(Q64226349)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30626880%20AND%20SRC:MED&resulttype=core&format=json

18 April 2020

title

A chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to SQLE inhibition (English)

1 reference

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18 April 2020

author

Christopher E Mahoney

1

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18 April 2020

Sebastian Hayes

5

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18 April 2020

Stefan Gross

16

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18 April 2020

Gromoslaw A Smolen

29

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18 April 2020

27

Thomas Roddy

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18 April 2020

author name string

David Pirman

2

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18 April 2020

Victor Chubukov

3

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18 April 2020

Taryn Sleger

4

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18 April 2020

Zi Peng Fan

6

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18 April 2020

Eric L Allen

7

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18 April 2020

Ying Chen

8

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18 April 2020

Lingling Huang

9

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18 April 2020

Meina Liu

10

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18 April 2020

Yingjia Zhang

11

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18 April 2020

Gabrielle McDonald

12

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18 April 2020

Rohini Narayanaswamy

13

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18 April 2020

Sung Choe

14

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18 April 2020

Yue Chen

15

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18 April 2020

Giovanni Cianchetta

17

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18 April 2020

Anil K Padyana

18

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18 April 2020

Stuart Murray

19

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18 April 2020

Wei Liu

20

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18 April 2020

Kevin M Marks

21

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18 April 2020

Joshua Murtie

22

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18 April 2020

Marion Dorsch

23

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18 April 2020

Shengfang Jin

24

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18 April 2020

Nelamangala Nagaraja

25

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18 April 2020

Scott A Biller

26

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18 April 2020

Janeta Popovici-Muller

28

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18 April 2020

language of work or name

English

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publication date

9 January 2019

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18 April 2020

published in

Nature Communications

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18 April 2020

volume

10

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18 April 2020

issue

1

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18 April 2020

page(s)

96

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Creative Commons Attribution 4.0 International

18 April 2020

copyright license

start time

9 January 2019

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

exact match

https://scigraph.springernature.com/pub.10.1038/s41467-018-07959-4

0 references

cites work

The evolving war on cancer

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7 January 2021

Feasibility of Large-Scale Genomic Testing to Facilitate Enrollment Onto Genomically Matched Clinical Trials

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7 January 2021

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

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7 January 2021

Systematic identification of genomic markers of drug sensitivity in cancer cells

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7 January 2021

Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset.

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7 January 2021

A landscape of pharmacogenomic interactions in cancer.

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7 January 2021

Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia.

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7 January 2021

Characterization of the cell of origin for small cell lung cancer

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7 January 2021

ASCL1 and NEUROD1 Reveal Heterogeneity in Pulmonary Neuroendocrine Tumors and Regulate Distinct Genetic Programs

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7 January 2021

Structure and inhibition mechanism of the catalytic domain of human squalene epoxidase

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7 January 2021

In vivo D2O labeling to quantify static and dynamic changes in cholesterol and cholesterol esters by high resolution LC/MS.

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7 January 2021

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

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7 January 2021

Chemical, pharmacokinetic and pharmacodynamic properties of statins: an update

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7 January 2021

Synthesis of novel 4,1-benzoxazepine derivatives as squalene synthase inhibitors and their inhibition of cholesterol synthesis

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7 January 2021

Selective inhibition of mammalian lanosterol 14 alpha-demethylase: a possible strategy for cholesterol lowering

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7 January 2021

Effects of distal cholesterol biosynthesis inhibitors on cell proliferation and cell cycle progression

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7 January 2021

Molecular cloning and expression of the human delta7-sterol reductase

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7 January 2021

Lipid droplets, lipophagy, and beyond

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7 January 2021

Flux analysis of cholesterol biosynthesis in vivo reveals multiple tissue and cell-type specific pathways

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7 January 2021

Comprehensive genomic profiles of small cell lung cancer

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7 January 2021

A drug repositioning approach identifies tricyclic antidepressants as inhibitors of small cell lung cancer and other neuroendocrine tumors.

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7 January 2021

A framework for identification of actionable cancer genome dependencies in small cell lung cancer

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7 January 2021

Assessment of ABT-263 activity across a cancer cell line collection leads to a potent combination therapy for small-cell lung cancer.

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7 January 2021

ASCL1 is a lineage oncogene providing therapeutic targets for high-grade neuroendocrine lung cancers

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7 January 2021

Squalene epoxidase is a bona fide oncogene by amplification with clinical relevance in breast cancer

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7 January 2021

A DLL3-targeted antibody-drug conjugate eradicates high-grade pulmonary neuroendocrine tumor-initiating cells in vivo

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7 January 2021

MYC Drives Progression of Small Cell Lung Cancer to a Variant Neuroendocrine Subtype with Vulnerability to Aurora Kinase Inhibition.

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7 January 2021

Inosine Monophosphate Dehydrogenase Dependence in a Subset of Small Cell Lung Cancers

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7 January 2021

A century of cholesterol and coronaries: from plaques to genes to statins

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7 January 2021

Targeting tumor cell metabolism with statins.

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7 January 2021

Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway

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7 January 2021

Cholesteryl ester accumulation induced by PTEN loss and PI3K/AKT activation underlies human prostate cancer aggressiveness

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7 January 2021

The cancer-associated microprotein CASIMO1 controls cell proliferation and interacts with squalene epoxidase modulating lipid droplet formation

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7 January 2021

Terbinafine: mode of action and properties of the squalene epoxidase inhibition

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7 January 2021

Squalene is lipotoxic to yeast cells defective in lipid droplet biogenesis

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7 January 2021

Understanding the Intersections between Metabolism and Cancer Biology

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7 January 2021

MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells

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7 January 2021

MTAP Deletions in Cancer Create Vulnerability to Targeting of the MAT2A/PRMT5/RIOK1 Axis.

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7 January 2021

Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5

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7 January 2021

Current Advances in 5-Aminolevulinic Acid Mediated Photodynamic Therapy.

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7 January 2021

NB-598: a potent competitive inhibitor of squalene epoxidase

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12 December 2020

Cholesterol metabolism: use of D2O for determination of synthesis rate in cell culture

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12 December 2020

Ro 48-8.071, a new 2,3-oxidosqualene:lanosterol cyclase inhibitor lowering plasma cholesterol in hamsters, squirrel monkeys, and minipigs: comparison to simvastatin.

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12 December 2020

Both the immunosuppressant SR31747 and the antiestrogen tamoxifen bind to an emopamil-insensitive site of mammalian Delta8-Delta7 sterol isomerase.

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12 December 2020

Unravelling the biology of SCLC: implications for therapy

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12 December 2020

Retrospective on Cholesterol Homeostasis: The Central Role of Scap

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12 December 2020

Squalene epoxidase drives NAFLD-induced hepatocellular carcinoma and is a pharmaceutical target

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12 December 2020

Dropping in on lipid droplets: insights into cellular stress and cancer

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12 December 2020

10.1038/S41467-018-07959-4

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30626880%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

18 April 2020

ADS bibcode

2019NatCo..10...96M

0 references

0 references

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18 April 2020

PubMed publication ID

30626880

1 reference