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c-FLIP, a master anti-apoptotic regulator
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scholarly article
1 reference
stated in
Europe PubMed Central
PMCID
4817998
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23070002%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 February 2020
title
c-FLIP, a master anti-apoptotic regulator
(English)
1 reference
stated in
Europe PubMed Central
PMCID
4817998
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23070002%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 February 2020
main subject
apoptotic process
0 references
author name string
A R Safa
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMCID
4817998
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23070002%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 February 2020
language of work or name
English
0 references
publication date
1 October 2012
1 reference
stated in
Europe PubMed Central
PMCID
4817998
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23070002%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 February 2020
published in
Experimental Oncology
1 reference
stated in
Europe PubMed Central
PMCID
4817998
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23070002%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 February 2020
volume
34
1 reference
stated in
Europe PubMed Central
PMCID
4817998
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23070002%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 February 2020
issue
3
1 reference
stated in
Europe PubMed Central
PMCID
4817998
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23070002%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 February 2020
page(s)
176-184
1 reference
stated in
Europe PubMed Central
PMCID
4817998
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23070002%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 February 2020
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Reduced CaM/FLIP binding by a single point mutation in c-FLIP(L) modulates Fas-mediated apoptosis and decreases tumorigenesis
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Itch/AIP4-independent proteasomal degradation of cFLIP induced by the histone deacetylase inhibitor SAHA sensitizes breast tumour cells to TRAIL.
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Triggering of death receptor apoptotic signaling by human papillomavirus 16 E2 protein in cervical cancer cell lines is mediated by interaction with c-FLIP.
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Rocaglamide breaks TRAIL resistance in HTLV-1-associated adult T-cell leukemia/lymphoma by translational suppression of c-FLIP expression
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29 September 2017
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Modulation of Wnt signaling by the nuclear localization of cellular FLIP-L.
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29 September 2017
Cellular FLICE-inhibitory protein (c-FLIP) signalling: a key regulator of receptor-mediated apoptosis in physiologic context and in cancer
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29 September 2017
A novel PTEN-dependent link to ubiquitination controls FLIPS stability and TRAIL sensitivity in glioblastoma multiforme
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29 September 2017
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29 September 2017
Down-regulation of AMP-activated protein kinase sensitizes DU145 carcinoma to Fas-induced apoptosis via c-FLIP degradation
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29 September 2017
A single nucleotide polymorphism determines protein isoform production of the human c-FLIP protein
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PKC-mediated phosphorylation regulates c-FLIP ubiquitylation and stability
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29 September 2017
Expression and biological significance of c-FLIP in human hepatocellular carcinomas
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29 September 2017
c-FLIP knockdown induces ligand-independent DR5-, FADD-, caspase-8-, and caspase-9-dependent apoptosis in breast cancer cells
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29 September 2017
Mitogen-activated protein kinase kinase 1/2 inhibitors and 17-allylamino-17-demethoxygeldanamycin synergize to kill human gastrointestinal tumor cells in vitro via suppression of c-FLIP-s levels and activation of CD95.
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29 September 2017
Overexpression of cFLIPs inhibits oxaliplatin-mediated apoptosis through enhanced XIAP stability and Akt activation in human renal cancer cells
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29 September 2017
Vorinostat and sorafenib synergistically kill tumor cells via FLIP suppression and CD95 activation
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29 September 2017
Cisplatin induces p53-dependent FLICE-like inhibitory protein ubiquitination in ovarian cancer cells.
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29 September 2017
FLIP as an anti-cancer therapeutic target
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29 September 2017
Cellular FLICE-like inhibitory protein (C-FLIP): a novel target for cancer therapy
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29 September 2017
Gli2 upregulates cFlip and renders basal cell carcinoma cells resistant to death ligand-mediated apoptosis
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Calmodulin binding to cellular FLICE-like inhibitory protein modulates Fas-induced signalling
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29 September 2017
The relationship between c-FLIP expression and human papillomavirus E2 gene disruption in cervical carcinogenesis
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29 September 2017
Apoptosis in the treatment of cancer: a promise kept?
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29 September 2017
mTOR-independent translational control of the extrinsic cell death pathway by RalA.
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29 September 2017
The many shapes of mitochondrial death
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29 September 2017
Androgen receptor and prostate apoptosis response factor-4 target the c-FLIP gene to determine survival and apoptosis in the prostate gland
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cFLIP regulation of lymphocyte activation and development
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29 September 2017
Identification of small molecules that sensitize resistant tumor cells to tumor necrosis factor-family death receptors
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29 September 2017
Rapid turnover of c-FLIPshort is determined by its unique C-terminal tail
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29 September 2017
Cellular FLIP (long form) regulates CD8+ T cell activation through caspase-8-dependent NF-kappa B activation
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29 September 2017
Inhibition of CaMKII-mediated c-FLIP expression sensitizes malignant melanoma cells to TRAIL-induced apoptosis.
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29 September 2017
Fas-associated protein with death domain (FADD)-independent recruitment of c-FLIPL to death receptor 5.
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29 September 2017
Cellular FLIP inhibits beta-catenin ubiquitylation and enhances Wnt signaling.
