(Q28259292)

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

The Ras superfamily at a glance

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

Geranylgeranyltransferase I inhibitors target RalB to inhibit anchorage-dependent growth and induce apoptosis and RalA to inhibit anchorage-independent growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

Identification of a novel prenyl and palmitoyl modification at the CaaX motif of Cdc42 that regulates RhoGDI binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

RalA-exocyst-dependent recycling endosome trafficking is required for the completion of cytokinesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

Plasma membrane recruitment of RalGDS is critical for Ras-dependent Ral activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

ralGDS family members interact with the effector loop of ras p21.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

Identification of a novel RalGDS-related protein as a candidate effector for Ras and Rap1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

Ras-dependent activation of the small GTPase Ral.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

Activation of the small GTPase Ral in platelets.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

R-Ras regulates exocytosis by Rgl2/Rlf-mediated activation of RalA on endosomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

The anti-inflammatory TIPE2 is an inhibitor of the oncogenic Ras.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

RalGDS couples growth factor signaling to Akt activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

Guanine exchange factor RalGDS mediates exocytosis of Weibel-Palade bodies from endothelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

Regulation of Ras signaling specificity by protein kinase C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

The Rgr oncogene (homologous to RalGDS) induces transformation and gene expression by activating Ras, Ral and Rho mediated pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

The Rgr oncogene induces tumorigenesis in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

The human Rgr oncogene is overexpressed in T-cell malignancies and induces transformation by acting as a GEF for Ras and Ral.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

Identification and characterization of a new family of guanine nucleotide exchange factors for the ras-related GTPase Ral

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

RalGEF2, a pleckstrin homology domain containing guanine nucleotide exchange factor for Ral

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

Functional analysis of RalGPS2, a murine guanine nucleotide exchange factor for RalA GTPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

Tuberous sclerosis tumor suppressor complex-like complexes act as GTPase-activating proteins for Ral GTPases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

Adipocytes contain a novel complex similar to the tuberous sclerosis complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

A Ral GAP complex links PI 3-kinase/Akt signaling to RalA activation in insulin action

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

The tuberous sclerosis complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

GEFs and GAPs: critical elements in the control of small G proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

The GTPase-activating protein Rap1GAP uses a catalytic asparagine

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

The Rap-RapGAP complex: GTP hydrolysis without catalytic glutamine and arginine residues

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

GARNL1, a major RalGAP α subunit in skeletal muscle, regulates insulin-stimulated RalA activation and GLUT4 trafficking via interaction with 14-3-3 proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

Negative regulation of the RalGAP complex by 14-3-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

κB-Ras proteins regulate both NF-κB-dependent inflammation and Ral-dependent proliferation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

GAP control: regulating the regulators of small GTPases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

The brain exocyst complex interacts with RalA in a GTP-dependent manner: identification of a novel mammalian Sec3 gene and a second Sec15 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

The exocyst complex binds the small GTPase RalA to mediate filopodia formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

Structural basis of the interaction between RalA and Sec5, a subunit of the sec6/8 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

Exo84 and Sec5 are competitive regulatory Sec6/8 effectors to the RalA GTPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

Regulation of platelet dense granule secretion by the Ral GTPase-exocyst pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

RalA-exocyst interaction mediates GTP-dependent exocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

RalA and RalB function as the critical GTP sensors for GTP-dependent exocytosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

Munc13-4 is a GTP-Rab27-binding protein regulating dense core granule secretion in platelets.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

Small GTP-binding protein Ral is involved in cAMP-mediated release of von Willebrand factor from endothelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

Mammalian exocyst complex is required for the docking step of insulin vesicle exocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

Involvement of Exoc3l, a protein structurally related to the exocyst subunit Sec6, in insulin secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

The RalA GTPase is a central regulator of insulin exocytosis from pancreatic islet beta cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

Activation of RalA is required for insulin-stimulated Glut4 trafficking to the plasma membrane via the exocyst and the motor protein Myo1c

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

Ral GTPases regulate cell-mediated cytotoxicity in NK cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

Control of secondary granule release in neutrophils by Ral GTPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

Dual role of the exocyst in AMPA receptor targeting and insertion into the postsynaptic membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

Ral mediates activity-dependent growth of postsynaptic membranes via recruitment of the exocyst.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

Ral-GTPase influences the regulation of the readily releasable pool of synaptic vesicles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

Sec6/8 complex is recruited to cell-cell contacts and specifies transport vesicle delivery to the basal-lateral membrane in epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

RalA but not RalB enhances polarized delivery of membrane proteins to the basolateral surface of epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

RalA promotes a direct exocyst-Par6 interaction to regulate polarity in neuronal development

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

RalB mobilizes the exocyst to drive cell migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

RalA and RalB: antagonistic relatives in cancer cell migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

The small GTPase Ral mediates SDF-1-induced migration of B cells and multiple myeloma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

RalA activation at nascent lamellipodia of epidermal growth factor-stimulated Cos7 cells and migrating Madin-Darby canine kidney cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

Ral-regulated interaction between Sec5 and paxillin targets Exocyst to focal complexes during cell migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

Centriolin anchoring of exocyst and SNARE complexes at the midbody is required for secretory-vesicle-mediated abscission

