(Q91559574)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30760864%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

title

Transmission of α-synuclein seeds in neurodegenerative disease: recent developments (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30760864%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

2

John Q Trojanowski

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30760864%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

author name string

Richard J Karpowicz

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30760864%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

Virginia M-Y Lee

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30760864%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

publication date

13 February 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30760864%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

published in

Laboratory Investigation

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30760864%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

volume

99

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30760864%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

issue

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30760864%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

page(s)

971-981

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30760864%20AND%20SRC:MED&resulttype=core&format=json

An essay on the shaking palsy. 1817.

23 April 2020

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7 January 2021

Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice

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7 January 2021

Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice

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7 January 2021

Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration

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7 January 2021

Progressive aggregation of alpha-synuclein and selective degeneration of lewy inclusion-bearing neurons in a mouse model of parkinsonism

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7 January 2021

Lewy body extracts from Parkinson disease brains trigger α-synuclein pathology and neurodegeneration in mice and monkeys.

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7 January 2021

Exogenous α-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death

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7 January 2021

Lewy body-like α-synuclein aggregates resist degradation and impair macroautophagy

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7 January 2021

Exogenous alpha-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells

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7 January 2021

Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds

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7 January 2021

Novel heparan mimetics potently inhibit the scrapie prion protein and its endocytosis

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7 January 2021

Heparan sulfate is a cellular receptor for purified infectious prions.

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7 January 2021

Specific glycosaminoglycan chain length and sulfation patterns are required for cell uptake of tau versus α-synuclein and β-amyloid aggregates.

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7 January 2021

Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3.

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7 January 2021

Suppression of dynamin GTPase decreases α-synuclein uptake by neuronal and oligodendroglial cells: a potent therapeutic target for synucleinopathy

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7 January 2021

α-Synuclein Amyloids Hijack Prion Protein to Gain Cell Entry, Facilitate Cell-to-Cell Spreading and Block Prion Replication.

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7 January 2021

Autophagy inhibition promotes SNCA/alpha-synuclein release and transfer via extracellular vesicles with a hybrid autophagosome-exosome-like phenotype.

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7 January 2021

Intercellular transfer of pathogenic α-synuclein by extracellular vesicles is induced by the lipid peroxidation product 4-hydroxynonenal

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7 January 2021

Brain-derived exosomes from dementia with Lewy bodies propagate α-synuclein pathology

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7 January 2021

Tunneling nanotubes spread fibrillar α-synuclein by intercellular trafficking of lysosomes

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7 January 2021

Α-synuclein immunotherapy blocks uptake and templated propagation of misfolded α-synuclein and neurodegeneration

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7 January 2021

Antibody-aided clearance of extracellular α-synuclein prevents cell-to-cell aggregate transmission

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7 January 2021

Direct Observation of α-Synuclein Amyloid Aggregates in Endocytic Vesicles of Neuroblastoma Cells

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7 January 2021

Membrane binding, internalization, and sorting of alpha-synuclein in the cell

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7 January 2021

Selective imaging of internalized proteopathic α-synuclein seeds in primary neurons reveals mechanistic insight into transmission of synucleinopathies.

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7 January 2021

Neuron-to-neuron transmission of α-synuclein fibrils through axonal transport

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7 January 2021

Axonal transport and secretion of fibrillar forms of α-synuclein, Aβ42 peptide and HTTExon 1

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7 January 2021

Alpha-synuclein induces lysosomal rupture and cathepsin dependent reactive oxygen species following endocytosis

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7 January 2021

Impaired endo-lysosomal membrane integrity accelerates the seeding progression of α-synuclein aggregates

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7 January 2021

Effects of Serine 129 Phosphorylation on α-Synuclein Aggregation, Membrane Association, and Internalization

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7 January 2021

Proteolysis of α-synuclein fibrils in the lysosomal pathway limits induction of inclusion pathology.

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7 January 2021

Physiological carboxy-truncation of α-synuclein potentiates the prion-like formation of pathological inclusions

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7 January 2021

Formation of α-synuclein Lewy neurite-like aggregates in axons impedes the transport of distinct endosomes

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7 January 2021

α-Synuclein fibril-induced paradoxical structural and functional defects in hippocampal neurons.

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7 January 2021

Crosstalk between Lysosomes and Mitochondria in Parkinson's Disease

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7 January 2021

Identification of a highly neurotoxic α-synuclein species inducing mitochondrial damage and mitophagy in Parkinson's disease

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7 January 2021

Differential α-synuclein expression contributes to selective vulnerability of hippocampal neuron subpopulations to fibril-induced toxicity.

1 reference

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7 January 2021

Fibril growth and seeding capacity play key roles in α-synuclein-mediated apoptotic cell death

1 reference

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7 January 2021

Dopamine promotes formation and secretion of non-fibrillar alpha-synuclein oligomers.

1 reference

https://api.crossref.org/works/10.1038%2FS41374-019-0195-Z

7 January 2021

Lipid peroxidation product 4-hydroxy-2-nonenal promotes seeding-capable oligomer formation and cell-to-cell transfer of α-synuclein

1 reference

https://api.crossref.org/works/10.1038%2FS41374-019-0195-Z

7 January 2021

Autophagic failure promotes the exocytosis and intercellular transfer of α-synuclein.

1 reference

https://api.crossref.org/works/10.1038%2FS41374-019-0195-Z

7 January 2021

Unconventional secretion of misfolded proteins promotes adaptation to proteasome dysfunction in mammalian cells.

1 reference

https://api.crossref.org/works/10.1038%2FS41374-019-0195-Z

7 January 2021

DNAJC5 facilitates USP19-dependent unconventional secretion of misfolded cytosolic proteins.

