(Q57458019)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30327435%20AND%20SRC:MED&resulttype=core&format=json

29 April 2020

title

Physiological C-terminal truncation of α-synuclein potentiates the prion-like formation of pathological inclusions (English)

1 reference

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29 April 2020

1 reference

Zachary A Sorrentino

1

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29 April 2020

Niran Vijayaraghavan

2

1 reference

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29 April 2020

Kimberly-Marie Gorion

3

1 reference

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29 April 2020

Cara J Riffe

4

1 reference

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29 April 2020

Kevin H Strang

5

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29 April 2020

Jason Caldwell

6

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29 April 2020

Benoit I Giasson

7

1 reference

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29 April 2020

language of work or name

English

0 references

publication date

16 October 2018

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30327435%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

29 April 2020

published in

1 reference

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29 April 2020

volume

293

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29 April 2020

issue

49

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29 April 2020

page(s)

18914-18932

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describes a project that uses

29 April 2020

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6295729/fullTextXML

inferred from PubMed Central ID database lookup

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A panel of epitope-specific antibodies detects protein domains distributed throughout human alpha-synuclein in Lewy bodies of Parkinson's disease

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Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid

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Fiber diffraction of synthetic alpha-synuclein filaments shows amyloid-like cross-beta conformation

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Immunohistochemical and biochemical studies demonstrate a distinct profile of alpha-synuclein permutations in multiple system atrophy

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A hydrophobic stretch of 12 amino acid residues in the middle of alpha-synuclein is essential for filament assembly.

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Stress-induced aggregation profiles of GST-alpha-synuclein fusion proteins: role of the C-terminal acidic tail of alpha-synuclein in protein thermosolubility and stability

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An alternatively spliced form of rodent alpha-synuclein forms intracellular inclusions in vitro: role of the carboxy-terminus in alpha-synuclein aggregation

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Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases

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Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy

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12 December 2020

Impact of the acidic C-terminal region comprising amino acids 109-140 on alpha-synuclein aggregation in vitro

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12 December 2020

The E46K mutation in alpha-synuclein increases amyloid fibril formation.

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12 December 2020

Release of long-range tertiary interactions potentiates aggregation of natively unstructured alpha-synuclein

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12 December 2020

Aggregation promoting C-terminal truncation of alpha-synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease-linked mutations

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12 December 2020

A precipitating role for truncated alpha-synuclein and the proteasome in alpha-synuclein aggregation: implications for pathogenesis of Parkinson disease

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12 December 2020

Cleavage of alpha-synuclein by calpain: potential role in degradation of fibrillized and nitrated species of alpha-synuclein.

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12 December 2020

Pathological changes in dopaminergic nerve cells of the substantia nigra and olfactory bulb in mice transgenic for truncated human alpha-synuclein(1-120): implications for Lewy body disorders.

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12 December 2020

Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease

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12 December 2020

Selective loss of nigral dopamine neurons induced by overexpression of truncated human alpha-synuclein in mice

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12 December 2020

Aggregated alpha-synuclein mediates dopaminergic neurotoxicity in vivo.

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12 December 2020

Calpain-cleavage of alpha-synuclein: connecting proteolytic processing to disease-linked aggregation

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12 December 2020

Investigation of alpha-synuclein fibril structure by site-directed spin labeling

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12 December 2020

The effect of truncated human alpha-synuclein (1-120) on dopaminergic cells in a transgenic mouse model of Parkinson's disease

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12 December 2020

Sequence Determinants for Amyloid Fibrillogenesis of Human alpha-Synuclein

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12 December 2020

Role of different regions of alpha-synuclein in the assembly of fibrils.

