(Q90452178)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30042330%20AND%20SRC:MED&resulttype=core&format=json

14 April 2020

title

Can Stemness and Chemoresistance Be Therapeutically Targeted via Signaling Pathways in Ovarian Cancer? (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30042330%20AND%20SRC:MED&resulttype=core&format=json

14 April 2020

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30042330%20AND%20SRC:MED&resulttype=core&format=json

14 April 2020

author name string

Lynn Roy

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30042330%20AND%20SRC:MED&resulttype=core&format=json

14 April 2020

publication date

24 July 2018

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30042330%20AND%20SRC:MED&resulttype=core&format=json

14 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30042330%20AND%20SRC:MED&resulttype=core&format=json

14 April 2020

volume

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30042330%20AND%20SRC:MED&resulttype=core&format=json

14 April 2020

issue

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30042330%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

14 April 2020

copyright license

start time

24 July 2018

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

The clonal evolution of tumor cell populations

1 reference

12 December 2020

Somatic mutations in the BRCA1 gene in sporadic ovarian tumours.

1 reference

12 December 2020

Somatic and germline mutations of the BRCA2 gene in sporadic ovarian cancer

1 reference

12 December 2020

Frequency of germline and somatic BRCA1 mutations in ovarian cancer

1 reference

12 December 2020

The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype

1 reference

12 December 2020

Frequency of BRCA1 dysfunction in ovarian cancer

1 reference

12 December 2020

Inactivation of BRCA1 and BRCA2 in ovarian cancer

1 reference

12 December 2020

Grading ovarian serous carcinoma using a two-tier system

1 reference

12 December 2020

AKT and mTOR phosphorylation is frequently detected in ovarian cancer and can be targeted to disrupt ovarian tumor cell growth

1 reference

12 December 2020

Stem and progenitor-like cells contribute to the aggressive behavior of human epithelial ovarian cancer

1 reference

12 December 2020

Treatment goals in ovarian cancer

1 reference

12 December 2020

Notch3 gene amplification in ovarian cancer

1 reference

12 December 2020

Ovarian cancer side population defines cells with stem cell-like characteristics and Mullerian Inhibiting Substance responsiveness

1 reference

12 December 2020

The role of constitutively active signal transducer and activator of transcription 3 in ovarian tumorigenesis and prognosis

1 reference

12 December 2020

Wnt/beta-catenin signaling in development and disease

1 reference

12 December 2020

A protein interaction network for pluripotency of embryonic stem cells

1 reference

12 December 2020

AKT mediates the pro-survival effects of KIT in ovarian cancer cells and is a determinant of sensitivity to imatinib mesylate

1 reference

12 December 2020

High-grade ovarian serous carcinoma exhibits significantly higher p16 expression than low-grade serous carcinoma and serous borderline tumour.

1 reference

12 December 2020

Differences of chemoresistance assay between invasive micropapillary/low-grade serous ovarian carcinoma and high-grade serous ovarian carcinoma

1 reference

12 December 2020

beta-Catenin signaling in biological control and cancer.

1 reference

12 December 2020

Neoadjuvant chemotherapy for low-grade serous carcinoma of the ovary or peritoneum

1 reference

12 December 2020

Histologic subtypes of ovarian carcinoma: an overview.

1 reference

12 December 2020

Hyaluronan-CD44 interaction activates stem cell marker Nanog, Stat-3-mediated MDR1 gene expression, and ankyrin-regulated multidrug efflux in breast and ovarian tumor cells

1 reference

12 December 2020

Identification and characterization of ovarian cancer-initiating cells from primary human tumors

1 reference

12 December 2020

Jagged-1 and Notch3 juxtacrine loop regulates ovarian tumor growth and adhesion

1 reference

12 December 2020

Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of beta-catenin in mice

1 reference

12 December 2020

Cancer stem cells in solid tumours: accumulating evidence and unresolved questions

1 reference

12 December 2020

Epigenetic regulation of CD133 and tumorigenicity of CD133+ ovarian cancer cells

1 reference

12 December 2020

Ovarian cancer: emerging concept on cancer stem cells

1 reference

12 December 2020

Aberrant activation of hedgehog signaling pathway in ovarian cancers: effect on prognosis, cell invasion and differentiation

1 reference

12 December 2020

Role of hedgehog signaling in ovarian cancer

1 reference

12 December 2020

Molecular phenotyping of human ovarian cancer stem cells unravels the mechanisms for repair and chemoresistance

1 reference

12 December 2020

Recurrent low-grade serous ovarian carcinoma is relatively chemoresistant

1 reference

12 December 2020

Ovarian carcinoma pathology and genetics: recent advances

1 reference

12 December 2020

CD133 expression defines a tumor initiating cell population in primary human ovarian cancer

1 reference

12 December 2020

The epidermal growth factor receptor responsive miR-125a represses mesenchymal morphology in ovarian cancer cells.

