depend on T cell factor 1

1 reference

12 December 2020

Transcriptional analysis of HIV-specific CD8+ T cells shows that PD-1 inhibits T cell function by upregulating BATF

1 reference

12 December 2020

Cutting edge: The transcription factor eomesodermin enables CD8+ T cells to compete for the memory cell niche.

1 reference

12 December 2020

Role of antigen persistence and dose for CD4+ T-cell exhaustion and recovery

1 reference

12 December 2020

Are senescence and exhaustion intertwined or unrelated processes that compromise immunity?

1 reference

12 December 2020

Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8+ T cell responses during chronic infection.

1 reference

12 December 2020

PD-L1 co-stimulation contributes to ligand-induced T cell receptor down-modulation on CD8+ T cells

1 reference

12 December 2020

1 reference

12 December 2020

Tight regulation of memory CD8(+) T cells limits their effectiveness during sustained high viral load

1 reference

12 December 2020

Chronic virus infection enforces demethylation of the locus that encodes PD-1 in antigen-specific CD8(+) T cells.

1 reference

12 December 2020

Regulation of immune responses by mTOR.

1 reference

12 December 2020

PD-1 blockade during chronic SIV infection reduces hyperimmune activation and microbial translocation in rhesus macaques

1 reference

12 December 2020

Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2.

1 reference

12 December 2020

Selective effects of PD-1 on Akt and Ras pathways regulate molecular components of the cell cycle and inhibit T cell proliferation

1 reference

12 December 2020

IL-10 mediated regulation of liver inflammation during acute murine cytomegalovirus infection

1 reference

12 December 2020

Transcriptional control of effector and memory CD8+ T cell differentiation

1 reference

12 December 2020

Network analysis reveals centrally connected genes and pathways involved in CD8+ T cell exhaustion versus memory.

1 reference

12 December 2020

Technical Advance: Fluorescent reporter reveals insights into eomesodermin biology in cytotoxic lymphocytes.

1 reference

12 December 2020

Progenitor and terminal subsets of CD8+ T cells cooperate to contain chronic viral infection.

1 reference

12 December 2020

In vivo blockade of the PD-1 receptor suppresses HIV-1 viral loads and improves CD4+ T cell levels in humanized mice

1 reference

12 December 2020

Evolving role of 2B4/CD244 in T and NK cell responses during virus infection.

1 reference

12 December 2020

Metabolic regulation of T lymphocytes

1 reference

12 December 2020

Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling.

1 reference

12 December 2020

Increased T-bet is associated with senescence of influenza virus-specific CD8 T cells in aged humans

1 reference

12 December 2020

Molecular signatures of T-cell inhibition in HIV-1 infection

1 reference

12 December 2020

The third signal cytokine IL-12 rescues the anti-viral function of exhausted HBV-specific CD8 T cells

1 reference

12 December 2020

PD-1 promotes immune exhaustion by inducing antiviral T cell motility paralysis

1 reference

12 December 2020

The integration of T cell migration, differentiation and function

1 reference

12 December 2020

Metabolic pathways in immune cell activation and quiescence

1 reference

12 December 2020

T cells expressing a chimeric antigen receptor that binds hepatitis B virus envelope proteins control virus replication in mice.

1 reference

12 December 2020

IL-21 restricts virus-driven Treg cell expansion in chronic LCMV infection.

1 reference

12 December 2020

A randomized, double-blind, placebo-controlled assessment of BMS-936558, a fully human monoclonal antibody to programmed death-1 (PD-1), in patients with chronic hepatitis C virus infection

1 reference

12 December 2020

Nivolumab plus ipilimumab in advanced melanoma

1 reference

12 December 2020

Networking at the level of host immunity: immune cell interactions during persistent viral infections

1 reference

12 December 2020

Cutting edge: Prolonged exposure to HIV reinforces a poised epigenetic program for PD-1 expression in virus-specific CD8 T cells

1 reference

12 December 2020

Role of regulatory T cells during virus infection

1 reference

12 December 2020

Myeloid-derived suppressor cells: the dark knight or the joker in viral infections?