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12 December 2020

Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease

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12 December 2020

Characterization of antibodies that selectively detect alpha-synuclein in pathological inclusions

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12 December 2020

The fold of alpha-synuclein fibrils

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12 December 2020

Cathepsin D is the main lysosomal enzyme involved in the degradation of alpha-synuclein and generation of its carboxy-terminally truncated species

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12 December 2020

Conditional transgenic mice expressing C-terminally truncated human alpha-synuclein (alphaSyn119) exhibit reduced striatal dopamine without loss of nigrostriatal pathway dopaminergic neurons

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12 December 2020

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein

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12 December 2020

A novel, high-efficiency cellular model of fibrillar alpha-synuclein inclusions and the examination of mutations that inhibit amyloid formation

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12 December 2020

Non-classical exocytosis of alpha-synuclein is sensitive to folding states and promoted under stress conditions

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12 December 2020

SNARE protein redistribution and synaptic failure in a transgenic mouse model of Parkinson's disease

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12 December 2020

Co-expression of C-terminal truncated alpha-synuclein enhances full-length alpha-synuclein-induced pathology.

1 reference

12 December 2020

The Conformation and the Aggregation Kinetics of α-Synuclein Depend on the Proline Residues in Its C-Terminal Region

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12 December 2020

Role of matrix metalloproteinase 3-mediated alpha-synuclein cleavage in dopaminergic cell death

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12 December 2020

Residue-specific fluorescent probes of α-synuclein: detection of early events at the N- and C-termini during fibril assembly

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12 December 2020

Induction of intracellular tau aggregation is promoted by α-synuclein seeds and provides novel insights into the hyperphosphorylation of tau.

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12 December 2020

Conserved C-terminal charge exerts a profound influence on the aggregation rate of α-synuclein

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12 December 2020

E46K human alpha-synuclein transgenic mice develop Lewy-like and tau pathology associated with age-dependent, detrimental motor impairment

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12 December 2020

N-terminal deletion does not affect α-synuclein membrane binding, self-association and toxicity in human neuroblastoma cells, unlike yeast

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12 December 2020

α-synuclein phosphorylation and truncation are normal events in the adult human brain

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12 December 2020

Critical role of truncated α-synuclein and aggregates in Parkinson's disease and incidental Lewy body disease

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12 December 2020

Direct observation of the interconversion of normal and toxic forms of α-synuclein

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12 December 2020

Role of C-terminal negative charges and tyrosine residues in fibril formation of α-synuclein.

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12 December 2020

100 years of Lewy pathology

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12 December 2020

Site-specific perturbations of alpha-synuclein fibril structure by the Parkinson's disease associated mutations A53T and E46K

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12 December 2020

Distinct α-synuclein strains differentially promote tau inclusions in neurons

1 reference

12 December 2020

Structural and functional characterization of two alpha-synuclein strains

1 reference

12 December 2020

Induction of CNS α-synuclein pathology by fibrillar and non-amyloidogenic recombinant α-synuclein

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12 December 2020

Direct observation of heterogeneous amyloid fibril growth kinetics via two-color super-resolution microscopy

1 reference

12 December 2020

Unlike twins: an NMR comparison of two α-synuclein polymorphs featuring different toxicity

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12 December 2020

Amyloidogenic α-synuclein seeds do not invariably induce rapid, widespread pathology in mice

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12 December 2020

Solution conditions determine the relative importance of nucleation and growth processes in α-synuclein aggregation

1 reference

12 December 2020

Lys-63-linked ubiquitination by E3 ubiquitin ligase Nedd4-1 facilitates endosomal sequestration of internalized α-synuclein

1 reference

12 December 2020

The H50Q mutation enhances α-synuclein aggregation, secretion, and toxicity

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12 December 2020

Intramuscular injection of α-synuclein induces CNS α-synuclein pathology and a rapid-onset motor phenotype in transgenic mice.

1 reference

12 December 2020

Quantitative measurement of intact alpha-synuclein proteoforms from post-mortem control and Parkinson's disease brain tissue by intact protein mass spectrometry

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12 December 2020

Behavioural deficits in transgenic mice expressing human truncated (1-120 amino acid) alpha-synuclein

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12 December 2020

Lysosomal enzyme cathepsin B enhances the aggregate forming activity of exogenous α-synuclein fibrils

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12 December 2020

The role of the acidic domain of α-synuclein in amyloid fibril formation: a molecular dynamics study

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12 December 2020

Cysteine cathepsins are essential in lysosomal degradation of α-synuclein.

