(Q64244523)

2

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Xing-Ning Lai

3

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Xue-Qiao Jiao

4

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Jun-Ping Xiong

5

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Li-Xia Xiong

Creative Commons Attribution

6

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language of work or name

English

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publication date

11 February 2019

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13 November 2020

15 December 2020

1 May 2021

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13 November 2020

15 December 2020

1 May 2021

8

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issue

2

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page(s)

146

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copyright license

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13 November 2020

15 December 2020

1 May 2021

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The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing

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12 December 2020

Human tumor cell lines with EGF receptor gene amplification in the absence of aberrant sized mRNAs

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12 December 2020

Anti-angiogenesis: new concept for therapy of solid tumors

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12 December 2020

Identification of a new catenin: the tyrosine kinase substrate p120cas associates with E-cadherin complexes

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12 December 2020

The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway

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12 December 2020

Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death

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12 December 2020

Interleukin 6 induces the expression of vascular endothelial growth factor

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12 December 2020

Cell migration: a physically integrated molecular process

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12 December 2020

Pyrrolidine dithiocarbamate inhibits the production of interleukin-6, interleukin-8, and granulocyte-macrophage colony-stimulating factor by human endothelial cells in response to inflammatory mediators: modulation of NF-kappa B and AP-1 transcripti

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12 December 2020

Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes

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12 December 2020

Apoptosis CED-4 is a stranger no more

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12 December 2020

Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K.

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12 December 2020

Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase

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12 December 2020

Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization

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12 December 2020

DNA damaging agents induce expression of Fas ligand and subsequent apoptosis in T lymphocytes via the activation of NF-kappa B and AP-1.

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12 December 2020

Toxin-induced activation of Rho GTP-binding protein increases Bcl-2 expression and influences mitochondrial homeostasis

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12 December 2020

Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1.

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12 December 2020

Regulation of a promoter of the fibroblast growth factor 1 gene in prostate and breast cancer cells

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12 December 2020

Cleavage and activation of p21-activated protein kinase gamma-PAK by CPP32 (caspase 3). Effects of autophosphorylation on activity

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12 December 2020

Control of cell cycle progression by c-Jun is p53 dependent

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12 December 2020

NF-kappaB functions as both a proapoptotic and antiapoptotic regulatory factor within a single cell type

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12 December 2020

Ras-GTPase activating protein inhibition specifically induces apoptosis of tumour cells

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12 December 2020

Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics

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12 December 2020

BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M.

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12 December 2020

p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis

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12 December 2020

Translocation of SAPK/JNK to mitochondria and interaction with Bcl-x(L) in response to DNA damage

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12 December 2020

Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha

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12 December 2020

Functional cooperation between the microtubule and actin cytoskeletons

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12 December 2020

Stimulation of NFkappa B activity by multiple signaling pathways requires PAK1.

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12 December 2020

The small GTPases Ras, Rac, and Cdc42 transcriptionally regulate expression of human fibroblast growth factor 1

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12 December 2020

Regulatable Expression of p21-activated Kinase-1 Promotes Anchorage-independent Growth and Abnormal Organization of Mitotic Spindles in Human Epithelial Breast Cancer Cells

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12 December 2020

Chronic Myeloid Leukemia with Increased Granulocyte Progenitors in Mice Lacking JunB Expression in the Myeloid Lineage

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12 December 2020

The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity

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12 December 2020

Cdc42 is a substrate for caspases and influences Fas-induced apoptosis

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12 December 2020

Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions

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12 December 2020

Signaling mediated by the closely related mammalian Rho family GTPases TC10 and Cdc42 suggests distinct functional pathways

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12 December 2020

Cooperation between STAT3 and c-jun suppresses Fas transcription.

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12 December 2020

Central role of p53 on regulation of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) expression in mammary carcinoma

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12 December 2020

Trp(56) of rac1 specifies interaction with a subset of guanine nucleotide exchange factors

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12 December 2020

Rho regulates p21(CIP1), cyclin D1, and checkpoint control in mammary epithelial cells

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12 December 2020

Evolutionary conservation of microtubule-capture mechanisms

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12 December 2020

Live or let die: the cell's response to p53

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12 December 2020

The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini.