1 reference

12 December 2020

Immunotherapy of chronic hepatitis C virus infection with antibodies against programmed cell death-1 (PD-1).

1 reference

12 December 2020

Hypoxia-inducible factors enhance the effector responses of CD8(+) T cells to persistent antigen.

1 reference

12 December 2020

Tolerance and exhaustion: defining mechanisms of T cell dysfunction

1 reference

12 December 2020

Genetic disruption of CD8+ Treg activity enhances the immune response to viral infection

1 reference

12 December 2020

Differential impact of PD-1 and/or interleukin-10 blockade on HIV-1-specific CD4 T cell and antigen-presenting cell functions

1 reference

12 December 2020

Blockade of PD-1 immunosuppression boosts CAR T-cell therapy

1 reference

12 December 2020

Molecular and transcriptional basis of CD4⁺ T cell dysfunction during chronic infection

1 reference

12 December 2020

Pathological functions of interleukin-22 in chronic liver inflammation and fibrosis with hepatitis B virus infection by promoting T helper 17 cell recruitment

1 reference

12 December 2020

Interleukin-21: a double-edged sword with therapeutic potential

1 reference

12 December 2020

Epigenetic manipulation restores functions of defective CD8⁺ T cells from chronic viral infection

1 reference

12 December 2020

Interplay between regulatory T cells and PD-1 in modulating T cell exhaustion and viral control during chronic LCMV infection

1 reference

12 December 2020

Transforming growth factor β-mediated suppression of antitumor T cells requires FoxP1 transcription factor expression

1 reference

12 December 2020

The Many Unknowns Concerning the Bioenergetics of Exhaustion and Senescence during Chronic Viral Infection

1 reference

12 December 2020

The transcription factor FoxO1 sustains expression of the inhibitory receptor PD-1 and survival of antiviral CD8(+) T cells during chronic infection

1 reference

12 December 2020

Chronic hepatitis C virus infection triggers spontaneous differential expression of biosignatures associated with T cell exhaustion and apoptosis signaling in peripheral blood mononucleocytes

1 reference

12 December 2020

Manipulating IL-10 signalling blockade for better immunotherapy.

1 reference

12 December 2020

T cell exhaustion during persistent viral infections

1 reference

12 December 2020

The transcription factor NFAT promotes exhaustion of activated CD8⁺ T cells.

1 reference

12 December 2020

Retracted: The protein LEM promotes CD8⁺ T cell immunity through effects on mitochondrial respiration

1 reference

12 December 2020

Attrition of TCR Vα7.2+ CD161++ MAIT cells in HIV-tuberculosis co-infection is associated with elevated levels of PD-1 expression

1 reference

12 December 2020

Interleukin-17 and innate immunity in infections and chronic inflammation

1 reference

12 December 2020

Immune Response in Hepatitis B Virus Infection

1 reference

12 December 2020

Molecular and cellular insights into T cell exhaustion

1 reference

12 December 2020

Generation of knock-in primary human T cells using Cas9 ribonucleoproteins.

1 reference

12 December 2020

IL-21 and probiotic therapy improve Th17 frequencies, microbial translocation, and microbiome in ARV-treated, SIV-infected macaques

1 reference

12 December 2020

Adoptive Cell Therapy--Tumor-Infiltrating Lymphocytes, T-Cell Receptors, and Chimeric Antigen Receptors.

1 reference

12 December 2020

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

1 reference

12 December 2020

Peripheral loss of CD8(+) CD161(++) TCRVα7·2(+) mucosal-associated invariant T cells in chronic hepatitis C virus-infected patients

1 reference

12 December 2020

Activation of the PD-1/PD-L1 immune checkpoint confers tumor cell chemoresistance associated with increased metastasis.

1 reference

12 December 2020

The emerging role of interferon regulatory factor 9 in the antiviral host response and beyond

1 reference

12 December 2020

Metabolic regulation of immune responses: therapeutic opportunities

1 reference

12 December 2020

Distinct Metabolic Requirements of Exhausted and Functional Virus-Specific CD8 T Cells in the Same Host.

