(Q107392243)

1

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Javier A Jaimes

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Miya K Bidon

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Marco R Straus

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Susan Daniel

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Gary R Whittaker

A transmembrane serine protease is linked to the severe acute respiratory syndrome coronavirus receptor and activates virus entry

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language of work or name

English

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publication date

12 February 2021

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published in

ACS Infectious Diseases

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volume

7

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issue

2

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page(s)

264-272

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cites work

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https://api.crossref.org/works/10.1021/ACSINFECDIS.0C00701

Computational prediction of furin cleavage sites by a hybrid method and understanding mechanism underlying diseases

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Mechanisms of coronavirus cell entry mediated by the viral spike protein

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The crystal structure of the proprotein processing proteinase furin explains its stringent specificity

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Fusion of Enveloped Viruses in Endosomes

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Prediction of proprotein convertase cleavage sites

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Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia

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Efficient activation of the severe acute respiratory syndrome coronavirus spike protein by the transmembrane protease TMPRSS2.

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The lysosomal cysteine proteases

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Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry

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Receptor usage and cell entry of bat coronavirus HKU4 provide insight into bat-to-human transmission of MERS coronavirus

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Host cell entry of Middle East respiratory syndrome coronavirus after two-step, furin-mediated activation of the spike protein

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Evidence that TMPRSS2 activates the severe acute respiratory syndrome coronavirus spike protein for membrane fusion and reduces viral control by the humoral immune response

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Ready, set, fuse! The coronavirus spike protein and acquisition of fusion competence

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Different residues in the SARS-CoV spike protein determine cleavage and activation by the host cell protease TMPRSS2.

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alpha1-Antitrypsin Portland, a bioengineered serpin highly selective for furin: application as an antipathogenic agent

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Proteolytic processing of Middle East respiratory syndrome coronavirus spikes expands virus tropism

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FurinDB: A database of 20-residue furin cleavage site motifs, substrates and their associated drugs

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Epidemiology and cause of severe acute respiratory syndrome (SARS) in Guangdong, People's Republic of China, in February, 2003.

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Proprotein convertase models based on the crystal structures of furin and kexin: explanation of their specificity

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The Pore-forming Toxin Proaerolysin Is Activated by Furin

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Middle East Respiratory Syndrome Coronavirus Spike Protein Is Not Activated Directly by Cellular Furin during Viral Entry into Target Cells

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Production of Pseudotyped Particles to Study Highly Pathogenic Coronaviruses in a Biosafety Level 2 Setting

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A Novel Coronavirus from Patients with Pneumonia in China, 2019

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The proximal origin of SARS-CoV-2

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Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

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SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

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Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

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The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade

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Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV

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Coronavirus membrane fusion mechanism offers as a potential target for antiviral development

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Ca2+ ions promote fusion of Middle East respiratory syndrome coronavirus with host cells and increase infectivity

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Phylogenetic Analysis and Structural Modeling of SARS-CoV-2 Spike Protein Reveals an Evolutionary Distinct and Proteolytically Sensitive Activation Loop

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A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells

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Proteolytic Cleavage of the SARS-CoV-2 Spike Protein and the Role of the Novel S1/S2 Site

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SARS-CoV-2 and bat RaTG13 spike glycoprotein structures inform on virus evolution and furin-cleavage effects

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TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells

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Evolutionary origins of the SARS-CoV-2 sarbecovirus lineage responsible for the COVID-19 pandemic

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A palindromic RNA sequence as a common breakpoint contributor to copy-choice recombination in SARS-COV-2

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A Single Immunization with Nucleoside-Modified mRNA Vaccines Elicits Strong Cellular and Humoral Immune Responses against SARS-CoV-2 in Mice

1 July 2021

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Characterisation of SARS-CoV-2 Lentiviral Pseudotypes and Correlation between Pseudotype-Based Neutralisation Assays and Live Virus-Based Micro Neutralisation Assays

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Seasonal coronavirus protective immunity is short-lasting

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Furin Inhibitors Block SARS-CoV-2 Spike Protein Cleavage to Suppress Virus Production and Cytopathic Effects

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