(Q77364348)

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Inhibition of desipramine hydroxylation (Cytochrome P450-2D6) in vitro by quinidine and by viral protease inhibitors: relation to drug interactions in vivo

scientific article published on 01 October 1998

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scholarly article

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5 December 2019

Inhibition of desipramine hydroxylation (Cytochrome P450-2D6) in vitro by quinidine and by viral protease inhibitors: relation to drug interactions in vivo (English)

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9758674%20AND%20SRC:MED&resulttype=core&format=json

5 December 2019

Richard I. Shader

6

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5 December 2019

Jerold S. Harmatz

5

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Harmatz JS

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5 December 2019

David J. Greenblatt

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Greenblatt DJ

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5 December 2019

Lisa L. von Moltke

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von Moltke LL

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5 December 2019

author name string

Duan SX

3

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5 December 2019

Daily JP

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5 December 2019

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publication date

1 October 1998

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5 December 2019

Journal of Pharmaceutical Sciences

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5 December 2019

87

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5 December 2019

10

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5 December 2019

1184-1189

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5 December 2019

Antiretroviral therapy for HIV infection in 1998: updated recommendations of the International AIDS Society-USA Panel

1 reference

https://api.crossref.org/works/10.1021%2FJS980197H

7 January 2021

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Antiretroviral therapy for patients with HIV disease

1 reference

https://api.crossref.org/works/10.1021%2FJS980197H

7 January 2021

based on heuristic

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HIV-protease inhibitors

1 reference

https://api.crossref.org/works/10.1021%2FJS980197H

7 January 2021

based on heuristic

inferred from DOI database lookup

Protease inhibitors in patients with HIV disease. Clinically important pharmacokinetic considerations

1 reference

https://api.crossref.org/works/10.1021%2FJS980197H

7 January 2021

based on heuristic

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Saquinavir pharmacokinetics alone and in combination with ritonavir in HIV-infected patients

1 reference

https://api.crossref.org/works/10.1021%2FJS980197H

7 January 2021

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Toxicity, efficacy, plasma drug concentrations and protease mutations in patients with advanced HIV infection treated with ritonavir plus saquinavir. Swiss HIV Cohort Study

1 reference

https://api.crossref.org/works/10.1021%2FJS980197H

7 January 2021

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Pharmacokinetic enhancement of inhibitors of the human immunodeficiency virus protease by coadministration with ritonavir.

1 reference

https://api.crossref.org/works/10.1021%2FJS980197H

7 January 2021

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The human hepatic cytochromes P450 involved in drug metabolism

1 reference

https://api.crossref.org/works/10.1021%2FJS980197H

7 January 2021

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Relationship of in vitro data on drug metabolism to in vivo pharmacokinetics and drug interactions: implications for diazepam disposition in humans.

1 reference

https://api.crossref.org/works/10.1021%2FJS980197H

7 January 2021

based on heuristic

inferred from DOI database lookup

P450 enzymes. Inhibition mechanisms, genetic regulation and effects of liver disease

1 reference

https://api.crossref.org/works/10.1021%2FJS980197H

7 January 2021

based on heuristic

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Protease inhibitors as inhibitors of human cytochromes P450: high risk associated with ritonavir

1 reference

https://api.crossref.org/works/10.1021%2FJS980197H

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibitors of alprazolam metabolism in vitro: effect of serotonin-reuptake-inhibitor antidepressants, ketoconazole and quinidine

1 reference

https://api.crossref.org/works/10.1021%2FJS980197H

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of alprazolam and desipramine hydroxylation in vitro by paroxetine and fluvoxamine: comparison with other selective serotonin reuptake inhibitor antidepressants

1 reference

https://api.crossref.org/works/10.1021%2FJS980197H

7 January 2021

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Inhibition of terfenadine metabolism in vitro by azole antifungal agents and by selective serotonin reuptake inhibitor antidepressants: relation to pharmacokinetic interactions in vivo

1 reference

https://api.crossref.org/works/10.1021%2FJS980197H

7 January 2021

based on heuristic

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In vitro prediction of the terfenadine-ketoconazole pharmacokinetic interaction.

1 reference

https://api.crossref.org/works/10.1021%2FJS980197H

7 January 2021

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Midazolam hydroxylation by human liver microsomes in vitro: inhibition by fluoxetine, norfluoxetine, and by azole antifungal agents.

1 reference

https://api.crossref.org/works/10.1021%2FJS980197H

7 January 2021

based on heuristic

inferred from DOI database lookup

In vitro approaches to predicting drug interactions in vivo.

1 reference

https://api.crossref.org/works/10.1021%2FJS980197H

7 January 2021

based on heuristic

inferred from DOI database lookup

Metabolism of drugs by cytochrome P450 3A isoforms. Implications for drug interactions in psychopharmacology.

1 reference

https://api.crossref.org/works/10.1021%2FJS980197H

7 January 2021

based on heuristic

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Inhibition by paroxetine of desipramine metabolism in extensive but not in poor metabolizers of sparteine

1 reference

https://api.crossref.org/works/10.1021%2FJS980197H

7 January 2021

based on heuristic

inferred from DOI database lookup

Desipramine pharmacokinetics when coadministered with paroxetine or sertraline in extensive metabolizers

1 reference

https://api.crossref.org/works/10.1021%2FJS980197H

7 January 2021

based on heuristic

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Relationship between plasma desipramine levels, CYP2D6 phenotype and clinical response to desipramine: a prospective study

1 reference

https://api.crossref.org/works/10.1021%2FJS980197H

7 January 2021

based on heuristic

inferred from DOI database lookup

The debrisoquine hydroxylation test predicts steady-state plasma levels of desipramine

1 reference

https://api.crossref.org/works/10.1021%2FJS980197H

7 January 2021

based on heuristic

inferred from DOI database lookup

Phenotypic consistency in hydroxylation of desmethylimipramine and debrisoquine in healthy subjects and in human liver microsomes

1 reference

https://api.crossref.org/works/10.1021%2FJS980197H

7 January 2021

based on heuristic

inferred from DOI database lookup

Quinidine inhibits the 2-hydroxylation of imipramine and desipramine but not the demethylation of imipramine

1 reference

https://api.crossref.org/works/10.1021%2FJS980197H

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of desipramine 2-hydroxylation by quinidine and quinine

1 reference

https://api.crossref.org/works/10.1021%2FJS980197H

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of desmethylimipramine 2-hydroxylation by drugs in human liver microsomes.

1 reference

https://api.crossref.org/works/10.1021%2FJS980197H

7 January 2021

based on heuristic

inferred from DOI database lookup

Differential inhibition of cytochrome P450 isoforms by the protease inhibitors, ritonavir, saquinavir and indinavir

1 reference

https://api.crossref.org/works/10.1021%2FJS980197H

7 January 2021

based on heuristic

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Hepatic and intestinal metabolism of indinavir, an HIV protease inhibitor, in rat and human microsomes. Major role of CYP3A

1 reference

https://api.crossref.org/works/10.1021%2FJS980197H

7 January 2021

based on heuristic

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Use of in vitro and in vivo data to estimate the likelihood of metabolic pharmacokinetic interactions

1 reference

https://api.crossref.org/works/10.1021%2FJS980197H

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of human cytochrome P450-3A isoforms by fluoxetine and norfluoxetine: in vitro and in vivo studies

1 reference

https://api.crossref.org/works/10.1021%2FJS980197H

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1021/JS980197H

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9758674%20AND%20SRC:MED&resulttype=core&format=json

5 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9758674%20AND%20SRC:MED&resulttype=core&format=json

5 December 2019

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