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12 December 2020

Cdc42 regulates GSK-3beta and adenomatous polyposis coli to control cell polarity

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12 December 2020

Biology of the p21-activated kinases

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12 December 2020

Tumour-cell invasion and migration: diversity and escape mechanisms

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12 December 2020

Activated Cdc42 Sequesters c-Cbl and Prevents EGF Receptor Degradation

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12 December 2020

Cell migration: integrating signals from front to back

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12 December 2020

Cross-talk between estrogen receptor and growth factor pathways as a molecular target for overcoming endocrine resistance

1 reference

12 December 2020

MicroRNAs: genomics, biogenesis, mechanism, and function

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12 December 2020

DEF6, a novel PH-DH-like domain protein, is an upstream activator of the Rho GTPases Rac1, Cdc42, and RhoA.

1 reference

12 December 2020

Cofilin promotes actin polymerization and defines the direction of cell motility

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12 December 2020

MAP kinases and cell migration

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12 December 2020

AP-1 subunits: quarrel and harmony among siblings

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12 December 2020

Resveratrol and estradiol rapidly activate MAPK signaling through estrogen receptors alpha and beta in endothelial cells

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12 December 2020

Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets

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12 December 2020

The tension mounts: mechanics meets morphogenesis and malignancy

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12 December 2020

Nuclear movement regulated by Cdc42, MRCK, myosin, and actin flow establishes MTOC polarization in migrating cells

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12 December 2020

IQGAP1: a key regulator of adhesion and migration

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12 December 2020

Induction of interleukin-8 preserves the angiogenic response in HIF-1alpha-deficient colon cancer cells.

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12 December 2020

Information networks in the mammary gland.

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12 December 2020

The making of filopodia

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12 December 2020

Role of Rac1 and Cdc42 in hypoxia induced p53 and von Hippel-Lindau suppression and HIF1alpha activation

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12 December 2020

Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro.

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12 December 2020

Growth and motility inhibition of breast cancer cells by epidermal growth factor receptor degradation is correlated with inactivation of Cdc42.

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12 December 2020

Tumor invasion in the absence of epithelial-mesenchymal transition: podoplanin-mediated remodeling of the actin cytoskeleton

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12 December 2020

Multifaceted role of Rho proteins in angiogenesis

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12 December 2020

The ARP2/3 complex: an actin nucleator comes of age

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12 December 2020

ROCK signaling mediates the adoption of different modes of migration and invasion in human mammary epithelial tumor cells

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12 December 2020

Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells

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12 December 2020

Prognostic markers in triple-negative breast cancer

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12 December 2020

A paxillin tyrosine phosphorylation switch regulates the assembly and form of cell-matrix adhesions.

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12 December 2020

Estrogen and resveratrol regulate Rac and Cdc42 signaling to the actin cytoskeleton of metastatic breast cancer cells

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12 December 2020

Oncogenic inhibition by a deleted in liver cancer gene requires cooperation between tensin binding and Rho-specific GTPase-activating protein activities

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12 December 2020

The cofilin pathway in breast cancer invasion and metastasis

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12 December 2020

Depletion of procathepsin D gene expression by RNA interference: a potential therapeutic target for breast cancer

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12 December 2020

Focal adhesion assembly

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12 December 2020

Triple negative breast cancer: molecular profiling and prognostic impact in adjuvant anthracycline-treated patients

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12 December 2020

IQGAP1 stimulates proliferation and enhances tumorigenesis of human breast epithelial cells

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12 December 2020

Roles of multidrug resistance genes in breast cancer chemoresistance

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12 December 2020

Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells

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12 December 2020

The BCL-2 protein family: opposing activities that mediate cell death

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12 December 2020

Pak1 and Pak2 mediate tumor cell invasion through distinct signaling mechanisms

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12 December 2020

P21-activated kinase is required for mitotic progression and regulates Plk1.

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12 December 2020

An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors

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12 December 2020

mda-9/Syntenin: more than just a simple adapter protein when it comes to cancer metastasis

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12 December 2020

The interaction of IQGAP1 with the exocyst complex is required for tumor cell invasion downstream of Cdc42 and RhoA.

