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The mammalian tribbles homolog TRIB3, glucose homeostasis, and cardiovascular diseases
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scholarly article
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PubMed
title
The mammalian tribbles homolog TRIB3, glucose homeostasis, and cardiovascular diseases
(English)
1 reference
stated in
PubMed
main subject
glucose
0 references
cardiovascular disease
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based on heuristic
inferred from title
author name string
Sabrina Prudente
series ordinal
1
1 reference
stated in
Crossref
Giorgio Sesti
series ordinal
2
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stated in
Crossref
Assunta Pandolfi
series ordinal
3
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stated in
Crossref
Francesco Andreozzi
series ordinal
4
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stated in
Crossref
Agostino Consoli
series ordinal
5
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stated in
Crossref
Vincenzo Trischitta
series ordinal
6
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stated in
Crossref
language of work or name
English
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stated in
PubMed
publication date
August 2012
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stated in
PubMed
published in
Endocrine Reviews
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stated in
PubMed
volume
33
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PubMed
issue
4
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PubMed
page(s)
526-46
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PubMed
cites work
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
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Endoplasmic reticulum stress and the inflammatory basis of metabolic disease
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Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI
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Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans
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TRB2, a mouse Tribbles ortholog, suppresses adipocyte differentiation by inhibiting AKT and C/EBPbeta
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Skeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3
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TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism
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TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death
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Human tribbles, a protein family controlling mitogen-activated protein kinase cascades
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TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver
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Tyrosine dephosphorylation and deactivation of insulin receptor substrate-1 by protein-tyrosine phosphatase 1B. Possible facilitation by the formation of a ternary complex with the Grb2 adaptor protein
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SINK Is a p65-interacting Negative Regulator of NF-κB-dependent Transcription
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Defects of the insulin receptor substrate (IRS) system in human metabolic disorders
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Newly identified loci that influence lipid concentrations and risk of coronary artery disease
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Effect of TRB3 on insulin and nutrient-stimulated hepatic p70 S6 kinase activity
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21 March 2017
The functional Q84R polymorphism of mammalian Tribbles homolog TRB3 is associated with insulin resistance and related cardiovascular risk in Caucasians from Italy
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Characterization of human NIPK (TRB3, SKIP3) gene activation in stressful conditions
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The Gly972-->Arg amino acid polymorphism in IRS-1 impairs insulin secretion in pancreatic beta cells
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Large-scale gene-centric analysis identifies novel variants for coronary artery disease
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Dose-dependent effects of alcohol on insulin signaling: partial explanation for biphasic alcohol impact on human health
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Mouse NIPK interacts with ATF4 and affects its transcriptional activity
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The lipid phosphatase SHIP2 controls insulin sensitivity
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Increased levels of the Akt-specific phosphatase PH domain leucine-rich repeat protein phosphatase (PHLPP)-1 in obese participants are associated with insulin resistance.
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28 September 2017
Tribbles in disease: Signaling pathways important for cellular function and neoplastic transformation
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28 September 2017
Knockdown of the gene encoding Drosophila tribbles homologue 3 (Trib3) improves insulin sensitivity through peroxisome proliferator-activated receptor-γ (PPAR-γ) activation in a rat model of insulin resistance
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Insulin says NO to cardiovascular disease
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Dissociation between fatty liver and insulin resistance: the role of adipose triacylglycerol lipase
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28 September 2017
Endoplasmic reticulum stress response in an INS-1 pancreatic beta-cell line with inducible expression of a folding-deficient proinsulin
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The pseudokinase tribbles homolog 3 interacts with ATF4 to negatively regulate insulin exocytosis in human and mouse beta cells.
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UPR-mediated TRIB3 expression correlates with reduced AKT phosphorylation and inability of interleukin 6 to overcome palmitate-induced apoptosis in RINm5F cells.
