(Q27318284)

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Huntington's disease induced cardiac amyloidosis is reversed by modulating protein folding and oxidative stress pathways in the Drosophila heart

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Huntington's disease induced cardiac amyloidosis is reversed by modulating protein folding and oxidative stress pathways in the Drosophila heart (English)

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Huntington's disease

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protein folding

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Sanford Bernstein

5

object named as

Sanford I Bernstein

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author name string

Girish C Melkani

1

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Adriana S Trujillo

2

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Raul Ramos

3

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Rolf Bodmer

4

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Karen Ocorr

6

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publication date

2013

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9

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12

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e1004024

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Creative Commons Attribution 4.0 International

19 December 2013

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April 2022 Public Data File from Crossref

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3868535/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Mutations affecting the cytoplasmic functions of the co-chaperone DNAJB6 cause limb-girdle muscular dystrophy

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21 March 2017

High-content chemical and RNAi screens for suppressors of neurotoxicity in a Huntington's disease model

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21 March 2017

The UNC-45 chaperone is critical for establishing myosin-based myofibrillar organization and cardiac contractility in the Drosophila heart model

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21 March 2017

KCNQ potassium channel mutations cause cardiac arrhythmias in Drosophila that mimic the effects of aging

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21 March 2017

Tau promotes neurodegeneration via DRP1 mislocalization in vivo

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21 March 2017

A mighty small heart: the cardiac proteome of adult Drosophila melanogaster

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21 March 2017

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21 March 2017

The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans

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7 April 2017

Proteotoxicity and cardiac dysfunction--Alzheimer's disease of the heart?

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28 September 2017

Huntingtin fragments and SOD1 mutants form soluble oligomers in the cell

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28 September 2017

The ultrastructure of Drosophila heart cells

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28 September 2017

Resveratrol inhibits inflammatory responses via the mammalian target of rapamycin signaling pathway in cultured LPS-stimulated microglial cells

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28 September 2017

Protein aggregates in Huntington's disease.

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28 September 2017

Protein misfolding detected early in pathogenesis of transgenic mouse model of Huntington disease using amyloid seeding assay

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28 September 2017

Resveratrol inhibits mTOR signaling by targeting DEPTOR.

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28 September 2017

Desmin-related cardiomyopathy: an unfolding story

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28 September 2017

Mitochondrial fusion is regulated by Reaper to modulate Drosophila programmed cell death

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28 September 2017

Drosophila UNC-45 accumulates in embryonic blastoderm and in muscles, and is essential for muscle myosin stability

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28 September 2017

Abnormal mitochondrial dynamics, mitochondrial loss and mutant huntingtin oligomers in Huntington's disease: implications for selective neuronal damage

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28 September 2017

Mitochondrial fission and cristae disruption increase the response of cell models of Huntington's disease to apoptotic stimuli

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28 September 2017

ERK activation by the polyphenols fisetin and resveratrol provides neuroprotection in multiple models of Huntington's disease

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28 September 2017

HSPB7 is the most potent polyQ aggregation suppressor within the HSPB family of molecular chaperones

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28 September 2017

Drosophila acinus encodes a novel regulator of endocytic and autophagic trafficking.

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28 September 2017

Polyglutamine induced misfolding of huntingtin exon1 is modulated by the flanking sequences

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28 September 2017

Polyglutamine toxicity in non-neuronal cells

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28 September 2017

A genomewide RNA interference screen for modifiers of aggregates formation by mutant Huntingtin in Drosophila

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28 September 2017

Resveratrol reduces endothelial oxidative stress by modulating the gene expression of superoxide dismutase 1 (SOD1), glutathione peroxidase 1 (GPx1) and NADPH oxidase subunit (Nox4).

1 reference

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28 September 2017

Formation of polyglutamine inclusions in a wide range of non-CNS tissues in the HdhQ150 knock-in mouse model of Huntington's disease

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28 September 2017

Fluorescent labeling of Drosophila heart structures

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28 September 2017

Drosophila melanogaster as a model system for genetics of postnatal cardiac function

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28 September 2017

Semi-automated Optical Heartbeat Analysis of small hearts.

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28 September 2017

Beyond the brain: widespread pathology in Huntington's disease

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3868535

28 September 2017

A new method for detection and quantification of heartbeat parameters in Drosophila, zebrafish, and embryonic mouse hearts

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28 September 2017

Protein misfolding inside cells: the case of huntingtin and Huntington's disease

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28 September 2017

Cardiomyocyte expression of a polyglutamine preamyloid oligomer causes heart failure.

