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Receptor tyrosine kinases exert dominant control over PI3K signaling in human KRAS mutant colorectal cancers
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scholarly article
1 reference
stated in
PubMed
PubMed ID
21985784
retrieved
13 November 2016
title
Receptor tyrosine kinases exert dominant control over PI3K signaling in human KRAS mutant colorectal cancers
(English)
1 reference
stated in
PubMed
PubMed ID
21985784
retrieved
13 November 2016
author
Kwok Kin Wong
series ordinal
11
object named as
Kwok-Kin Wong
0 references
Jeffrey A Meyerhardt
series ordinal
8
object named as
Jeffrey A Meyerhardt
0 references
author name string
Hiromichi Ebi
series ordinal
1
0 references
Ryan B Corcoran
series ordinal
2
0 references
Anurag Singh
series ordinal
3
0 references
Zhao Chen
series ordinal
4
0 references
Youngchul Song
series ordinal
5
0 references
Eugene Lifshits
series ordinal
6
0 references
David P Ryan
series ordinal
7
0 references
Cyril Benes
series ordinal
9
0 references
Jeffrey Settleman
series ordinal
10
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Lewis C Cantley
series ordinal
12
0 references
Jeffrey A Engelman
series ordinal
13
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language of work or name
English
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publication date
November 2011
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published in
Journal of Clinical Investigation
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volume
121
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issue
11
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page(s)
4311-21
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cites work
Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer
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20 March 2017
Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers
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20 March 2017
K-ras mutations and benefit from cetuximab in advanced colorectal cancer.
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PubMed Central
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20 March 2017
Genomic alterations of anaplastic lymphoma kinase may sensitize tumors to anaplastic lymphoma kinase inhibitors
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20 March 2017
KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab.
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20 March 2017
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20 March 2017
Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice
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PubMed Central
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20 March 2017
MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
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20 March 2017
KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer.
1 reference
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PubMed Central
reference URL
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20 March 2017
KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204842
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20 March 2017
EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204842
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20 March 2017
EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy
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PubMed Central
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20 March 2017
Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204842
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20 March 2017
Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gamma
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PubMed Central
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20 March 2017
Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204842
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20 March 2017
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204842
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20 March 2017
SH2 domains recognize specific phosphopeptide sequences
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PubMed Central
reference URL
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20 March 2017
Targeting RAS signalling pathways in cancer therapy
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204842
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20 March 2017
Involvement of phosphatidylinositol 3-kinase, but not RalGDS, in TC21/R-Ras2-mediated transformation
1 reference
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PubMed Central
reference URL
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Factors underlying sensitivity of cancers to small-molecule kinase inhibitors
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PubMed Central
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Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer
1 reference
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PubMed Central
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Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes
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PubMed Central
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High expression levels of total IGF-1R and sensitivity of NSCLC cells in vitro to an anti-IGF-1R antibody (R1507)
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20 March 2017
Phosphatidylinositol 3-kinase mediates bronchioalveolar stem cell expansion in mouse models of oncogenic K-ras-induced lung cancer
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20 March 2017
mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt
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7 April 2017
Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors
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PubMed Central
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7 April 2017
Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K
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reference URL
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7 April 2017
Phosphatidylinositol-3-OH kinase as a direct target of Ras
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204842
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7 April 2017
PIK3CA mutation uncouples tumor growth and cyclin D1 regulation from MEK/ERK and mutant KRAS signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204842
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29 September 2017
4E-BP1 is a key effector of the oncogenic activation of the AKT and ERK signaling pathways that integrates their function in tumors
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204842
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29 September 2017
Specific apoptosis induction by the dual PI3K/mTor inhibitor NVP-BEZ235 in HER2 amplified and PIK3CA mutant breast cancer cells
1 reference
stated in
PubMed Central
reference URL
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29 September 2017
Differential induction of apoptosis in HER2 and EGFR addicted cancers following PI3K inhibition.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204842
retrieved
29 September 2017
Identifying genotype-dependent efficacy of single and combined PI3K- and MAPK-pathway inhibition in cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204842
retrieved
29 September 2017
Ras signaling and therapies
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204842
retrieved
29 September 2017
A gene expression signature associated with "K-Ras addiction" reveals regulators of EMT and tumor cell survival
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204842
retrieved
29 September 2017
Mutations and response to epidermal growth factor receptor inhibitors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204842
retrieved
29 September 2017
PTEN-deficient cancers depend on PIK3CB.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204842
retrieved
29 September 2017
Acquired resistance to EGFR tyrosine kinase inhibitors in cancer cells is mediated by loss of IGF-binding proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204842
retrieved
29 September 2017
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1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204842
retrieved
29 September 2017
K-Ras promotes growth transformation and invasion of immortalized human pancreatic cells by Raf and phosphatidylinositol 3-kinase signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204842
retrieved
29 September 2017
Reduction in the requirement of oncogenic Ras signaling to activation of PI3K/AKT pathway during tumor maintenance
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204842
retrieved
29 September 2017
Activation of RalA is critical for Ras-induced tumorigenesis of human cells.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204842
retrieved
29 September 2017
ErbB-3 mediates phosphoinositide 3-kinase activity in gefitinib-sensitive non-small cell lung cancer cell lines
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204842
retrieved
29 September 2017
Distinct requirements for Ras oncogenesis in human versus mouse cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204842
retrieved
29 September 2017
Regulation of the p85/p110alpha phosphatidylinositol 3'-kinase. Distinct roles for the n-terminal and c-terminal SH2 domains
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204842
retrieved
29 September 2017
Defective posttranslational processing activates the tyrosine kinase encoded by the MET proto-oncogene (hepatocyte growth factor receptor).
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204842
retrieved
29 September 2017
Heterogeneity of receptor function in colon carcinoma cells determined by cross-talk between type I insulin-like growth factor receptor and epidermal growth factor receptor
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204842
retrieved
2 June 2018
In vivo antitumor activity of NVP-AEW541-A novel, potent, and selective inhibitor of the IGF-IR kinase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204842
retrieved
2 June 2018
Herceptin-induced inhibition of phosphatidylinositol-3 kinase and Akt Is required for antibody-mediated effects on p27, cyclin D1, and antitumor action
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204842
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2 June 2018
Success and failure on the ras pathway.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204842
retrieved
27 November 2018
KRAS wild-type state predicts survival and is associated to early radiological response in metastatic colorectal cancer treated with cetuximab
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204842
retrieved
27 November 2018
Oncogenic activation of the RAS/RAF signaling pathway impairs the response of metastatic colorectal cancers to anti-epidermal growth factor receptor antibody therapies.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204842
retrieved
27 November 2018
Stopping ras in its tracks
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21985784
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21985784
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1172/JCI57909
1 reference
stated in
PubMed
PubMed ID
21985784
retrieved
13 November 2016
PMCID
3204842
1 reference
stated in
PubMed
PubMed ID
21985784
retrieved
13 November 2016
PubMed ID
21985784
1 reference
stated in
PubMed
PubMed ID
21985784
retrieved
13 November 2016
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