(Q81127104)

English

The AKT/I kappa B kinase pathway promotes angiogenic/metastatic gene expression in colorectal cancer by activating nuclear factor-kappa B and beta-catenin

scientific article published on 01 February 2005

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15592509%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

The AKT/I kappa B kinase pathway promotes angiogenic/metastatic gene expression in colorectal cancer by activating nuclear factor-kappa B and beta-catenin (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15592509%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

colorectal cancer

1 reference

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inferred from title

colorectal carcinoma

1 reference

based on heuristic

inferred from title

author name string

Anju Agarwal

1

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15592509%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

Kingshuk Das

2

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15592509%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

Natalia Lerner

3

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15592509%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

Swati Sathe

4

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15592509%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

Muzaffer Cicek

5

1 reference

Europe PubMed Central

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6 January 2020

Graham Casey

6

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15592509%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

Nywana Sizemore

7

1 reference

Europe PubMed Central

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6 January 2020

publication date

1 February 2005

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Europe PubMed Central

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6 January 2020

number of pages

11

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inferred from page(s)

1 reference

Europe PubMed Central

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6 January 2020

24

1 reference

Europe PubMed Central

PubMed publication ID

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6 January 2020

6

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PubMed publication ID

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6 January 2020

1021-1031

1 reference

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PubMed publication ID

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6 January 2020

https://scigraph.springernature.com/pub.10.1038/sj.onc.1208296

0 references

A nucleosomal function for IkappaB kinase-alpha in NF-kappaB-dependent gene expression

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Piceatannol inhibits TNF-induced NF-kappaB activation and NF-kappaB-mediated gene expression through suppression of IkappaBalpha kinase and p65 phosphorylation

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Function and activation of NF-kappa B in the immune system

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uPAR: a versatile signalling orchestrator

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Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

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Clinical significance of vascular endothelial growth factor C expression and angiogenesis at the deepest invasive site of advanced colorectal carcinoma

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Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2.

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The PTEN tumor suppressor protein inhibits tumor necrosis factor-induced nuclear factor kappa B activity

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IKK beta and phosphatidylinositol 3-kinase/Akt participate in non-pathogenic Gram-negative enteric bacteria-induced RelA phosphorylation and NF-kappa B activation in both primary and intestinal epithelial cell lines

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The angiogenic switch for vascular endothelial growth factor (VEGF)-A, VEGF-B, VEGF-C, and VEGF-D in the adenoma-carcinoma sequence during colorectal cancer progression

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Interleukin-8 as a macrophage-derived mediator of angiogenesis

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Tumor suppressor MMAC/PTEN inhibits cytokine-induced NFkappaB activation without interfering with the IkappaB degradation pathway

1 reference

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Regulation of beta-catenin function by the IkappaB kinases

1 reference

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Severe liver degeneration in mice lacking the IkappaB kinase 2 gene

1 reference

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IKKalpha, IKKbeta, and NEMO/IKKgamma are each required for the NF-kappa B-mediated inflammatory response program.

1 reference

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7 January 2021

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NF-kappaB in cancer: a marked target

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7 January 2021

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Nuclear factor-kappa B is upregulated in colorectal cancer

1 reference

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7 January 2021

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Akt stimulates the transactivation potential of the RelA/p65 Subunit of NF-kappa B through utilization of the Ikappa B kinase and activation of the mitogen-activated protein kinase p38.

1 reference

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7 January 2021

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PTEN blocks tumor necrosis factor-induced NF-kappa B-dependent transcription by inhibiting the transactivation potential of the p65 subunit

1 reference

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NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase

1 reference

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Her-2/neu overexpression induces NF-kappaB via a PI3-kinase/Akt pathway involving calpain-mediated degradation of IkappaB-alpha that can be inhibited by the tumor suppressor PTEN.

1 reference

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Aberrant rel/nfkb genes and activity in human cancer

1 reference

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IkappaB kinases phosphorylate NF-kappaB p65 subunit on serine 536 in the transactivation domain

1 reference

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Tumor necrosis factor-alpha-induced IKK phosphorylation of NF-kappaB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway

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Regulation of interleukin-8 expression by tumor-associated stress factors

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Structure, regulation and function of NF-kappa B

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Distinct roles of the Ikappa B kinase alpha and beta subunits in liberating nuclear factor kappa B (NF-kappa B) from Ikappa B and in phosphorylating the p65 subunit of NF-kappa B.

1 reference

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Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

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Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN

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Embryonic lethality, liver degeneration, and impaired NF-kappa B activation in IKK-beta-deficient mice

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Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells

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NF-kappa B: a lesson in family values

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A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle

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Histone H3 phosphorylation by IKK-alpha is critical for cytokine-induced gene expression

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IKK beta plays an essential role in the phosphorylation of RelA/p65 on serine 536 induced by lipopolysaccharide

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