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Targeting sirtuin 1 to improve metabolism: all you need is NAD(+)?
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PubMed
title
Targeting sirtuin 1 to improve metabolism: all you need is NAD(+)?
(English)
1 reference
stated in
PubMed
author
Carles Cantó
object named as
C. Canto
series ordinal
1
0 references
Johan Auwerx
series ordinal
2
object named as
J. Auwerx
1 reference
stated in
Crossref
language of work or name
English
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stated in
PubMed
publication date
January 2012
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stated in
PubMed
published in
Pharmacological Reviews
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stated in
PubMed
volume
64
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stated in
PubMed
issue
1
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stated in
PubMed
page(s)
166-87
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stated in
PubMed
cites work
Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase
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The evolutionarily conserved longevity determinants HCF-1 and SIR-2.1/SIRT1 collaborate to regulate DAF-16/FOXO
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The first identification of lysine malonylation substrates and its regulatory enzyme
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21 March 2017
MST1 promotes apoptosis through regulating Sirt1-dependent p53 deacetylation
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PubMed Central
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21 March 2017
SIRT1 deacetylates and inhibits SREBP-1C activity in regulation of hepatic lipid metabolism
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PubMed Central
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21 March 2017
SIRT1 promotes the central adaptive response to diet restriction through activation of the dorsomedial and lateral nuclei of the hypothalamus
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PubMed Central
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21 March 2017
SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10.
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21 March 2017
A novel pathway regulates memory and plasticity via SIRT1 and miR-134
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PubMed Central
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21 March 2017
Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK-SIRT1-PGC-1alpha pathway
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PubMed Central
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21 March 2017
DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1
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PubMed Central
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21 March 2017
SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1
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PubMed Central
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21 March 2017
JNK1 phosphorylates SIRT1 and promotes its enzymatic activity
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PubMed Central
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21 March 2017
CK2 is the regulator of SIRT1 substrate-binding affinity, deacetylase activity and cellular response to DNA-damage
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PubMed Central
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21 March 2017
Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis
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PubMed Central
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21 March 2017
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
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PubMed Central
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21 March 2017
Carboxy-terminal phosphorylation of SIRT1 by protein kinase CK2
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PubMed Central
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21 March 2017
A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange
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PubMed Central
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21 March 2017
miR-34a repression of SIRT1 regulates apoptosis
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PubMed Central
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21 March 2017
The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control
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21 March 2017
SIRT1 regulates circadian clock gene expression through PER2 deacetylation
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PubMed Central
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21 March 2017
Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span
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PubMed Central
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21 March 2017
A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice
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PubMed Central
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21 March 2017
SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin
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PubMed Central
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21 March 2017
A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy
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PubMed Central
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21 March 2017
Negative regulation of the deacetylase SIRT1 by DBC1
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PubMed Central
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21 March 2017
DBC1 is a negative regulator of SIRT1
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PubMed Central
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21 March 2017
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
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PubMed Central
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21 March 2017
Nampt/PBEF/Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme
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PubMed Central
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21 March 2017
Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity
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PubMed Central
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21 March 2017
SIRT1 deacetylates and positively regulates the nuclear receptor LXR
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PubMed Central
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21 March 2017
Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival
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PubMed Central
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21 March 2017
SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
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21 March 2017
Elevation of cellular NAD levels by nicotinic acid and involvement of nicotinic acid phosphoribosyltransferase in human cells
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PubMed Central
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21 March 2017
Sirtuin functions in health and disease
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PubMed Central
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21 March 2017
SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
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21 March 2017
Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
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21 March 2017
SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
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21 March 2017
Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
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21 March 2017
GPR109A (PUMA-G/HM74A) mediates nicotinic acid-induced flushing
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PubMed Central
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21 March 2017
Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses
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PubMed Central
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21 March 2017
Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins
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21 March 2017
SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1
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PubMed Central
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21 March 2017
Sir2 mediates longevity in the fly through a pathway related to calorie restriction
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21 March 2017
Large-scale characterization of HeLa cell nuclear phosphoproteins
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21 March 2017
Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma
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PubMed Central
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21 March 2017
Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase
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21 March 2017
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
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PubMed Central
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21 March 2017
The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase
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PubMed Central
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21 March 2017
The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis
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PubMed Central
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21 March 2017
SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
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21 March 2017
The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
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21 March 2017
hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
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21 March 2017
Negative control of p53 by Sir2alpha promotes cell survival under stress
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21 March 2017
The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms
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PubMed Central
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21 March 2017
Resveratrol improves health and survival of mice on a high-calorie diet
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
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21 March 2017
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
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21 March 2017
A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis
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PubMed Central
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21 March 2017
Nicotinamide riboside promotes Sir2 silencing and extends lifespan via Nrk and Urh1/Pnp1/Meu1 pathways to NAD+.