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12 December 2020

Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism

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12 December 2020

Propagation of alpha-synuclein pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies

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12 December 2020

Haploinsufficiency of cathepsin D leads to lysosomal dysfunction and promotes cell-to-cell transmission of α-synuclein aggregates

1 reference

12 December 2020

Cellular response of human neuroblastoma cells to α-synuclein fibrils, the main constituent of Lewy bodies

1 reference

12 December 2020

Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading

1 reference

12 December 2020

ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine Neurons.

1 reference

12 December 2020

Neuroinflammation in Synucleinopathies

1 reference

12 December 2020

Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein.

1 reference

12 December 2020

Structural Effects of Two Camelid Nanobodies Directed to Distinct C-Terminal Epitopes on α-Synuclein

1 reference

12 December 2020

Proteolysis of α-synuclein fibrils in the lysosomal pathway limits induction of inclusion pathology

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12 December 2020

Lysosomal trafficking defects link Parkinson's disease with Gaucher's disease.

1 reference

12 December 2020

Molecular and Biological Compatibility with Host Alpha-Synuclein Influences Fibril Pathogenicity

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12 December 2020

Like prions: the propagation of aggregated tau and α-synuclein in neurodegeneration.

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12 December 2020

α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies

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12 December 2020

Potential Modes of Intercellular α-Synuclein Transmission

1 reference

12 December 2020

Intrastriatal injection of α-synuclein can lead to widespread synucleinopathy independent of neuroanatomic connectivity

1 reference

12 December 2020

α-Synuclein fibril-induced inclusion spread in rats and mice correlates with dopaminergic Neurodegeneration.

1 reference

12 December 2020

Asparagine endopeptidase cleaves α-synuclein and mediates pathologic activities in Parkinson's disease.

1 reference

12 December 2020

Generation and characterization of new monoclonal antibodies targeting the PHF1 and AT8 epitopes on human tau.

1 reference

12 December 2020

A novel panel of α-synuclein antibodies reveal distinctive staining profiles in synucleinopathies.

1 reference

12 December 2020

Modification of C Terminus Provides New Insights into the Mechanism of α-Synuclein Aggregation

1 reference

12 December 2020

C-Terminal Truncated α-Synuclein Fibrils Contain Strongly Twisted β-Sheets.

1 reference

12 December 2020

Comparison of the in vivo induction and transmission of α-synuclein pathology by mutant α-synuclein fibril seeds in transgenic mice

1 reference

12 December 2020

Excessive burden of lysosomal storage disorder gene variants in Parkinson's disease.

1 reference

12 December 2020

Distinct differences in prion-like seeding and aggregation between tau protein variants provide mechanistic insights into tauopathies

1 reference

12 December 2020

The genetics of Parkinson disease

1 reference

12 December 2020

Identification of a highly neurotoxic α-synuclein species inducing mitochondrial damage and mitophagy in Parkinson's disease

1 reference

12 December 2020

The coming of age of chaperone-mediated autophagy.

1 reference

12 December 2020

Cellular milieu imparts distinct pathological α-synuclein strains in α-synucleinopathies

1 reference

12 December 2020

Is Parkinson's disease a lysosomal disorder?

1 reference

12 December 2020

Cryo-EM structure of alpha-synuclein fibrils

1 reference

12 December 2020

Localized Induction of Wild-Type and Mutant Alpha-Synuclein Aggregation Reveals Propagation along Neuroanatomical Tracts

1 reference

12 December 2020

The effect of truncation on prion-like properties of α-synuclein

1 reference

12 December 2020

Amyloid fibril structure of α-synuclein determined by cryo-electron microscopy

1 reference

12 December 2020

Membrane binding, internalization, and sorting of alpha-synuclein in the cell

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.RA118.005603

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30327435%20AND%20SRC:MED&resulttype=core&format=json

29 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30327435%20AND%20SRC:MED&resulttype=core&format=json

29 April 2020

PubMed publication ID

30327435

1 reference