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TGF-β signaling via TAK1 pathway: role in kidney fibrosis
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title
TGF-β signaling via TAK1 pathway: role in kidney fibrosis
(English)
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stated in
PubMed
author name string
Mary E. Choi
series ordinal
1
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stated in
Crossref
Yan Ding
series ordinal
2
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stated in
Crossref
Sung Il Kim
series ordinal
3
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stated in
Crossref
language of work or name
English
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stated in
PubMed
publication date
May 2012
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stated in
PubMed
published in
Seminars in Nephrology
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stated in
PubMed
volume
32
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stated in
PubMed
issue
3
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stated in
PubMed
page(s)
244-52
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stated in
PubMed
cites work
Ablation of TAK1 upregulates reactive oxygen species and selectively kills tumor cells
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PubMed Central
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7 April 2017
The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3407377
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7 April 2017
Protein phosphatase 6 down-regulates TAK1 kinase activation in the IL-1 signaling pathway
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3407377
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7 April 2017
Disabled-2 (Dab2) mediates transforming growth factor beta (TGFbeta)-stimulated fibronectin synthesis through TGFbeta-activated kinase 1 and activation of the JNK pathway
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PubMed Central
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7 April 2017
TAB3, a new binding partner of the protein kinase TAK1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3407377
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7 April 2017
Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling
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PubMed Central
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7 April 2017
Tumor necrosis factor-alpha-induced IKK phosphorylation of NF-kappaB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway
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PubMed Central
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7 April 2017
Regulation of the interleukin-1-induced signaling pathways by a novel member of the protein phosphatase 2C family (PP2Cepsilon)
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7 April 2017
p38 MAPK phosphorylation and NF-kappa B activation in human crescentic glomerulonephritis
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PubMed Central
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7 April 2017
Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism
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PubMed Central
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7 April 2017
Structural basis of Smad2 recognition by the Smad anchor for receptor activation
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7 April 2017
The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3407377
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7 April 2017
TGF-beta signal transduction
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PubMed Central
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7 April 2017
TAK1 mediates the ceramide signaling to stress-activated protein kinase/c-Jun N-terminal kinase
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3407377
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7 April 2017
TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3407377
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7 April 2017
Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death
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PubMed Central
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7 April 2017
Mechanisms of TGF-beta signaling from cell membrane to the nucleus
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PubMed Central
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7 April 2017
TAK1 mitogen-activated protein kinase kinase kinase is activated by autophosphorylation within its activation loop
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PubMed Central
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7 April 2017
TGF-beta signalling from cell membrane to nucleus through SMAD proteins
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7 April 2017
Smad-dependent and Smad-independent pathways in TGF-beta family signalling
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7 April 2017
HER2/Neu- and TAK1-mediated up-regulation of the transforming growth factor beta inhibitor Smad7 via the ETS protein ER81
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PubMed Central
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7 April 2017
Regulation of the TAK1 signaling pathway by protein phosphatase 2C
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7 April 2017
TGFbeta signaling in growth control, cancer, and heritable disorders
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7 April 2017
Phosphorylation-dependent activation of TAK1 mitogen-activated protein kinase kinase kinase by TAB1
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PubMed Central
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7 April 2017
Role of transforming growth factor beta in human disease
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7 April 2017
ATF-2 is a common nuclear target of Smad and TAK1 pathways in transforming growth factor-beta signaling
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7 April 2017
Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease
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Pirfenidone in idiopathic pulmonary fibrosis
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7 April 2017
Smad transcription factors
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7 April 2017
TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains
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LC3 conjugation system in mammalian autophagy
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7 April 2017
Wnt activates the Tak1/Nemo-like kinase pathway
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7 April 2017
Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction
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Transforming growth factor beta in tissue fibrosis
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Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis
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28 September 2017
Transforming growth factor beta-activated kinase 1 (TAK1) kinase adaptor, TAK1-binding protein 2, plays dual roles in TAK1 signaling by recruiting both an activator and an inhibitor of TAK1 kinase in tumor necrosis factor signaling pathway
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Autophagy is activated by TGF-beta and potentiates TGF-beta-mediated growth inhibition in human hepatocellular carcinoma cells.
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28 September 2017
Transforming growth factor-beta (TGF-beta1) activates TAK1 via TAB1-mediated autophosphorylation, independent of TGF-beta receptor kinase activity in mesangial cells
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28 September 2017
TAK1 activates AMPK-dependent cytoprotective autophagy in TRAIL-treated epithelial cells.