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PubMed Central
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21 March 2017
Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans
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PubMed Central
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21 March 2017
Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae
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21 March 2017
Elimination of replication block protein Fob1 extends the life span of yeast mother cells.
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21 March 2017
The membrane of peroxisomes in Saccharomyces cerevisiae is impermeable to NAD(H) and acetyl-CoA under in vivo conditions.
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21 March 2017
RETRACTED: Metabolic regulation of SIRT1 transcription via a HIC1:CtBP corepressor complex
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PubMed Central
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21 March 2017
Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1
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21 March 2017
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
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21 March 2017
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
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21 March 2017
PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
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21 March 2017
Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
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21 March 2017
Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
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21 March 2017
MicroRNA 132 regulates nutritional stress-induced chemokine production through repression of SirT1
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
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21 March 2017
Conserved metabolic regulatory functions of sirtuins
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PubMed Central
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21 March 2017
Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
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21 March 2017
p53 regulates mitochondrial respiration
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
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21 March 2017
LXRS and FXR: the yin and yang of cholesterol and fat metabolism
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21 March 2017
Mechanism of human SIRT1 activation by resveratrol
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21 March 2017
Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1
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21 March 2017
SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
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21 March 2017
Substrate-specific activation of sirtuins by resveratrol
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21 March 2017
The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector
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21 March 2017
Mammalian SIRT1 represses forkhead transcription factors
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21 March 2017
Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha
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21 March 2017
NAD metabolism and sirtuins: metabolic regulation of protein deacetylation in stress and toxicity
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21 March 2017
Nucleocytoplasmic shuttling of the NAD+-dependent histone deacetylase SIRT1
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21 March 2017
Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase
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21 March 2017
PARP-2, A novel mammalian DNA damage-dependent poly(ADP-ribose) polymerase
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21 March 2017
Poly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feeding
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21 March 2017
SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis
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21 March 2017
Poly(ADP-ribose) polymerase-1-dependent cardiac myocyte cell death during heart failure is mediated by NAD+ depletion and reduced Sir2alpha deacetylase activity
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21 March 2017
The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism
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21 March 2017
The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells
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21 March 2017
Poly(ADP-ribose) polymerase null mouse cells synthesize ADP-ribose polymers
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21 March 2017
SIRT1 transgenic mice show phenotypes resembling calorie restriction
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7 April 2017
Sirtuin activators mimic caloric restriction and delay ageing in metazoans
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7 April 2017
Recent progress in the biology and physiology of sirtuins
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7 April 2017
Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1
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7 April 2017
AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy
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7 April 2017
AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha
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7 April 2017
Sirtuins in mammals: insights into their biological function
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7 April 2017
SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytes
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7 April 2017
Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration
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7 April 2017
A central role for JNK in obesity and insulin resistance
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7 April 2017
CREB regulates hepatic gluconeogenesis through the coactivator PGC-1
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7 April 2017
Extrachromosomal rDNA circles--a cause of aging in yeast
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7 April 2017
Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans
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28 September 2017
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PubMed Central
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28 November 2018
Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila
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28 September 2017
Ageing: longevity hits a roadblock
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28 September 2017
Regulation of Caenorhabditis elegans lifespan by sir-2.1 transgenes
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28 September 2017
Sirtuin 1 (SIRT1) deacetylase activity is not required for mitochondrial biogenesis or peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) deacetylation following endurance exercise.
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28 September 2017
Franklin H. Epstein Lecture: Sirtuins, aging, and medicine
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28 September 2017
Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration
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28 September 2017
Interference between PARPs and SIRT1: a novel approach to healthy ageing?
