(Q37078025)

18 August 2017

Class IA phosphatidylinositol 3-kinase in pancreatic β cells controls insulin secretion by multiple mechanisms (English)

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18 August 2017

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C Ronald Kahn

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18 August 2017

2

Kohjiro Ueki

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18 August 2017

19

Takashi Kadowaki

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18 August 2017

Kazuma Kaneko

1

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18 August 2017

Noriko Takahashi

3

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18 August 2017

Shinji Hashimoto

4

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18 August 2017

Masayuki Okamoto

5

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18 August 2017

Motoharu Awazawa

6

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18 August 2017

Yukiko Okazaki

7

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18 August 2017

Mitsuru Ohsugi

8

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18 August 2017

Kazunori Inabe

9

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18 August 2017

Toshihiro Umehara

10

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18 August 2017

Masashi Yoshida

11

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18 August 2017

Masafumi Kakei

12

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18 August 2017

Tadahiro Kitamura

13

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18 August 2017

Ji Luo

14

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18 August 2017

Rohit N Kulkarni

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18 August 2017

Haruo Kasai

17

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18 August 2017

1 December 2010

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18 August 2017

14

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inferred from page(s)

published in

Cell Metabolism

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18 August 2017

12

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6

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18 August 2017

619-632

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describes a project that uses

18 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3736578/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Insulin signaling regulates mitochondrial function in pancreatic beta-cells

29 September 2017

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Cx36 makes channels coupling human pancreatic beta-cells, and correlates with insulin expression

29 September 2017

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Insulin signaling in the pancreatic beta-cell

29 September 2017

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Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice

29 September 2017

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Two cAMP-dependent pathways differentially regulate exocytosis of large dense-core and small vesicles in mouse beta-cells

29 September 2017

1 reference

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The p85alpha regulatory subunit of phosphoinositide 3-kinase potentiates c-Jun N-terminal kinase-mediated insulin resistance

29 September 2017

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29 September 2017

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Mechanisms linking obesity to insulin resistance and type 2 diabetes

29 September 2017

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Connexin36 and pancreatic beta-cell functions

29 September 2017

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Phosphoinositide 3-kinase regulatory subunit p85alpha suppresses insulin action via positive regulation of PTEN.

29 September 2017

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The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

29 September 2017

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Critical nodes in signalling pathways: insights into insulin action

29 September 2017

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Impaired gene and protein expression of exocytotic soluble N-ethylmaleimide attachment protein receptor complex proteins in pancreatic islets of type 2 diabetic patients

29 September 2017

1 reference

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RIP-Cre revisited, evidence for impairments of pancreatic beta-cell function

29 September 2017

1 reference

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Class IA phosphoinositide 3-kinase regulates heart size and physiological cardiac hypertrophy

29 September 2017

1 reference

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Rab27a mediates the tight docking of insulin granules onto the plasma membrane during glucose stimulation

29 September 2017

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Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus

29 September 2017

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Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes

29 September 2017

1 reference

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Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

29 September 2017

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Sequential exocytosis of insulin granules is associated with redistribution of SNAP25

29 September 2017

1 reference

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Positive and Negative Roles of p85α and p85β Regulatory Subunits of Phosphoinositide 3-Kinase in Insulin Signaling

29 September 2017

1 reference

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Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

29 September 2017

1 reference

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Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction?

29 September 2017

1 reference

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Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736578

Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736578

Islet beta cell expression of constitutively active Akt1/PKB alpha induces striking hypertrophy, hyperplasia, and hyperinsulinemia

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736578

Selective insulin signaling through A and B insulin receptors regulates transcription of insulin and glucokinase genes in pancreatic beta cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736578

Signaling through the p38 and p42/44 mitogen-activated families of protein kinases in pancreatic beta-cell proliferation.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736578

Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736578

Regulation of the p85/p110 phosphatidylinositol 3'-kinase: stabilization and inhibition of the p110alpha catalytic subunit by the p85 regulatory subunit

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736578

Abnormal splicing of the leptin receptor in diabetic mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736578

Glucose effects on beta-cell growth and survival require activation of insulin receptors and insulin receptor substrate 2.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736578

Increased p85/55/50 expression and decreased phosphotidylinositol 3-kinase activity in insulin-resistant human skeletal muscle

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736578

Loss of connexin36 channels alters beta-cell coupling, islet synchronization of glucose-induced Ca2+ and insulin oscillations, and basal insulin release.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736578

Decreased expression of t-SNARE, syntaxin 1, and SNAP-25 in pancreatic beta-cells is involved in impaired insulin secretion from diabetic GK rat islets: restoration of decreased t-SNARE proteins improves impaired insulin secretion

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736578

Insulin-feedback via PI3K-C2alpha activated PKBalpha/Akt1 is required for glucose-stimulated insulin secretion

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736578

Type 2 diabetes-a matter of beta-cell life and death?

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736578

Reduced β-cell mass and altered glucose sensing impair insulin-secretory function in βIRKO mice

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736578

Fusion pore dynamics and insulin granule exocytosis in the pancreatic islet

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736578

beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736578

Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736578

Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736578

Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736578

Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736578

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736578

Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKCλ/ζ

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736578

Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85 alpha

4 December 2018

1 reference

12 December 2020

The influence of genetic background on expression of mutations at the diabetes locus in the mouse. I. C57BL/KsJ and C57BL/6J strains

1 reference

12 December 2020

Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes

1 reference

12 December 2020

Ablation of PDK1 in pancreatic beta cells induces diabetes as a result of loss of beta cell mass

1 reference

12 December 2020

10.1016/J.CMET.2010.11.005

Identifiers

DOI

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18 August 2017

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18 August 2017

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