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The role and regulation of mTOR in T-lymphocyte function
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scholarly article
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PubMed
title
The role and regulation of mTOR in T-lymphocyte function
(English)
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stated in
PubMed
author name string
Thomas F. O’Brien
series ordinal
1
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Crossref
Xiao-Ping Zhong
series ordinal
2
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stated in
Crossref
language of work or name
English
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stated in
PubMed
publication date
June 2012
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stated in
PubMed
published in
Archivum Immunologiae et Therapiae Experimentalis
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PubMed
volume
60
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PubMed
issue
3
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PubMed
page(s)
173-81
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PubMed
cites work
mTOR regulates memory CD8 T-cell differentiation
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PubMed Central
reference URL
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7 April 2017
The TOR pathway comes of age
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PubMed Central
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7 April 2017
A complex interplay between Akt, TSC2 and the two mTOR complexes
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376380
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7 April 2017
Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning
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PubMed Central
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7 April 2017
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376380
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7 April 2017
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376380
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7 April 2017
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376380
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7 April 2017
RasGRP links T-cell receptor signaling to Ras
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PubMed Central
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7 April 2017
TOR signaling in growth and metabolism
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376380
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7 April 2017
TSC2 mediates cellular energy response to control cell growth and survival
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376380
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7 April 2017
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376380
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7 April 2017
Enhanced T cell responses due to diacylglycerol kinase zeta deficiency
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PubMed Central
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7 April 2017
Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376380
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Phosphatidic acid-mediated mitogenic activation of mTOR signaling
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7 April 2017
Properties and functions of diacylglycerol kinases
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PubMed Central
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7 April 2017
Mammalian diacylglycerol kinases, a family of lipid kinases with signaling functions
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PubMed Central
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7 April 2017
Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis
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PubMed Central
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7 April 2017
Modulation of the mammalian target of rapamycin pathway by diacylglycerol kinase-produced phosphatidic acid
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7 April 2017
Hierarchical phosphorylation of the translation inhibitor 4E-BP1
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PubMed Central
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Critical roles of RasGRP1 for invariant NKT cell development
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376380
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7 April 2017
RasGRP is essential for mouse thymocyte differentiation and TCR signaling
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PubMed Central
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7 April 2017
Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression
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PubMed Central
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7 April 2017
Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation
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PubMed Central
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7 April 2017
Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376380
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7 April 2017
Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376380
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7 April 2017
Regulation of T-cell survival and mitochondrial homeostasis by TSC1
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PubMed Central
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28 September 2017
Tight regulation of diacylglycerol-mediated signaling is critical for proper invariant NKT cell development
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PubMed Central
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28 September 2017
The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function
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PubMed Central
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28 September 2017
The tuberous sclerosis complex-mammalian target of rapamycin pathway maintains the quiescence and survival of naive T cells
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PubMed Central
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28 September 2017
The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2.
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PubMed Central
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28 September 2017
Negative regulation of mTOR activation by diacylglycerol kinases
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PubMed Central
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28 September 2017
Receptor signaling in immune cell development and function
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PubMed Central
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28 September 2017
mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376380
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28 September 2017
Enhancing CD8 T-cell memory by modulating fatty acid metabolism
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PubMed Central
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28 September 2017
Diacylglycerol kinases in immune cell function and self-tolerance
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PubMed Central
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28 September 2017
Synergistic control of T cell development and tumor suppression by diacylglycerol kinase alpha and zeta
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28 September 2017
Negative regulators in homeostasis of naïve peripheral T cells.
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PubMed Central
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28 September 2017
The TSC1-TSC2 complex is required for proper activation of mTOR complex 2
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376380
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28 September 2017
Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking
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PubMed Central
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28 September 2017
Signal transduction pathways and transcriptional regulation in the control of Th17 differentiation
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Effector and memory CTL differentiation
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28 September 2017
Impaired degranulation but enhanced cytokine production after Fc epsilonRI stimulation of diacylglycerol kinase zeta-deficient mast cells
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Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin
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28 September 2017
Raptor and mTOR: Subunits of a Nutrient-Sensitive Complex
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28 September 2017
NF-kappa B activation induced by T cell receptor/CD28 costimulation is mediated by protein kinase C-theta
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28 September 2017
Regulation of RasGRP via a phorbol ester-responsive C1 domain.
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Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k.
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28 September 2017
Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family
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28 September 2017
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28 September 2017
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28 September 2017
Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways
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31 May 2018
Diacylglycerol kinase zeta regulates microbial recognition and host resistance to Toxoplasma gondii
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21 January 2018
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Crossref
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21 January 2018
The mTOR kinase determines effector versus memory CD8+ T cell fate by regulating the expression of transcription factors T-bet and Eomesodermin
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Crossref
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21 January 2018
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21 January 2018
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Inhibition of Th1 Development Mediated by GATA-3 through an IL-4-Independent Mechanism
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Inhibition of cell cycle progression by rapamycin induces T cell clonal anergy even in the presence of costimulation
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Identifiers
DOI
10.1007/S00005-012-0171-4
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3030696
Dimensions Publication ID
1034489858
0 references
OpenCitations bibliographic resource ID
3030696
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3030696
PMC publication ID
3376380
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3030696
PubMed publication ID
22484804
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3030696
ResearchGate publication ID
223966216
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