(Q28504715)

English

ApoAI deficiency results in marked reductions in plasma cholesterol but no alterations in amyloid-beta pathology in a mouse model of Alzheimer's disease-like cerebral amyloidosis

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scholarly article

1 reference

PubMed publication ID

24 January 2017

ApoAI deficiency results in marked reductions in plasma cholesterol but no alterations in amyloid-beta pathology in a mouse model of Alzheimer's disease-like cerebral amyloidosis (English)

1 reference

PubMed publication ID

24 January 2017

Alzheimer's disease

1 reference

based on heuristic

inferred from title

0 references

Apolipoprotein A-I

1 reference

GOA release 2020-03-11

David M. Holtzman

11

object named as

David M. Holtzman

1 reference

PubMed publication ID

24 January 2017

1

object named as

Anne M. Fagan

1 reference

PubMed publication ID

24 January 2017

9

object named as

Kelly R. Bales

1 reference

PubMed publication ID

24 January 2017

Suzanne E Wahrle

8

object named as

Suzanne Wahrle

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PubMed publication ID

24 January 2017

Michael A Spinner

5

object named as

Michael Spinner

1 reference

PubMed publication ID

24 January 2017

Erin A Christopher

2

object named as

Erin Christopher

1 reference

PubMed publication ID

24 January 2017

Maia Parsadanian

4

object named as

Maia Parsadanian

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PubMed publication ID

24 January 2017

6

object named as

Melanie Watson

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PubMed publication ID

24 January 2017

author name string

Jennie W. Taylor

3

1 reference

PubMed publication ID

24 January 2017

John D. Fryer

7

1 reference

PubMed publication ID

24 January 2017

Steven M. Paul

10

1 reference

PubMed publication ID

24 January 2017

language of work or name

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publication date

1 October 2004

1 reference

PubMed publication ID

24 January 2017

The American Journal of Pathology

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PubMed publication ID

24 January 2017

165

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PubMed publication ID

24 January 2017

4

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PubMed publication ID

24 January 2017

1413–1422

1 reference

PubMed publication ID

24 January 2017

Alzheimer's disease: the cholesterol connection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618648

19 March 2017

Clusterin promotes amyloid plaque formation and is critical for neuritic toxicity in a mouse model of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618648

19 March 2017

Serum total cholesterol, apolipoprotein E epsilon 4 allele, and Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618648

19 March 2017

ApoA-I knockout mice: characterization of HDL metabolism in homozygotes and identification of a post-RNA mechanism of apoA-I up-regulation in heterozygotes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618648

19 March 2017

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618648

19 March 2017

Marked reduction of high density lipoprotein cholesterol in mice genetically modified to lack apolipoprotein A-I

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618648

19 March 2017

Secretion of apolipoprotein E by brain glia requires protein prenylation and is suppressed by statins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618648

29 September 2017

Pharmacological concentrations of the HMG-CoA reductase inhibitor lovastatin decrease the formation of the Alzheimer beta-amyloid peptide in vitro and in patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618648

29 September 2017

Cholesterol, A beta and Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618648

29 September 2017

A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618648

29 September 2017

Cholesterol-dependent formation of GM1 ganglioside-bound amyloid beta-protein, an endogenous seed for Alzheimer amyloid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618648

29 September 2017

Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618648

29 September 2017

Statins and the risk of dementia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618648

29 September 2017

Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618648

29 September 2017

Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618648

29 September 2017

Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618648

29 September 2017

Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618648

29 September 2017

The role of cholesterol in the biosynthesis of beta-amyloid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618648

29 September 2017

Expression of human apolipoprotein E reduces amyloid-beta deposition in a mouse model of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618648

29 September 2017

Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618648

29 September 2017

Dietary fat intake and the risk of incident dementia in the Rotterdam Study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618648

29 September 2017

Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618648

29 September 2017

Statins do more than just lower cholesterol

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618648

29 September 2017

Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618648

29 September 2017

New stereological methods for counting neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618648

29 September 2017

Biosynthesis of high density lipoprotein by chicken liver: intracellular transport and proteolytic processing of nascent apolipoprotein A-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618648

29 September 2017

Pathophysiology of reverse cholesterol transport. Insights from inherited disorders of lipoprotein metabolism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618648

29 September 2017

Synthesis of apolipoprotein A-1 in pig brain microvascular endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618648

29 September 2017

Phenotypes of apolipoprotein B and apolipoprotein E after liver transplantation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618648

29 September 2017

Apolipoproteins in human cerebrospinal fluid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618648

29 September 2017

High density lipoprotein as a protective factor against coronary heart disease. The Framingham Study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618648

29 September 2017

Increased amyloid- levels in APPSWE transgenic mice treated chronically with a physiological high-fat high-cholesterol diet

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618648

2 June 2018

Differences in the Abeta40/Abeta42 ratio associated with cerebrospinal fluid lipoproteins as a function of apolipoprotein E genotype.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618648

2 June 2018

Decreased high-density lipoprotein cholesterol and serum apolipoprotein AI concentrations are highly correlated with the severity of Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618648

2 June 2018

Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618648

2 June 2018

MK-801 neurotoxicity in male mice: histologic effects and chronic impairment in spatial learning.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618648

2 June 2018

Fibrillogenesis in Alzheimer's disease of amyloid beta peptides and apolipoprotein E.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618648

