(Q39410832)

11 September 2017

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title

The Role of Lipids Interacting with α-Synuclein in the Pathogenesis of Parkinson's Disease (English)

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11 September 2017

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Céline Galvagnion

1

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publication date

30 June 2017

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Journal of Parkinson's disease

11 September 2017

published in

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11 September 2017

volume

7

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11 September 2017

issue

3

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11 September 2017

page(s)

433-450

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Creative Commons Attribution-NonCommercial 4.0 International

11 September 2017

copyright license

start time

8 August 2017

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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https://api.crossref.org/works/10.3233%2FJPD-171103

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21 January 2018

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Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro

21 January 2018

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Molecular anatomy of a trafficking organelle

21 January 2018

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Membrane lipids: where they are and how they behave

21 January 2018

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https://api.crossref.org/works/10.3233%2FJPD-171103

Update of the LIPID MAPS comprehensive classification system for lipids

21 January 2018

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https://api.crossref.org/works/10.3233%2FJPD-171103

Multiple tight phospholipid-binding modes of alpha-synuclein revealed by solution NMR spectroscopy

21 January 2018

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https://api.crossref.org/works/10.3233%2FJPD-171103

A broken alpha -helix in folded alpha -Synuclein

21 January 2018

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https://api.crossref.org/works/10.3233%2FJPD-171103

Direct observation of the three regions in α-synuclein that determine its membrane-bound behaviour

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

Adsorption of α-synuclein to supported lipid bilayers: positioning and role of electrostatics

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

Depth of α-synuclein in a bilayer determined by fluorescence, neutron reflectometry, and computation.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

Structural Ensembles of Membrane-bound α-Synuclein Reveal the Molecular Determinants of Synaptic Vesicle Affinity

21 January 2018

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https://api.crossref.org/works/10.3233%2FJPD-171103

Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes

21 January 2018

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https://api.crossref.org/works/10.3233%2FJPD-171103

α-Synuclein interactions with phospholipid model membranes: Key roles for electrostatic interactions and lipid-bilayer structure

21 January 2018

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https://api.crossref.org/works/10.3233%2FJPD-171103

Chemical properties of lipids strongly affect the kinetics of the membrane-induced aggregation of α-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

Monomeric synucleins generate membrane curvature

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

α-Synuclein-induced tubule formation in lipid bilayers

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

Membrane Curvature Induction and Tubulation Are Common Features of Synucleins and Apolipoproteins

21 January 2018

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https://api.crossref.org/works/10.3233%2FJPD-171103

Membrane remodeling by α-synuclein and effects on amyloid formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

Biophysics of α-synuclein induced membrane remodelling

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

α-Synuclein-induced membrane remodeling is driven by binding affinity, partition depth, and interleaflet order asymmetry.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

α-Synuclein senses lipid packing defects and induces lateral expansion of lipids leading to membrane remodeling

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

Quantification of alpha-synuclein binding to lipid vesicles using fluorescence correlation spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

The association of alpha-synuclein with membranes affects bilayer structure, stability, and fibril formation

21 January 2018

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https://api.crossref.org/works/10.3233%2FJPD-171103

Defective membrane interactions of familial Parkinson's disease mutant A30P alpha-synuclein

21 January 2018

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https://api.crossref.org/works/10.3233%2FJPD-171103

A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

β-Synuclein suppresses both the initiation and amplification steps of α-synuclein aggregation via competitive binding to surfaces.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

Definition of a molecular pathway mediating α-synuclein neurotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

Acceleration of α-synuclein aggregation by exosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

Alpha-synuclein adopts an alpha-helical conformation in the presence of polyunsaturated fatty acids to hinder micelle formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

GM1 specifically interacts with alpha-synuclein and inhibits fibrillation

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

Structural and morphological characterization of aggregated species of α-synuclein induced by docosahexaenoic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

The formation of highly soluble oligomers of alpha-synuclein is regulated by fatty acids and enhanced in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

Autophagic lysosome reformation dysfunction in glucocerebrosidase deficient cells: relevance to Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

Elevated levels of oxidized cholesterol metabolites in Lewy body disease brains accelerate alpha-synuclein fibrilization

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

A Human Neural Crest Stem Cell-Derived Dopaminergic Neuronal Model Recapitulates Biochemical Abnormalities in GBA1 Mutation Carriers.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

iPSC-derived neurons from GBA1-associated Parkinson's disease patients show autophagic defects and impaired calcium homeostasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

Altered Fatty Acid Composition of Dopaminergic Neurons Expressing α-Synuclein and Human Brains with α-Synucleinopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

A New Glucocerebrosidase Chaperone Reduces α-Synuclein and Glycolipid Levels in iPSC-Derived Dopaminergic Neurons from Patients with Gaucher Disease and Parkinsonism

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

Glucocerebrosidase deficiency in substantia nigra of parkinson disease brains

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

N-alpha-acetylation of α-synuclein increases its helical folding propensity, GM1 binding specificity and resistance to aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

Preparation and Characterization of Stable α-Synuclein Lipoprotein Particles

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

α-Synuclein oligomers with broken helical conformation form lipoprotein nanoparticles

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

α-Synuclein oligomers induced by docosahexaenoic acid affect membrane integrity

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

Glucocerebrosidase deficiency accelerates the accumulation of proteinase K-resistant α-synuclein and aggravates neurodegeneration in a Drosophila model of Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

Exposure to long chain polyunsaturated fatty acids triggers rapid multimerization of synucleins.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

Membrane lipid co-aggregation with α-synuclein fibrils.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

Adsorption of alpha-synuclein on lipid bilayers: modulating the structure and stability of protein assemblies

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

Clustering of alpha-synuclein on supported lipid bilayers: role of anionic lipid, protein, and divalent ion concentration

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

An analytical solution to the kinetics of breakable filament assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

Secondary nucleation of monomers on fibril surface dominates α-synuclein aggregation and provides autocatalytic amyloid amplification

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

Surface effects on aggregation kinetics of amyloidogenic peptides.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

Solution conditions determine the relative importance of nucleation and growth processes in α-synuclein aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

Chemical kinetics for drug discovery to combat protein aggregation diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

Lipid binding inhibits alpha-synuclein fibril formation

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

Alpha-synuclein, lipids and Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

Arachidonic acid mediates the formation of abundant alpha-helical multimers of alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

α-Synuclein structural features inhibit harmful polyunsaturated fatty acid oxidation, suggesting roles in neuroprotection

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

Alpha-synuclein-glucocerebrosidase interactions in pharmacological Gaucher models: a biological link between Gaucher disease and parkinsonism.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

Glucocerebrosidase inhibition causes mitochondrial dysfunction and free radical damage

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

Polyunsaturated fatty acids induce alpha-synuclein-related pathogenic changes in neuronal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

N-terminal region of alpha-synuclein is essential for the fatty acid-induced oligomerization of the molecules.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

Alpha-synuclein sequesters arachidonic acid to modulate SNARE-mediated exocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

alpha-Synuclein locus triplication causes Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

Alpha-synuclein locus duplication as a cause of familial Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

Glucocerebrosidase mutations and the pathogenesis of Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

Phenotype, diagnosis, and treatment of Gaucher's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

Viable mouse models of acid beta-glucosidase deficiency: the defect in Gaucher disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

Gaucher disease mouse models: point mutations at the acid beta-glucosidase locus combined with low-level prosaposin expression lead to disease variants.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

Accumulation and distribution of α-synuclein and ubiquitin in the CNS of Gaucher disease mouse models

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

Acid β-glucosidase mutants linked to Gaucher disease, Parkinson disease, and Lewy body dementia alter α-synuclein processing.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

CNS expression of glucocerebrosidase corrects alpha-synuclein pathology and memory in a mouse model of Gaucher-related synucleinopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

Mitochondria and quality control defects in a mouse model of Gaucher disease--links to Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on tyrosine hydroxylase and alpha-synuclein in human neuroblastoma SH-SY5Y cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

Ambroxol effects in glucocerebrosidase and α-synuclein transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

Elevated GM3 plasma concentration in idiopathic Parkinson's disease: A lipidomic analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

Intracellular cholesterol modifies the ERAD of glucocerebrosidase in Gaucher disease patients

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

The N370S (Asn370-->Ser) mutation affects the capacity of glucosylceramidase to interact with anionic phospholipid-containing membranes and saposin C

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

Glucosylceramide modulates membrane traffic along the endocytic pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

The late endosome/lysosome-anchored p18-mTORC1 pathway controls terminal maturation of lysosomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

Lipid sorting and multivesicular endosome biogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

Total cholesterol and the risk of Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

Dietary fats, cholesterol and iron as risk factors for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

Dietary fatty acids and the risk of Parkinson disease: the Rotterdam study

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

Serum cholesterol and the progression of Parkinson's disease: results from DATATOP.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

Does the oxysterol 27-hydroxycholesterol underlie Alzheimer's disease-Parkinson's disease overlap?

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

Lipid pathway alterations in Parkinson's disease primary visual cortex

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

Oxysterols: From cholesterol metabolites to key mediators.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

Oxysterols, cholesterol homeostasis, and Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

Gene-gene interaction between heme oxygenase-1 and liver X receptor-beta and Alzheimer's disease risk

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

The oxysterol 27-hydroxycholesterol regulates α-synuclein and tyrosine hydroxylase expression levels in human neuroblastoma cells through modulation of liver X receptors and estrogen receptors--relevance to Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

Regulation of alpha-synuclein expression by liver X receptor ligands in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

Alpha-synuclein and familial variants affect the chain order and the thermotropic phase behavior of anionic lipid vesicles

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-171103

21 January 2018

Identifiers

DOI

10.3233/JPD-171103

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11 September 2017

1 reference