1 reference

12 December 2020

Pluripotency factors Lin28 and Oct4 identify a sub-population of stem cell-like cells in ovarian cancer

1 reference

12 December 2020

CD24+ cells from hierarchically organized ovarian cancer are enriched in cancer stem cells.

1 reference

12 December 2020

Driver mutations in TP53 are ubiquitous in high grade serous carcinoma of the ovary

1 reference

12 December 2020

Ovarian cancer stem-like side-population cells are tumourigenic and chemoresistant

1 reference

12 December 2020

Targeting Hedgehog--a cancer stem cell pathway

1 reference

12 December 2020

Somatic mutations in BRCA1 and BRCA2 could expand the number of patients that benefit from poly (ADP ribose) polymerase inhibitors in ovarian cancer

1 reference

12 December 2020

Notch3 Overexpression Is Related to the Recurrence of Ovarian Cancer and Confers Resistance to Carboplatin

1 reference

12 December 2020

Cancer stem-like cells can be isolated with drug selection in human ovarian cancer cell line SKOV3.

1 reference

12 December 2020

Regulation of inflammation by the NF-κB pathway in ovarian cancer stem cells

1 reference

12 December 2020

Frequent mutations of chromatin remodeling gene ARID1A in ovarian clear cell carcinoma

1 reference

12 December 2020

Are all pelvic (nonuterine) serous carcinomas of tubal origin?

1 reference

12 December 2020

Targeting aldehyde dehydrogenase cancer stem cells in ovarian cancer

1 reference

12 December 2020

Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways

1 reference

12 December 2020

Cancer stem cell niche: the place to be

1 reference

12 December 2020

Side population is increased in paclitaxel-resistant ovarian cancer cell lines regardless of resistance to cisplatin.

1 reference

12 December 2020

Surgical debulking of ovarian cancer: what difference does it make?

1 reference

12 December 2020

The cancer stem cell: premises, promises and challenges

1 reference

12 December 2020

Aldehyde dehydrogenase in combination with CD133 defines angiogenic ovarian cancer stem cells that portend poor patient survival

1 reference

12 December 2020

Histologic, molecular, and cytogenetic features of ovarian cancers: implications for diagnosis and treatment.

1 reference

12 December 2020

Diverse mechanisms for activation of Wnt signalling in the ovarian tumour microenvironment

1 reference

12 December 2020

Hedgehog signaling pathway regulates the growth of ovarian cancer spheroid forming cells

1 reference

12 December 2020

Morphological subtypes of ovarian carcinoma: a review with emphasis on new developments and pathogenesis

1 reference

12 December 2020

Targeting the notch ligand JAGGED1 in both tumor cells and stroma in ovarian cancer

1 reference

12 December 2020

Ovarian cancer cells with the CD117 phenotype are highly tumorigenic and are related to chemotherapy outcome

1 reference

12 December 2020

Stem cell pathways contribute to clinical chemoresistance in ovarian cancer

1 reference

12 December 2020

ALDH1-bright epithelial ovarian cancer cells are associated with CD44 expression, drug resistance, and poor clinical outcome

1 reference

12 December 2020

Inhibition of Gli1 results in altered c-Jun activation, inhibition of cisplatin-induced upregulation of ERCC1, XPD and XRCC1, and inhibition of platinum-DNA adduct repair

1 reference

12 December 2020

Identification of a potential ovarian cancer stem cell gene expression profile from advanced stage papillary serous ovarian cancer

1 reference

12 December 2020

High-grade serous ovarian cancer arises from fallopian tube in a mouse model

1 reference

12 December 2020

Ovarian cancer stem cell markers: prognostic and therapeutic implications

1 reference

12 December 2020

Defining NOTCH3 target genes in ovarian cancer

1 reference

12 December 2020

High frequency of allelic loss at the BRCA1 locus in ovarian cancers: clinicopathologic and molecular associations.

1 reference

12 December 2020

Ovarian low-grade serous carcinoma: a comprehensive update

1 reference

12 December 2020

Embryonic stem cell markers.

