(Q86561168)

English

Distinct and opposing roles for the phosphatidylinositol 3-OH kinase catalytic subunits p110α and p110β in the regulation of insulin secretion from rodent and human beta cells

scientific article published on 09 April 2013

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23568272%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Distinct and opposing roles for the phosphatidylinositol 3-OH kinase catalytic subunits p110α and p110β in the regulation of insulin secretion from rodent and human beta cells (English)

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23568272%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Patrick E. Macdonald

9

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Europe PubMed Central

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28 February 2020

author name string

J Kolic

1

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28 February 2020

A F Spigelman

2

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28 February 2020

G Plummer

3

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28 February 2020

E Leung

4

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28 February 2020

C Hajmrle

5

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28 February 2020

T Kin

6

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28 February 2020

A M J Shapiro

7

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28 February 2020

J E Manning Fox

8

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28 February 2020

publication date

9 April 2013

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28 February 2020

1 reference

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28 February 2020

56

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28 February 2020

6

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28 February 2020

1339-1349

1 reference

Europe PubMed Central

PubMed publication ID

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28 February 2020

https://scigraph.springernature.com/pub.10.1007/s00125-013-2882-4

0 references

p110δ, a novel phosphoinositide 3-kinase in leukocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/23568272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of PI3K in immune cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/23568272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Class IA phosphatidylinositol 3-kinase in pancreatic β cells controls insulin secretion by multiple mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/23568272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wortmannin, a PI3-kinase inhibitor: promoting effect on insulin secretion from pancreatic beta cells through a cAMP-dependent pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/23568272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The PI 3-kinase isoforms p110(alpha) and p110(beta) have differential roles in PDGF- and insulin-mediated signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/23568272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wortmannin, a microbial product inhibitor of myosin light chain kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/23568272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PI 3-kinase p110beta: a new target for antithrombotic therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/23568272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene expression heterogeneity in human islet endocrine cells in vitro: the insulin signalling cascade.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23568272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23568272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A link between insulin resistance and hyperinsulinemia: inhibitors of phosphatidylinositol 3-kinase augment glucose-induced insulin secretion from islets of lean, but not obese, rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23568272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23568272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin feedback alters mitochondrial activity through an ATP-sensitive K+ channel-dependent pathway in mouse islets and beta-cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/23568272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The phosphatidylinositol 3-kinase inhibitor LY294002 potently blocks K(V) currents via a direct mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/23568272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired glucose-stimulated insulin secretion, enhanced intraperitoneal insulin tolerance, and increased beta-cell mass in mice lacking the p110gamma isoform of phosphoinositide 3-kinase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23568272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of acutely inhibiting PI3K isoforms and mTOR on regulation of glucose metabolism in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/23568272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23568272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction

1 reference

https://pubmed.ncbi.nlm.nih.gov/23568272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphatidylinositol 3-kinase inhibitors reveal a unique mechanism of enhancing insulin secretion in 832/13 rat insulinoma cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23568272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/23568272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-feedback via PI3K-C2alpha activated PKBalpha/Akt1 is required for glucose-stimulated insulin secretion

1 reference

https://pubmed.ncbi.nlm.nih.gov/23568272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-like growth factor I (IGF-I)-stimulated pancreatic beta-cell growth is glucose-dependent. Synergistic activation of insulin receptor substrate-mediated signal transduction pathways by glucose and IGF-I in INS-1 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/23568272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphoinositide 3-kinase p110beta activity: key role in metabolism and mammary gland cancer but not development

1 reference

https://pubmed.ncbi.nlm.nih.gov/23568272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A PI3-kinase signaling code for insulin-triggered insertion of glucose transporters into the plasma membrane

1 reference

https://pubmed.ncbi.nlm.nih.gov/23568272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphatidylinositol 3-kinase suppresses glucose-stimulated insulin secretion by affecting post-cytosolic [Ca(2+)] elevation signals

1 reference

https://pubmed.ncbi.nlm.nih.gov/23568272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acute inhibition of PI3K-PDK1-Akt pathway potentiates insulin secretion through upregulation of newcomer granule fusions in pancreatic β-cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/23568272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human target validation of phosphoinositide 3-kinase (PI3K)β: effects on platelets and insulin sensitivity, using AZD6482 a novel PI3Kβ inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/23568272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphoinositide 3-kinase catalytic subunit deletion and regulatory subunit deletion have opposite effects on insulin sensitivity in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/23568272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucose-dependent insulinotropic polypeptide is a growth factor for beta (INS-1) cells by pleiotropic signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/23568272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85 alpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/23568272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PI3K p110α/Akt signaling negatively regulates secretion of the intestinal peptide neurotensin through interference of granule transport.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23568272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Class II phosphoinositide 3-kinase regulates exocytosis of insulin granules in pancreatic beta cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/23568272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23568272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of biphasic insulin-granule exocytosis - roles of the cytoskeleton, small GTPases and SNARE proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/23568272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphoinositide kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/23568272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin receptor activation inhibits insulin secretion from human islets of Langerhans

1 reference

https://pubmed.ncbi.nlm.nih.gov/23568272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin granule recruitment and exocytosis is dependent on p110gamma in insulinoma and human beta-cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/23568272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphatidylinositol(4,5)bisphosphate coordinates actin-mediated mobilization and translocation of secretory vesicles to the plasma membrane of chromaffin cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23568272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PI3K p110 alpha and p110 beta have differential effects on Akt activation and protection against oxidative stress-induced apoptosis in myoblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/23568272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PI 3-kinase and cancer: changing accents

1 reference

https://pubmed.ncbi.nlm.nih.gov/23568272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of insulin signaling elements in human beta-cells: autocrine regulation of insulin gene expression.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23568272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass

1 reference

https://pubmed.ncbi.nlm.nih.gov/23568272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Class IA phosphoinositide 3-kinase regulates heart size and physiological cardiac hypertrophy

1 reference

https://pubmed.ncbi.nlm.nih.gov/23568272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Islet beta cell expression of constitutively active Akt1/PKB alpha induces striking hypertrophy, hyperplasia, and hyperinsulinemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/23568272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/23568272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Voltage-gated and resting membrane currents recorded from B-cells in intact mouse pancreatic islets.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23568272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PI3K-signalling in B- and T-cells: insights from gene-targeted mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/23568272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SUMOylation regulates insulin exocytosis downstream of secretory granule docking in rodents and humans.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23568272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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