(Q78653254)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12480299%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

title

Polymorphic CYP2C19 and N-acetylation: human variability in kinetics and pathway-related uncertainty factors (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12480299%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

author name string

J L C M Dorne

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12480299%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

K Walton

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12480299%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

A G Renwick

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12480299%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

publication date

1 February 2003

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12480299%20AND%20SRC:MED&resulttype=core&format=json

Food and Chemical Toxicology

15 December 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12480299%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

volume

41

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12480299%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

issue

2

1 reference

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15 December 2019

page(s)

225-245

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12480299%20AND%20SRC:MED&resulttype=core&format=json

Selective effect of liver disease on the activities of specific metabolizing enzymes: investigation of cytochromes P450 2C19 and 2D6.

15 December 2019

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2802%2900210-7

7 January 2021

Pharmacokinetics of isoniazid in the elderly

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2802%2900210-7

7 January 2021

Effect of omeprazole treatment on diazepam plasma levels in slow versus normal rapid metabolizers of omeprazole.

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2802%2900210-7

7 January 2021

Pharmacokinetics of various single intravenous and oral doses of omeprazole

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2802%2900210-7

7 January 2021

Pharmacokinetics of orally administered omeprazole in children. International Pediatric Omeprazole Pharmacokinetic Group

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2802%2900210-7

7 January 2021

Pharmacokinetics and effect on caffeine metabolism of the proton pump inhibitors, omeprazole, lansoprazole, and pantoprazole

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2802%2900210-7

7 January 2021

Diazepam metabolism by human liver microsomes is mediated by both S-mephenytoin hydroxylase and CYP3A isoforms

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2802%2900210-7

7 January 2021

Pharmacokinetics of [14C]omeprazole in patients with liver cirrhosis

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2802%2900210-7

7 January 2021

Polymorphic hydroxylation of S-mephenytoin and omeprazole metabolism in Caucasian and Chinese subjects

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2802%2900210-7

7 January 2021

Importance of genetic factors in the regulation of diazepam metabolism: relationship to S-mephenytoin, but not debrisoquin, hydroxylation phenotype.

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2802%2900210-7

7 January 2021

Carbamazepine treatment induces the CYP3A4 catalysed sulphoxidation of omeprazole, but has no or less effect on hydroxylation via CYP2C19.

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2802%2900210-7

7 January 2021

Inhibition of the sulfoxidation of omeprazole by ketoconazole in poor and extensive metabolizers of S-mephenytoin.

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2802%2900210-7

7 January 2021

Pharmacokinetics of hexobarbital in acute hepatitis and after apparent recovery

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2802%2900210-7

7 January 2021

In vitro proguanil activation to cycloguanil by human liver microsomes is mediated by CYP3A isoforms as well as by S-mephenytoin hydroxylase

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2802%2900210-7

7 January 2021

Age-associated stereoselective alterations in hexobarbital metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2802%2900210-7

7 January 2021

Interphenotype differences in disposition and effect on gastrin levels of omeprazole--suitability of omeprazole as a probe for CYP2C19

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2802%2900210-7

7 January 2021

Kinetic discrimination of three sulfamethazine acetylation phenotypes

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2802%2900210-7

7 January 2021

Oral bioavailability of omeprazole before and after chronic therapy in patients with duodenal ulcer

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2802%2900210-7

7 January 2021

Uncertainty factors for chemical risk assessment. human variability in the pharmacokinetics of CYP1A2 probe substrates

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2802%2900210-7

7 January 2021

Human variability in glucuronidation in relation to uncertainty factors for risk assessment

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2802%2900210-7

7 January 2021

Human variability in polymorphic CYP2D6 metabolism: is the kinetic default uncertainty factor adequate?

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2802%2900210-7

7 January 2021

Human variability in CYP3A4 metabolism and CYP3A4-related uncertainty factors for risk assessment

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2802%2900210-7

7 January 2021

Comparative bioavailability study of two oral omeprazole formulations after single and repeated administrations in healthy volunteers

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2802%2900210-7

7 January 2021

CYP2C19 genotype status and effect of omeprazole on intragastric pH in humans

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2802%2900210-7

7 January 2021

Risk evaluation: criteria arising from legal traditions and experience with quantitative risk assessment in the United States

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2802%2900210-7

7 January 2021

Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress.