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Loss of insulin signaling in vascular endothelial cells accelerates atherosclerosis in apolipoprotein E null mice
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28 September 2017
Mixed lineage kinase-3 stabilizes and functionally cooperates with TRIBBLES-3 to compromise mitochondrial integrity in cytokine-induced death of pancreatic beta cells
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28 September 2017
Mammalian Tribbles homolog 3 impairs insulin action in skeletal muscle: role in glucose-induced insulin resistance
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28 September 2017
Beta-cell deterioration during diabetes: what's in the gun?
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28 September 2017
Acute exercise reverses TRB3 expression in the skeletal muscle and ameliorates whole body insulin sensitivity in diabetic mice
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28 September 2017
Akt and PTEN: beta-cell mass and pancreas plasticity.
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28 September 2017
Acute exercise reduces insulin resistance-induced TRB3 expression and amelioration of the hepatic production of glucose in the liver of diabetic mice.
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PubMed Central
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28 September 2017
Signal transduction mechanism of TRB3 in rats with non-alcoholic fatty liver disease
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28 September 2017
TRIB3 functional Q84R polymorphism is a risk factor for metabolic syndrome and carotid atherosclerosis
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28 September 2017
The TRIB3 Q84R polymorphism and risk of early-onset type 2 diabetes
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28 September 2017
TRIB3 [corrected] is implicated in glucotoxicity- and endoplasmic reticulum-stress-induced [corrected] beta-cell apoptosis
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PubMed Central
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28 September 2017
Insulin sensitivity: modulation by nutrients and inflammation
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28 September 2017
Insulin sensitivity measured with euglycemic clamp is independently associated with glomerular filtration rate in a community-based cohort
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28 September 2017
The role of membrane glycoprotein plasma cell antigen 1/ectonucleotide pyrophosphatase phosphodiesterase 1 in the pathogenesis of insulin resistance and related abnormalities
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28 September 2017
TRB3 suppresses adipocyte differentiation by negatively regulating PPARgamma transcriptional activity
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28 September 2017
The role for endoplasmic reticulum stress in diabetes mellitus
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28 September 2017
TRB3 blocks adipocyte differentiation through the inhibition of C/EBPbeta transcriptional activity
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28 September 2017
Cardiovascular actions of insulin
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28 September 2017
What is the best predictor of future type 2 diabetes?
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28 September 2017
C-reactive protein induces phosphorylation of insulin receptor substrate-1 on Ser307 and Ser 612 in L6 myocytes, thereby impairing the insulin signalling pathway that promotes glucose transport.
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28 September 2017
Interleukin-6 impairs the insulin signaling pathway, promoting production of nitric oxide in human umbilical vein endothelial cells
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28 September 2017
TRB3 modulates C2C12 differentiation by interfering with Akt activation
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28 September 2017
The twentieth century struggle to decipher insulin signalling
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28 September 2017
Tribbles: a family of kinase-like proteins with potent signalling regulatory function.
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28 September 2017
Dual role of transcription factor FoxO1 in controlling hepatic insulin sensitivity and lipid metabolism
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28 September 2017
Regulation of gene expression by alternative untranslated regions
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28 September 2017
Neurodegenerative disorders associated with diabetes mellitus
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28 September 2017
The metabolic syndrome and chronic kidney disease in U.S. adults
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28 September 2017
Putting the brakes on insulin signaling.
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28 September 2017
The common Arg972 polymorphism in insulin receptor substrate-1 causes apoptosis of human pancreatic islets
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PubMed Central
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28 September 2017
The TRIB3 R84 variant is associated with increased carotid intima-media thickness in vivo and with enhanced MAPK signalling in human endothelial cells
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PubMed Central
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31 May 2018
Aberrant hepatic TRIB3 gene expression in insulin-resistant obese humans.
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31 May 2018
TRB3 function in cardiac endoplasmic reticulum stress.
