(Q28394921)

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Triterpenoid modulation of IL-17 and Nrf-2 expression ameliorates neuroinflammation and promotes remyelination in autoimmune encephalomyelitis

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scholarly article

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Triterpenoid modulation of IL-17 and Nrf-2 expression ameliorates neuroinflammation and promotes remyelination in autoimmune encephalomyelitis (English)

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1

object named as

Tej K Pareek

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9

object named as

Karen T Liby

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author name string

Abdelmadjid Belkadi

2

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Sashi Kesavapany

3

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Anita Zaremba

4

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Sook L Loh

5

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Lianhua Bai

6

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Mark L Cohen

7

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Colin Meyer

8

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Robert H Miller

10

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Michael B Sporn

11

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John J Letterio

12

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language of work or name

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publication date

2011

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Scientific Reports

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1

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201

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copyright license

Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported

1 December 2011

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April 2022 Public Data File from Crossref

copyright status

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Neuroprotective effect of Nrf2/ARE activators, CDDO ethylamide and CDDO trifluoroethylamide, in a mouse model of amyotrophic lateral sclerosis

1 reference

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19 March 2017

Vacuolar leukoencephalopathy with widespread astrogliosis in mice lacking transcription factor Nrf2

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242013

19 March 2017

Bone morphogenetic proteins promote gliosis in demyelinating spinal cord lesions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242013

19 March 2017

On the origins of triterpenoid skeletal diversity

2 references

https://api.crossref.org/works/10.1038/SREP00201

22 April 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242013

29 September 2017

Multiple sclerosis

1 reference

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7 April 2017

Bardoxolone methyl and kidney function in CKD with type 2 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242013

29 September 2017

Autocrine transforming growth factor-β1 promotes in vivo Th17 cell differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242013

29 September 2017

Fumaric acid and its esters: an emerging treatment for multiple sclerosis with antioxidative mechanism of action

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242013

29 September 2017

Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242013

29 September 2017

Th17 cell, the new player of neuroinflammatory process in multiple sclerosis.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242013

29 September 2017

Triterpenoids CDDO-ethyl amide and CDDO-trifluoroethyl amide improve the behavioral phenotype and brain pathology in a transgenic mouse model of Huntington's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242013

29 September 2017

The absence of the pro-antioxidant transcription factor Nrf2 exacerbates experimental autoimmune encephalomyelitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242013

29 September 2017

Regulation of Th17 cell differentiation and EAE induction by MAP3K NIK.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242013

29 September 2017

Triterpenoid CDDO-methylamide improves memory and decreases amyloid plaques in a transgenic mouse model of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242013

29 September 2017

The transcription factor Nrf2 is a therapeutic target against brain inflammation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242013

29 September 2017

A function for IL-7R for CD4+CD25+Foxp3+ T regulatory cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242013

29 September 2017

The synthetic triterpenoid CDDO-methyl ester modulates microglial activities, inhibits TNF production, and provides dopaminergic neuroprotection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242013

29 September 2017

Triterpenoid CDDO-methyl ester inhibits the Janus-activated kinase-1 (JAK1)-->signal transducer and activator of transcription-3 (STAT3) pathway by direct inhibition of JAK1 and STAT3

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242013

29 September 2017

Hematopoietic prostaglandin D2 synthase controls the onset and resolution of acute inflammation through PGD2 and 15-deoxyDelta12 14 PGJ2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242013

29 September 2017

Oxidative stress and excitotoxicity: a therapeutic issue in multiple sclerosis?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242013

29 September 2017

Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242013

29 September 2017

Heme oxygenase-1 and carbon monoxide suppress autoimmune neuroinflammation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242013

29 September 2017

The synthetic triterpenoid 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole blocks nuclear factor-kappaB activation through direct inhibition of IkappaB kinase beta

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242013

29 September 2017

The synthetic triterpenoid CDDO-Imidazolide suppresses STAT phosphorylation and induces apoptosis in myeloma and lung cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242013

29 September 2017

Pharmacological activities of natural triterpenoids and their therapeutic implications.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242013

29 September 2017

Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242013

29 September 2017

Antioxidants and polyunsaturated fatty acids in multiple sclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242013

29 September 2017

Oleanolic acid and ursolic acid: research perspectives

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242013

29 September 2017

The role of oxidative stress in the pathogenesis of multiple sclerosis: the need for effective antioxidant therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242013

29 September 2017

Adeno-associated viral-mediated catalase expression suppresses optic neuritis in experimental allergic encephalomyelitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242013

29 September 2017

Nitric oxide localized to spinal cords of mice with experimental allergic encephalomyelitis: an electron paramagnetic resonance study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242013