1 reference

12 December 2020

Invasive ductal carcinoma of the breast with the "triple-negative" phenotype: prognostic implications of EGFR immunoreactivity

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12 December 2020

The polarity protein Par6 induces cell proliferation and is overexpressed in breast cancer

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12 December 2020

Frequently increased epidermal growth factor receptor (EGFR) copy numbers and decreased BRCA1 mRNA expression in Japanese triple-negative breast cancers

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12 December 2020

NF-kappaB-YY1-miR-29 regulatory circuitry in skeletal myogenesis and rhabdomyosarcoma

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12 December 2020

Cdc42 controls spindle orientation to position the apical surface during epithelial morphogenesis

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12 December 2020

Elevated p21-activated kinase 2 activity results in anchorage-independent growth and resistance to anticancer drug-induced cell death

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12 December 2020

Ena/VASP: towards resolving a pointed controversy at the barbed end

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12 December 2020

Matrix invasion by tumour cells: a focus on MT1-MMP trafficking to invadopodia.

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12 December 2020

Actin dynamics at the leading edge: from simple machinery to complex networks.

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12 December 2020

Matrix density-induced mechanoregulation of breast cell phenotype, signaling and gene expression through a FAK-ERK linkage

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12 December 2020

I-BAR domains, IRSp53 and filopodium formation

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12 December 2020

Delta-catenin is required for the maintenance of neural structure and function in mature cortex in vivo

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12 December 2020

Surfactin induces apoptosis in human breast cancer MCF-7 cells through a ROS/JNK-mediated mitochondrial/caspase pathway

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12 December 2020

Ubc9 promotes breast cell invasion and metastasis in a sumoylation-independent manner

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12 December 2020

Autocrine VEGF signaling synergizes with EGFR in tumor cells to promote epithelial cancer development

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12 December 2020

c-Abl, Lamellipodin, and Ena/VASP proteins cooperate in dorsal ruffling of fibroblasts and axonal morphogenesis

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12 December 2020

Shepherding AKT and androgen receptor by Ack1 tyrosine kinase

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12 December 2020

Cell cycle proteins in epithelial cell differentiation: implications for breast cancer

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12 December 2020

The Cdc42 GEF Intersectin 2 controls mitotic spindle orientation to form the lumen during epithelial morphogenesis.

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12 December 2020

Transcriptional suppression of mir-29b-1/mir-29a promoter by c-Myc, hedgehog, and NF-kappaB.

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12 December 2020

HER2/ErbB2-induced breast cancer cell migration and invasion require p120 catenin activation of Rac1 and Cdc42

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12 December 2020

PKCzeta regulates cell polarisation and proliferation restriction during mammary acinus formation.

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12 December 2020

Expression of CD44 3'-untranslated region regulates endogenous microRNA functions in tumorigenesis and angiogenesis

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12 December 2020

EGFR expression and gene copy number in triple-negative breast carcinoma.

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12 December 2020

Invasion of breast cancer cells into collagen matrix requires TGF-α and Cdc42 signaling

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12 December 2020

Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer.

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12 December 2020

Novel inhibitors of Rac1 in metastatic breast cancer.

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12 December 2020

EGFR expression correlates with decreased disease-free survival in triple-negative breast cancer: a retrospective analysis based on a tissue microarray.

1 reference

12 December 2020

Par6B and atypical PKC regulate mitotic spindle orientation during epithelial morphogenesis

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12 December 2020

Effect of microRNA-206 on cytoskeleton remodelling by downregulating Cdc42 in MDA-MB-231 cells.

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12 December 2020

Actin structure and function.

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12 December 2020

Cdc42 in oncogenic transformation, invasion, and tumorigenesis

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12 December 2020

Life at the leading edge

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12 December 2020

The 'invisible hand': regulation of RHO GTPases by RHOGDIs

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12 December 2020

Epidermal growth factor receptor gene amplification and protein overexpression in basal-like carcinoma of the breast

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12 December 2020

Profiling of EGFR mRNA and protein expression in 471 breast cancers compared with 10 normal tissues: a candidate biomarker to predict EGFR inhibitor effectiveness.

