(Q79412060)

English

Regulation of the proapoptotic BH3-only protein BIM by glucocorticoids, survival signals and proteasome in chronic lymphocytic leukemia cells

scientific article published on 07 December 2006

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scholarly article

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17151701%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

Regulation of the proapoptotic BH3-only protein BIM by glucocorticoids, survival signals and proteasome in chronic lymphocytic leukemia cells (English)

1 reference

Europe PubMed Central

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22 December 2019

chronic lymphocytic leukemia

1 reference

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Daniel Iglesias-Serret

1

1 reference

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22 December 2019

8

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22 December 2019

author name string

M de Frias

2

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22 December 2019

A F Santidrián

3

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22 December 2019

L Coll-Mulet

4

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22 December 2019

A M Cosialls

5

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22 December 2019

M Barragán

6

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22 December 2019

A Domingo

7

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22 December 2019

G Pons

9

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22 December 2019

publication date

7 December 2006

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22 December 2019

1 reference

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22 December 2019

21

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22 December 2019

2

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22 December 2019

281-287

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22 December 2019

https://scigraph.springernature.com/pub.10.1038/sj.leu.2404483

0 references

Chronic lymphocytic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404483

7 January 2021

based on heuristic

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Involvement of protein kinase C and phosphatidylinositol 3-kinase pathways in the survival of B-cell chronic lymphocytic leukemia cells.

1 reference

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7 January 2021

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Bryostatin and CD40-ligand enhance apoptosis resistance and induce expression of cell survival genes in B-cell chronic lymphocytic leukaemia.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404483

7 January 2021

based on heuristic

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CD40 stimulation of B-cell chronic lymphocytic leukaemia cells enhances the anti-apoptotic profile, but also Bid expression and cells remain susceptible to autologous cytotoxic T-lymphocyte attack.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404483

7 January 2021

based on heuristic

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Spontaneous and drug-induced apoptosis is mediated by conformational changes of Bax and Bak in B-cell chronic lymphocytic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404483

7 January 2021

based on heuristic

inferred from DOI database lookup

Chronic lymphocytic leukemia cells display p53-dependent drug-induced Puma upregulation

1 reference

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7 January 2021

based on heuristic

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MDM2 antagonists activate p53 and synergize with genotoxic drugs in B-cell chronic lymphocytic leukemia cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404483

7 January 2021

based on heuristic

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Expression and transcriptional regulation of functionally distinct Bmf isoforms in B-chronic lymphocytic leukemia cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404483

7 January 2021

based on heuristic

inferred from DOI database lookup

Bim: a novel member of the Bcl-2 family that promotes apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404483

7 January 2021

based on heuristic

inferred from DOI database lookup

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404483

7 January 2021

based on heuristic

inferred from DOI database lookup

Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404483

7 January 2021

based on heuristic

inferred from DOI database lookup

Nomenclature of dynein light chain-linked BH3-only protein Bim isoforms.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404483

7 January 2021

based on heuristic

inferred from DOI database lookup

Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404483

7 January 2021

based on heuristic

inferred from DOI database lookup

BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404483

7 January 2021

based on heuristic

inferred from DOI database lookup

Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim inhibits BCR stimulation-induced apoptosis and deletion of autoreactive B cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404483

7 January 2021

based on heuristic

inferred from DOI database lookup

Negative selection of semimature CD4(+)8(-)HSA+ thymocytes requires the BH3-only protein Bim but is independent of death receptor signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404483

7 January 2021

based on heuristic

inferred from DOI database lookup

Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404483

7 January 2021

based on heuristic

inferred from DOI database lookup

Microarray analysis uncovers the induction of the proapoptotic BH3-only protein Bim in multiple models of glucocorticoid-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404483

7 January 2021

based on heuristic

inferred from DOI database lookup

The pro-apoptotic protein Bim is a convergence point for cAMP/protein kinase A- and glucocorticoid-promoted apoptosis of lymphoid cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404483

