(Q24305044)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22323612%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

title

DNA cleavage and opening reactions of human topoisomerase IIα are regulated via Mg2+-mediated dynamic bending of gate-DNA (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22323612%20AND%20SRC:MED&resulttype=core&format=json

DNA topoisomerase II alpha

22 January 2020

main subject

1 reference

GOA release 2020-03-11

DNA binding, bending

1 reference

GOA release 2020-03-11

author

Sanghwa Lee

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22323612%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

Joseph E Deweese

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22323612%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

6

Neil Osheroff

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22323612%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

author name string

Seung-Ryoung Jung

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22323612%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

Kang Heo

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22323612%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

Jo Ann W Byl

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22323612%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

Sungchul Hohng

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22323612%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

language of work or name

English

0 references

publication date

9 February 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22323612%20AND%20SRC:MED&resulttype=core&format=json

Proceedings of the National Academy of Sciences of the United States of America

22 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22323612%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

volume

109

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22323612%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

issue

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22323612%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

page(s)

2925-2930

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22323612%20AND%20SRC:MED&resulttype=core&format=json

Targeting DNA topoisomerase II in cancer chemotherapy

22 January 2020

cites work

1 reference

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How do site-specific DNA-binding proteins find their targets?

19 March 2017

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Cellular roles of dna topoisomerases: a molecular perspective

19 March 2017

1 reference

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DNA topoisomerases: structure, function, and mechanism

19 March 2017

1 reference

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Structural basis of type II topoisomerase inhibition by the anticancer drug etoposide

19 March 2017

1 reference

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Type IIA topoisomerase inhibition by a new class of antibacterial agents

19 March 2017

1 reference

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Structural basis of gate-DNA breakage and resealing by type II topoisomerases

19 March 2017

1 reference

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A novel and unified two-metal mechanism for DNA cleavage by type II and IA topoisomerases

19 March 2017

1 reference

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Structural insight into the quinolone-DNA cleavage complex of type IIA topoisomerases

19 March 2017

1 reference

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Structural basis for gate-DNA recognition and bending by type IIA topoisomerases

19 March 2017

1 reference

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DNA topoisomerases and their poisoning by anticancer and antibacterial drugs

19 March 2017

1 reference

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DNA-induced narrowing of the gyrase N-gate coordinates T-segment capture and strand passage

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3286967

Protein induced fluorescence enhancement as a single molecule assay with short distance sensitivity

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3286967

Direct measurement of DNA bending by type IIA topoisomerases: implications for non-equilibrium topology simplification

27 September 2017

1 reference

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Use of divalent metal ions in the DNA cleavage reaction of topoisomerase IV.

27 September 2017

1 reference

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Cellular strategies for regulating DNA supercoiling: a single-molecule perspective

27 September 2017

1 reference

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The use of divalent metal ions by type II topoisomerases.

27 September 2017

1 reference

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Origins of specificity in protein-DNA recognition.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3286967

The DNA-gate of Bacillus subtilis gyrase is predominantly in the closed conformation during the DNA supercoiling reaction

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3286967

DNA topoisomerase II and its growing repertoire of biological functions.

27 September 2017

1 reference

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Effects of magnesium and related divalent metal ions in topoisomerase structure and function.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3286967

The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothing

27 September 2017

1 reference

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DNA topoisomerases: harnessing and constraining energy to govern chromosome topology

27 September 2017

1 reference

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Human topoisomerase IIalpha uses a two-metal-ion mechanism for DNA cleavage

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3286967

A practical guide to single-molecule FRET

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3286967

Coupling between ATP binding and DNA cleavage by DNA topoisomerase II: A unifying kinetic and structural mechanism.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3286967

Using 3'-bridging phosphorothiolates to isolate the forward DNA cleavage reaction of human topoisomerase IIalpha

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3286967

Single-molecule and ensemble fluorescence assays for a functionally important conformational change in T7 DNA polymerase

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3286967

DNA topoisomerase II selects DNA cleavage sites based on reactivity rather than binding affinity.

27 September 2017

1 reference

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Unlocking and opening a DNA gate

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3286967

Single-molecule measurements of the opening and closing of the DNA gate by eukaryotic topoisomerase II

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3286967

Interdomain communication in DNA topoisomerase II. DNA binding and enzyme activation.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3286967

Structure, molecular mechanisms, and evolutionary relationships in DNA topoisomerases

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3286967

Kinetic analysis of human topoisomerase IIalpha and beta DNA binding by surface plasmon resonance.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3286967

A two-drug model for etoposide action against human topoisomerase IIalpha

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3286967

Site-specific DNA cleavage by Chlorella virus topoisomerase II.

27 September 2017

1 reference

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Human topoisomerase IIalpha possesses an intrinsic nucleic acid specificity for DNA ligation. Use of 5' covalently activated oligonucleotide substrates to study enzyme mechanism

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3286967

Recognition of specific DNA sequences.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3286967

Probing the interaction between two single molecules: fluorescence resonance energy transfer between a single donor and a single acceptor.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3286967

On the coupling between ATP usage and DNA transport by yeast DNA topoisomerase II.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3286967

Diffusion-controlled macromolecular interactions

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3286967

Eukaryotic topoisomerase II. Characterization of enzyme turnover

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3286967

DNA topoisomerase poisons as antitumor drugs

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3286967

Effects of quinolone derivatives on eukaryotic topoisomerase II. A novel mechanism for enhancement of enzyme-mediated DNA cleavage.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3286967

DNA sequence selectivity of topoisomerases and topoisomerase poisons.

30 May 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1115704109

Coordinating the two protomer active sites of human topoisomerase IIalpha: nicks as topoisomerase II poisons

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1115704109

The role of GyrB in the DNA cleavage-religation reaction of DNA gyrase: a proposed two metal-ion mechanism

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1115704109

Inducible overexpression, purification, and active site mapping of DNA topoisomerase II from the yeast Saccharomyces cerevisiae

21 January 2018

1 reference

12 December 2020

The capture of a DNA double helix by an ATP-dependent protein clamp: a key step in DNA transport by type II DNA topoisomerases

1 reference

12 December 2020

DNA transport by a type II DNA topoisomerase: evidence in favor of a two-gate mechanism

1 reference

12 December 2020

Spontaneous DNA lesions poison human topoisomerase IIalpha and stimulate cleavage proximal to leukemic 11q23 chromosomal breakpoints

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.1115704109

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22323612%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

ADS bibcode

2012PNAS..109.2925L

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22323612%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22323612%20AND%20SRC:MED&resulttype=core&format=json