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PubMed Central
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31 May 2018
Insulin regulates TRB3 and other stress-responsive gene expression through induction of C/EBPbeta
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31 May 2018
PI3K activates negative and positive signals to regulate TRB3 expression in hepatic cells
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410226
retrieved
31 May 2018
Glucose, dexamethasone, and the unfolded protein response regulate TRB3 mRNA expression in 3T3-L1 adipocytes and L6 myotubes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410226
retrieved
31 May 2018
Metabolic syndrome vs Framingham Risk Score for prediction of coronary heart disease, stroke, and type 2 diabetes mellitus
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410226
retrieved
31 May 2018
Relationship between several surrogate estimates of insulin resistance and quantification of insulin-mediated glucose disposal in 490 healthy nondiabetic volunteers
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410226
retrieved
31 May 2018
Slow glucose removal rate and hyperinsulinemia precede the development of type II diabetes in the offspring of diabetic parents.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410226
retrieved
31 May 2018
UPR induces transient burst of apoptosis in islets of early lactating rats through reduced AKT phosphorylation via ATF4/CHOP stimulation of TRB3 expression.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410226
retrieved
28 November 2018
TRIB3 R84 variant affects glucose homeostasis by altering the interplay between insulin sensitivity and secretion
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410226
retrieved
28 November 2018
APPL1 potentiates insulin-mediated inhibition of hepatic glucose production and alleviates diabetes via Akt activation in mice.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410226
retrieved
28 November 2018
Association of TRB3 gene Q84R polymorphism with type 2 diabetes mellitus in Chinese population
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410226
retrieved
28 November 2018
Role of the ENPP1 K121Q polymorphism in glucose homeostasis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410226
retrieved
28 November 2018
Overexpression of TRB3 gene in adipose tissue of rats with high fructose-induced metabolic syndrome
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410226
retrieved
28 November 2018
Glutamine to arginine substitution at amino acid 84 of mammalian tribbles homolog TRIB3 and CKD in whites with type 2 diabetes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410226
retrieved
28 November 2018
TRB3 inhibits the transcriptional activation of stress-regulated genes by a negative feedback on the ATF4 pathway.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410226
retrieved
28 November 2018
Genetic deletion of Trb3, the mammalian Drosophila tribbles homolog, displays normal hepatic insulin signaling and glucose homeostasis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410226
retrieved
28 November 2018
Metabolic syndrome as a precursor of cardiovascular disease and type 2 diabetes mellitus
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410226
retrieved
28 November 2018
Predictors of and longitudinal changes in insulin sensitivity and secretion preceding onset of type 2 diabetes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410226
retrieved
28 November 2018
PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410226
retrieved
28 November 2018
G972R IRS-1 variant impairs insulin regulation of endothelial nitric oxide synthase in cultured human endothelial cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410226
retrieved
28 November 2018
Insulin resistance in non-diabetic subjects is associated with increased incidence of myocardial infarction and death
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410226
retrieved
28 November 2018
Insulin secretory function is impaired in isolated human islets carrying the Gly(972)-->Arg IRS-1 polymorphism
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410226
retrieved
28 November 2018
The Gly972Arg polymorphism in the insulin receptor substrate-1 gene contributes to the variation in insulin secretion in normal glucose-tolerant humans
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410226
retrieved
28 November 2018
Tribbles coordinates mitosis and morphogenesis in Drosophila by regulating string/CDC25 proteolysis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410226
retrieved
28 November 2018
Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410226
retrieved
28 November 2018
Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of Pima Indians
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410226
retrieved
28 November 2018
ENPP1 Q121 Variant, Increased Pulse Pressure and Reduced Insulin Signaling, and Nitric Oxide Synthase Activity in Endothelial Cells
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22577090
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
TRIB3 R84 Variant Is Associated With Impaired Insulin-Mediated Nitric Oxide Production in Human Endothelial Cells
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22577090
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Insulin resistance in essential hypertension
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22577090
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1210/ER.2011-1042
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4974708
OpenCitations bibliographic resource ID
4974708
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4974708
PMCID
3410226
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4974708
PubMed ID
22577090
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4974708
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