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The role of mTOR signaling in Alzheimer disease
scientific article
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scholarly article
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title
The role of mTOR signaling in Alzheimer disease
(English)
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main subject
Alzheimer's disease
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based on heuristic
inferred from title
author name string
Salvatore Oddo
series ordinal
1
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language of work or name
English
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publication date
1 January 2012
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published in
Frontiers in bioscience
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volume
4
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page(s)
941-52
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cites work
Naturally secreted amyloid-beta increases mammalian target of rapamycin (mTOR) activity via a PRAS40-mediated mechanism
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Alzheimer's Disease
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Cannabinoid modulation of hippocampal long-term memory is mediated by mTOR signaling
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Specification of neuronal polarity regulated by local translation of CRMP2 and Tau via the mTOR-p70S6K pathway
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PIM1 protein kinase regulates PRAS40 phosphorylation and mTOR activity in FDCP1 cells
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ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery
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PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4111148
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29 September 2017
Lithium delays progression of amyotrophic lateral sclerosis
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4111148
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29 September 2017
Binding of rapamycin analogs to calcium channels and FKBP52 contributes to their neuroprotective activities
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4111148
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29 September 2017
Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4111148
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29 September 2017
Polyglutamine diseases: emerging concepts in pathogenesis and therapy
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4111148
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29 September 2017
Evidence of Abeta- and transgene-dependent defects in ERK-CREB signaling in Alzheimer's models
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4111148
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29 September 2017
Autophagy and neurodegeneration: when the cleaning crew goes on strike
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4111148
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29 September 2017
Amyloid-beta peptides induce several chemokine mRNA expressions in the primary microglia and Ra2 cell line via the PI3K/Akt and/or ERK pathway
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4111148
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29 September 2017
Lysosomal turnover, but not a cellular level, of endogenous LC3 is a marker for autophagy
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4111148
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29 September 2017
Autophagy and aging: the importance of maintaining "clean" cells
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4111148
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29 September 2017
Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4111148
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29 September 2017
Dysregulation of the TSC-mTOR pathway in human disease
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PubMed Central
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29 September 2017
Autophagy: many paths to the same end.
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29 September 2017
An RNA-dependent protein kinase is involved in tunicamycin-induced apoptosis and Alzheimer's disease
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4111148
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29 September 2017
Compartmentalized synthesis and degradation of proteins in neurons.
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4111148
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29 September 2017
mTor is required for hypertrophy of Pten-deficient neuronal soma in vivo
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4111148
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29 September 2017
Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer's disease-related cognitive deficits
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4111148
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29 September 2017
A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4111148
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29 September 2017
A transient, neuron-wide form of CREB-mediated long-term facilitation can be stabilized at specific synapses by local protein synthesis.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4111148
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29 September 2017
Parkin mediates beclin-dependent autophagic clearance of defective mitochondria and ubiquitinated Abeta in AD models
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PubMed Central
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2 June 2018
Vulnerability of dentate granule cells to disruption of arc expression in human amyloid precursor protein transgenic mice.
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2 June 2018
2010 Alzheimer's disease facts and figures
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27 November 2018
The role of mTOR signaling in controlling mammalian life span: what a fungicide teaches us about longevity
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27 November 2018
mTOR signaling in epileptogenesis: too much of a good thing?
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27 November 2018
Diffusion of docosahexaenoic and eicosapentaenoic acids through the blood-brain barrier: An in situ cerebral perfusion study.
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27 November 2018
Rapamycin inhibits mTORC1, but not completely.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4111148
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27 November 2018
A central role for autophagy in Alzheimer-type neurodegeneration.
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PubMed Central
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27 November 2018
Blocking Abeta42 accumulation delays the onset and progression of tau pathology via the C terminus of heat shock protein70-interacting protein: a mechanistic link between Abeta and tau pathology.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4111148
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27 November 2018
Genetically augmenting tau levels does not modulate the onset or progression of Abeta pathology in transgenic mice
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4111148
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27 November 2018
Induction of matrix metalloproteinases (MMP3, MMP12 and MMP13) expression in the microglia by amyloid-beta stimulation via the PI3K/Akt pathway.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4111148
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27 November 2018
Translational control via the mammalian target of rapamycin pathway is critical for the formation and stability of long-term fear memory in amygdala neurons.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4111148
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27 November 2018
TOR-mediated cell-cycle activation causes neurodegeneration in a Drosophila tauopathy model.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4111148
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27 November 2018
Rapamycin alleviates toxicity of different aggregate-prone proteins
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4111148
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27 November 2018
Temporal profile of amyloid-beta (Abeta) oligomerization in an in vivo model of Alzheimer disease. A link between Abeta and tau pathology
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4111148
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27 November 2018
Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4111148
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27 November 2018
Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4111148
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27 November 2018
Phosphorylated eukaryotic translation factor 4E is elevated in Alzheimer brain.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4111148
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27 November 2018
Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4111148
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27 November 2018
Activation of the cell stress kinase PKR in Alzheimer's disease and human amyloid precursor protein transgenic mice
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4111148
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27 November 2018
Phosphorylation of eukaryotic initiation factor-2alpha (eIF2alpha) is associated with neuronal degeneration in Alzheimer's disease.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4111148
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27 November 2018
Effect of the Alzheimer amyloid fragment Abeta(25-35) on Akt/PKB kinase and survival of PC12 cells
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27 November 2018
Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4111148
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27 November 2018
Dose-dependent pharmacokinetics of rapamycin-28-N,N-dimethylglycinate in the mouse.
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PubMed Central
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27 November 2018
Aggregation of secreted amyloid beta-protein into sodium dodecyl sulfate-stable oligomers in cell culture
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PubMed Central
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27 November 2018
Identifiers
DOI
10.2741/S310
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2085266
OpenCitations bibliographic resource ID
2085266
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2085266
PMCID
4111148
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2085266
PubMed ID
22202101
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2085266
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