(Q60950122)

2

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Francesco Dotta

object named as

Francesco Dotta

7

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author name string

Laura Nigi

1

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Giuliana Ventriglia

3

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Noemi Brusco

4

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Francesca Mancarella

5

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Caterina Formichi

6

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Guido Sebastiani

International Journal of Molecular Sciences

8

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language of work or name

English

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publication date

22 November 2018

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13 March 2019

14 March 2019

24 March 2019

17 November 2019

20 November 2019

26 August 2020

14 November 2020

4 February 2021

8 references

13 March 2019

14 March 2019

24 March 2019

17 November 2019

20 November 2019

26 August 2020

14 November 2020

4 February 2021

19

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page(s)

3705

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issue

12

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copyright license

Creative Commons Attribution

8 references

13 March 2019

14 March 2019

24 March 2019

17 November 2019

20 November 2019

26 August 2020

14 November 2020

4 February 2021

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on focus list of Wikimedia project

ScienceSource

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cites work

The syndromes of insulin resistance and acanthosis nigricans. Insulin-receptor disorders in man.

1 reference

12 December 2020

Glycogen synthase kinase-3 from rabbit skeletal muscle. Separation from cyclic-AMP-dependent protein kinase and phosphorylase kinase

1 reference

12 December 2020

Expression, characterization, and crystallization of the catalytic core of the human insulin receptor protein-tyrosine kinase domain

1 reference

12 December 2020

Inhibition of the translocation of GLUT1 and GLUT4 in 3T3-L1 cells by the phosphatidylinositol 3-kinase inhibitor, wortmannin

1 reference

12 December 2020

Enhanced insulin action due to targeted GLUT4 overexpression exclusively in muscle.

1 reference

12 December 2020

Recombinant human insulin-like growth factor I increases insulin sensitivity and improves glycemic control in type II diabetes

1 reference

12 December 2020

Insulin signal transduction and the IRS proteins

1 reference

12 December 2020

Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation

1 reference

12 December 2020

Phosphorylation of insulin receptor substrate 1 by glycogen synthase kinase 3 impairs insulin action

1 reference

12 December 2020

Peripheral but not hepatic insulin resistance in mice with one disrupted allele of the glucose transporter type 4 (GLUT4) gene

1 reference

12 December 2020

GLUT4 heterozygous knockout mice develop muscle insulin resistance and diabetes

1 reference

12 December 2020

Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.

1 reference

12 December 2020

Prevention of insulin resistance and diabetes in mice heterozygous for GLUT4 ablation by transgenic complementation of GLUT4 in skeletal muscle.

1 reference

12 December 2020

The role of glycogen synthase kinase 3beta in insulin-stimulated glucose metabolism

1 reference

12 December 2020

Circulating levels of free insulin-like growth factors in obese subjects: the impact of type 2 diabetes.

1 reference

12 December 2020

Reduced glucose uptake precedes insulin signaling defects in adipocytes from heterozygous GLUT4 knockout mice

1 reference

12 December 2020

Potential role of glycogen synthase kinase-3 in skeletal muscle insulin resistance of type 2 diabetes

1 reference

12 December 2020

Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance.

1 reference

12 December 2020

Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver

1 reference

12 December 2020

Metabolic adaptations in skeletal muscle overexpressing GLUT4: effects on muscle and physical activity

1 reference

12 December 2020

Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

1 reference

12 December 2020

Defective insulin-induced GLUT4 translocation in skeletal muscle of high fat-fed rats is associated with alterations in both Akt/protein kinase B and atypical protein kinase C (zeta/lambda) activities

1 reference

12 December 2020

Functional inactivation of the IGF-I and insulin receptors in skeletal muscle causes type 2 diabetes

1 reference

12 December 2020

Circulating concentrations of insulin-like growth factor-I and development of glucose intolerance: a prospective observational study

1 reference

12 December 2020

Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor

1 reference

12 December 2020

The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth

1 reference

12 December 2020

The nuclear RNase III Drosha initiates microRNA processing

1 reference

12 December 2020

Insulin-like growth factor 1 promoter polymorphism influences insulin gene variable number of tandem repeat-associated risk for juvenile onset type 1 diabetes.