7 January 2021

based on heuristic

inferred from DOI database lookup

BH3-only proteins Puma and Bim are rate-limiting for gamma-radiation- and glucocorticoid-induced apoptosis of lymphoid cells in vivo.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404483

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of glucocorticoid-induced apoptosis by targeting the major splice variants of BIM mRNA with small interfering RNA and short hairpin RNA.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404483

7 January 2021

based on heuristic

inferred from DOI database lookup

Dexamethasone resistance in B-cell precursor childhood acute lymphoblastic leukemia occurs downstream of ligand-induced nuclear translocation of the glucocorticoid receptor.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404483

7 January 2021

based on heuristic

inferred from DOI database lookup

Genome-wide array-based CGH for mantle cell lymphoma: identification of homozygous deletions of the proapoptotic gene BIM.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404483

7 January 2021

based on heuristic

inferred from DOI database lookup

cAMP-mediated growth inhibition in fibroblasts is not mediated via mitogen-activated protein (MAP) kinase (ERK) inhibition. cAMP-dependent protein kinase induces a temporal shift in growth factor-stimulated MAP kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404483

7 January 2021

based on heuristic

inferred from DOI database lookup

Expression profiling via novel multiplex assay allows rapid assessment of gene regulation in defined signalling pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404483

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulatory phosphorylation of Bim: sorting out the ERK from the JNK

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404483

7 January 2021

based on heuristic

inferred from DOI database lookup

The Noxa/Mcl-1 axis regulates susceptibility to apoptosis under glucose limitation in dividing T cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404483

7 January 2021

based on heuristic

inferred from DOI database lookup

Bim is a suppressor of Myc-induced mouse B cell leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404483

7 January 2021

based on heuristic

inferred from DOI database lookup

Roles of Bim in apoptosis of normal and Bcr-Abl-expressing hematopoietic progenitors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404483

7 January 2021

based on heuristic

inferred from DOI database lookup

Low-level expression of proapoptotic Bcl-2-interacting mediator in leukemic cells in patients with chronic myeloid leukemia: role of BCR/ABL, characterization of underlying signaling pathways, and reexpression by novel pharmacologic compounds.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404483

7 January 2021

based on heuristic

inferred from DOI database lookup

Transcriptional and translational control of Mcl-1 during apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404483

7 January 2021

based on heuristic

inferred from DOI database lookup

Downregulation of Bim, a proapoptotic relative of Bcl-2, is a pivotal step in cytokine-initiated survival signaling in murine hematopoietic progenitors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404483

7 January 2021

based on heuristic

inferred from DOI database lookup

Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404483

7 January 2021

based on heuristic

inferred from DOI database lookup

Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404483

7 January 2021

based on heuristic

inferred from DOI database lookup

Activation of ERK1/2 by deltaRaf-1:ER* represses Bim expression independently of the JNK or PI3K pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404483

7 January 2021

based on heuristic

inferred from DOI database lookup

Nerve growth factor (NGF) down-regulates the Bcl-2 homology 3 (BH3) domain-only protein Bim and suppresses its proapoptotic activity by phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404483

7 January 2021

based on heuristic

inferred from DOI database lookup

Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404483

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function.

1 reference

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7 January 2021

based on heuristic

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Survival of leukemic B cells promoted by engagement of the antigen receptor

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Sustained signaling through the B-cell receptor induces Mcl-1 and promotes survival of chronic lymphocytic leukemia B cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404483

7 January 2021

based on heuristic

inferred from DOI database lookup

Role of Bim in the survival pathway induced by Raf in epithelial cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404483

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of a DEF-type docking domain for extracellular signal-regulated kinases 1/2 that directs phosphorylation and turnover of the BH3-only protein BimEL.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404483

7 January 2021

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Phase II clinical experience with the novel proteasome inhibitor bortezomib in patients with indolent non-Hodgkin's lymphoma and mantle cell lymphoma

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

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