(Q64067743)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30962421%20AND%20SRC:MED&resulttype=core&format=json

2 May 2020

title

A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30962421%20AND%20SRC:MED&resulttype=core&format=json

2 May 2020

1 reference

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30962421%20AND%20SRC:MED&resulttype=core&format=json

2 May 2020

Rebecca Deasy

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30962421%20AND%20SRC:MED&resulttype=core&format=json

2 May 2020

Toni K Choueiri

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30962421%20AND%20SRC:MED&resulttype=core&format=json

2 May 2020

Jesse S Boehm

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30962421%20AND%20SRC:MED&resulttype=core&format=json

2 May 2020

John G Doench

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30962421%20AND%20SRC:MED&resulttype=core&format=json

2 May 2020

Clary B Clish

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30962421%20AND%20SRC:MED&resulttype=core&format=json

2 May 2020

Paul A Clemons

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30962421%20AND%20SRC:MED&resulttype=core&format=json

2 May 2020

Stuart Schreiber

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30962421%20AND%20SRC:MED&resulttype=core&format=json

2 May 2020

13

Sabina Signoretti

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30962421%20AND%20SRC:MED&resulttype=core&format=json

2 May 2020

author name string

Yilong Zou

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30962421%20AND%20SRC:MED&resulttype=core&format=json

2 May 2020

Michael J Palte

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30962421%20AND%20SRC:MED&resulttype=core&format=json

2 May 2020

Amy A Deik

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30962421%20AND%20SRC:MED&resulttype=core&format=json

2 May 2020

Haoxin Li

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30962421%20AND%20SRC:MED&resulttype=core&format=json

2 May 2020

Wenyu Wang

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30962421%20AND%20SRC:MED&resulttype=core&format=json

2 May 2020

Yuen-Yi Tseng

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30962421%20AND%20SRC:MED&resulttype=core&format=json

2 May 2020

Maria Kost-Alimova

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30962421%20AND%20SRC:MED&resulttype=core&format=json

2 May 2020

Vlado Dančík

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30962421%20AND%20SRC:MED&resulttype=core&format=json

2 May 2020

Elizaveta S Leshchiner

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30962421%20AND%20SRC:MED&resulttype=core&format=json

2 May 2020

Vasanthi S Viswanathan

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30962421%20AND%20SRC:MED&resulttype=core&format=json

2 May 2020

Bridget K Wagner

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30962421%20AND%20SRC:MED&resulttype=core&format=json

2 May 2020

language of work or name

English

0 references

publication date

8 April 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30962421%20AND%20SRC:MED&resulttype=core&format=json

2 May 2020

published in

Nature Communications

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30962421%20AND%20SRC:MED&resulttype=core&format=json

2 May 2020

volume

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30962421%20AND%20SRC:MED&resulttype=core&format=json

2 May 2020

issue

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30962421%20AND%20SRC:MED&resulttype=core&format=json

2 May 2020

page(s)

1617

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30962421%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

2 May 2020

copyright license

start time

8 April 2019

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

describes a project that uses

RStudio

1 reference

18 June 2022

https://europepmc.org/article/PMC/6453886

inferred from PubMed Central ID database lookup

exact match

https://scigraph.springernature.com/pub.10.1038/s41467-019-09277-9

0 references

cites work

Systemic Therapy for Metastatic Renal-Cell Carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09277-9

7 January 2021

Gynecologic Cancer InterGroup (GCIG) consensus review for clear cell carcinoma of the uterine corpus and cervix.

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09277-9

7 January 2021

Clear-cell carcinomas of thyroid gland: a clinicopathological study of 13 cases

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09277-9

7 January 2021

Clear cell hepatocellular carcinoma: origin, metabolic traits and fate of glycogenotic clear and ground glass cells

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09277-9

7 January 2021

Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09277-9

7 January 2021

Metabolic reprogramming in clear cell renal cell carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09277-9

7 January 2021

Understanding the Intersections between Metabolism and Cancer Biology

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09277-9

7 January 2021

Targeting Cancer Metabolism: Dietary and Pharmacologic Interventions

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09277-9

7 January 2021

Correlating chemical sensitivity and basal gene expression reveals mechanism of action.

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09277-9

7 January 2021

Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset.

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09277-9

7 January 2021

An interactive resource to identify cancer genetic and lineage dependencies targeted by small molecules.

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09277-9

7 January 2021

The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09277-9

7 January 2021

Regulation of ferroptotic cancer cell death by GPX4

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09277-9

7 January 2021

Glutathione peroxidase 4 and vitamin E cooperatively prevent hepatocellular degeneration

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09277-9

7 January 2021

Ferroptosis and cell death mechanisms in Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09277-9

7 January 2021

Ferroptosis, but Not Necroptosis, Is Important in Nephrotoxic Folic Acid-Induced AKI.

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09277-9

7 January 2021

Characterization of ferroptosis in murine models of hemochromatosis.

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09277-9

7 January 2021

PEBP1 Wardens Ferroptosis by Enabling Lipoxygenase Generation of Lipid Death Signals.

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09277-9

7 January 2021

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09277-9

7 January 2021

Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition.

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09277-9

7 January 2021

Multi-stage Differentiation Defines Melanoma Subtypes with Differential Vulnerability to Drug-Induced Iron-Dependent Oxidative Stress.

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09277-9

7 January 2021

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09277-9

7 January 2021

Defining a Cancer Dependency Map.

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09277-9

7 January 2021

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09277-9

7 January 2021

Synchronized renal tubular cell death involves ferroptosis.