2 June 2018

Familial deficiency of apolipoproteins A-I and C-III and precocious coronary-artery disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618648

2 June 2018

Lipoproteins and their receptors in the central nervous system. Characterization of the lipoproteins in cerebrospinal fluid and identification of apolipoprotein B,E(LDL) receptors in the brain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618648

2 June 2018

Secretion of apolipoprotein E by an astrocytoma cell line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618648

2 June 2018

Apolipoprotein Eepsilon4 modifies Alzheimer's disease onset in an E280A PS1 kindred.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618648

27 November 2018

Brain region-dependent increases in beta-amyloid and apolipoprotein E levels in hypercholesterolemic rabbits

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618648

27 November 2018

Treatment with simvastatin in patients with Alzheimer's disease lowers both alpha- and beta-cleaved amyloid precursor protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618648

27 November 2018

Novel role for apolipoprotein E in the central nervous system. Modulation of sulfatide content

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618648

27 November 2018

Effects of statins on human cerebral cholesterol metabolism and secretion of Alzheimer amyloid peptide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618648

27 November 2018

Treatment with simvastatin in normocholesterolemic patients with Alzheimer's disease: A 26-week randomized, placebo-controlled, double-blind trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618648

27 November 2018

Plaque-associated disruption of CSF and plasma amyloid-beta (Abeta) equilibrium in a mouse model of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618648

27 November 2018

Human and murine ApoE markedly alters A beta metabolism before and after plaque formation in a mouse model of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618648

27 November 2018

Human apolipoprotein E4 accelerates beta-amyloid deposition in APPsw transgenic mouse brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618648

27 November 2018

Cholesterol accumulates in senile plaques of Alzheimer disease patients and in transgenic APP(SW) mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618648

27 November 2018

Differential effects of lovastatin treatment on brain cholesterol levels in normal and apoE-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618648

27 November 2018

APOE epsilon 4 influences the manifestation of Alzheimer's disease in adults with Down's syndrome.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618648

27 November 2018

Apolipoprotein E facilitates neuritic and cerebrovascular plaque formation in an Alzheimer's disease model.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618648

27 November 2018

Alterations of Alzheimer's disease in the cholesterol-fed rabbit, including vascular inflammation. Preliminary observations.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618648

27 November 2018

Unique lipoproteins secreted by primary astrocytes from wild type, apoE (-/-), and human apoE transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618648

27 November 2018

APOE genotype, plasma lipids, lipoproteins, and AD in community elderly.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618648

27 November 2018

Lipoprotein-free amyloidogenic peptides in plasma are elevated in patients with sporadic Alzheimer's disease and Down's syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618648

27 November 2018

Elevated low-density lipoprotein in Alzheimer's disease correlates with brain abeta 1-42 levels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618648

27 November 2018

Modulation of secreted beta-amyloid precursor protein and amyloid beta-peptide in brain by cholesterol

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618648

27 November 2018

Glial fibrillary acidic protein-apolipoprotein E (apoE) transgenic mice: astrocyte-specific expression and differing biological effects of astrocyte-secreted apoE3 and apoE4 lipoproteins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618648

27 November 2018

Expression of apolipoprotein A-I in porcine brain endothelium in vitro.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618648

27 November 2018

Synthesis of apolipoprotein AI by peripheral tissues of the rooster. A possible mechanism of cellular cholesterol efflux.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618648

27 November 2018

Interactions of apolipoprotein E genotype, total cholesterol level, age, and sex in prediction of Alzheimer's disease: a case-control study

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2963399-8

7 January 2021

Apolipoprotein E polymorphism and atherosclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2963399-8

7 January 2021

Apolipoprotein E, Alzheimer's disease and Down's syndrome.

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2963399-8

7 January 2021

The soluble form of Alzheimer's amyloid beta protein is complexed to high density lipoprotein 3 and very high density lipoprotein in normal human plasma

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2963399-8

7 January 2021

Biochemical characterization of Alzheimer's soluble amyloid beta protein in human cerebrospinal fluid: association with high density lipoproteins

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2963399-8

7 January 2021

Increased density of cortical apolipoprotein E immunoreactive neurons in rabbit brain after dietary administration of cholesterol

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2963399-8

7 January 2021

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2963399-8

7 January 2021

Lipid binding to amyloid beta-peptide aggregates: preferential binding of cholesterol as compared with phosphatidylcholine and fatty acids

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2963399-8

7 January 2021

Amyloid-associated proteins α1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2963399-8

7 January 2021

Effects of genotype and diet on cholesterol efflux into plasma and lipoproteins of normal, apolipoprotein A-I-, and apolipoprotein E-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2963399-8

7 January 2021

Lack of apoA-I is not associated with increased susceptibility to atherosclerosis in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2963399-8

7 January 2021

Plasma apolipoprotein A-1 absence associated with a marked reduction of high density lipoproteins and premature coronary artery disease

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2963399-8

7 January 2021

A DNA insertion in the apolipoprotein A-I gene of patients with premature atherosclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2963399-8

7 January 2021

Brain expression of apolipoproteins E, J, and A-I in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2963399-8

7 January 2021

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10.1016/S0002-9440(10)63399-8

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PubMed publication ID

1 reference

PubMed publication ID

24 January 2017

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