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Requirement of transforming growth factor beta-activated kinase 1 for transforming growth factor beta-induced alpha-smooth muscle actin expression and extracellular matrix contraction in fibroblasts
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TRAF6 mediates Smad-independent activation of JNK and p38 by TGF-beta
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TAK1-binding protein 1, TAB1, mediates osmotic stress-induced TAK1 activation but is dispensable for TAK1-mediated cytokine signaling
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28 September 2017
Non-Smad TGF-beta signals
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Transforming growth factor-beta-activated kinase-1 (TAK1), a MAP3K, interacts with Smad proteins and interferes with osteogenesis in murine mesenchymal progenitors
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28 September 2017
Evidence for a role of MSK1 in transforming growth factor-beta-mediated responses through p38alpha and Smad signaling pathways
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28 September 2017
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28 September 2017
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28 September 2017
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28 September 2017
Transforming growth factor-beta-induced mobilization of actin cytoskeleton requires signaling by small GTPases Cdc42 and RhoA
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28 September 2017
Stimulation of pro-alpha(1)(I) collagen by TGF-beta(1) in mesangial cells: role of the p38 MAPK pathway
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28 September 2017
TAK1 mediates an activation signal from toll-like receptor(s) to nuclear factor-kappaB in lipopolysaccharide-stimulated macrophages
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28 September 2017
TGF-beta induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway
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28 September 2017
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28 September 2017
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28 September 2017
Production of transforming growth factor beta 1 during repair of arterial injury
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28 September 2017
Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for activation of p38alpha and p38delta MAPK isoforms by TGF-beta 1 in murine mesangial cells.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3407377
retrieved
31 May 2018
Phosphatidylinositol 3-kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition and cell migration.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3407377
retrieved
31 May 2018
Extracellular signal-regulated kinase and the small GTP-binding protein, Rac, contribute to the effects of transforming growth factor-beta1 on gene expression
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3407377
retrieved
31 May 2018
Transforming growth factor beta activation of p44mapk in proliferating cultures of epithelial cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3407377
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31 May 2018
TGF-β1-activated kinase-1 regulates inflammation and fibrosis in the obstructed kidney.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3407377
retrieved
28 November 2018
JNK signalling in human and experimental renal ischaemia/reperfusion injury.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3407377
retrieved
28 November 2018
Role of MKK3-p38 MAPK signalling in the development of type 2 diabetes and renal injury in obese db/db mice.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3407377
retrieved
28 November 2018
Protective effects of FR167653 on chronic allograft nephropathy by inhibiting p38 MAPK in rats.
1 reference
stated in
PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3407377
retrieved
28 November 2018
Pirfenidone Slows Renal Function Decline in Patients with Focal Segmental Glomerulosclerosis
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3407377
retrieved
28 November 2018
A pathogenic role for c-Jun amino-terminal kinase signaling in renal fibrosis and tubular cell apoptosis.
1 reference
stated in
PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3407377
retrieved
28 November 2018
Critical roles of threonine 187 phosphorylation in cellular stress-induced rapid and transient activation of transforming growth factor-beta-activated kinase 1 (TAK1) in a signaling complex containing TAK1-binding protein TAB1 and TAB2.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3407377
retrieved
28 November 2018
Abnormal p38 mitogen-activated protein kinase signalling in human and experimental diabetic nephropathy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3407377
retrieved
28 November 2018
Requirement of TGF-beta receptor-dependent activation of c-Jun N-terminal kinases (JNKs)/stress-activated protein kinases (Sapks) for TGF-beta up-regulation of the urokinase-type plasminogen activator receptor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3407377
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28 November 2018
Transforming growth factor-beta1 induces collagen synthesis and accumulation via p38 mitogen-activated protein kinase (MAPK) pathway in cultured L(6)E(9) myoblasts
1 reference
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PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22835455
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
It's a Smad world: regulation of TGF-beta signaling in the kidney
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22835455
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Involvement of the p38 mitogen-activated protein kinase pathway in transforming growth factor-beta-induced gene expression
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22835455
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Transforming growth factor-beta activation of phosphatidylinositol 3-kinase is independent of Smad2 and Smad3 and regulates fibroblast responses via p21-activated kinase-2
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22835455
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Recombinant human anti–transforming growth factor β1 antibody therapy in systemic sclerosis: A multicenter, randomized, placebo-controlled phase I/II trial of CAT-192
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22835455
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
TGF-beta-activated kinase 1 and TAK1-binding protein 1 cooperate to mediate TGF-beta1-induced MKK3-p38 MAPK activation and stimulation of type I collagen
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22835455
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Chronic kidney disease as a global public health problem: approaches and initiatives - a position statement from Kidney Disease Improving Global Outcomes
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22835455
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
A pathogenic role for JNK signaling in experimental anti-GBM glomerulonephritis
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22835455
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
MKK3-p38 signaling promotes apoptosis and the early inflammatory response in the obstructed mouse kidney
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22835455
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
A dominant negative TAK1 inhibits cellular fibrotic responses induced by TGF-beta
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22835455
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
p38 Mitogen-activated protein kinase activation and cell localization in human glomerulonephritis: correlation with renal injury
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22835455
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
The role of p38alpha mitogen-activated protein kinase activation in renal fibrosis
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22835455
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Evidence for a role of Rho-like GTPases and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) in transforming growth factor beta-mediated signaling
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22835455
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
TAK1 is activated in the myocardium after pressure overload and is sufficient to provoke heart failure in transgenic mice.
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22835455
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1016/J.SEMNEPHROL.2012.04.003
0 references
PMCID
3407377
1 reference
stated in
PubMed
PubMed ID
22835455
1 reference
stated in
PubMed
ResearchGate publication ID
230572187
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