1 reference

12 December 2020

Cancer stem cells: current status and evolving complexities

1 reference

12 December 2020

c-Kit mediates chemoresistance and tumor-initiating capacity of ovarian cancer cells through activation of Wnt/β-catenin-ATP-binding cassette G2 signaling.

1 reference

12 December 2020

Cancerous ovarian stem cells: obscure targets for therapy but relevant to chemoresistance.

1 reference

12 December 2020

1 reference

12 December 2020

Ovarian cancer stem cells: working towards the root of stemness

1 reference

12 December 2020

WNT signalling pathways as therapeutic targets in cancer

1 reference

12 December 2020

Mechanisms of chemoresistance in cancer stem cells

1 reference

12 December 2020

Ovarian surface epithelium at the junction area contains a cancer-prone stem cell niche

1 reference

12 December 2020

The molecular fingerprint of high grade serous ovarian cancer reflects its fallopian tube origin

1 reference

12 December 2020

Ovarian tumor initiating cell populations persist following paclitaxel and carboplatin chemotherapy treatment in vivo

1 reference

12 December 2020

Ovarian cancer stem cells: Molecular concepts and relevance as therapeutic targets

1 reference

12 December 2020

Enrichment of ovarian cancer stem-like cells is associated with epithelial to mesenchymal transition through an miRNA-activated AKT pathway

1 reference

12 December 2020

The stem cell markers Oct4A, Nanog and c-Myc are expressed in ascites cells and tumor tissue of ovarian cancer patients.

1 reference

12 December 2020

Transformation of the fallopian tube secretory epithelium leads to high-grade serous ovarian cancer in Brca;Tp53;Pten models

1 reference

12 December 2020

Loss of ARID1A expression and its relationship with PI3K-Akt pathway alterations and ZNF217 amplification in ovarian clear cell carcinoma.

1 reference

12 December 2020

The role of the PTEN/PI3K/Akt pathway on prognosis in epithelial ovarian cancer: a meta-analysis

1 reference

12 December 2020

Recent concepts of ovarian carcinogenesis: type I and type II

1 reference

12 December 2020

Inhibition of the JAK2/STAT3 pathway in ovarian cancer results in the loss of cancer stem cell-like characteristics and a reduced tumor burden

1 reference

12 December 2020

Lgr5 marks stem/progenitor cells in ovary and tubal epithelia

1 reference

12 December 2020

ROR1 expression correlated with poor clinical outcome in human ovarian cancer

1 reference

12 December 2020

PI3K/AKT/mTOR signaling pathway as a therapeutic target for ovarian cancer

1 reference

12 December 2020

Akt confers cisplatin chemoresistance in human gynecological carcinoma cells by modulating PPM1D stability.

1 reference

12 December 2020

Enrichment for chemoresistant ovarian cancer stem cells from human cell lines

1 reference

12 December 2020

Epithelial ovarian cancer stem cells: underlying complexity of a simple paradigm

1 reference

12 December 2020

ARID3B increases ovarian tumor burden and is associated with a cancer stem cell gene signature

1 reference

12 December 2020

Ovarian cancer stem cells express ROR1, which can be targeted for anti-cancer-stem-cell therapy

1 reference

12 December 2020

Predictive markers of chemoresistance in advanced stages epithelial ovarian carcinoma

1 reference

12 December 2020

Pathobiology of ovarian carcinomas

1 reference

12 December 2020

The ovary is an alternative site of origin for high-grade serous ovarian cancer in mice

1 reference

12 December 2020

CD24+ Ovarian Cancer Cells Are Enriched for Cancer-Initiating Cells and Dependent on JAK2 Signaling for Growth and Metastasis

1 reference

12 December 2020

Primary chemotherapy versus primary surgery for newly diagnosed advanced ovarian cancer (CHORUS): an open-label, randomised, controlled, non-inferiority trial.

1 reference

12 December 2020

Should All Cases of High-Grade Serous Ovarian, Tubal, and Primary Peritoneal Carcinomas Be Reclassified as Tubo-Ovarian Serous Carcinoma?

1 reference

12 December 2020

Prognostic value of cancer stem cell marker CD133 in ovarian cancer: a meta-analysis

1 reference

12 December 2020

Specific TP53 Mutants Overrepresented in Ovarian Cancer Impact CNV, TP53 Activity, Responses to Nutlin-3a, and Cell Survival.

