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Novel therapeutic targets of tumor metabolism
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PubMed
review article
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Europe PubMed Central
title
Novel therapeutic targets of tumor metabolism
(English)
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author name string
Rigel J. Kishton
series ordinal
1
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stated in
Crossref
Jeffrey C. Rathmell
series ordinal
2
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stated in
Crossref
language of work or name
English
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stated in
PubMed
publication date
2015
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stated in
PubMed
published in
The Cancer Journal
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stated in
PubMed
volume
21
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stated in
PubMed
issue
2
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stated in
PubMed
page(s)
62-9
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PubMed
cites work
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Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation
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Glucose transporter 1-mediated glucose uptake is limiting for B-cell acute lymphoblastic leukemia anabolic metabolism and resistance to apoptosis.
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Breast cancer stem cells rely on fermentative glycolysis and are sensitive to 2-deoxyglucose treatment.
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The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function
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Inflammatory T cell responses rely on amino acid transporter ASCT2 facilitation of glutamine uptake and mTORC1 kinase activation
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Metabolic reprogramming is required for antibody production that is suppressed in anergic but exaggerated in chronically BAFF-exposed B cells
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28 September 2017
Inhibition of glutaminase selectively suppresses the growth of primary acute myeloid leukemia cells with IDH mutations.
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28 September 2017
MYC-driven accumulation of 2-hydroxyglutarate is associated with breast cancer prognosis.
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28 September 2017
Hexokinase-2-mediated aerobic glycolysis is integral to cerebellar neurogenesis and pathogenesis of medulloblastoma
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Clinical significance of L-type amino acid transporter 1 expression as a prognostic marker and potential of new targeting therapy in biliary tract cancer
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Targeting lactate metabolism for cancer therapeutics
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28 September 2017
Brain tumor initiating cells adapt to restricted nutrition through preferential glucose uptake.
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28 September 2017
Hexokinase 2 is required for tumor initiation and maintenance and its systemic deletion is therapeutic in mouse models of cancer
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A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence.
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28 September 2017
p63 regulates glutaminase 2 expression.
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28 September 2017
Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway.
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28 September 2017
(R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible
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28 September 2017
SLC1A5 mediates glutamine transport required for lung cancer cell growth and survival
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28 September 2017
ATF4 regulates MYC-mediated neuroblastoma cell death upon glutamine deprivation.
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28 September 2017
Expression of pyruvate dehydrogenase kinase-1 in gastric cancer as a potential therapeutic target
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28 September 2017
Glutaminase isoenzymes as key regulators in metabolic and oxidative stress against cancer.
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28 September 2017
IDH mutations in acute myeloid leukemia
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28 September 2017
A small-molecule inhibitor of glucose transporter 1 downregulates glycolysis, induces cell-cycle arrest, and inhibits cancer cell growth in vitro and in vivo.
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28 September 2017
Multiple myeloma exhibits novel dependence on GLUT4, GLUT8, and GLUT11: implications for glucose transporter-directed therapy
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28 September 2017
Reverse TCA cycle flux through isocitrate dehydrogenases 1 and 2 is required for lipogenesis in hypoxic melanoma cells
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28 September 2017
Frequent mutation of isocitrate dehydrogenase (IDH)1 and IDH2 in cholangiocarcinoma identified through broad-based tumor genotyping
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28 September 2017
Ollier disease and Maffucci syndrome are caused by somatic mosaic mutations of IDH1 and IDH2.
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28 September 2017
Galloflavin (CAS 568-80-9): a novel inhibitor of lactate dehydrogenase.
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28 September 2017
Comparative metabolic flux profiling of melanoma cell lines: beyond the Warburg effect
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28 September 2017
A phase II study of AT-101 (Gossypol) in chemotherapy-sensitive recurrent extensive-stage small cell lung cancer.
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28 September 2017
Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality
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28 September 2017
Revisiting the TCA cycle: signaling to tumor formation
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28 September 2017
Akt-dependent glucose metabolism promotes Mcl-1 synthesis to maintain cell survival and resistance to Bcl-2 inhibition.
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28 September 2017
IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumours
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28 September 2017
Discovery of N-hydroxyindole-based inhibitors of human lactate dehydrogenase isoform A (LDH-A) as starvation agents against cancer cells.
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28 September 2017
Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets.
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28 September 2017
Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme
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28 September 2017
CC3/TIP30 regulates metabolic adaptation of tumor cells to glucose limitation
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28 September 2017
Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1.
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28 September 2017
Warburg effect in chemosensitivity: targeting lactate dehydrogenase-A re-sensitizes taxol-resistant cancer cells to taxol
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28 September 2017
Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction
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28 September 2017
Glioblastoma cells require glutamate dehydrogenase to survive impairments of glucose metabolism or Akt signaling
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28 September 2017
An open-label, multicenter, phase I/II study of single-agent AT-101 in men with castrate-resistant prostate cancer
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28 September 2017
Tumor suppressors and cell metabolism: a recipe for cancer growth
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28 September 2017
IDH1 mutations at residue p.R132 (IDH1(R132)) occur frequently in high-grade gliomas but not in other solid tumors
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28 September 2017
Analysis of the IDH1 codon 132 mutation in brain tumors
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28 September 2017
Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth.