1 reference

12 December 2020

A family with severe insulin resistance and diabetes due to a mutation in AKT2.

1 reference

12 December 2020

PDK1, the master regulator of AGC kinase signal transduction

1 reference

12 December 2020

Identification of mammalian microRNA host genes and transcription units

1 reference

12 December 2020

Differential contribution of insulin receptor substrates 1 versus 2 to insulin signaling and glucose uptake in l6 myotubes.

1 reference

12 December 2020

A crucial role for GW182 and the DCP1:DCP2 decapping complex in miRNA-mediated gene silencing

1 reference

12 December 2020

Tissue-specific roles of IRS proteins in insulin signaling and glucose transport

1 reference

12 December 2020

miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting

1 reference

12 December 2020

Drosophila lacking microRNA miR-278 are defective in energy homeostasis

1 reference

12 December 2020

Critical nodes in signalling pathways: insights into insulin action

1 reference

12 December 2020

Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation

1 reference

12 December 2020

siRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle

1 reference

12 December 2020

mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes

1 reference

12 December 2020

Activated FOXO-mediated insulin resistance is blocked by reduction of TOR activity.

1 reference

12 December 2020

Regulation of insulin receptor function

1 reference

12 December 2020

Characterization and identification of microRNA core promoters in four model species

1 reference

12 December 2020

Switching from repression to activation: microRNAs can up-regulate translation

1 reference

12 December 2020

Isoform-specific defects of insulin stimulation of Akt/protein kinase B (PKB) in skeletal muscle cells from type 2 diabetic patients

1 reference

12 December 2020

Transgenic mice overexpressing human G972R IRS-1 show impaired insulin action and insulin secretion.

1 reference

12 December 2020

Emerging role for AS160/TBC1D4 and TBC1D1 in the regulation of GLUT4 traffic

1 reference

12 December 2020

Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation

1 reference

12 December 2020

miR-375 targets 3'-phosphoinositide-dependent protein kinase-1 and regulates glucose-induced biological responses in pancreatic beta-cells

1 reference

12 December 2020

Circulating microRNAs as stable blood-based markers for cancer detection

1 reference

12 December 2020

Chromatin structure analyses identify miRNA promoters

1 reference

12 December 2020

Unsaturated fatty acids inhibit the expression of tumor suppressor phosphatase and tensin homolog (PTEN) via microRNA-21 up-regulation in hepatocytes

1 reference

12 December 2020

Liver-specific deletion of protein-tyrosine phosphatase 1B (PTP1B) improves metabolic syndrome and attenuates diet-induced endoplasmic reticulum stress

1 reference

12 December 2020

Biogenesis of small RNAs in animals

1 reference

12 December 2020

MicroRNAs: target recognition and regulatory functions

1 reference

12 December 2020

MicroRNAs induced during adipogenesis that accelerate fat cell development are downregulated in obesity

1 reference

12 December 2020

Many roads to maturity: microRNA biogenesis pathways and their regulation

1 reference

12 December 2020

A C-terminal silencing domain in GW182 is essential for miRNA function

1 reference

12 December 2020

Features of mammalian microRNA promoters emerge from polymerase II chromatin immunoprecipitation data

1 reference

12 December 2020

CHANGES IN microRNA (miR) profile and effects of miR-320 in insulin-resistant 3T3-L1 adipocytes

1 reference

12 December 2020

Reciprocal regulation of microRNA-1 and insulin-like growth factor-1 signal transduction cascade in cardiac and skeletal muscle in physiological and pathological conditions

1 reference

12 December 2020

Structure and activity of putative intronic miRNA promoters

1 reference

12 December 2020

Specific roles of the p110alpha isoform of phosphatidylinsositol 3-kinase in hepatic insulin signaling and metabolic regulation

1 reference

12 December 2020

Plasma microRNA profiling reveals loss of endothelial miR-126 and other microRNAs in type 2 diabetes

1 reference

12 December 2020

Expression of adipose microRNAs is sensitive to dietary conjugated linoleic acid treatment in mice

1 reference

12 December 2020

Lipid accumulation impairs adiponectin-mediated induction of activin A by increasing TGFbeta in primary human hepatocytes

1 reference

12 December 2020

Insulin signaling: inositol phosphates get into the Akt.