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2802%2900210-7

7 January 2021

The pharmacokinetics and activation of proguanil in man: consequences of variability in drug metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2802%2900210-7

7 January 2021

Isoniazid disposition, comparison of isoniazid phenotyping methods in and acetylator distribution of Japanese patients with idiopathic systemic lupus erythematosus and control subjects

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2802%2900210-7

7 January 2021

The effect of antacids and metoclopramide on omeprazole absorption and disposition

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2802%2900210-7

7 January 2021

Pharmacokinetics of intravenous omeprazole in children

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2802%2900210-7

7 January 2021

Effect of single and repeated intravenous doses of omeprazole on pentagastrin stimulated gastric acid secretion and pharmacokinetics in man.

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2802%2900210-7

7 January 2021

Fluvoxamine inhibits the CYP2C19-catalyzed bioactivation of chloroguanide*

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2802%2900210-7

7 January 2021

Predictability of the effects of race or ethnicity on pharmacokinetics of drugs.

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2802%2900210-7

7 January 2021

Pharmacokinetics of isoniazid: influence of age

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2802%2900210-7

7 January 2021

Metabolism of aromatic amines: relationships of N-acetylation, O-acetylation, N,O-acetyltransfer and deacetylation in human liver and urinary bladder

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2802%2900210-7

7 January 2021

A simple pharmacokinetic method for separating the three acetylation phenotypes: a preliminary report

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2802%2900210-7

7 January 2021

Biliary excretion of intravenous [14C] omeprazole in humans

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2802%2900210-7

7 January 2021

The absorption and excretion of paludrine in the human subject.

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2802%2900210-7

7 January 2021

The anti-secretory effect and pharmacokinetics of omeprazole in chronic liver disease

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2802%2900210-7

7 January 2021

Polymorphism of human acetyltransferases

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2802%2900210-7

7 January 2021

Pharmacokinetics of [14C]omeprazole in patients with impaired renal function

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2802%2900210-7

7 January 2021

Dose-dependent changes in sulfamethazine kinetics in rapid and slow isoniazid acetylators

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2802%2900210-7

7 January 2021

The pharmacokinetics of omeprazole in humans--a study of single intravenous and oral doses

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2802%2900210-7

7 January 2021

Data-derived safety factors for the evaluation of food additives and environmental contaminants

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2802%2900210-7

7 January 2021

Human variability and noncancer risk assessment- An analysis of the default uncertainty factor

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2802%2900210-7

7 January 2021

Disposition of hexobarbital in intra- and extrahepatic cholestasis in man and the influence of drug metabolism-inducing agents

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2802%2900210-7

7 January 2021

CYP2C19 genotype and pharmacokinetics of three proton pump inhibitors in healthy subjects

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2802%2900210-7

7 January 2021

Metabolic disposition of proguanil in extensive and poor metabolisers of S-mephenytoin 4'-hydroxylation recruited from an Indonesian population

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2802%2900210-7

7 January 2021

Incidence of S-mephenytoin hydroxylation deficiency in a Korean population and the interphenotypic differences in diazepam pharmacokinetics.

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2802%2900210-7

7 January 2021

The effect of glucose on acetylation status

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2802%2900210-7

7 January 2021

Rapid effect of lansoprazole on intragastric pH: a crossover comparison with omeprazole

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2802%2900210-7

7 January 2021

Pharmacokinetics of orally administered hexobarbital in plasma and saliva of healthy subjects.

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2802%2900210-7

7 January 2021

The CYP2C19 enzyme polymorphism

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2802%2900210-7

7 January 2021

Comparison of the kinetic disposition and metabolism of E3810, a new proton pump inhibitor, and omeprazole in relation to S-mephenytoin 4′-hydroxylation status

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2802%2900210-7

7 January 2021

Diazepam metabolism in native Chinese poor and extensive hydroxylators of S-mephenytoin: interethnic differences in comparison with white subjects.

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2802%2900210-7

7 January 2021

Induction of drug metabolism in man after rifampicin treatment measured by increased hexobarbital and tolbutamide clearance

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2802%2900210-7

7 January 2021

10.1016/S0278-6915(02)00210-7

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12480299%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

1 reference