1 reference

12 December 2020

[Effects of Cdc42 overexpression on the estrogen-enhanced multidrug resistance in breast cancer cells]

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12 December 2020

Activator protein 1 (AP-1) contributes to EpCAM-dependent breast cancer invasion

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12 December 2020

Ganoderic acid DM, a natural triterpenoid, induces DNA damage, G1 cell cycle arrest and apoptosis in human breast cancer cells.

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12 December 2020

The Rho GTPase Cdc42 is required for primary mammary epithelial cell morphogenesis in vitro

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12 December 2020

Molecular characterization of EGFR and EGFR-downstream pathways in triple negative breast carcinomas with basal like features

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12 December 2020

Protein expression, gene amplification, and mutational analysis of EGFR in triple-negative breast cancer.

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12 December 2020

Rare oncogenic mutations of predictive markers for targeted therapy in triple-negative breast cancer

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12 December 2020

Ganoderma lucidum extract induces G1 cell cycle arrest, and apoptosis in human breast cancer cells.

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12 December 2020

Clinicopathologic features of molecular subtypes of triple negative breast cancer based on immunohistochemical markers

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12 December 2020

A novel small-molecule screening strategy identifies mitoxantrone as a RhoGTPase inhibitor.

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12 December 2020

SIAH ubiquitin ligases target the nonreceptor tyrosine kinase ACK1 for ubiquitinylation and proteasomal degradation

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12 December 2020

The noncoding RNA MALAT1 is a critical regulator of the metastasis phenotype of lung cancer cells

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12 December 2020

Doxorubicin: an update on anticancer molecular action, toxicity and novel drug delivery systems.

1 reference

12 December 2020

PRDM14 ensures naive pluripotency through dual regulation of signaling and epigenetic pathways in mouse embryonic stem cells

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12 December 2020

miR-23b regulates cytoskeletal remodeling, motility and metastasis by directly targeting multiple transcripts

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12 December 2020

Retracted: Role of Activated Rac1/Cdc42 in Mediating Endothelial Cell Proliferation and Tumor Angiogenesis in Breast Cancer

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12 December 2020

IBP regulates epithelial-to-mesenchymal transition and the motility of breast cancer cells via Rac1, RhoA and Cdc42 signaling pathways

1 reference

12 December 2020

MicroRNA-23b regulates cellular architecture and impairs motogenic and invasive phenotypes during cancer progression

1 reference

12 December 2020

Cdc42 overexpression induces hyperbranching in the developing mammary gland by enhancing cell migration.

1 reference

12 December 2020

Ganoderiol A-enriched extract suppresses migration and adhesion of MDA-MB-231 cells by inhibiting FAK-SRC-paxillin cascade pathway

1 reference

12 December 2020

Lamellipodin and the Scar/WAVE complex cooperate to promote cell migration in vivo

1 reference

12 December 2020

High EGFR gene copy number predicts poor outcome in triple-negative breast cancer.

1 reference

12 December 2020

miR-888 in MCF-7 side population sphere cells directly targets E-cadherin

1 reference

12 December 2020

Long noncoding RNA MALAT1 regulates endothelial cell function and vessel growth

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12 December 2020

Altering FAK-paxillin interactions reduces adhesion, migration and invasion processes

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12 December 2020

MALAT1 promotes the proliferation and metastasis of gallbladder cancer cells by activating the ERK/MAPK pathway

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12 December 2020

Long noncoding RNA plays a key role in metastasis and prognosis of hepatocellular carcinoma

1 reference

12 December 2020

Advances in Preventive Therapy for Estrogen-Receptor-Negative Breast Cancer

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12 December 2020

Development of EHop-016: a small molecule inhibitor of Rac.

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12 December 2020

Rho GTPases in collective cell migration

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12 December 2020

Modulation of ERK5 is a novel mechanism by which Cdc42 regulates migration of breast cancer cells.

1 reference

12 December 2020

δ-catenin promotes the malignant phenotype in breast cancer

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12 December 2020

FGFR1 mediates recombinant thrombomodulin domain-induced angiogenesis.

