(Q90040549)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31505793%20AND%20SRC:MED&resulttype=core&format=json

10 April 2020

review article

1 reference

title

The Proteolytic Regulation of Virus Cell Entry by Furin and Other Proprotein Convertases (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31505793%20AND%20SRC:MED&resulttype=core&format=json

10 April 2020

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31505793%20AND%20SRC:MED&resulttype=core&format=json

10 April 2020

publication date

9 September 2019

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31505793%20AND%20SRC:MED&resulttype=core&format=json

10 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31505793%20AND%20SRC:MED&resulttype=core&format=json

10 April 2020

volume

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31505793%20AND%20SRC:MED&resulttype=core&format=json

10 April 2020

issue

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31505793%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

10 April 2020

copyright license

start time

9 September 2019

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

Testicular expression of PC4 in the rat: molecular diversity of a novel germ cell-specific Kex2/subtilisin-like proprotein convertase

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12 December 2020

Influenza virus hemagglutinin with multibasic cleavage site is activated by furin, a subtilisin-like endoprotease

1 reference

12 December 2020

Engineered serine protease inhibitor prevents furin-catalyzed activation of the fusion glycoprotein and production of infectious measles virus.

1 reference

12 December 2020

Proteolytic processing of human cytomegalovirus glycoprotein B (gpUL55) is mediated by the human endoprotease furin.

1 reference

12 December 2020

Processing of viral glycoproteins by the subtilisin-like endoprotease furin and its inhibition by specific peptidylchloroalkylketones

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12 December 2020

Activation of an influenza virus A/turkey/Oregon/71 HA insertion variant by the subtilisin-like endoprotease furin

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12 December 2020

Proprotein-processing endoproteases PC6 and furin both activate hemagglutinin of virulent avian influenza viruses.

1 reference

12 December 2020

Proteolytic cleavage of wild type and mutants of the F protein of human parainfluenza virus type 3 by two subtilisin-like endoproteases, furin and Kex2.

1 reference

12 December 2020

Inhibition of HIV-1 gp160-dependent membrane fusion by a furin-directed alpha 1-antitrypsin variant

1 reference

12 December 2020

Sequence specificity of furin, a proprotein-processing endoprotease, for the hemagglutinin of a virulent avian influenza virus.

1 reference

12 December 2020

Arg15-Lys17-Arg18 turkey ovomucoid third domain inhibits human furin.

1 reference

12 December 2020

Comparative cellular processing of the human immunodeficiency virus (HIV-1) envelope glycoprotein gp160 by the mammalian subtilisin/kexin-like convertases

1 reference

12 December 2020

The role of eukaryotic subtilisin-like endoproteases for the activation of human immunodeficiency virus glycoproteins in natural host cells

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12 December 2020

Comparative processing of bovine leukemia virus envelope glycoprotein gp72 by subtilisin/kexin-like mammalian convertases.

1 reference

12 December 2020

Inhibition of intracellular proteolytic processing of soluble proproteins by an engineered alpha 2-macroglobulin containing a furin recognition sequence in the bait region

1 reference

12 December 2020

Inhibition of soluble recombinant furin by human proteinase inhibitor 8

1 reference

12 December 2020

Processing of the Ebola virus glycoprotein by the proprotein convertase furin

1 reference

12 December 2020

Biochemical analysis of the secreted and virion glycoproteins of Ebola virus

1 reference

12 December 2020

The role of subtilisin-like proprotein convertases for cleavage of the measles virus fusion glycoprotein in different cell types

1 reference

12 December 2020

Endoproteolytic processing of the ebola virus envelope glycoprotein: cleavage is not required for function.