1 reference

12 December 2020

Gene silencing by microRNAs: contributions of translational repression and mRNA decay

1 reference

12 December 2020

Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism

1 reference

12 December 2020

Increased levels of the Akt-specific phosphatase PH domain leucine-rich repeat protein phosphatase (PHLPP)-1 in obese participants are associated with insulin resistance.

1 reference

12 December 2020

The induction of microRNA targeting IRS-1 is involved in the development of insulin resistance under conditions of mitochondrial dysfunction in hepatocytes

1 reference

12 December 2020

miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signaling

1 reference

12 December 2020

MicroRNA-126 inhibits ischemia-induced retinal neovascularization via regulating angiogenic growth factors

1 reference

12 December 2020

MicroRNAs 103 and 107 regulate insulin sensitivity

1 reference

12 December 2020

MicroRNA 144 impairs insulin signaling by inhibiting the expression of insulin receptor substrate 1 in type 2 diabetes mellitus

1 reference

12 December 2020

The Lin28/let-7 axis regulates glucose metabolism

1 reference

12 December 2020

Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1

1 reference

12 December 2020

MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship

1 reference

12 December 2020

MicroRNAs in stress signaling and human disease

1 reference

12 December 2020

Downregulation of miR-181a upregulates sirtuin-1 (SIRT1) and improves hepatic insulin sensitivity

1 reference

12 December 2020

Differential expression of microRNAs in adipose tissue after long-term high-fat diet-induced obesity in mice

1 reference

12 December 2020

Plant-derived polyphenols regulate expression of miRNA paralogs miR-103/107 and miR-122 and prevent diet-induced fatty liver disease in hyperlipidemic mice

1 reference

12 December 2020

Efficiency and specificity in microRNA biogenesis

1 reference

12 December 2020

Regulation of glucose transport by insulin: traffic control of GLUT4.

1 reference

12 December 2020

Decrease of microRNA-122 causes hepatic insulin resistance by inducing protein tyrosine phosphatase 1B, which is reversed by licorice flavonoid

1 reference

12 December 2020

Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2

1 reference

12 December 2020

Validation of [18F]fluorodeoxyglucose and positron emission tomography (PET) for the measurement of intestinal metabolism in pigs, and evidence of intestinal insulin resistance in patients with morbid obesity.

1 reference

12 December 2020

MiRNA-181b suppresses IGF-1R and functions as a tumor suppressor gene in gliomas

1 reference

12 December 2020

The insulin receptor: both a prototypical and atypical receptor tyrosine kinase.

1 reference

12 December 2020

Downregulation of miR-383 promotes glioma cell invasion by targeting insulin-like growth factor 1 receptor

1 reference

12 December 2020

miR-135a targets IRS2 and regulates insulin signaling and glucose uptake in the diabetic gastrocnemius skeletal muscle.

1 reference

12 December 2020

The induction of miR-96 by mitochondrial dysfunction causes impaired glycogen synthesis through translational repression of IRS-1 in SK-Hep1 cells.

1 reference

12 December 2020

Regulation of IRS1/Akt insulin signaling by microRNA-128a during myogenesis

1 reference

12 December 2020

Circulating microRNAs as novel biomarkers for diabetes mellitus

1 reference

12 December 2020

Diversifying microRNA sequence and function

1 reference

12 December 2020

Adult-specific functions of animal microRNAs

1 reference

12 December 2020

miRISC recruits decapping factors to miRNA targets to enhance their degradation

1 reference

12 December 2020

The emerging role of miR-375 in cancer

1 reference

12 December 2020

miRBase: annotating high confidence microRNAs using deep sequencing data

1 reference

12 December 2020

Insulin signaling, resistance, and the metabolic syndrome: insights from mouse models into disease mechanisms

1 reference

12 December 2020

Adipocyte-derived factors impair insulin signaling in differentiated human vascular smooth muscle cells via the upregulation of miR-143.