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09277-9

7 January 2021

Clear cell carcinomas of the ovary and kidney: clarity through genomics

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09277-9

7 January 2021

Gene Expression Profiles of Serous, Endometrioid, and Clear Cell Subtypes of Ovarian and Endometrial Cancer

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09277-9

7 January 2021

Integrative bioinformatics links HNF1B with clear cell carcinoma and tumor-associated thrombosis

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09277-9

7 January 2021

Cost and cost-effectiveness studies in urologic oncology using large administrative databases

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09277-9

7 January 2021

Malignant tumors with clear cell morphology: a comparative immunohistochemical study with renal cell carcinoma antibody, Pax8, steroidogenic factor 1, and brachyury

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09277-9

7 January 2021

Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09277-9

7 January 2021

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09277-9

7 January 2021

Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09277-9

7 January 2021

Oxygen sensing, hypoxia-inducible factors, and disease pathophysiology

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09277-9

7 January 2021

Transcriptional regulation and functional implication of the grass carp CITED1 (gcCITED1) in the negative regulation of HIF-1.

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09277-9

7 January 2021

The VHL/HIF axis in clear cell renal carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09277-9

7 January 2021

HIF2α-Dependent Lipid Storage Promotes Endoplasmic Reticulum Homeostasis in Clear-Cell Renal Cell Carcinoma.

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09277-9

7 January 2021

Tumour suppression by the human von Hippel-Lindau gene product

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09277-9

7 January 2021

Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09277-9

7 January 2021

Expression of hypoxia-inducible factor 1alpha, hypoxia-inducible factor 2alpha, and von Hippel-Lindau protein in epithelial ovarian neoplasms and allelic loss of von Hippel-Lindau gene: nuclear expression of hypoxia-inducible factor 1alpha is an ind

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09277-9

7 January 2021

EGLN1/c-Myc Induced Lymphoid-Specific Helicase Inhibits Ferroptosis through Lipid Metabolic Gene Expression Changes

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09277-9

7 January 2021

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09277-9

7 January 2021

Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis.

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09277-9

7 January 2021

Triglycerides Promote Lipid Homeostasis during Hypoxic Stress by Balancing Fatty Acid Saturation

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09277-9

7 January 2021

Lipidomic Signatures and Associated Transcriptomic Profiles of Clear Cell Renal Cell Carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09277-9

7 January 2021

Hypoxia-inducible lipid droplet-associated protein inhibits adipose triglyceride lipase.

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09277-9

7 January 2021

Inhibition of intracellular lipolysis promotes human cancer cell adaptation to hypoxia

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09277-9

7 January 2021

Common genetic variants at the 11q13.3 renal cancer susceptibility locus influence binding of HIF to an enhancer of cyclin D1 expression.

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09277-9

7 January 2021

Hypoxia-inducible protein 2 Hig2/Hilpda mediates neutral lipid accumulation in macrophages and contributes to atherosclerosis in apolipoprotein E-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09277-9

7 January 2021

Differential expression of hypoxia-inducible protein 2 among different histological types of epithelial ovarian cancer and in clear cell adenocarcinomas

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09277-9

7 January 2021

Paraganglioma and phaeochromocytoma: from genetics to personalized medicine

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09277-9

7 January 2021

Targeting renal cell carcinoma with a HIF-2 antagonist.

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09277-9

7 January 2021

On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09277-9

7 January 2021

The G(0)/G(1) switch gene 2 regulates adipose lipolysis through association with adipose triglyceride lipase

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09277-9

7 January 2021

Patatin-like phospholipase domain-containing protein 3 promotes transfer of essential fatty acids from triglycerides to phospholipids in hepatic lipid droplets.

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09277-9

7 January 2021

Dynamics and functions of lipid droplets

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09277-9

7 January 2021

Development of small-molecule probes that selectively kill cells induced to express mutant RAS

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09277-9

7 January 2021

Unsaturated fatty acids down-regulate srebp isoforms 1a and 1c by two mechanisms in HEK-293 cells

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09277-9

7 January 2021

Orthologous CRISPR-Cas9 enzymes for combinatorial genetic screens.

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09277-9

7 January 2021

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9.

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09277-9

7 January 2021

Uncoupling of sgRNAs from their associated barcodes during PCR amplification of combinatorial CRISPR screens.

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09277-9

7 January 2021

Alternative to the soft-agar assay that permits high-throughput drug and genetic screens for cellular transformation

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09277-9

7 January 2021

ROCK inhibitor and feeder cells induce the conditional reprogramming of epithelial cells

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09277-9

7 January 2021

Re: Growth of cell lines and clinical specimens of human non-small cell lung cancer in a serum-free defined medium

1 reference

12 December 2020

Growth of cell lines and clinical specimens of human non-small cell lung cancer in a serum-free defined medium.

1 reference

12 December 2020

Clinical characteristics of clear cell carcinoma of the ovary: a distinct histologic type with poor prognosis and resistance to platinum-based chemotherapy

1 reference

12 December 2020

Primary clear cell ductal adenocarcinoma of the pancreas: a case report and clinicopathologic literature review

1 reference

12 December 2020

Lipid Desaturation Is a Metabolic Marker and Therapeutic Target of Ovarian Cancer Stem Cells.

1 reference

12 December 2020

Overexpression of PLIN2 is a prognostic marker and attenuates tumor progression in clear cell renal cell carcinoma.

1 reference

12 December 2020

PLIN3 is up-regulated and correlates with poor prognosis in clear cell renal cell carcinoma

1 reference

12 December 2020

10.1038/S41467-019-09277-9

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30962421%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

2 May 2020

ADS bibcode

2019NatCo..10.1617Z

0 references

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30962421%20AND%20SRC:MED&resulttype=core&format=json

2 May 2020

PubMed publication ID

30962421

1 reference