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28 September 2017
Age related changes in NAD+ metabolism oxidative stress and Sirt1 activity in wistar rats
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28 September 2017
Novel targeted therapeutics: inhibitors of MDM2, ALK and PARP.
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28 September 2017
PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation
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28 September 2017
PARP-2 regulates SIRT1 expression and whole-body energy expenditure
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28 September 2017
Design, synthesis and biological characterization of novel inhibitors of CD38.
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28 September 2017
CREB and the CRTC co-activators: sensors for hormonal and metabolic signals
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28 September 2017
Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB
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28 September 2017
Telomere dysfunction induces metabolic and mitochondrial compromise.
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28 September 2017
FoxO1 mediates an autofeedback loop regulating SIRT1 expression
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28 September 2017
Liver steatosis and increased ChREBP expression in mice carrying a liver specific SIRT1 null mutation under a normal feeding condition
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28 September 2017
SIRT1: recent lessons from mouse models.
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28 September 2017
Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer.
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28 September 2017
Mitochondrial biogenesis and peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) deacetylation by physical activity: intact adipocytokine signaling is required
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28 September 2017
SIRT1 is regulated by a PPAR{γ}-SIRT1 negative feedback loop associated with senescence
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28 September 2017
SIRT1 is essential for normal cognitive function and synaptic plasticity
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28 September 2017
AMP-activated protein kinase and its downstream transcriptional pathways
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28 September 2017
The PARP side of the nucleus: molecular actions, physiological outcomes, and clinical targets
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28 September 2017
Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP.
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28 September 2017
Uncoupling of acetylation from phosphorylation regulates FoxO1 function independent of its subcellular localization.
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28 September 2017
Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation
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28 September 2017
Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca(2+) and AMPK/SIRT1.
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28 September 2017
Lack of SIRT1 (Mammalian Sirtuin 1) activity leads to liver steatosis in the SIRT1+/- mice: a role of lipid mobilization and inflammation
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28 September 2017
Resveratrol, sirtuins, and the promise of a DR mimetic
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28 September 2017
Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle
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28 September 2017
A pathway involving farnesoid X receptor and small heterodimer partner positively regulates hepatic sirtuin 1 levels via microRNA-34a inhibition
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28 September 2017
SIRT1 mRNA expression may be associated with energy expenditure and insulin sensitivity
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28 September 2017
Deleted in breast cancer-1 regulates SIRT1 activity and contributes to high-fat diet-induced liver steatosis in mice
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28 September 2017
Neuronal SIRT1 regulates endocrine and behavioral responses to calorie restriction
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28 September 2017
The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways
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28 September 2017
SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity
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28 September 2017
AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol
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28 September 2017
Skeletal muscle NAMPT is induced by exercise in humans
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28 September 2017
dSir2 and Dmp53 interact to mediate aspects of CR-dependent lifespan extension in D. melanogaster
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28 September 2017
Caloric restriction, SIRT1 and longevity
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28 September 2017
Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation.
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28 September 2017
Sirt7-dependent inhibition of cell growth and proliferation might be instrumental to mediate tissue integrity during aging.
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28 September 2017
MiR-34, SIRT1 and p53: the feedback loop
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28 September 2017
Phosphorylation regulates SIRT1 function.
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28 September 2017
SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes
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28 September 2017
Concurrent regulation of AMP-activated protein kinase and SIRT1 in mammalian cells
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28 September 2017
The genetic ablation of SRC-3 protects against obesity and improves insulin sensitivity by reducing the acetylation of PGC-1{alpha}.
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28 September 2017
SirT1 gain of function increases energy efficiency and prevents diabetes in mice
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28 September 2017
Nicotinamide phosphoribosyl transferase/pre-B cell colony-enhancing factor/visfatin is required for lymphocyte development and cellular resistance to genotoxic stress
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28 September 2017
A complex barcode underlies the heterogeneous response of p53 to stress
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28 September 2017
Sirt1 protects against high-fat diet-induced metabolic damage
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28 September 2017
Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
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28 September 2017
The role of FoxO in the regulation of metabolism.