1 reference

12 December 2020

MicroRNA-494, upregulated by tumor necrosis factor-α, desensitizes insulin effect in C2C12 muscle cells

1 reference

12 December 2020

MiRNA-145 is involved in the development of resistin-induced insulin resistance in HepG2 cells.

1 reference

12 December 2020

Akt/PKB activation and insulin signaling: a novel insulin signaling pathway in the treatment of type 2 diabetes

1 reference

12 December 2020

MicroRNA-145 suppresses hepatocellular carcinoma by targeting IRS1 and its downstream Akt signaling

1 reference

12 December 2020

Induction of miR-29a by saturated fatty acids impairs insulin signaling and glucose uptake through translational repression of IRS-1 in myocytes.

1 reference

12 December 2020

Diminished skeletal muscle microRNA expression with aging is associated with attenuated muscle plasticity and inhibition of IGF-1 signaling

1 reference

12 December 2020

Long-term inhibition of miR-21 leads to reduction of obesity in db/db mice

1 reference

12 December 2020

Saturated fatty acid-induced miR-195 impairs insulin signaling and glycogen metabolism in HepG2 cells.

1 reference

12 December 2020

Correcting the expression of miRNA-155 represses PP2Ac and enhances the release of IL-2 in PBMCs of juvenile SLE patients.

1 reference

12 December 2020

Insulin in the brain: its pathophysiological implications for States related with central insulin resistance, type 2 diabetes and Alzheimer's disease

1 reference

12 December 2020

Pathologic Regulation of Collagen I by an Aberrant Protein Phosphatase 2A/Histone Deacetylase C4/MicroRNA-29 Signal Axis in Idiopathic Pulmonary Fibrosis Fibroblasts

1 reference

12 December 2020

Regulation of IGF -1 signaling by microRNAs

1 reference

12 December 2020

miR-128-3p suppresses hepatocellular carcinoma proliferation by regulating PIK3R1 and is correlated with the prognosis of HCC patients

1 reference

12 December 2020

MiR-26b modulates insulin sensitivity in adipocytes by interrupting the PTEN/PI3K/AKT pathway.

1 reference

12 December 2020

The eIF4E-Binding Protein 4E-T Is a Component of the mRNA Decay Machinery that Bridges the 5' and 3' Termini of Target mRNAs

1 reference

12 December 2020

Circulating miRNAs as intercellular messengers, potential biomarkers and therapeutic targets for Type 2 diabetes

1 reference

12 December 2020

MiR-19a regulates PTEN expression to mediate glycogen synthesis in hepatocytes

1 reference

12 December 2020

Obesity-induced miR-15b is linked causally to the development of insulin resistance through the repression of the insulin receptor in hepatocytes.

1 reference

12 December 2020

MiR-499-5p Contributes to Hepatic Insulin Resistance by Suppressing PTEN.

1 reference

12 December 2020

MicroRNA-181b Improves Glucose Homeostasis and Insulin Sensitivity by Regulating Endothelial Function in White Adipose Tissue

1 reference

12 December 2020

MiR-126 Suppresses the Glucose-Stimulated Proliferation via IRS-2 in INS-1 β Cells

1 reference

12 December 2020

MicroRNA 152 regulates hepatic glycogenesis by targeting PTEN.

1 reference

12 December 2020

MicroRNA-20a-5p contributes to hepatic glycogen synthesis through targeting p63 to regulate p53 and PTEN expression

1 reference

12 December 2020

The Promise and Challenge of Therapeutic MicroRNA Silencing in Diabetes and Metabolic Diseases

1 reference

12 December 2020

MicroRNA-214 Reduces Insulin-like Growth Factor-1 (IGF-1) Receptor Expression and Downstream mTORC1 Signaling in Renal Carcinoma Cells

1 reference

12 December 2020

Understanding microRNA-mediated gene regulatory networks through mathematical modelling.

1 reference

12 December 2020

Pancreas-enriched miRNAs are altered in the circulation of subjects with diabetes: a pilot cross-sectional study.