1 reference

12 December 2020

A protein-based therapeutic for human cytomegalovirus infection

1 reference

12 December 2020

Proteolytic processing of Marburg virus glycoprotein

1 reference

12 December 2020

Targeted infection of endothelial cells by avian influenza virus A/FPV/Rostock/34 (H7N1) in chicken embryos

1 reference

12 December 2020

Polyarginines are potent furin inhibitors

1 reference

12 December 2020

Engineered eglin c variants inhibit yeast and human proprotein processing proteases, Kex2 and furin

1 reference

12 December 2020

Implication of the proprotein convertases furin, PC5 and PC7 in the cleavage of surface glycoproteins of Hong Kong, Ebola and respiratory syncytial viruses: a comparative analysis with fluorogenic peptides

1 reference

12 December 2020

The serpins are an expanding superfamily of structurally similar but functionally diverse proteins. Evolution, mechanism of inhibition, novel functions, and a revised nomenclature

1 reference

12 December 2020

Cleavage of the human respiratory syncytial virus fusion protein at two distinct sites is required for activation of membrane fusion

1 reference

12 December 2020

Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses

1 reference

12 December 2020

Reverse genetics demonstrates that proteolytic processing of the Ebola virus glycoprotein is not essential for replication in cell culture

1 reference

12 December 2020

Furin Processing and Proteolytic Activation of Semliki Forest Virus

1 reference

12 December 2020

Efficient intracellular assembly of papillomaviral vectors

1 reference

12 December 2020

Drosophila serpin 4 functions as a neuroserpin-like inhibitor of subtilisin-like proprotein convertases.

1 reference

12 December 2020

The Spn4 gene of Drosophila encodes a potent furin-directed secretory pathway serpin

1 reference

12 December 2020

Ubiquitous activation of the Nipah virus fusion protein does not require a basic amino acid at the cleavage site

1 reference

12 December 2020

Polyarginine inhibits gp160 processing by furin and suppresses productive human immunodeficiency virus type 1 infection

1 reference

12 December 2020

A structural perspective of the flavivirus life cycle

1 reference

12 December 2020

Maturation of papillomavirus capsids

1 reference

12 December 2020

Endosomal proteolysis of the Ebola virus glycoprotein is necessary for infection

1 reference

12 December 2020

Cutting back on pro-protein convertases: the latest approaches to pharmacological inhibition

1 reference

12 December 2020

Multiple organ infection and the pathogenesis of SARS.

1 reference

12 December 2020

Cathepsin L is involved in proteolytic processing of the Hendra virus fusion protein

1 reference

12 December 2020

Crimean-congo hemorrhagic fever virus glycoprotein precursor is cleaved by Furin-like and SKI-1 proteases to generate a novel 38-kilodalton glycoprotein

1 reference

12 December 2020

Cleavage of the papillomavirus minor capsid protein, L2, at a furin consensus site is necessary for infection

1 reference

12 December 2020

A proprotein convertase-inhibiting serpin with an endoplasmic reticulum targeting signal from Branchiostoma lanceolatum, a close relative of vertebrates

1 reference

12 December 2020

The serpin proteinase inhibitor 8: an endogenous furin inhibitor released from human platelets

1 reference

12 December 2020

Role of endosomal cathepsins in entry mediated by the Ebola virus glycoprotein

1 reference

12 December 2020

Furin cleavage potentiates the membrane fusion-controlling intersubunit disulfide bond isomerization activity of leukemia virus Env.

1 reference

12 December 2020

Proteolytic activation of influenza viruses by serine proteases TMPRSS2 and HAT from human airway epithelium

1 reference

12 December 2020

Short polybasic peptide sequences are potent inhibitors of PC5/6 and PC7: Use of positional scanning-synthetic peptide combinatorial libraries as a tool for the optimization of inhibitory sequences

1 reference

12 December 2020

Synthetic small molecule furin inhibitors derived from 2,5-dideoxystreptamine

1 reference

12 December 2020

Proteolytic processing of the Ebola virus glycoprotein is not critical for Ebola virus replication in nonhuman primates

1 reference

12 December 2020

Targeting host cell furin proprotein convertases as a therapeutic strategy against bacterial toxins and viral pathogens

1 reference

12 December 2020

Proteolysis of the Ebola virus glycoproteins enhances virus binding and infectivity

1 reference

12 December 2020

Blockage of filoviral glycoprotein processing by use of a protein-based inhibitor

1 reference

12 December 2020

Heparin enhances the furin cleavage of HIV-1 gp160 peptides.