1 reference

12 December 2020

Human CAR T cells with cell-intrinsic PD-1 checkpoint blockade resist tumor-mediated inhibition

1 reference

12 December 2020

Demethylation of the PD-1 Promoter Is Imprinted during the Effector Phase of CD8 T Cell Exhaustion.

1 reference

12 December 2020

Blimp-1-mediated CD4 T cell exhaustion causes CD8 T cell dysfunction during chronic toxoplasmosis.

1 reference

12 December 2020

Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8(+) T Cell Exhaustion

1 reference

12 December 2020

Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy

1 reference

12 December 2020

Hepatitis C virus (HCV) RNA profiles among chronic HIV/HCV-coinfected individuals in ESPRIT; spontaneous HCV RNA clearance observed in nine individuals.

1 reference

12 December 2020

Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade

1 reference

12 December 2020

The epigenetic landscape of T cell exhaustion.

1 reference

12 December 2020

Dynamic Changes in Chromatin Accessibility Occur in CD8+ T Cells Responding to Viral Infection.

1 reference

12 December 2020

Targeting type I interferon-mediated activation restores immune function in chronic HIV infection

1 reference

12 December 2020

CAR T-cell therapy of solid tumors.

1 reference

12 December 2020

Targeting mitochondrial dysfunction can restore antiviral activity of exhausted HBV-specific CD8 T cells in chronic hepatitis B.

1 reference

12 December 2020

The role of metabolic reprogramming in T cell fate and function

1 reference

12 December 2020

Negative Checkpoint Regulatory Molecule 2B4 (CD244) Upregulation Is Associated with Invariant Natural Killer T Cell Alterations and Human Immunodeficiency Virus Disease Progression

1 reference

12 December 2020

Clinical Trial of the Anti-PD-L1 Antibody BMS-936559 in HIV-1 Infected Participants on Suppressive Antiretroviral Therapy

1 reference

12 December 2020

Mitochondrial Control and Guidance of Cellular Activities of T Cells

1 reference

12 December 2020

Regulation of inflammation by microbiota interactions with the host.

1 reference

12 December 2020

Persistent infection due to a small-colony variant of Burkholderia pseudomallei leads to PD-1 upregulation on circulating immune cells and mononuclear infiltration in viscera of experimental BALB/c mice.

1 reference

12 December 2020

IRF9 Prevents CD8+ T Cell Exhaustion in an Extrinsic Manner during Acute Lymphocytic Choriomeningitis Virus Infection

1 reference

12 December 2020

PD1 signal transduction pathways in T cells.

1 reference

12 December 2020

Unlocking the epigenetic code of T cell exhaustion

1 reference

12 December 2020

PD-1/PD-L1 interaction up-regulates MDR1/P-gp expression in breast cancer cells via PI3K/AKT and MAPK/ERK pathways

1 reference

12 December 2020

Transcription Factor IRF4 Promotes CD8+ T Cell Exhaustion and Limits the Development of Memory-like T Cells during Chronic Infection.

1 reference

12 December 2020

CD8 T Cell Exhaustion in Chronic Infection and Cancer: Opportunities for Interventions.

1 reference

12 December 2020

Hyper-Expression of PD-1 Is Associated with the Levels of Exhausted and Dysfunctional Phenotypes of Circulating CD161++TCR iVα7.2+ Mucosal-Associated Invariant T Cells in Chronic Hepatitis B Virus Infection.

1 reference

12 December 2020

A mobile endocytic network connects clathrin-independent receptor endocytosis to recycling and promotes T cell activation.

1 reference

12 December 2020

Epigenomic-Guided Mass Cytometry Profiling Reveals Disease-Specific Features of Exhausted CD8 T Cells

1 reference

12 December 2020

T cell senescence and CAR-T cell exhaustion in hematological malignancies.

1 reference

12 December 2020

Viral Persistence and Chronicity in Hepatitis C Virus Infection: Role of T-Cell Apoptosis, Senescence and Exhaustion

1 reference

12 December 2020