(Q36631664)

15 August 2017

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title

The twentieth century struggle to decipher insulin signalling (English)

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15 August 2017

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Philip Cohen

1

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PubMed ID

17057754

15 August 2017

language of work or name

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1 November 2006

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Nature Reviews Molecular Cell Biology

15 August 2017

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15 August 2017

7

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15 August 2017

867-873

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15 August 2017

11

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https://scigraph.springernature.com/pub.10.1038/nrm2043

15 August 2017

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cites work

Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1

1 reference

Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses.

21 January 2018

1 reference

Inhibition of the translocation of GLUT1 and GLUT4 in 3T3-L1 cells by the phosphatidylinositol 3-kinase inhibitor, wortmannin

21 January 2018

1 reference

Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation

21 January 2018

1 reference

Identification of multifunctional ATP-citrate lyase kinase as the alpha-isoform of glycogen synthase kinase-3

21 January 2018

1 reference

Glycogen synthase kinase-3 is rapidly inactivated in response to insulin and phosphorylates eukaryotic initiation factor eIF-2B.

21 January 2018

1 reference

The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: evidence that wortmannin blocks activation of the mitogen-activated prote

21 January 2018

1 reference

Inactivation of glycogen synthase kinase-3 beta by phosphorylation: new kinase connections in insulin and growth-factor signalling

21 January 2018

1 reference

Specific binding of the Akt-1 protein kinase to phosphatidylinositol 3,4,5-trisphosphate without subsequent activation

21 January 2018

1 reference

Loss of the hepatic glycogen-binding subunit (GL) of protein phosphatase 1 underlies deficient glycogen synthesis in insulin-dependent diabetic rats and in adrenalectomized starved rats.

21 January 2018

1 reference

Identification of the separate domains in the hepatic glycogen-targeting subunit of protein phosphatase 1 that interact with phosphorylase a, glycogen and protein phosphatase 1.

21 January 2018

1 reference

Insulin-induced phosphorylation and activation of cyclic nucleotide phosphodiesterase 3B by the serine-threonine kinase Akt

21 January 2018

1 reference

Evidence that insulin causes translocation of glucose transport activity to the plasma membrane from an intracellular storage site

21 January 2018

1 reference

Insulin-regulatable tissues express a unique insulin-sensitive glucose transport protein

31 March 2020

1 reference

Identification of a novel gene encoding an insulin-responsive glucose transporter protein

31 March 2020

1 reference

Molecular cloning and characterization of an insulin-regulatable glucose transporter

31 March 2020

1 reference

Insulin-mediated effect on the activity of UDPG-glycogen transglucosylase of muscle

31 March 2020

1 reference

STUDIES ON UDPG-ALPHA-GLUCAN TRANSGLUCOSYLASE. III. INTERCONVERSION OF TWO FORMS OF MUSCLE UDPG-ALPHA-GLUCAN TRANSGLUCOSYLASE BY A PHOSPHORYLATION-DEPHOSPHORYLATION REACTION SEQUENCE

31 March 2020

1 reference

Influence Of Epinephrine and Insulin on Uridine Diphosphate Glucose-α-Glucan Transferase and Phosphorylase in Muscle

31 March 2020

1 reference

Glycogen synthetase kinase 2 (GSK 2); the identification of a new protein kinase in skeletal muscle

31 March 2020

1 reference

Glycogen Synthase Kinase-3 from Rabbit Skeletal Muscle

31 March 2020

1 reference

Effect of insulin on the phosphorylation of adipose tissue protein

31 March 2020

1 reference

Insulin stimulates the phosphorylation of the 95,000-dalton subunit of its own receptor

31 March 2020

1 reference

Insulin activates a tyrosine-specific protein kinase in extracts of 3T3-L1 adipocytes and human placenta.