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28 September 2017
Hypoxic regulation of PFKFB-3 and PFKFB-4 gene expression in gastric and pancreatic cancer cell lines and expression of PFKFB genes in gastric cancers
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28 September 2017
Critical roles of glutamine as nitrogen donors in purine and pyrimidine nucleotide synthesis: asparaginase treatment in childhood acute lymphoblastic leukemia.
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28 September 2017
Ras transformation requires metabolic control by 6-phosphofructo-2-kinase
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28 September 2017
Amino acid transporters ASCT2 and LAT1 in cancer: partners in crime?
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380246
retrieved
28 September 2017
The TCA cycle and tumorigenesis: the examples of fumarate hydratase and succinate dehydrogenase.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380246
retrieved
28 September 2017
Lactate dehydrogenase-5 (LDH-5) overexpression in non-small-cell lung cancer tissues is linked to tumour hypoxia, angiogenic factor production and poor prognosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380246
retrieved
28 September 2017
Efficacy of dichloroacetate as a lactate-lowering drug
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380246
retrieved
28 September 2017
Facilitated glucose transporter protein type 1 (GLUT1) deficiency syndrome: impaired glucose transport into brain-- a review
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380246
retrieved
28 September 2017
Mammalian hexokinases and their abnormal expression in cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380246
retrieved
28 September 2017
c-Myc transactivation of LDH-A: implications for tumor metabolism and growth
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380246
retrieved
28 September 2017
Transport and direct utilization of gamma-glutamylcyst(e)ine for glutathione synthesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380246
retrieved
28 September 2017
Control of liver 6-phosphofructokinase by fructose 2,6-bisphosphate and other effectors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380246
retrieved
28 September 2017
Distribution of glucose transporter messenger RNA transcripts in tissues of rat and man.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380246
retrieved
28 September 2017
Sites of phosphorylation on pyruvate dehydrogenase from bovine kidney and heart
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380246
retrieved
28 September 2017
Evidence that glutamine, not sugar, is the major energy source for cultured HeLa cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380246
retrieved
28 September 2017
Pancreatic cancers rely on a novel glutamine metabolism pathway to maintain redox balance
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380246
retrieved
31 May 2018
Glucose addiction of TSC null cells is caused by failed mTORC1-dependent balancing of metabolic demand with supply
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380246
retrieved
31 May 2018
Pyruvate dehydrogenase and pyruvate dehydrogenase kinase expression in non small cell lung cancer and tumor-associated stroma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380246
retrieved
31 May 2018
The mechanism of insulin resistance caused by HIV protease inhibitor therapy.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380246
retrieved
31 May 2018
Wide expression of the human erythrocyte glucose transporter Glut1 in human cancers.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380246
retrieved
31 May 2018
Fructose 2,6-bisphosphate, the probably structure of the glucose- and glucagon-sensitive stimulator of phosphofructokinase.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380246
retrieved
31 May 2018
Regulation of 6-phosphofructo-1-kinase activity in ras-transformed rat-1 fibroblasts
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380246
retrieved
31 May 2018
Evolution of a gene. Multiple genes for LDH isozymes provide a model of the evolution of gene structure, function and regulation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380246
retrieved
31 May 2018
Targeting amino acid transport in metastatic castration-resistant prostate cancer: effects on cell cycle, cell growth, and tumor development.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380246
retrieved
28 November 2018
Selection of cancer cells with repressed mitochondria triggers colon cancer progression
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380246
retrieved
28 November 2018
Lactate dehydrogenase 5 expression in squamous cell head and neck cancer relates to prognosis following radical or postoperative radiotherapy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380246
retrieved
28 November 2018
Effect of 2-deoxy-D-glucose on various malignant cell lines in vitro.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380246
retrieved
28 November 2018
Lactate dehydrogenase 5 (LDH5) relates to up-regulated hypoxia inducible factor pathway and metastasis in colorectal cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380246
retrieved
28 November 2018
2-deoxy-D-glucose increases the efficacy of adriamycin and paclitaxel in human osteosarcoma and non-small cell lung cancers in vivo
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380246
retrieved
28 November 2018
Determinants of glutamine dependence and utilization by normal and tumor-derived breast cell lines
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25815845
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
LACTIC DEHYDROGENASES: FUNCTIONS OF THE TWO TYPES RATES OF SYNTHESIS OF THE TWO MAJOR FORMS CAN BE CORRELATED WITH METABOLIC DIFFERENTIATION
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25815845
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Glycolytic enzymes in breast cancer, benign breast disease and normal breast tissue
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25815845
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Overexpression of the neutral amino acid transporter ASCT2 in human colorectal adenocarcinoma
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25815845
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1097/PPO.0000000000000099
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1820255
Fatcat ID
release_e532ffzacfdwddu6fa6zie7t6y
1 reference
stated in
Fatcat
reference URL
https://api.fatcat.wiki/v0/release/e532ffzacfdwddu6fa6zie7t6y
retrieved
24 November 2022
based on heuristic
mapped directly with Wikidata item
OpenCitations bibliographic resource ID
1820255
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1820255
PMC publication ID
4380246
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1820255
PubMed publication ID
25815845
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1820255
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