(Q90392109)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30033062%20AND%20SRC:MED&resulttype=core&format=json

13 April 2020

title

The role of TREM2 in Alzheimer's disease and other neurodegenerative disorders (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30033062%20AND%20SRC:MED&resulttype=core&format=json

13 April 2020

1 reference

Susana Carmona

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30033062%20AND%20SRC:MED&resulttype=core&format=json

13 April 2020

Kathleen Zahs

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30033062%20AND%20SRC:MED&resulttype=core&format=json

13 April 2020

Elizabeth Wu

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30033062%20AND%20SRC:MED&resulttype=core&format=json

13 April 2020

Kelly Dakin

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30033062%20AND%20SRC:MED&resulttype=core&format=json

13 April 2020

Jose Bras

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30033062%20AND%20SRC:MED&resulttype=core&format=json

13 April 2020

Rita Guerreiro

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30033062%20AND%20SRC:MED&resulttype=core&format=json

13 April 2020

publication date

17 July 2018

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30033062%20AND%20SRC:MED&resulttype=core&format=json

13 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30033062%20AND%20SRC:MED&resulttype=core&format=json

13 April 2020

volume

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30033062%20AND%20SRC:MED&resulttype=core&format=json

13 April 2020

issue

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30033062%20AND%20SRC:MED&resulttype=core&format=json

13 April 2020

page(s)

721-730

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30033062%20AND%20SRC:MED&resulttype=core&format=json

TREM2 variants: new keys to decipher Alzheimer disease pathogenesis

13 April 2020

cites work

1 reference

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7 January 2021

TREM2 in Neurodegenerative Diseases

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

TREM-2, triggering receptor expressed on myeloid cell-2, negatively regulates TLR responses in dendritic cells

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

Sequential proteolytic processing of the triggering receptor expressed on myeloid cells-2 (TREM2) protein by ectodomain shedding and γ-secretase-dependent intramembranous cleavage

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

TREM2 shedding by cleavage at the H157-S158 bond is accelerated for the Alzheimer's disease-associated H157Y variant

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

ADAM17 is the main sheddase for the generation of human triggering receptor expressed in myeloid cells (hTREM2) ectodomain and cleaves TREM2 after Histidine 157.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

TREM2 Variants in Alzheimer's Disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

1 reference

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7 January 2021

Using exome sequencing to reveal mutations in TREM2 presenting as a frontotemporal dementia-like syndrome without bone involvement

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

Insights into TREM2 biology by network analysis of human brain gene expression data

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

Alzheimer's disease-associated TREM2 variants exhibit either decreased or increased ligand-dependent activation.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

Investigating the role of rare heterozygous TREM2 variants in Alzheimer's disease and frontotemporal dementia.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

TREM2 and Neurodegenerative Disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

Triggering receptor expressed on myeloid cells 2 variant is rare in late-onset Alzheimer's disease in Han Chinese individuals

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

Association study of TREM2 polymorphism rs75932628 with late-onset Alzheimer's disease in Chinese Han population

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

Investigation of TREM2, PLD3, and UNC5C variants in patients with Alzheimer's disease from mainland China.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

Identification of a rare coding variant in TREM2 in a Chinese individual with Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

Association Study of the TREM2 Gene and Identification of a Novel Variant in Exon 2 in Iranian Patients with Late-Onset Alzheimer's Disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

Lack of genetic association between TREM2 and late-onset Alzheimer's disease in a Japanese population.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

Exome array study did not identify novel variants in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

The rare TREM2 R47H variant exerts only a modest effect on Alzheimer disease risk.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

R47H Variant of TREM2 Associated With Alzheimer Disease in a Large Late-Onset Family: Clinical, Genetic, and Neuropathological Study

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

A rare coding variant in TREM2 increases risk for Alzheimer's disease in Han Chinese

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

TREM2 is associated with increased risk for Alzheimer's disease in African Americans

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

Missense variant in TREML2 protects against Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

A candidate regulatory variant at the TREM gene cluster associates with decreased Alzheimer's disease risk and increased TREML1 and TREM2 brain gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

R47H TREM2 variant increases risk of typical early-onset Alzheimer's disease but not of prion or frontotemporal dementia

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

Investigation of triggering receptor expressed on myeloid cells 2 variant in the Wisconsin Registry for Alzheimer's Prevention

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

More evidence for association of a rare TREM2 mutation (R47H) with Alzheimer's disease risk.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

The triggering receptor expressed on myeloid cells 2 (TREM2) is associated with enhanced inflammation, neuropathological lesions and increased risk for Alzheimer's dementia