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PubMed Central
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29 September 2017
Activation of caspases-8 and -10 by FLIP(L).
1 reference
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PubMed Central
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29 September 2017
Long form of cellular FLICE-inhibitory protein interacts with Daxx and prevents Fas-induced JNK activation
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PubMed Central
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29 September 2017
Phosphatidylinositide 3-Kinase Priming Couples c-FLIP to T Cell Activation
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PubMed Central
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29 September 2017
Cisplatin down-regulation of cellular Fas-associated death domain-like interleukin-1beta-converting enzyme-like inhibitory proteins to restore tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human melanoma cells
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29 September 2017
Cellular FLICE-inhibitory protein: an attractive therapeutic target?
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29 September 2017
Apoptosis control in syncytia induced by the HIV type 1-envelope glycoprotein complex: role of mitochondria and caspases.
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retrieved
29 September 2017
Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4817998
retrieved
29 September 2017
Ubiquitin-specific protease 8 links the PTEN-Akt-AIP4 pathway to the control of FLIPS stability and TRAIL sensitivity in glioblastoma multiforme
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4817998
retrieved
2 June 2018
Sensitization of human K562 leukemic cells to TRAIL-induced apoptosis by inhibiting the DNA-PKcs/Akt-mediated cell survival pathway.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4817998
retrieved
2 June 2018
Identification of c-FLIP(L) and c-FLIP(S) as critical regulators of death receptor-induced apoptosis in pancreatic cancer cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4817998
retrieved
27 November 2018
ATM kinase activity modulates cFLIP protein levels: potential interplay between DNA damage signalling and TRAIL-induced apoptosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4817998
retrieved
27 November 2018
The long isoform of cellular FLIP is essential for T lymphocyte proliferation through an NF-kappaB-independent pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4817998
retrieved
27 November 2018
Heat shock protein 90alpha recruits FLIPS to the death-inducing signaling complex and contributes to TRAIL resistance in human glioma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4817998
retrieved
27 November 2018
Low-dose BBR3610 toxicity in colon cancer cells is p53-independent and enhanced by inhibition of epidermal growth factor receptor (ERBB1)-phosphatidyl inositol 3 kinase signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4817998
retrieved
27 November 2018
Mitochondrial regulation of apoptotic cell death.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4817998
retrieved
27 November 2018
The c-FLIP-NH2 terminus (p22-FLIP) induces NF-kappaB activation.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4817998
retrieved
27 November 2018
cFLIP expression correlates with tumour progression and patient outcome in non-Hodgkin lymphomas of low grade of malignancy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4817998
retrieved
27 November 2018
Translational regulation of TRAIL sensitivity.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4817998
retrieved
27 November 2018
c-FLIP inhibits chemotherapy-induced colorectal cancer cell death
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4817998
retrieved
27 November 2018
Expression of cellular FLICE/caspase-8 inhibitory protein is associated with malignant potential in endometrial carcinoma.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4817998
retrieved
27 November 2018
c-FLIP expression in bladder urothelial carcinomas: its role in resistance to Fas-mediated apoptosis and clinicopathologic correlations
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4817998
retrieved
27 November 2018
Overexpression of cellular FLICE-inhibitory protein (FLIP) in gastric adenocarcinoma.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4817998
retrieved
27 November 2018
Calcium/calmodulin-dependent protein kinase II regulation of c-FLIP expression and phosphorylation in modulation of Fas-mediated signaling in malignant glioma cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4817998
retrieved
27 November 2018
Bile acids stimulate cFLIP phosphorylation enhancing TRAIL-mediated apoptosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4817998
retrieved
27 November 2018
Induction of apoptosis in 9-nitrocamptothecin-treated DU145 human prostate carcinoma cells correlates with de novo synthesis of CD95 and CD95 ligand and down-regulation of c-FLIP(short).
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4817998
retrieved
27 November 2018
Cisplatin (CDDP) sensitizes human osteosarcoma cell to Fas/CD95-mediated apoptosis by down-regulating FLIP-L expression.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4817998
retrieved
27 November 2018
Crystal structure of a viral FLIP: insights into FLIP-mediated inhibition of death receptor signaling
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23070002
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Overexpression of cFLIP in head and neck squamous cell carcinoma and its clinicopathologic correlations
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23070002
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Overexpression of FLIPL is an independent marker of poor prognosis in colorectal cancer patients
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23070002
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
c-Flip protein expression in Burkitt's lymphomas is associated with a poor clinical outcome
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23070002
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Cleavage of BID during cytotoxic drug and UV radiation-induced apoptosis occurs downstream of the point of Bcl-2 action and is catalysed by caspase-3: a potential feedback loop for amplification of apoptosis-associated mitochondrial cytochrome c rel
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23070002
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
OpenCitations bibliographic resource ID
1687280
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1687280
PMCID
4817998
2 references
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1687280
stated in
Europe PubMed Central
PMCID
4817998
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23070002%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 February 2020
PubMed ID
23070002
2 references
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1687280
stated in
Europe PubMed Central
PMCID
4817998
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23070002%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 February 2020
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