1 reference

12 December 2020

MiR-181a Targets PHLPP2 to Augment AKT Signaling and Regulate Proliferation and Apoptosis in Human Keloid Fibroblasts.

1 reference

12 December 2020

Induction of miR-96 by Dietary Saturated Fatty Acids Exacerbates Hepatic Insulin Resistance through the Suppression of INSR and IRS-1.

1 reference

12 December 2020

IRS-2 Partially Compensates for the Insulin Signal Defects in IRS-1-/- Mice Mediated by miR-33.

1 reference

12 December 2020

Adipose-derived circulating miRNAs regulate gene expression in other tissues

1 reference

12 December 2020

Circulating microRNAs and diabetes mellitus: a novel tool for disease prediction, diagnosis, and staging?

1 reference

12 December 2020

miR-181 elevates Akt signaling by co-targeting PHLPP2 and INPP4B phosphatases in luminal breast cancer.

1 reference

12 December 2020

Imbalanced Insulin Actions in Obesity and Type 2 Diabetes: Key Mouse Models of Insulin Signaling Pathway

1 reference

12 December 2020

Altered miR-29 Expression in Type 2 Diabetes Influences Glucose and Lipid Metabolism in Skeletal Muscle.

1 reference

12 December 2020

PHLPP: a putative cellular target during insulin resistance and type 2 diabetes

1 reference

12 December 2020

PP2A catalytic subunit silence by microRNA-429 activates AMPK and protects osteoblastic cells from dexamethasone

1 reference

12 December 2020

Adipose Tissue Macrophage-Derived Exosomal miRNAs Can Modulate In Vivo and In Vitro Insulin Sensitivity

1 reference

12 December 2020

MicroRNA-126 inhibits cell viability and invasion in a diabetic retinopathy model via targeting IRS-1.

1 reference

12 December 2020

Insulin Receptor Isoforms in Physiology and Disease: An Updated View.

1 reference

12 December 2020

Decreased serum microRNA-21 level is associated with obesity in healthy and type 2 diabetic subjects.

1 reference

12 December 2020

MicroRNAs as therapeutic targets for the treatment of diabetes mellitus and its complications

1 reference

12 December 2020

Skeletal Muscle-Specific Deletion of MKP-1 Reveals a p38 MAPK/JNK/Akt Signaling Node that Regulates Obesity-Induced Insulin Resistance.

1 reference

12 December 2020

Identification of microRNA that represses IRS-1 expression in liver.

1 reference

12 December 2020

Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums.

1 reference

12 December 2020

miR-214-Dependent Increase of PHLPP2 Levels Mediates the Impairment of Insulin-Stimulated Akt Activation in Mouse Aortic Endothelial Cells Exposed to Methylglyoxal.

1 reference

12 December 2020

miR-19b enhances proliferation and apoptosis resistance via the EGFR signaling pathway by targeting PP2A and BIM in non-small cell lung cancer.

1 reference

12 December 2020

Increased expression of microRNA-15a and microRNA-15b in skeletal muscle from adult offspring of women with diabetes in pregnancy.

1 reference

12 December 2020

Anti-miRNA oligonucleotides: A comprehensive guide for design.

1 reference

12 December 2020

Association of MiR-146a Expression and Type 2 Diabetes Mellitus: A Meta-Analysis.

1 reference

12 December 2020

MicroRNA and Microvascular Complications of Diabetes.

1 reference

12 December 2020

Saturated fatty acids-induced miR-424-5p aggravates insulin resistance via targeting insulin receptor in hepatocytes

1 reference

12 December 2020

microRNA-205-5p is a modulator of insulin sensitivity that inhibits FOXO function

1 reference

12 December 2020

The effect of cellular context on miR-155-mediated gene regulation in four major immune cell types

1 reference

12 December 2020

Diabesity and brain disturbances: A metabolic perspective

1 reference

12 December 2020

Network of three specific microRNAs influence type 2 diabetes through inducing insulin resistance in muscle cell lines

1 reference

12 December 2020

Circulating miR-143-3p inhibition protects against insulin resistance in Metabolic Syndrome via targeting of the insulin-like growth factor 2 receptor

1 reference

12 December 2020