(Q27649995)

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Minimal Pharmacophoric Elements and Fragment Hopping, an Approach Directed at Molecular Diversity and Isozyme Selectivity. Design of Selective Neuronal Nitric Oxide Synthase Inhibitors

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scholarly article

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Minimal Pharmacophoric Elements and Fragment Hopping, an Approach Directed at Molecular Diversity and Isozyme Selectivity. Design of Selective Neuronal Nitric Oxide Synthase Inhibitors (English)

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molecular design

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Haitao (mark) Ji

1

object named as

Haitao Ji

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author name string

Benjamin Z Stanton

2

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Jotaro Igarashi

3

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Huiying Li

4

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Pavel Martásek

5

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Linda J Roman

6

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Thomas L Poulos

7

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Richard B Silverman

8

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language of work or name

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publication date

26 March 2008

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Journal of the American Chemical Society

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130

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12

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3900-14

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Structural basis for dipeptide amide isoform-selective inhibition of neuronal nitric oxide synthase

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2929563

27 November 2018

Reduced amide bond peptidomimetics. (4S)-N-(4-amino-5-[aminoakyl]aminopentyl)-N'-nitroguanidines, potent and highly selective inhibitors of neuronal nitric oxide synthase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2929563

27 November 2018

GRID/CPCA: a new computational tool to design selective ligands.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2929563

27 November 2018

Consensus scoring: A method for obtaining improved hit rates from docking databases of three-dimensional structures into proteins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2929563

27 November 2018

N(omega)-Nitroarginine-containing dipeptide amides. Potent and highly selective inhibitors of neuronal nitric oxide synthase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2929563

27 November 2018

X-SITE: use of empirically derived atomic packing preferences to identify favourable interaction regions in the binding sites of proteins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2929563

27 November 2018

Functionality maps of binding sites: a multiple copy simultaneous search method

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2929563

27 November 2018

Discovery and development of neuronal nitric oxide synthase inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/18321097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitors of HIV-1 protease by using in situ click chemistry

1 reference

https://pubmed.ncbi.nlm.nih.gov/18321097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Properties of known drugs. 2. Side chains

1 reference

https://pubmed.ncbi.nlm.nih.gov/18321097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Custom chemical microarray production and affinity fingerprinting for the S1 pocket of factor VIIa

1 reference

https://pubmed.ncbi.nlm.nih.gov/18321097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Design of isoform-selective inhibitors of nitric oxide synthase

1 reference

https://pubmed.ncbi.nlm.nih.gov/18321097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Click chemistry in situ: acetylcholinesterase as a reaction vessel for the selective assembly of a femtomolar inhibitor from an array of building blocks

1 reference

https://pubmed.ncbi.nlm.nih.gov/18321097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deconstructing fragment-based inhibitor discovery

1 reference

https://pubmed.ncbi.nlm.nih.gov/18321097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drug rings database with web interface. A tool for identifying alternative chemical rings in lead discovery programs

1 reference

https://pubmed.ncbi.nlm.nih.gov/18321097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development of new hydrogen-bond descriptors and their application to comparative molecular field analyses

1 reference

https://pubmed.ncbi.nlm.nih.gov/18321097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/JA0772041

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