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Crystal Structure of Human Aurora B in Complex with INCENP and VX-680
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title
Crystal Structure of Human Aurora B in Complex with INCENP and VX-680
(English)
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main subject
drug discovery
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crystal structure
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author
Andrea Musacchio
series ordinal
3
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Jonathan M Elkins
object named as
Jonathan M Elkins
series ordinal
1
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Stefan Knapp
object named as
Stefan Knapp
series ordinal
4
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Stefano Santaguida
object named as
Stefano Santaguida
series ordinal
2
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language of work or name
English
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publication date
13 September 2012
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published in
Journal of Medicinal Chemistry
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volume
55
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issue
17
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page(s)
7841-8
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describes a project that uses
ImageJ
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stated in
Europe PubMed Central
retrieved
11 June 2022
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3621106/fullTextXML
based on heuristic
inferred from PubMed Central ID database lookup
cites work
Phosphorylation at serine 331 is required for Aurora B activation.
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PubMed Central
reference URL
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20 March 2017
Selective Aurora Kinase Inhibitors Identified Using a Taxol-Induced Checkpoint Sensitivity Screen
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20 March 2017
Crystal Structures of ABL-Related Gene (ABL2) in Complex with Imatinib, Tozasertib (VX-680), and a Type I Inhibitor of the Triazole Carbothioamide Class
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20 March 2017
Modulation of kinase-inhibitor interactions by auxiliary protein binding: crystallography studies on Aurora A interactions with VX-680 and with TPX2
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20 March 2017
Molecular basis of drug resistance in aurora kinases
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20 March 2017
Reversine, a novel Aurora kinases inhibitor, inhibits colony formation of human acute myeloid leukemia cells
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Discovery of selective aminothiazole aurora kinase inhibitors
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20 March 2017
Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites
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20 March 2017
Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchange
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Structural basis of Aurora-A activation by TPX2 at the mitotic spindle
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20 March 2017
Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis
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20 March 2017
Structures of the cancer-related Aurora-A, FAK, and EphA2 protein kinases from nanovolume crystallography
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20 March 2017
Crystal structure of aurora-2, an oncogenic serine/threonine kinase
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20 March 2017
Phasercrystallographic software
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20 March 2017
Scaling and assessment of data quality
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20 March 2017
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20 March 2017
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Size-Distribution Analysis of Macromolecules by Sedimentation Velocity Ultracentrifugation and Lamm Equation Modeling
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Chromosomal passengers: conducting cell division
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7 April 2017
Size-distribution analysis of proteins by analytical ultracentrifugation: strategies and application to model systems
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Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine
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29 September 2017
High-throughput production of human proteins for crystallization: the SGC experience.
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Discovery of GSK1070916, a potent and selective inhibitor of Aurora B/C kinase
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29 September 2017
MK-5108, a highly selective Aurora-A kinase inhibitor, shows antitumor activity alone and in combination with docetaxel
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The Aurora kinase family in cell division and cancer.
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29 September 2017
Discovery, synthesis, and in vivo activity of a new class of pyrazoloquinazolines as selective inhibitors of aurora B kinase
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29 September 2017
Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase
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29 September 2017
The chromosomal passenger complex: guiding Aurora-B through mitosis
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29 September 2017
Macromolecular size-and-shape distributions by sedimentation velocity analytical ultracentrifugation.
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29 September 2017
Mechanism of Aurora B activation by INCENP and inhibition by hesperadin
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3621106
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29 September 2017
Aurora-kinase inhibitors as anticancer agents
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29 September 2017
VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo
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stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3621106
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29 September 2017
Biochemical characterization of GSK1070916, a potent and selective inhibitor of Aurora B and Aurora C kinases with an extremely long residence time1.
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3621106
retrieved
27 November 2018
Activation segment exchange: a common mechanism of kinase autophosphorylation?
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3621106
retrieved
27 November 2018
Structural basis for potent inhibition of the Aurora kinases and a T315I multi-drug resistant mutant form of Abl kinase by VX-680.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3621106
retrieved
27 November 2018
Structure of the kinase domain of an imatinib-resistant Abl mutant in complex with the Aurora kinase inhibitor VX-680.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3621106
retrieved
27 November 2018
Binding of TPX2 to Aurora A alters substrate and inhibitor interactions
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22920039
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1021/JM3008954
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PMC publication ID
3621106
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PubMed publication ID
22920039
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ResearchGate publication ID
230738357
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