29 September 2017

In vivo expression of inducible nitric oxide synthase in experimentally induced neurologic diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242013

29 September 2017

The high-output nitric oxide pathway: role and regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242013

29 September 2017

Nitric oxide, a biological effector. Electron paramagnetic resonance detection of nitrosyl-iron-protein complexes in whole cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242013

29 September 2017

Mechanisms of oxidative damage in multiple sclerosis and a cell therapy approach to treatment.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242013

2 June 2018

Suppression of rat thromboxane synthase gene transcription by peroxisome proliferator-activated receptor gamma in macrophages via an interaction with NRF2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242013

2 June 2018

Quantitative and qualitative changes in gene expression patterns characterize the activity of plaques in multiple sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FSREP00201

21 January 2018

Impaired peroxisomal function in the central nervous system with inflammatory disease of experimental autoimmune encephalomyelitis animals and protection by lovastatin treatment.

1 reference

https://api.crossref.org/works/10.1038%2FSREP00201

21 January 2018

Biliverdin reductase, a major physiologic cytoprotectant, suppresses experimental autoimmune encephalomyelitis.

1 reference

https://api.crossref.org/works/10.1038%2FSREP00201

21 January 2018

Heme oxygenase-1 plays an important protective role in experimental autoimmune encephalomyelitis

1 reference

https://api.crossref.org/works/10.1038%2FSREP00201

21 January 2018

Effect of naturally occurring triterpenoids glycyrrhizic acid, ursolic acid, oleanolic acid and nomilin on the immune system

1 reference

https://api.crossref.org/works/10.1038%2FSREP00201

21 January 2018

Beneficial actions of oleanolic acid in an experimental model of multiple sclerosis: a potential therapeutic role

1 reference

https://api.crossref.org/works/10.1038%2FSREP00201

21 January 2018

Dietary compounds prevent oxidative damage and nitric oxide production by cells involved in demyelinating disease.

1 reference

https://api.crossref.org/works/10.1038%2FSREP00201

21 January 2018

Interleukin-17 promotes autoimmunity by triggering a positive-feedback loop via interleukin-6 induction.

1 reference

https://api.crossref.org/works/10.1038%2FSREP00201

21 January 2018

Hemin exerts multiple protective mechanisms and attenuates dextran sulfate sodium-induced colitis

1 reference

https://api.crossref.org/works/10.1038%2FSREP00201

21 January 2018

Erythropoietin enhances endogenous haem oxygenase-1 and represses immune responses to ameliorate experimental autoimmune encephalomyelitis

1 reference

https://api.crossref.org/works/10.1038%2FSREP00201

21 January 2018

Reduced cortisol levels in cerebrospinal fluid and differential distribution of 11beta-hydroxysteroid dehydrogenases in multiple sclerosis: implications for lesion pathogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSREP00201

21 January 2018

Variation in interleukin 7 receptor α chain (IL7R) influences risk of multiple sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FSREP00201

21 January 2018

Demyelination: the role of reactive oxygen and nitrogen species.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242013

27 November 2018

Spontaneous and mechanically evoked activity due to central demyelinating lesion

1 reference

https://api.crossref.org/works/10.1038%2FSREP00201

21 January 2018

Modulation of acute inflammation by endogenous nitric oxide

1 reference

https://pubmed.ncbi.nlm.nih.gov/22355716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inducible nitric oxide synthase gene expression and enzyme activity correlate with disease activity in murine experimental autoimmune encephalomyelitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22355716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/22355716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytokine actions in the central nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/22355716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of bardoxolone methyl on kidney function in patients with T2D and Stage 3b-4 CKD

1 reference

https://pubmed.ncbi.nlm.nih.gov/22355716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of the inducible isoform of nitric oxide synthase in the central nervous system of mice correlates with the severity of actively induced experimental allergic encephalomyelitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22355716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reactive oxygen species are involved in the pathogenesis of experimental allergic encephalomyelitis in Lewis rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/22355716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hemin-induced activation of the thioredoxin gene by Nrf2. A differential regulation of the antioxidant responsive element by a switch of its binding factors

1 reference

https://pubmed.ncbi.nlm.nih.gov/22355716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Therapeutic efficacy of IL-17 neutralization in murine experimental autoimmune encephalomyelitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22355716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased intrathecal synthesis of prostaglandin D2 synthase in the cerebrospinal fluid of patients with acute inflammatory demyelinating polyneuropathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/22355716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/SREP00201

1 reference

Consolidated OpenCitations Corpus – April 2017

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Dimensions Publication ID

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release_q3vqaudlv5eq3ph6bcy5idj65e

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OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

ResearchGate publication ID

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Springer Nature article ID

10.1038/srep00201

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