1 reference

12 December 2020

The activation and physiological functions of the proprotein convertases

1 reference

12 December 2020

A small-molecule furin inhibitor inhibits cancer cell motility and invasiveness

1 reference

12 December 2020

Substrate cleavage analysis of furin and related proprotein convertases. A comparative study

1 reference

12 December 2020

Inhibition of Chikungunya virus infection in cultured human muscle cells by furin inhibitors: impairment of the maturation of the E2 surface glycoprotein

1 reference

12 December 2020

Cathepsin L functionally cleaves the severe acute respiratory syndrome coronavirus class I fusion protein upstream of rather than adjacent to the fusion peptide

1 reference

12 December 2020

Changing the Protease Specificity for Activation of a Flavivirus, Tick-Borne Encephalitis Virus

1 reference

12 December 2020

Molecular characterization and complete genome sequence of avian paramyxovirus type 4 prototype strain duck/Hong Kong/D3/75

1 reference

12 December 2020

Functional importance of dengue virus maturation: infectious properties of immature virions

1 reference

12 December 2020

Proteolytic activation of the 1918 influenza virus hemagglutinin

1 reference

12 December 2020

Complete sequence of the genome of avian paramyxovirus type 9 and comparison with other paramyxoviruses

1 reference

12 December 2020

Cleavage of Epstein-Barr virus glycoprotein B is required for full function in cell-cell fusion with both epithelial and B cells

1 reference

12 December 2020

Activation of the SARS coronavirus spike protein via sequential proteolytic cleavage at two distinct sites

1 reference

12 December 2020

Inhibition of furin/proprotein convertase-catalyzed surface and intracellular processing by small molecules

1 reference

12 December 2020

Mutagenesis of varicella-zoster virus glycoprotein B: putative fusion loop residues are essential for viral replication, and the furin cleavage motif contributes to pathogenesis in skin tissue in vivo

1 reference

12 December 2020

Proteolytic activation of the spike protein at a novel RRRR/S motif is implicated in furin-dependent entry, syncytium formation, and infectivity of coronavirus infectious bronchitis virus in cultured cells

1 reference

12 December 2020

Targeting the proteolytic processing of the viral glycoprotein precursor is a promising novel antiviral strategy against arenaviruses

1 reference

12 December 2020

The initial steps leading to papillomavirus infection occur on the basement membrane prior to cell surface binding

1 reference

12 December 2020

A novel enediynyl peptide inhibitor of furin that blocks processing of proPDGF-A, B and proVEGF-C.

1 reference

12 December 2020

The role of furin in papillomavirus infection

1 reference

12 December 2020

Potent inhibitors of furin and furin-like proprotein convertases containing decarboxylated P1 arginine mimetics

1 reference

12 December 2020

Initiation of duck hepatitis B virus infection requires cleavage by a furin-like protease

1 reference

12 December 2020

Selective and potent furin inhibitors protect cells from anthrax without significant toxicity

1 reference

12 December 2020

Novel type II transmembrane serine proteases, MSPL and TMPRSS13, Proteolytically activate membrane fusion activity of the hemagglutinin of highly pathogenic avian influenza viruses and induce their multicycle replication

1 reference

12 December 2020

Current understanding of the mechanism of HPV infection

1 reference

12 December 2020

Antiviral activity of a small-molecule inhibitor of arenavirus glycoprotein processing by the cellular site 1 protease

1 reference

12 December 2020

Glycoprotein organization of Chikungunya virus particles revealed by X-ray crystallography

1 reference

12 December 2020

Cooperative cleavage of the R peptide in the Env trimer of Moloney murine leukemia virus facilitates its maturation for fusion competence

1 reference

12 December 2020

Recombinant Sendai viruses expressing fusion proteins with two furin cleavage sites mimic the syncytial and receptor-independent infection properties of respiratory syncytial virus

1 reference

12 December 2020

Different host cell proteases activate the SARS-coronavirus spike-protein for cell-cell and virus-cell fusion

1 reference

12 December 2020

Mutations in the fusion protein cleavage site of avian paramyxovirus serotype 2 increase cleavability and syncytium formation but do not increase viral virulence in chickens

1 reference

12 December 2020

Role of host cellular proteases in the pathogenesis of influenza and influenza-induced multiple organ failure

1 reference

12 December 2020

Ebola virus glycoprotein needs an additional trigger, beyond proteolytic priming for membrane fusion

1 reference

12 December 2020

Proprotein convertases in health and disease

1 reference

12 December 2020

Filoviruses require endosomal cysteine proteases for entry but exhibit distinct protease preferences

1 reference

12 December 2020

Mutation of the f-protein cleavage site of avian paramyxovirus type 7 results in furin cleavage, fusion promotion, and increased replication in vitro but not increased replication, tissue tropism, or virulence in chickens

1 reference

12 December 2020

On the cutting edge of proprotein convertase pharmacology: from molecular concepts to clinical applications

1 reference

12 December 2020

Antibodies against the envelope glycoprotein promote infectivity of immature dengue virus serotype 2

1 reference

12 December 2020

Highly potent inhibitors of proprotein convertase furin as potential drugs for treatment of infectious diseases

1 reference

12 December 2020

Maturation cleavage of the murine leukemia virus Env precursor separates the transmembrane subunits to prime it for receptor triggering

1 reference

12 December 2020

The biology and therapeutic targeting of the proprotein convertases

1 reference

12 December 2020

Furin inhibitors: importance of the positive formal charge and beyond.

1 reference

12 December 2020

Characterization of cellular furin content as a potential factor determining the susceptibility of cultured human and animal cells to coronavirus infectious bronchitis virus infection

1 reference

12 December 2020

The Multi-Leu peptide inhibitor discriminates between PACE4 and furin and exhibits antiproliferative effects on prostate cancer cells

1 reference

12 December 2020

Matriptase, HAT, and TMPRSS2 activate the hemagglutinin of H9N2 influenza A viruses

1 reference

12 December 2020

High-resolution analysis and functional mapping of cleavage sites and substrate proteins of furin in the human proteome

1 reference

12 December 2020

Retracted: Mutations in the Fusion Protein Cleavage Site of Avian Paramyxovirus Serotype 4 Confer Increased Replication and Syncytium Formation In Vitro but Not Increased Replication and Pathogenicity in Chickens and Ducks

1 reference

12 December 2020

Host cell entry of respiratory syncytial virus involves macropinocytosis followed by proteolytic activation of the F protein

1 reference

12 December 2020

Identification of serpin determinants of specificity and selectivity for furin inhibition through studies of α1PDX (α1-protease inhibitor Portland)-serpin B8 and furin active-site loop chimeras

1 reference

12 December 2020

Glycoprotein B cleavage is important for murid herpesvirus 4 to infect myeloid cells

1 reference

12 December 2020

A novel activation mechanism of avian influenza virus H9N2 by furin.

1 reference

12 December 2020

Design, synthesis, and structure-activity relationship studies of a potent PACE4 inhibitor

1 reference

12 December 2020

Optimization of furin inhibitors to protect against the activation of influenza hemagglutinin H5 and Shiga toxin.

1 reference

12 December 2020

Furin cleavage of the Moloney murine leukemia virus Env precursor reorganizes the spike structure.

1 reference

12 December 2020

The nuclear retention signal of HPV16 L2 protein is essential for incoming viral genome to transverse the trans-Golgi network

1 reference

12 December 2020

Host cell entry of Middle East respiratory syndrome coronavirus after two-step, furin-mediated activation of the spike protein

1 reference

12 December 2020

Ebola virus envelope glycoprotein derived peptide in human Furin-bound state: computational studies

1 reference

12 December 2020

Host cell proteases: Critical determinants of coronavirus tropism and pathogenesis

1 reference

12 December 2020

Kallikrein-8 Proteolytically Processes Human Papillomaviruses in the Extracellular Space To Facilitate Entry into Host Cells

1 reference

12 December 2020

Recovery of Recombinant Crimean Congo Hemorrhagic Fever Virus Reveals a Function for Non-structural Glycoproteins Cleavage by Furin

1 reference

12 December 2020

A Single Point Mutation Creating a Furin Cleavage Site in the Spike Protein Renders Porcine Epidemic Diarrhea Coronavirus Trypsin Independent for Cell Entry and Fusion.

1 reference

12 December 2020

Novel Furin Inhibitors with Potent Anti-infectious Activity

1 reference

12 December 2020

Identification of potent and compartment-selective small molecule furin inhibitors using cell-based assays.

1 reference

12 December 2020

Peptidomimetic furin inhibitor MI-701 in combination with oseltamivir and ribavirin efficiently blocks propagation of highly pathogenic avian influenza viruses and delays high level oseltamivir resistance in MDCK cells

1 reference

12 December 2020

Influenza virus activating host proteases: Identification, localization and inhibitors as potential therapeutics

1 reference

12 December 2020

Cationic Cell-Penetrating Peptides Are Potent Furin Inhibitors

1 reference

12 December 2020

Cleavage of a Neuroinvasive Human Respiratory Virus Spike Glycoprotein by Proprotein Convertases Modulates Neurovirulence and Virus Spread within the Central Nervous System

1 reference

12 December 2020

Cleavage of the HPV16 Minor Capsid Protein L2 during Virion Morphogenesis Ablates the Requirement for Cellular Furin during De Novo Infection

1 reference

12 December 2020

Glycoprotein B of equine herpesvirus type 1 has two recognition sites for subtilisin-like proteases that are cleaved by furin

1 reference

12 December 2020

The 3.8 Å resolution cryo-EM structure of Zika virus

1 reference

12 December 2020

Zika virus impairs growth in human neurospheres and brain organoids

1 reference

12 December 2020

Furin Cleavage of L2 during Papillomavirus Infection: Minimal Dependence on Cyclophilins

1 reference

12 December 2020

Comparative Analysis Between Flaviviruses Reveals Specific Neural Stem Cell Tropism for Zika Virus in the Mouse Developing Neocortex

1 reference

12 December 2020

Structure of the unliganded form of the proprotein convertase furin suggests activation by a substrate-induced mechanism

1 reference

12 December 2020

Proteolytic processing of Middle East respiratory syndrome coronavirus spikes expands virus tropism

1 reference

12 December 2020

Zika Virus Pathogenesis and Tissue Tropism

1 reference

12 December 2020

Persistence of Zika Virus in Body Fluids — Preliminary Report

1 reference

12 December 2020

Elongated and Shortened Peptidomimetic Inhibitors of the Proprotein Convertase Furin

1 reference

12 December 2020

Effects of NS2B-NS3 protease and furin inhibition on West Nile and Dengue virus replication

1 reference

12 December 2020

A central region in the minor capsid protein of papillomaviruses facilitates viral genome tethering and membrane penetration for mitotic nuclear entry

1 reference

12 December 2020

Positively Selected Sites at HCMV gB Furin Processing Region and Their Effects in Cleavage Efficiency

1 reference

12 December 2020

Optimization of Substrate-Analogue Furin Inhibitors

1 reference

12 December 2020

Effect of fusion protein cleavage site sequence on generation of a genotype VII Newcastle disease virus vaccine.

1 reference

12 December 2020

Structure of a cleavage-independent HIV Env recapitulates the glycoprotein architecture of the native cleaved trimer.

1 reference

12 December 2020

Middle East Respiratory Syndrome Coronavirus Spike Protein Is Not Activated Directly by Cellular Furin during Viral Entry into Target Cells

1 reference

12 December 2020

Microarray analysis of human keratinocytes from different anatomic sites reveals site-specific immune signaling and responses to human papillomavirus type 16 transfection.

1 reference

12 December 2020

TMPRSS2 Contributes to Virus Spread and Immunopathology in the Airways of Murine Models after Coronavirus Infection

1 reference

12 December 2020

Design, Synthesis, and Characterization of Macrocyclic Inhibitors of the Proprotein Convertase Furin

1 reference

12 December 2020

Specific and Selective Inhibitors of Proprotein Convertases Engineered by Transferring Serpin B8 Reactive-Site and Exosite Determinants of Reactivity to the Serpin α1PDX

1 reference

12 December 2020

Identifiers

DOI

10.3390/V11090837

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31505793%20AND%20SRC:MED&resulttype=core&format=json

10 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31505793%20AND%20SRC:MED&resulttype=core&format=json

10 April 2020

PubMed publication ID

31505793

1 reference