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Is Parkinson's disease a lysosomal disorder?
scientific article published on 01 August 2018
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Europe PubMed Central
PMC publication ID
6061679
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29860491%20AND%20SRC:MED&resulttype=core&format=json
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29 March 2020
title
Is Parkinson's disease a lysosomal disorder?
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
6061679
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29860491%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 March 2020
main subject
Parkinson's disease
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inferred from title
author
ANDRES KLEIN
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMC publication ID
6061679
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29860491%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 March 2020
author name string
Joseph R Mazzulli
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2
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Europe PubMed Central
PMC publication ID
6061679
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29860491%20AND%20SRC:MED&resulttype=core&format=json
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29 March 2020
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English
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publication date
1 August 2018
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6061679
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retrieved
29 March 2020
published in
Brain
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Europe PubMed Central
PMC publication ID
6061679
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29860491%20AND%20SRC:MED&resulttype=core&format=json
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29 March 2020
volume
141
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Europe PubMed Central
PMC publication ID
6061679
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29860491%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 March 2020
issue
8
1 reference
stated in
Europe PubMed Central
PMC publication ID
6061679
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29860491%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 March 2020
page(s)
2255-2262
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Europe PubMed Central
PMC publication ID
6061679
reference URL
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29 March 2020
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30 November 2018
Genetic and pathological links between Parkinson's disease and the lysosomal disorder Sanfilippo syndrome
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30 November 2018
A mutation in VPS35, encoding a subunit of the retromer complex, causes late-onset Parkinson disease
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Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease
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Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies
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Alpha-synuclein interacts with Glucocerebrosidase providing a molecular link between Parkinson and Gaucher diseases
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30 November 2018
Lysosomal storage disorders and Parkinson's disease: Gaucher disease and beyond
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30 November 2018
Pathogenic lysosomal depletion in Parkinson's disease
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Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro
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Chaperone-mediated autophagy markers in Parkinson disease brains
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Multicenter analysis of glucocerebrosidase mutations in Parkinson's disease.
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30 November 2018
Alterations in lysosomal and proteasomal markers in Parkinson's disease: relationship to alpha-synuclein inclusions
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30 November 2018
Enhanced autophagy and mitochondrial aberrations in murine G(M1)-gangliosidosis
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30 November 2018
Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy
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30 November 2018
Intracellular cholesterol modifies the ERAD of glucocerebrosidase in Gaucher disease patients
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30 November 2018
Cholesterol accumulation is associated with lysosomal dysfunction and autophagic stress in Npc1 -/- mouse brain
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30 November 2018
Effects of the cholesterol-lowering compound methyl-beta-cyclodextrin in models of alpha-synucleinopathy
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30 November 2018
Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models
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30 November 2018
Elevated levels of oxidized cholesterol metabolites in Lewy body disease brains accelerate alpha-synuclein fibrilization
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30 November 2018
Lysosomal pathology associated with alpha-synuclein accumulation in transgenic models using an eGFP fusion protein.
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30 November 2018
Heterozygous Niemann-Pick disease type C presenting with tremor.
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6061679
retrieved
30 November 2018
Parkinsonism among Gaucher disease carriers
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6061679
retrieved
30 November 2018
Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6061679
retrieved
30 November 2018
The cell biology of lysosomal storage disorders
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6061679
retrieved
30 November 2018
Axonal dystrophy of dorsal root ganglion sensory neurons in a mouse model of Niemann-Pick disease type C.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6061679
retrieved
30 November 2018
Dynamic movements of organelles containing Niemann-Pick C1 protein: NPC1 involvement in late endocytic events
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6061679
retrieved
30 November 2018
A hydrophobic stretch of 12 amino acid residues in the middle of alpha-synuclein is essential for filament assembly.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6061679
retrieved
30 November 2018
Interaction of human alpha-Synuclein and Parkinson's disease variants with phospholipids. Structural analysis using site-directed mutagenesis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6061679
retrieved
30 November 2018
Mutant and wild type human alpha-synucleins assemble into elongated filaments with distinct morphologies in vitro
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/29860491
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
In situ and in vitro study of colocalization and segregation of alpha-synuclein, ubiquitin, and lipids in Lewy bodies
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/29860491
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Chaperoning the SNAREs: a role in preventing neurodegeneration?
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/29860491
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1093/BRAIN/AWY147
1 reference
stated in
Europe PubMed Central
PMC publication ID
6061679
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29860491%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 March 2020
PMC publication ID
6061679
1 reference
stated in
Europe PubMed Central
PMC publication ID
6061679
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29860491%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 March 2020
PubMed publication ID
29860491
1 reference
stated in
Europe PubMed Central
PMC publication ID
6061679
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29860491%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 March 2020
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