31 March 2020

1 reference

Insulin rapidly stimulates tyrosine phosphorylation of a Mr-185,000 protein in intact cells

31 March 2020

1 reference

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

31 March 2020

1 reference

Activation of phosphatidylinositol 3-kinase by insulin

31 March 2020

1 reference

Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity

31 March 2020

1 reference

Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate

31 March 2020

1 reference

An inositol tetrakisphosphate-containing phospholipid in activated neutrophils

31 March 2020

1 reference

Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases

31 March 2020

1 reference

Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase

31 March 2020

1 reference

cDNA cloning of a Novel 85 kd protein that has SH2 domains and regulates binding of PI3-kinase to the PDGF β-receptor

31 March 2020

1 reference

Phosphatidylinositol 3-kinase: structure and expression of the 110 kd catalytic subunit

31 March 2020

1 reference

Insulin-stimulated GLUT4 translocation is relevant to the phosphorylation of IRS-1 and the activity of PI3-kinase

31 March 2020

1 reference

The α-isoform of glycogen synthase kinase-3 from rabbit skeletal muscle is inactivated by p70 S6 kinase or MAP kinase-activated protein kinase-1 in vitro

31 March 2020

1 reference

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

31 March 2020

1 reference

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

31 March 2020

1 reference

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

31 March 2020

1 reference

Mechanism of activation of protein kinase B by insulin and IGF-1

31 March 2020

1 reference

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

31 March 2020

1 reference

Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B

31 March 2020

1 reference

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

31 March 2020

1 reference

Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates.

31 March 2020

1 reference

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

31 March 2020

1 reference

mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes

31 March 2020

1 reference

PDK1, the master regulator of AGC kinase signal transduction

31 March 2020

1 reference

Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

31 March 2020

1 reference

Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis

31 March 2020

1 reference

daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans

31 March 2020

1 reference

From mice to men: insights into the insulin resistance syndromes

31 March 2020

1 reference

GSK3 inhibitors: development and therapeutic potential

31 March 2020

1 reference

A central role for JNK in obesity and insulin resistance

31 March 2020

1 reference

Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex.

31 March 2020

1 reference

Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation

31 March 2020

1 reference

Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade

31 March 2020

1 reference

AMPK: a key sensor of fuel and energy status in skeletal muscle

31 March 2020

1 reference

Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene

31 March 2020

1 reference

Structure-based design of selective and potent inhibitors of protein-tyrosine phosphatase beta

31 March 2020

1 reference

Crystal structure of the phosphatidylinositol 3,4-bisphosphate-binding pleckstrin homology (PH) domain of tandem PH-domain-containing protein 1 (TAPP1): molecular basis of lipid specificity

31 March 2020

1 reference

Interaction of the protein tyrosine phosphatase PTPL1 with the PtdIns(3,4)P2-binding adaptor protein TAPP1

31 March 2020

1 reference

Crystal structure of the PTPL1/FAP-1 human tyrosine phosphatase mutated in colorectal cancer: evidence for a second phosphotyrosine substrate recognition pocket

31 March 2020

1 reference

Lipid phosphatases as drug discovery targets for type 2 diabetes.

31 March 2020

1 reference

Purification of the hepatic glycogen-associated form of protein phosphatase-1 by microcystin-Sepharose affinity chromatography

31 March 2020

1 reference

Phosphorylase a is an allosteric inhibitor of the glycogen and microsomal forms of rat hepatic protein phosphatase-1

31 March 2020

1 reference

The Control of Glycogen Metabolism in the Liver

31 March 2020

1 reference

Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase

31 March 2020

1 reference

Signaling pathway involved in the activation of heart 6-phosphofructo-2-kinase by insulin

31 March 2020

1 reference

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

31 March 2020

1 reference

Full intracellular retention of GLUT4 requires AS160 Rab GTPase activating protein

31 March 2020

1 reference

Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction

31 March 2020

1 reference

The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin

31 March 2020

1 reference

Role of AMP-activated protein kinase in mechanism of metformin action

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRM2043

1 reference

15 August 2017

1 reference

PubMed ID

17057754