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12 December 2020

The Rac Inhibitor EHop-016 Inhibits Mammary Tumor Growth and Metastasis in a Nude Mouse Model

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12 December 2020

Pharmacokinetics of Rac inhibitor EHop-016 in mice by ultra-performance liquid chromatography tandem mass spectrometry

1 reference

12 December 2020

miR-29b defines the pro-/anti-proliferative effects of S100A7 in breast cancer

1 reference

12 December 2020

Evidence for biological effects of metformin in operable breast cancer: biomarker analysis in a pre-operative window of opportunity randomized trial

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12 December 2020

KLF5 promotes breast cancer proliferation, migration and invasion in part by upregulating the transcription of TNFAIP2.

1 reference

12 December 2020

R-Ketorolac Targets Cdc42 and Rac1 and Alters Ovarian Cancer Cell Behaviors Critical for Invasion and Metastasis

1 reference

12 December 2020

Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer

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12 December 2020

Role of EMT in Metastasis and Therapy Resistance

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12 December 2020

MALAT1 induced migration and invasion of human breast cancer cells by competitively binding miR-1 with cdc42.

1 reference

12 December 2020

MicroRNA-548j functions as a metastasis promoter in human breast cancer by targeting Tensin1

1 reference

12 December 2020

Paxillin, a novel controller in the signaling of estrogen to FAK/N-WASP/Arp2/3 complex in breast cancer cells.

1 reference

12 December 2020

Deregulation of Rho GTPases in cancer

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12 December 2020

Structural Mechanisms and Drug Discovery Prospects of Rho GTPases

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12 December 2020

Rho GTPases: Regulation and roles in cancer cell biology

1 reference

12 December 2020

MDA-9/Syntenin (SDCBP) modulates small GTPases RhoA and Cdc42 via transforming growth factor β1 to enhance epithelial-mesenchymal transition in breast cancer

1 reference

12 December 2020

The non-receptor tyrosine kinase TNK2/ACK1 is a novel therapeutic target in triple negative breast cancer

1 reference

12 December 2020

RAC1 GTP-ase signals Wnt-beta-catenin pathway mediated integrin-directed metastasis-associated tumor cell phenotypes in triple negative breast cancers

1 reference

12 December 2020

Negative regulation of CDC42 expression and cell cycle progression by miR-29a in breast cancer.

1 reference

12 December 2020

Model-based unsupervised learning informs metformin-induced cell-migration inhibition through an AMPK-independent mechanism in breast cancer

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12 December 2020

Characterization of a Dual Rac/Cdc42 Inhibitor MBQ-167 in Metastatic Cancer.

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12 December 2020

Phenotypic characterisation of breast cancer: the role of CDC42.

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12 December 2020

Cdc42 Signaling Pathway Inhibition as a Therapeutic Target in Ras-Related Cancers

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12 December 2020

Prognostic impact of EGFR and cytokeratin 5/6 immunohistochemical expression in triple-negative breast cancer

1 reference

12 December 2020

High glucose levels promote the proliferation of breast cancer cells through GTPases

1 reference

12 December 2020

High expression of Rac1 is correlated with partial reversed cell polarity and poor prognosis in invasive ductal carcinoma of the breast

1 reference

12 December 2020

Glucose insult elicits hyperactivation of cancer stem cells through miR-424-cdc42-prdm14 signalling axis

1 reference

12 December 2020

The R-enantiomer of ketorolac delays mammary tumor development in mouse mammary tumor virus-polyoma middle T antigen (MMTV-PyMT) mice.

1 reference

12 December 2020

Targeting Rac and Cdc42 GTPases in Cancer

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12 December 2020

FGF Family: From Drug Development to Clinical Application

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12 December 2020

Targeting Cdc42 with the anticancer compound MBQ-167 inhibits cell polarity and growth in the budding yeast S. cerevisiae

1 reference

12 December 2020

Machine Learning Helps Identify New Drug Mechanisms in Triple-Negative Breast Cancer

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12 December 2020

Actin Cytoskeleton Remodeling Drives Breast Cancer Cell Escape from Natural Killer-Mediated Cytotoxicity

1 reference

12 December 2020

Relationship of Epidermal Growth Factor Receptor Expression with Clinical Symptoms and Metastasis of Invasive Breast Cancer

1 reference

12 December 2020

Evaluation of the prognostic value of all four HER family receptors in patients with metastatic breast cancer treated with trastuzumab: A Hellenic Cooperative Oncology Group (HeCOG) study

1 reference

12 December 2020