(Q28294279)

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Statins promote the degradation of extracellular amyloid {beta}-peptide by microglia via stimulation of exosome-associated insulin-degrading enzyme (IDE) secretion

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Statins promote the degradation of extracellular amyloid {beta}-peptide by microglia via stimulation of exosome-associated insulin-degrading enzyme (IDE) secretion (English)

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3-hydroxy-3-methylglutaryl-Coenzyme A reductase

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GOA release 2020-03-11

cytochrome P450, family 51

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GOA release 2020-03-11

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based on heuristic

inferred from title

author name string

Irfan Y Tamboli

1

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Esther Barth

2

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Leonie Christian

3

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Martin Siepmann

4

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Sathish Kumar

5

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Sandesh Singh

6

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Karen Tolksdorf

7

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Michael T Heneka

8

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Dieter Lütjohann

9

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Patrick Wunderlich

10

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Jochen Walter

11

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language of work or name

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publication date

26 November 2010

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Journal of Biological Chemistry

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285

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48

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37405-14

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Rab GTPases as coordinators of vesicle traffic

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2988346

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Statins reduce the neurofibrillary tangle burden in a mouse model of tauopathy

1 reference

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ApoE promotes the proteolytic degradation of Abeta

1 reference

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20 March 2017

Soluble oligomers of the amyloid beta-protein impair synaptic plasticity and behavior

1 reference

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20 March 2017

Active caspase-1 is a regulator of unconventional protein secretion

1 reference

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20 March 2017

Human amyloid-beta synthesis and clearance rates as measured in cerebrospinal fluid in vivo

1 reference

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20 March 2017

Metabolism of amyloid-beta peptide and Alzheimer's disease

1 reference

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20 March 2017

Cholesterol, lipid rafts, and disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2988346

20 March 2017

Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2988346

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1 reference

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Ceramide triggers budding of exosome vesicles into multivesicular endosomes

1 reference

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2988346

29 September 2017

Can statins prevent or help treat Alzheimer's disease?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2988346

29 September 2017

Insulin-degrading enzyme sorting in exosomes: a secretory pathway for a key brain amyloid-beta degrading protease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2988346

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Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2988346

29 September 2017

Statins: mechanisms of neuroprotection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2988346

29 September 2017

Therapeutic potential of statins in Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2988346

29 September 2017

Insulin-degrading enzyme is exported via an unconventional protein secretion pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2988346

29 September 2017

Detergent resistant membrane-associated IDE in brain tissue and cultured cells: Relevance to Abeta and insulin degradation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2988346

29 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2988346

29 September 2017

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2988346

29 September 2017

Unconventional mechanisms of protein transport to the cell surface of eukaryotic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2988346

29 September 2017

Itinerant exosomes: emerging roles in cell and tissue polarity

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2988346

29 September 2017

The role of the immune system in clearance of Abeta from the brain

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2988346

29 September 2017

New structures help the modeling of toxic amyloidbeta ion channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2988346

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2988346

29 September 2017

Geranylgeranyl pyrophosphate stimulates gamma-secretase to increase the generation of Abeta and APP-CTFgamma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2988346

29 September 2017

Statins reduce amyloid-beta production through inhibition of protein isoprenylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2988346

29 September 2017

Effect of HMG-CoA reductase inhibitors on beta-amyloid peptide levels: implications for Alzheimer's disease

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2988346

29 September 2017

Regulation of the lipidation of beta-secretase by statins

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2988346

29 September 2017

Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2988346

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Alzheimer's centennial legacy: prospects for rational therapeutic intervention targeting the Abeta amyloid pathway

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2988346

29 September 2017

Re-assessing the relationship between cholesterol, statins and Alzheimer's disease

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2988346

29 September 2017

Alzheimer's disease beta-amyloid peptides are released in association with exosomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2988346

29 September 2017

Amyloid excess in Alzheimer's disease: what is cholesterol to be blamed for?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2988346

29 September 2017

Statins inhibit the dimerization of beta-secretase via both isoprenoid- and cholesterol-mediated mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2988346

29 September 2017

Isoprenoids and Alzheimer's disease: a complex relationship

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2988346

29 September 2017

Isoprenylated proteins

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2988346

29 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2988346

29 September 2017

Membrane disordering effects of beta-amyloid peptides.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2988346

29 September 2017

The non-amyloidogenic pathway: structure and function of alpha-secretases

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2988346

29 September 2017

Cholesterol-independent effects of statins and new therapeutic targets: ischemic stroke and dementia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2988346

29 September 2017

Exosomes: endosomal-derived vesicles shipping extracellular messages

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2988346

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2988346

29 September 2017

Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-beta peptide in mouse brain.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2988346

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2988346

29 September 2017

Role of apoE/Abeta interactions in Alzheimer's disease: insights from transgenic mouse models

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2988346

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29 September 2017

Insulysin hydrolyzes amyloid beta peptides to products that are neither neurotoxic nor deposit on amyloid plaques.

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29 September 2017

Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors.

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29 September 2017

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29 September 2017

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29 September 2017

Inhibition of gamma-secretase causes increased secretion of amyloid precursor protein C-terminal fragments in association with exosomes

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Multivesicular bodies and autophagy in erythrocyte maturation

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2 June 2018

Neuronal membrane cholesterol loss enhances amyloid peptide generation

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2988346

2 June 2018

Clearance of extracellular and cell-associated amyloid beta peptide through viral expression of neprilysin in primary neurons.

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2 June 2018

Metabolic regulation of brain Abeta by neprilysin.

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21 January 2018

apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain

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21 January 2018

Statins are associated with a reduced risk of Alzheimer disease regardless of lipophilicity. The Rotterdam Study.

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21 January 2018

The road to LOAD: late-onset Alzheimer's disease and a possible way to block it.

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21 January 2018

Loss of gamma-secretase function impairs endocytosis of lipoprotein particles and membrane cholesterol homeostasis

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21 January 2018

Somatostatin regulates brain amyloid beta peptide Abeta42 through modulation of proteolytic degradation.

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21 January 2018

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