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

Frontobasal gray matter loss is associated with the TREM2 p.R47H variant

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

The role of TREM2 R47H as a risk factor for Alzheimer's disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

Cerebrospinal fluid soluble TREM2 is higher in Alzheimer disease and associated with mutation status

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

A TREM1 variant alters the accumulation of Alzheimer-related amyloid pathology

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

Cerebrospinal fluid soluble TREM2 in aging and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

Soluble TREM2 induces inflammatory responses and enhances microglial survival.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

Increased cerebrospinal fluid soluble TREM2 concentration in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early-stage Alzheimer's disease and associate with neuronal injury markers

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

Early changes in CSF sTREM2 in dominantly inherited Alzheimer's disease occur after amyloid deposition and neuronal injury

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

Elucidating the Role of TREM2 in Alzheimer's Disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

Characterization and clinical use of inflammatory cerebrospinal fluid protein markers in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

Humanized TREM2 mice reveal microglia-intrinsic and -extrinsic effects of R47H polymorphism.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

Disease Progression-Dependent Effects of TREM2 Deficiency in a Mouse Model of Alzheimer's Disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer's Disease Models.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

Expression and processing analyses of wild type and p.R47H TREM2 variant in Alzheimer's disease brains

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

Vps35-dependent recycling of Trem2 regulates microglial function.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

The Triggering Receptor Expressed on Myeloid Cells 2 Binds Apolipoprotein E.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2).

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

The Alzheimer's disease-associated TREM2 gene is regulated by p53 tumor suppressor protein.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

Silencing of TREM2 exacerbates tau pathology, neurodegenerative changes, and spatial learning deficits in P301S tau transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

Assignment of the locus for PLO-SL, a frontal-lobe dementia with bone cysts, to 19q13.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

The genetic causes of basal ganglia calcification, dementia, and bone cysts: DAP12 and TREM2.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

Nasu-Hakola disease (polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy): First report from India.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

C9ORF72 expansion does not affect the phenotype in Nasu-Hakola disease with the DAP12 mutation.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

Evidence of CNS β-amyloid deposition in Nasu-Hakola disease due to the TREM2 Q33X mutation.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

Alzheimer's disease pathology in Nasu-Hakola disease brains.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

Heterozygous TYROBP deletion (PLOSLFIN) is not a strong risk factor for cognitive impairment.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

Mutations in TYROBP are not a common cause of dementia in a Turkish cohort.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

Mutations in TREM2 lead to pure early-onset dementia without bone cysts.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

Novel compound heterozygous mutation in TREM2 found in a Turkish frontotemporal dementia-like family

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

Targeted exome sequencing reveals homozygous TREM2 R47C mutation presenting with behavioral variant frontotemporal dementia without bone involvement

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

Homozygous TREM2 mutation in a family with atypical frontotemporal dementia

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

Frontotemporal Dementia and Chorea Associated with a Compound Heterozygous TREM2 Mutation

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

A case of TREM2 mutation presenting with features of progressive non-fluent aphasia and without bone involvement.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

Variants in triggering receptor expressed on myeloid cells 2 are associated with both behavioral variant frontotemporal lobar degeneration and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

Investigation of the role of rare TREM2 variants in frontotemporal dementia subtypes

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

Heterozygous TREM2 mutations in frontotemporal dementia

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

TREM2 mutations are rare in a French cohort of patients with frontotemporal dementia

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

TREM2 rare variant p.R47H is not associated with Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

Triggering receptor expressed on myeloid cells 2 variants are rare in Parkinson's disease in a Han Chinese cohort

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

Assessment of TREM2 rs75932628 association with Parkinson's disease and multiple system atrophy in a Chinese population

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

Genetic analysis of TREM2 variants in Chinese Han patients with sporadic Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

Association study of TREM2 polymorphism rs75932628 with leucoaraiosis or Parkinson's disease in the Han Chinese population

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

TREM2 variant p.R47H as a risk factor for sporadic amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

Assessment of TREM2 rs75932628 association with amyotrophic lateral sclerosis in a Chinese population.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

TREM2 p.R47H substitution is not associated with dementia with Lewy bodies

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

Evaluating pathogenic dementia variants in posterior cortical atrophy

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

TREM2 R47H variant and risk of essential tremor: a cross-sectional international multicenter study

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2818%2930232-1

7 January 2021

10.1016/S1474-4422(18)30232-1

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30033062%20AND%20SRC:MED&resulttype=core&format=json

13 April 2020

1 reference