1 reference

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7 January 2021

Exosomal secretion of α-synuclein as protective mechanism after upstream blockage of macroautophagy.

1 reference

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7 January 2021

Conformational properties of alpha-synuclein in its free and lipid-associated states

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https://api.crossref.org/works/10.1038%2FS41374-019-0195-Z

7 January 2021

The function of α-synuclein

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https://api.crossref.org/works/10.1038%2FS41374-019-0195-Z

7 January 2021

Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes

1 reference

https://api.crossref.org/works/10.1038%2FS41374-019-0195-Z

7 January 2021

The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system

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7 January 2021

α-Synuclein promotes dilation of the exocytotic fusion pore.

1 reference

https://api.crossref.org/works/10.1038%2FS41374-019-0195-Z

7 January 2021

Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro

1 reference

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7 January 2021

Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2

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7 January 2021

α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

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7 January 2021

Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation

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7 January 2021

Cell biology. A unifying role for prions in neurodegenerative diseases

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7 January 2021

Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein.

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7 January 2021

Resonance assignments of an α-synuclein fibril prepared in Tris buffer at moderate ionic strength

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7 January 2021

Cryo-EM structure of alpha-synuclein fibrils

1 reference

https://api.crossref.org/works/10.1038%2FS41374-019-0195-Z

7 January 2021

Cryo-EM of full-length α-synuclein reveals fibril polymorphs with a common structural kernel

1 reference

https://api.crossref.org/works/10.1038%2FS41374-019-0195-Z

7 January 2021

Amyloid fibril structure of α-synuclein determined by cryo-electron microscopy

1 reference

https://api.crossref.org/works/10.1038%2FS41374-019-0195-Z

7 January 2021

Molecular and Biological Compatibility with Host Alpha-Synuclein Influences Fibril Pathogenicity

1 reference

https://api.crossref.org/works/10.1038%2FS41374-019-0195-Z

7 January 2021

Distinct α-synuclein strains differentially promote tau inclusions in neurons

1 reference

https://api.crossref.org/works/10.1038%2FS41374-019-0195-Z

7 January 2021

Cellular milieu imparts distinct pathological α-synuclein strains in α-synucleinopathies

1 reference

https://api.crossref.org/works/10.1038%2FS41374-019-0195-Z

7 January 2021

α-Synuclein strains cause distinct synucleinopathies after local and systemic administration

1 reference

https://api.crossref.org/works/10.1038%2FS41374-019-0195-Z

7 January 2021

Structural and functional characterization of two alpha-synuclein strains

1 reference

https://api.crossref.org/works/10.1038%2FS41374-019-0195-Z

7 January 2021

Exposure to bacterial endotoxin generates a distinct strain of α-synuclein fibril

1 reference

https://api.crossref.org/works/10.1038%2FS41374-019-0195-Z

7 January 2021

Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism

1 reference

https://api.crossref.org/works/10.1038%2FS41374-019-0195-Z

7 January 2021

MSA prions exhibit remarkable stability and resistance to inactivation

1 reference

https://api.crossref.org/works/10.1038%2FS41374-019-0195-Z

7 January 2021

Familial Parkinson's point mutation abolishes multiple system atrophy prion replication.

1 reference

https://api.crossref.org/works/10.1038%2FS41374-019-0195-Z

7 January 2021

α-Synuclein transfer between neurons and astrocytes indicates that astrocytes play a role in degradation rather than in spreading

1 reference

https://api.crossref.org/works/10.1038%2FS41374-019-0195-Z

7 January 2021

alpha-Synuclein locus triplication causes Parkinson's disease

1 reference

https://api.crossref.org/works/10.1038%2FS41374-019-0195-Z

7 January 2021

Haploinsufficiency of cathepsin D leads to lysosomal dysfunction and promotes cell-to-cell transmission of α-synuclein aggregates

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7 January 2021

Loss of glucocerebrosidase 1 activity causes lysosomal dysfunction and α-synuclein aggregation

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7 January 2021

Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase

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https://api.crossref.org/works/10.1038%2FS41374-019-0195-Z

7 January 2021

Deficiency of ATP13A2 leads to lysosomal dysfunction, α-synuclein accumulation, and neurotoxicity

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https://api.crossref.org/works/10.1038%2FS41374-019-0195-Z

7 January 2021

ATP13A2/PARK9 regulates secretion of exosomes and α-synuclein

1 reference

https://api.crossref.org/works/10.1038%2FS41374-019-0195-Z

7 January 2021

TMEM175 Is an Organelle K(+) Channel Regulating Lysosomal Function

1 reference

https://api.crossref.org/works/10.1038%2FS41374-019-0195-Z

7 January 2021

TMEM175 deficiency impairs lysosomal and mitochondrial function and increases α-synuclein aggregation

1 reference

https://api.crossref.org/works/10.1038%2FS41374-019-0195-Z

7 January 2021

A mutation in VPS35, encoding a subunit of the retromer complex, causes late-onset Parkinson disease

1 reference

https://api.crossref.org/works/10.1038%2FS41374-019-0195-Z

7 January 2021

VPS35 dysfunction impairs lysosomal degradation of α-synuclein and exacerbates neurotoxicity in a Drosophila model of Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1038%2FS41374-019-0195-Z

7 January 2021

Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease

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7 January 2021

Mutations in the gene LRRK2 encoding dardarin (PARK8) cause familial Parkinson's disease: clinical, pathological, olfactory and functional imaging and genetic data

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7 January 2021

Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases

1 reference

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7 January 2021

10.1038/S41374-019-0195-Z

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30760864%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30760864%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

PubMed publication ID

30760864

1 reference