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

Distinct roles of RalA and RalB in the progression of cytokinesis are supported by distinct RalGEFs

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

Exo70 interacts with the Arp2/3 complex and regulates cell migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

Ral GTPases regulate neurite branching through GAP-43 and the exocyst complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

Identification and characterization of Ral-binding protein 1, a potential downstream target of Ral GTPases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

An Eps homology (EH) domain protein that binds to the Ral-GTPase target, RalBP1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

Identification and characterization of a novel protein interacting with Ral-binding protein 1, a putative effector protein of Ral

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

Epsin binds to the EH domain of POB1 and regulates receptor-mediated endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

Small G protein Ral and its downstream molecules regulate endocytosis of EGF and insulin receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

RALBP1/RLIP76 depletion in mice suppresses tumor growth by inhibiting tumor neovascularization

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

Spatial regulation of VEGF receptor endocytosis in angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

RALA and RALBP1 regulate mitochondrial fission at mitosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

Transport of glutathione conjugates and chemotherapeutic drugs by RLIP76 (RALBP1): a novel link between G-protein and tyrosine kinase signaling and drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

RLIP76 is a major determinant of radiation sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

Involvement of Ral GTPase in v-Src-induced phospholipase D activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

Functional association between Arf and RalA in active phospholipase D complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

M-Sec promotes membrane nanotube formation by interacting with Ral and the exocyst complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

RalA interacts with ZONAB in a cell density-dependent manner and regulates its transcriptional activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

The small GTPase RalA targets filamin to induce filopodia

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

Direct binding of RalA to PKCη and its crucial role in morphological change during keratinocyte differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

The small GTPase RALA controls c-Jun N-terminal kinase-mediated FOXO activation by regulation of a JIP1 scaffold complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

The Drosophila Ral GTPase regulates developmental cell shape changes through the Jun NH(2)-terminal kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

The Ral/exocyst effector complex counters c-Jun N-terminal kinase-dependent apoptosis in Drosophila melanogaster

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

Ral GTPases contribute to regulation of cyclin D1 through activation of NF-kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

mTOR signaling in growth control and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

RalA functions as an indispensable signal mediator for the nutrient-sensing system

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

Ral and Rheb GTPase activating proteins integrate mTOR and GTPase signaling in aging, autophagy, and tumor cell invasion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

Phospholipase D mediates nutrient input to mammalian target of rapamycin complex 1 (mTORC1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

Creation of human tumour cells with defined genetic elements

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

Distinct requirements for Ras oncogenesis in human versus mouse cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

Activation of RalA is critical for Ras-induced tumorigenesis of human cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

Activation and involvement of Ral GTPases in colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

Dissection of RAS downstream pathways in melanomagenesis: a role for Ral in transformation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

Ral activation promotes melanomagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

Ral overactivation in malignant peripheral nerve sheath tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

RalA signaling pathway as a therapeutic target in hepatocellular carcinoma (HCC).

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

Signal pathways which promote invasion and metastasis: critical and distinct contributions of extracellular signal-regulated kinase and Ral-specific guanine exchange factor pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

Activation of the RalGEF/Ral pathway promotes prostate cancer metastasis to bone

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

Divergent roles for RalA and RalB in malignant growth of human pancreatic carcinoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

Downregulation of Ral GTPase-activating protein promotes tumor invasion and metastasis of bladder cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

Sec5 and Exo84 foster oncogenic ras-mediated tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

RalA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

The role of the exocyst in matrix metalloproteinase secretion and actin dynamics during tumor cell invadopodia formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

Endosomal WASH and exocyst complexes control exocytosis of MT1-MMP at invadopodia

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

RalB GTPase-mediated activation of the IkappaB family kinase TBK1 couples innate immune signaling to tumor cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

RalB and the exocyst mediate the cellular starvation response by direct activation of autophagosome assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

The deubiquitylase USP33 discriminates between RALB functions in autophagy and innate immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

Ral GTPase down-regulation stabilizes and reactivates p53 to inhibit malignant transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

p53 and its mutants in tumor cell migration and invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

Aberrant overexpression of the Rgl2 Ral small GTPase-specific guanine nucleotide exchange factor promotes pancreatic cancer growth through Ral-dependent and Ral-independent mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

Down-regulation of human DAB2IP gene expression mediated by polycomb Ezh2 complex and histone deacetylase in prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-kappaB

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

Identification of V23RalA-Ser194 as a critical mediator for Aurora-A-induced cellular motility and transformation by small pool expression screening.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

Aurora-A phosphorylates, activates, and relocalizes the small GTPase RalA

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

The tumor suppressor PP2A Abeta regulates the RalA GTPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

Phosphorylation by protein kinase Cα regulates RalB small GTPase protein activation, subcellular localization, and effector utilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

Phosphorylation of RalB is important for bladder cancer cell growth and metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

Genetic deletion of RALA and RALB small GTPases reveals redundant functions in development and tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

RalGDS is required for tumor formation in a model of skin carcinogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

The geranylgeranyltransferase-I inhibitor GGTI-298 arrests human tumor cells in G0/G1 and induces p21(WAF1/CIP1/SDI1) in a p53-independent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029

Discovery and characterization of small molecules that target the GTPase Ral

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVV029