(Q28477314)

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Induction of eosinophil apoptosis by the cyclin-dependent kinase inhibitor AT7519 promotes the resolution of eosinophil-dominant allergic inflammation

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21984938%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

Induction of eosinophil apoptosis by the cyclin-dependent kinase inhibitor AT7519 promotes the resolution of eosinophil-dominant allergic inflammation (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21984938%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

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14 February 2020

Christopher D Lucas

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14 February 2020

8

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14 February 2020

Mauro M Teixeira

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Mauro M Teixeira

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14 February 2020

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Ana L Alessandri

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14 February 2020

Andrew E Leitch

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14 February 2020

Tara A Sheldrake

5

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14 February 2020

David A Dorward

6

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14 February 2020

Nik Hirani

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14 February 2020

Lirlândia Pires de Sousa

9

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14 February 2020

John F Lyons

11

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14 February 2020

Christopher Haslett

12

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14 February 2020

Adriano G Rossi

13

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14 February 2020

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30 September 2011

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14 February 2020

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Europe PubMed Central

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14 February 2020

6

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14 February 2020

9

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Europe PubMed Central

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14 February 2020

e25683

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Europe PubMed Central

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14 February 2020

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Creative Commons Attribution 4.0 International

30 September 2011

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April 2022 Public Data File from Crossref

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Delayed treatment with systemic (S)-roscovitine provides neuroprotection and inhibits in vivo CDK5 activity increase in animal stroke models

1 reference

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19 March 2017

Apoptosis is essential for neutrophil functional shutdown and determines tissue damage in experimental pneumococcal meningitis

1 reference

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19 March 2017

Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), a novel cyclin dependent kinase inhibitor using fragment-based X-ray crystallography and structure based drug design

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3184151

19 March 2017

Cyclin-dependent kinase inhibitors enhance the resolution of inflammation by promoting inflammatory cell apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3184151

19 March 2017

Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-beta1 secretion and the resolution of inflammation

1 reference

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19 March 2017

Resolution of inflammation: the beginning programs the end

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7 April 2017

Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF

1 reference

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7 April 2017

A phase I pharmacokinetic and pharmacodynamic study of AT7519, a cyclin-dependent kinase inhibitor in patients with refractory solid tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3184151

29 September 2017

Effective caspase inhibition blocks neutrophil apoptosis and reveals Mcl-1 as both a regulator and a target of neutrophil caspase activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3184151

29 September 2017

Cyclin-dependent kinase 5 regulates endothelial cell migration and angiogenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3184151

29 September 2017

Transepithelial exit of leucocytes: inflicting, reflecting or resolving airway inflammation?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3184151

29 September 2017

Targeting granulocyte apoptosis: mechanisms, models, and therapies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3184151

29 September 2017

AT7519, a cyclin-dependent kinase inhibitor, exerts its effects by transcriptional inhibition in leukemia cell lines and patient samples

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3184151

29 September 2017

AT7519, A novel small molecule multi-cyclin-dependent kinase inhibitor, induces apoptosis in multiple myeloma via GSK-3beta activation and RNA polymerase II inhibition.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3184151

29 September 2017

Pivotal Advance: Pharmacological manipulation of inflammation resolution during spontaneously resolving tissue neutrophilia in the zebrafish

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29 September 2017

Cyclin-dependent kinase inhibitor drugs as potential novel anti-inflammatory and pro-resolution agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3184151

29 September 2017

The CDK inhibitor, R-roscovitine, promotes eosinophil apoptosis by down-regulation of Mcl-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3184151

29 September 2017

Immunobiology of asthma

1 reference

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29 September 2017

15-epi-lipoxin A4 inhibits myeloperoxidase signaling and enhances resolution of acute lung injury

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29 September 2017

Glucocorticoid resistance in inflammatory diseases.

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29 September 2017

Biological characterization of AT7519, a small-molecule inhibitor of cyclin-dependent kinases, in human tumor cell lines

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3184151

29 September 2017

Relevance of granulocyte apoptosis to resolution of inflammation at the respiratory mucosa.

1 reference

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29 September 2017

Alveolar macrophage phagocytosis is impaired in children with poorly controlled asthma

1 reference

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29 September 2017

Novel pharmacological strategies for driving inflammatory cell apoptosis and enhancing the resolution of inflammation.

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29 September 2017

Role of HMGB1 in apoptosis-mediated sepsis lethality

1 reference

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29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3184151

29 September 2017

The role of eosinophils in the pathogenesis of asthma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3184151

29 September 2017

Inflammatory resolution: new opportunities for drug discovery

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29 September 2017

Novel small molecule cyclin-dependent kinases modulators in human clinical trials

1 reference

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29 September 2017

Pharmacological inhibitors of cyclin-dependent kinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3184151

29 September 2017

Regulation of eosinophil and neutrophil apoptosis--similarities and differences

1 reference

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Attenuation of bleomycin-induced pneumopathy in mice by a caspase inhibitor

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Granulocyte apoptosis and its role in the resolution and control of lung inflammation

1 reference

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29 September 2017

Human circulating eosinophils secrete macrophage migration inhibitory factor (MIF). Potential role in asthma

1 reference

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29 September 2017

Modulation of multiple neutrophil functions by preparative methods or trace concentrations of bacterial lipopolysaccharide

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29 September 2017

Eosinophils, T-lymphocytes, mast cells, neutrophils, and macrophages in bronchial biopsy specimens from atopic subjects with asthma: comparison with biopsy specimens from atopic subjects without asthma and normal control subjects and relationship to

1 reference

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29 September 2017

The cyclin-dependent kinase inhibitor R-roscovitine down-regulates Mcl-1 to override pro-inflammatory signalling and drive neutrophil apoptosis.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0025683

21 January 2018

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1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0025683

21 January 2018

Effects of the cyclin-dependent kinase inhibitor R-roscovitine on eosinophil survival and clearance.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0025683

21 January 2018

Kinetics of pulmonary neutrophil recruitment and clearance in a natural and spontaneously resolving model of airway inflammation.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0025683

21 January 2018

Caspase inhibitor zVAD.fmk reduces infarct size after myocardial ischaemia and reperfusion in rats but not in mice

1 reference

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PDE4 inhibition drives resolution of neutrophilic inflammation by inducing apoptosis in a PKA-PI3K/Akt-dependent and NF-kappaB-independent manner

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0025683

21 January 2018

Inhibition of nuclear factor-kappaB activation un-masks the ability of TNF-alpha to induce human eosinophil apoptosis

1 reference

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21 January 2018

Nadir CD4 T Cell Count as Predictor and High CD4 T Cell Intrinsic Apoptosis as Final Mechanism of Poor CD4 T Cell Recovery in Virologically Suppressed HIV‐Infected Patients: Clinical Implications

1 reference

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21 January 2018

Immunosuppressive effects of apoptotic cells

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21 January 2018

In vitro and in vivo antitumor properties of the cyclin dependent kinase inhibitor CYC202 (R-roscovitine)

1 reference

https://pubmed.ncbi.nlm.nih.gov/21984938

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced eosinophil apoptosis in induced sputum correlates with asthma severity

1 reference

https://pubmed.ncbi.nlm.nih.gov/21984938

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The eosinophil and airway remodelling in asthma

1 reference

https://pubmed.ncbi.nlm.nih.gov/21984938

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-5 inhibits glucocorticoid-mediated apoptosis in human eosinophils

1 reference

https://pubmed.ncbi.nlm.nih.gov/21984938

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Eosinophil apoptosis and the resolution of airway inflammation in asthma

1 reference

https://pubmed.ncbi.nlm.nih.gov/21984938

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NF-κB Activation Is a Critical Regulator of Human Granulocyte Apoptosisin Vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/21984938

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Macrophage phagocytosis of apoptotic neutrophils is critically regulated by the opposing actions of pro-inflammatory and anti-inflammatory agents: key role for TNF-α

1 reference

https://pubmed.ncbi.nlm.nih.gov/21984938

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0025683

2 references

Consolidated OpenCitations Corpus – April 2017

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21984938%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

2011PLoSO...625683A

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OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PMC publication ID

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21984938%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

PubMed publication ID

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21984938%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

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