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28 September 2017

Dystrophin deficiency in Drosophila reduces lifespan and causes a dilated cardiomyopathy phenotype

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28 September 2017

The Drosophila Hand gene is required for remodeling of the developing adult heart and midgut during metamorphosis

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28 September 2017

Mitofusin-2 is a major determinant of oxidative stress-mediated heart muscle cell apoptosis

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28 September 2017

Cardiac dysfunction in the R6/2 mouse model of Huntington's disease

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28 September 2017

Antioxidants protect PINK1-dependent dopaminergic neurons in Drosophila

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28 September 2017

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28 September 2017

Oxidative stress promotes mutant huntingtin aggregation and mutant huntingtin-dependent cell death by mimicking proteasomal malfunction.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3868535

28 September 2017

Hand, an evolutionarily conserved bHLH transcription factor required for Drosophila cardiogenesis and hematopoiesis

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28 September 2017

Mitochondrial dysfunction and apoptosis underlie the pathogenic process in alpha-B-crystallin desmin-related cardiomyopathy

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28 September 2017

Reversal of amyloid-induced heart disease in desmin-related cardiomyopathy

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28 September 2017

Treatment with extracellular HSP70/HSC70 protein can reduce polyglutamine toxicity and aggregation

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28 September 2017

Desmin-related cardiomyopathy in transgenic mice: a cardiac amyloidosis

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28 September 2017

Huntington's disease: molecular basis of neurodegeneration

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28 September 2017

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1004024

21 January 2018

Molecular mechanisms of amyloidosis

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28 September 2017

Protein misfolding, amyloid formation, and neurodegeneration: a critical role for molecular chaperones?

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28 September 2017

Control of cardiac development by an evolutionarily conserved transcriptional network

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3868535

28 September 2017

Role of the myosin assembly protein UNC-45 as a molecular chaperone for myosin

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3868535

28 September 2017

Identities of sequestered proteins in aggregates from cells with induced polyglutamine expression

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28 September 2017

Causes of death in patients with Huntington's disease and in unaffected first degree relatives

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28 September 2017

MARF and Opa1 control mitochondrial and cardiac function in Drosophila

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3868535

31 May 2018

Biochemical and mechanical dysfunction in a mouse model of desmin-related myopathy

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3868535

31 May 2018

Protein misfolding and cardiac disease: establishing cause and effect

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31 May 2018

Amyloid precursor proteins inhibit heme oxygenase activity and augment neurotoxicity in Alzheimer's disease.

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31 May 2018

Heart development in Drosophila and vertebrates: conservation of molecular mechanisms.

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31 May 2018

Oxidative damage and metabolic dysfunction in Huntington's disease: selective vulnerability of the basal ganglia.

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31 May 2018

Causes of death in Huntington's Disease

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31 May 2018

A modified method for lead staining of thin sections.

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31 May 2018

Huntington's disease mortality in the United States

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31 May 2018

Formation of polyglutamine inclusions in non-CNS tissue

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21 January 2018

Gene expression in Huntington's disease skeletal muscle: a potential biomarker

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21 January 2018

Neurocardiac dysregulation and neurogenic arrhythmias in a transgenic mouse model of Huntington's disease

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21 January 2018

Analysis of oxidative events induced by expanded polyglutamine huntingtin exon 1 that are differentially restored by expression of heat shock proteins or treatment with an antioxidant.

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21 January 2018

Comparative analysis of superoxide dismutase activity between acute pharmacological models and a transgenic mouse model of Huntington's disease

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21 January 2018

Proteomic and oxidative stress analysis in human brain samples of Huntington disease.

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21 January 2018

Protection of cardiac mitochondria by overexpression of MnSOD reduces diabetic cardiomyopathy

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https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1004024

21 January 2018

Protective effect of resveratrol on beta-amyloid-induced oxidative PC12 cell death

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https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1004024

21 January 2018

Mitochondrial impairment in patients and asymptomatic mutation carriers of Huntington's disease

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https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1004024

21 January 2018

Hand is a direct target of Tinman and GATA factors during Drosophila cardiogenesis and hematopoiesis

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https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1004024

21 January 2018

Resveratrol attenuates doxorubicin-induced cardiomyocyte apoptosis in mice through SIRT1-mediated deacetylation of p53

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12 December 2020

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Effect of contractile activity on protein turnover in skeletal muscle mitochondrial subfractions

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inferred from PubMed ID database lookup

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10.1371/JOURNAL.PGEN.1004024

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