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PubMed Central
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28 September 2017
Mechanism of action of niacin
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
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28 September 2017
SirT1 regulates energy metabolism and response to caloric restriction in mice
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
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28 September 2017
FOXO transcription factors in ageing and cancer.
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PubMed Central
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28 September 2017
NAD+ and vitamin B3: from metabolism to therapies
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
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28 September 2017
Syntheses of nicotinamide riboside and derivatives: effective agents for increasing nicotinamide adenine dinucleotide concentrations in mammalian cells
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
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28 September 2017
Age-associated loss of Sirt1-mediated enhancement of glucose-stimulated insulin secretion in beta cell-specific Sirt1-overexpressing (BESTO) mice
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
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28 September 2017
SIRT1 sumoylation regulates its deacetylase activity and cellular response to genotoxic stress
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
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28 September 2017
SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
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28 September 2017
The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
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28 September 2017
Sirtuins: the 'magnificent seven', function, metabolism and longevity
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
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28 September 2017
Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
retrieved
28 September 2017
Sir2 and calorie restriction in yeast: a skeptical perspective.
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
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28 September 2017
PPARgamma in human and mouse physiology
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
retrieved
28 September 2017
Resveratrol stimulates glucose transport in C2C12 myotubes by activating AMP-activated protein kinase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
retrieved
28 September 2017
Resveratrol stimulates AMP kinase activity in neurons
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
retrieved
28 September 2017
Polyphenols stimulate AMP-activated protein kinase, lower lipids, and inhibit accelerated atherosclerosis in diabetic LDL receptor-deficient mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
retrieved
28 September 2017
The biochemistry of sirtuins.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
retrieved
28 September 2017
Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
retrieved
28 September 2017
Pre-B-cell colony-enhancing factor regulates NAD+-dependent protein deacetylase activity and promotes vascular smooth muscle cell maturation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
retrieved
28 September 2017
The nicotinic acid receptor--a new mechanism for an old drug
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
retrieved
28 September 2017
Calorie restriction extends yeast life span by lowering the level of NADH.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
retrieved
28 September 2017
FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
retrieved
28 September 2017
Influence of nicotinic acid on serum cholesterol in man.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
retrieved
28 September 2017
Nicotinamide mononucleotide activation of a new DNA-dependent polyadenylic acid synthesizing nuclear enzyme
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
retrieved
28 September 2017
Levels of nicotinamide adenine dinucleotide in extracellular body fluids of pigs may be growth-limiting for Actinobacillus pleuropneumoniae and Haemophilus parasuis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
retrieved
28 September 2017
Coactivator-dependent acetylation stabilizes members of the SREBP family of transcription factors.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
retrieved
28 September 2017
Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
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28 September 2017
Regulation of corepressor function by nuclear NADH.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
retrieved
28 September 2017
Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
retrieved
28 September 2017
Sir2 links chromatin silencing, metabolism, and aging
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
retrieved
28 September 2017
Expression of nitric oxide synthase in skeletal muscle: a novel role for nitric oxide as a modulator of insulin action
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
retrieved
28 September 2017
Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
retrieved
28 September 2017
Cloning and characterization of four SIR genes of Saccharomyces cerevisiae
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
retrieved
28 September 2017
The Involvement of Poly(ADP-ribose) Polymerase in the Degradation of NAD Caused by gamma-Radiation and N-Methyl-N-Nitrosourea
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
retrieved
28 September 2017
The effect of gamma radiation and neocarzinostatin of NAD and ATP levels in mouse leukaemia cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
retrieved
28 September 2017
Adenine nucleotide diphosphates: emerging second messengers acting via intracellular Ca2+ release
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
retrieved
28 September 2017
Efficacy of controlled-release niacin in treatment of metabolic syndrome: Correlation to surrogate markers of atherosclerosis, vascular reactivity, and inflammation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
retrieved
31 May 2018
Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
retrieved
31 May 2018
Inhibition of nicotinamide phosphoribosyltransferase: cellular bioenergetics reveals a mitochondrial insensitive NAD pool
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
retrieved
31 May 2018
Tissue-specific regulation of SIRT1 by calorie restriction
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
retrieved
31 May 2018