1 reference

12 December 2020

The Notch and Wnt pathways regulate stemness and differentiation in human fallopian tube organoids

1 reference

12 December 2020

Clinical relevance of CD44 surface expression in advanced stage serous epithelial ovarian cancer: a prospective study

1 reference

12 December 2020

Autotaxin Regulates Maintenance of Ovarian Cancer Stem Cells through Lysophosphatidic Acid-Mediated Autocrine Mechanism.

1 reference

12 December 2020

Morphologic, Immunophenotypic, and Molecular Features of Epithelial Ovarian Cancer

1 reference

12 December 2020

The Dualistic Model of Ovarian Carcinogenesis: Revisited, Revised, and Expanded

1 reference

12 December 2020

The NF-κB Pathway and Cancer Stem Cells

1 reference

12 December 2020

Association of Vasculogenic Mimicry Formation and CD133 Expression with Poor Prognosis in Ovarian Cancer

1 reference

12 December 2020

The prognostic value and clinicopathological significance of CD44 expression in ovarian cancer: a meta-analysis.

1 reference

12 December 2020

Wnt5a Signaling in Cancer

1 reference

12 December 2020

Low-grade serous ovarian cancer: A review

1 reference

12 December 2020

Ovarian carcinoma diagnosis: the clinical impact of 15 years of change

1 reference

12 December 2020

NANOG regulates epithelial-mesenchymal transition and chemoresistance in ovarian cancer

1 reference

12 December 2020

Pathogenesis and heterogeneity of ovarian cancer.

1 reference

12 December 2020

Molecular Characterization of Epithelial Ovarian Cancer: Implications for Diagnosis and Treatment

1 reference

12 December 2020

hPaf1/PD2 interacts with OCT3/4 to promote self-renewal of ovarian cancer stem cells.

1 reference

12 December 2020

SOX2 is required to maintain cancer stem cells in ovarian cancer.

1 reference

12 December 2020

Ovarian cancer stem cells more questions than answers

1 reference

12 December 2020

Exploring the clonal evolution of CD133/aldehyde-dehydrogenase-1 (ALDH1)-positive cancer stem-like cells from primary to recurrent high-grade serous ovarian cancer (HGSOC). A study of the Ovarian Cancer Therapy-Innovative Models Prolong Survival (OC

1 reference

12 December 2020

The Crosstalk between Ovarian Cancer Stem Cell Niche and the Tumor Microenvironment

1 reference

12 December 2020

NF-κB Participates in the Stem Cell Phenotype of Ovarian Cancer Cells

1 reference

12 December 2020

Molecular analysis of high-grade serous ovarian carcinoma with and without associated serous tubal intra-epithelial carcinoma.

1 reference

12 December 2020

NFκB Promotes Ovarian Tumorigenesis via Classical Pathways That Support Proliferative Cancer Cells and Alternative Pathways That Support ALDH+ Cancer Stem-like Cells.

1 reference

12 December 2020

Let-7d increases ovarian cancer cell sensitivity to a genistein analog by targeting c-Myc

1 reference

12 December 2020

Drug Resistance Driven by Cancer Stem Cells and Their Niche

1 reference

12 December 2020

STAT3/PIAS3 levels serve as "early signature" genes in the development of high-grade serous carcinoma from the fallopian tube.

1 reference

12 December 2020

PTEN loss in the fallopian tube induces hyperplasia and ovarian tumor formation.

1 reference

12 December 2020

LGR5 and LGR6 in stem cell biology and ovarian cancer.

1 reference

12 December 2020

In vitro and in vivo Limiting Dilution Assay for Colorectal Cancer.

1 reference

12 December 2020

JAK2/STAT3 pathway as a therapeutic target in ovarian cancers.

1 reference

12 December 2020

Activation of hedgehog signaling and its association with cisplatin resistance in ovarian epithelial tumors.

1 reference

12 December 2020

Surface markers of cancer stem-like cells of ovarian cancer and their clinical relevance.

1 reference

12 December 2020

CD133 Promotes Adhesion to the Ovarian Cancer Metastatic Niche.

1 reference

12 December 2020

Treatment of ovarian cancer by targeting the tumor stem cell-associated carbohydrate antigen, Sialyl-Thomsen-nouveau.

1 reference

12 December 2020

Identifiers

DOI

10.3390/CANCERS10080241

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30042330%20AND%20SRC:MED&resulttype=core&format=json

14 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30042330%20AND%20SRC:MED&resulttype=core&format=json

14 April 2020

PubMed publication ID

30042330

1 reference