Poly(ADP-ribose) polymerase-2 [corrected] controls adipocyte differentiation and adipose tissue function through the regulation of the activity of the retinoid X receptor/peroxisome proliferator-activated receptor-gamma [corrected] heterodimer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
retrieved
31 May 2018
Structure and enzymatic functions of human CD38.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
retrieved
31 May 2018
Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
retrieved
31 May 2018
Kinetic competence of the cADP-ribose-CD38 complex as an intermediate in the CD38/NAD+ glycohydrolase-catalysed reactions: implication for CD38 signalling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
retrieved
31 May 2018
The CD38/cyclic ADP-ribose system: a topological paradox
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
retrieved
31 May 2018
Characterization of two genes required for the position-effect control of yeast mating-type genes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
retrieved
31 May 2018
The management of nicotinamide and nicotinic acid in the mouse.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
retrieved
31 May 2018
SIRT1 transcription is decreased in visceral adipose tissue of morbidly obese patients with severe hepatic steatosis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
retrieved
31 May 2018
Inflammatory and age-related pathologies in mice with ectopic expression of human PARP-1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
retrieved
28 November 2018
PPARbeta/delta regulates the human SIRT1 gene transcription via Sp1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
retrieved
28 November 2018
Fasting promotes the expression of SIRT1, an NAD+ -dependent protein deacetylase, via activation of PPARalpha in mice.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
retrieved
28 November 2018
Niacin status, NAD distribution and ADP-ribose metabolism
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
retrieved
28 November 2018
Role of p53 in mitochondrial biogenesis and apoptosis in skeletal muscle.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
retrieved
28 November 2018
Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
retrieved
28 November 2018
Small RNA regulators of gene expression.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
retrieved
28 November 2018
C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
retrieved
28 November 2018
A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
retrieved
28 November 2018
SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
retrieved
28 November 2018
Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
retrieved
28 November 2018
Nutrient availability regulates SIRT1 through a forkhead-dependent pathway.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
retrieved
28 November 2018
Coenzyme specificity of Sir2 protein deacetylases: implications for physiological regulation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
retrieved
28 November 2018
Role of the nitric oxide pathway in AMPK-mediated glucose uptake and GLUT4 translocation in heart muscle
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
retrieved
28 November 2018
Peroxisome proliferator-activated receptor gamma coactivator-1alpha, as a transcription amplifier, is not essential for basal and hormone-induced phosphoenolpyruvate carboxykinase gene expression
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
retrieved
28 November 2018
Predominant expression of Sir2alpha, an NAD-dependent histone deacetylase, in the embryonic mouse heart and brain.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
retrieved
28 November 2018
Mitochondrial impairment in p53-deficient human cancer cells
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stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
retrieved
28 November 2018
Mechanism-based inhibitors of CD38: a mammalian cyclic ADP-ribose synthetase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
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28 November 2018
Effects of resveratrol on the rat brain respiratory chain.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
retrieved
28 November 2018
Large supplements of nicotinic acid and nicotinamide increase tissue NAD+ and poly(ADP-ribose) levels but do not affect diethylnitrosamine-induced altered hepatic foci in Fischer-344 rats.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616312
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28 November 2018
Extended-release niacin raises adiponectin and leptin
1 reference
stated in
PubMed
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https://pubmed.ncbi.nlm.nih.gov/22106091
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Extension of human cell lifespan by nicotinamide phosphoribosyltransferase
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22106091
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Digestion and Absorption of NAD by the Small Intestine of the Rat
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22106091
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
GCN5 acetyltransferase complex controls glucose metabolism through transcriptional repression of PGC-1alpha
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22106091
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Poly(ADP-ribose) polymerase is a catalytic dimer and the automodification reaction is intermolecular
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22106091
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Short-term adenosine monophosphate-activated protein kinase activator 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside treatment increases the sirtuin 1 protein expression in skeletal muscle
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22106091
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Regulation of SIRT 1 mediated NAD dependent deacetylation: a novel role for the multifunctional enzyme CD38
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22106091
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Endothelial nitric oxide synthase (eNOS) knockout mice have defective mitochondrial beta-oxidation
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22106091
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1124/PR.110.003905
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3920707
OpenCitations bibliographic resource ID
3920707
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3920707
PMCID
3616312
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3920707
PubMed ID
22106091
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3920707
ResearchGate publication ID
51817769
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