(Q30329989)

18 June 2017

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title

Recent trends in stabilizing protein structure upon encapsulation and release from bioerodible polymers. (English)

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18 June 2017

Caroline Pérez

1

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18 June 2017

Ingrid J Castellanos

2

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18 June 2017

Henry R Costantino

3

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18 June 2017

Wasfi Al-Azzam

4

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18 June 2017

Kai Griebenow

5

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18 June 2017

publication date

1 March 2002

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Journal of Pharmacy and Pharmacology

18 June 2017

published in

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18 June 2017

volume

54

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18 June 2017

issue

3

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18 June 2017

page(s)

301-313

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Enzymatic catalysis and dynamics in low-water environments

18 June 2017

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21 January 2018

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21 January 2018

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On the structural preservation of recombinant human growth hormone in a dried film of a synthetic biodegradable polymer

21 January 2018

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Reduction of structural perturbations in bovine serum albumin by non-aqueous microencapsulation

21 January 2018

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Non-aqueous encapsulation of excipient-stabilized spray-freeze dried BSA into poly(lactide-co-glycolide) microspheres results in release of native protein.

21 January 2018

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Encapsulation of bovine serum albumin in poly(lactide-co-glycolide) microspheres by the solid-in-oil-in-water technique

21 January 2018

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21 January 2018

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Stable formulations of recombinant human growth hormone and interferon-gamma for microencapsulation in biodegradable microspheres

21 January 2018

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Development of poly-(D,L-lactide--coglycolide) microsphere formulations containing recombinant human vascular endothelial growth factor to promote local angiogenesis

21 January 2018

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Solid-phase aggregation of proteins under pharmaceutically relevant conditions

21 January 2018

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Aggregation of a lyophilized pharmaceutical protein, recombinant human albumin: effect of moisture and stabilization by excipients

21 January 2018

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Effect of excipients on the stability and structure of lyophilized recombinant human growth hormone

21 January 2018

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Protein spray-freeze drying. Effect of atomization conditions on particle size and stability

21 January 2018

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Protein delivery from poly(lactic-co-glycolic acid) biodegradable microspheres: release kinetics and stability issues

21 January 2018

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Pegylation enhances protein stability during encapsulation in PLGA microspheres

21 January 2018

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Infrared spectroscopic studies of lyophilization- and temperature-induced protein aggregation

21 January 2018

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FTIR characterization of the secondary structure of proteins encapsulated within PLGA microspheres

21 January 2018

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Visual evidence of acidic environment within degrading poly(lactic-co-glycolic acid) (PLGA) microspheres

21 January 2018

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Lyophilization-induced reversible changes in the secondary structure of proteins

21 January 2018

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Nativelike enzyme properties are important for optimum activity in neat organic solvents

21 January 2018

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https://api.crossref.org/works/10.1211%2F0022357021778448

New advances in microsphere-based single-dose vaccines

21 January 2018

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https://api.crossref.org/works/10.1211%2F0022357021778448

Controlled drug delivery by biodegradable poly(ester) devices: different preparative approaches

21 January 2018

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https://api.crossref.org/works/10.1211%2F0022357021778448

The stabilization and encapsulation of human growth hormone into biodegradable microspheres

21 January 2018

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https://api.crossref.org/works/10.1211%2F0022357021778448

Why are enzymes less active in organic solvents than in water?

21 January 2018

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https://api.crossref.org/works/10.1211%2F0022357021778448

Novel systems for controlled delivery of macromolecules

21 January 2018

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https://api.crossref.org/works/10.1211%2F0022357021778448

Solid-state chemical stability of proteins and peptides

21 January 2018

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https://api.crossref.org/works/10.1211%2F0022357021778448

Sustained release of recombinant human insulin-like growth factor-I for treatment of diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778448

Encapsulation and stabilization of nerve growth factor into poly(lactic-co-glycolic) acid microspheres

21 January 2018

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https://api.crossref.org/works/10.1211%2F0022357021778448

1994 whitaker lecture: Polymers for drug delivery and tissue engineering

21 January 2018

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Biomaterials in drug delivery and tissue engineering: one laboratory's experience

21 January 2018

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https://api.crossref.org/works/10.1211%2F0022357021778448

Characterization of protein-loaded poly(epsilon-caprolactone) microparticles based on a factorial design

21 January 2018

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https://api.crossref.org/works/10.1211%2F0022357021778448

Moisture-induced aggregation of lyophilized proteins in the solid state

21 January 2018

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https://api.crossref.org/works/10.1211%2F0022357021778448

Effect of primary emulsions on microsphere size and protein-loading in the double emulsion process

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778448

Protein encapsulation into biodegradable microspheres by a novel S/O/W emulsion method using poly(ethylene glycol) as a protein micronization adjuvant

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778448

Erythropoietin loaded microspheres prepared from biodegradable LPLG-PEO-LPLG triblock copolymers: protein stabilization and in-vitro release properties.

21 January 2018

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https://api.crossref.org/works/10.1211%2F0022357021778448

Protein stabilization via hydrophilization. Covalent modification of trypsin and alpha-chymotrypsin

21 January 2018

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A new preparation method for protein loaded poly(D, L-lactic-co-glycolic acid) microspheres and protein release mechanism study

21 January 2018

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https://api.crossref.org/works/10.1211%2F0022357021778448

Improved activity and stability of lysozyme at the water/CH2Cl2 interface: enzyme unfolding and aggregation and its prevention by polyols

21 January 2018

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https://api.crossref.org/works/10.1211%2F0022357021778448

Dehydration-induced conformational transitions in proteins and their inhibition by stabilizers

21 January 2018

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Effect of crown ethers on structure, stability, activity, and enantioselectivity of subtilisin Carlsberg in organic solvents

21 January 2018

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https://api.crossref.org/works/10.1211%2F0022357021778448

New strategies for the microencapsulation of tetanus vaccine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778448

Solvent replacement for green processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778448

Drug microencapsulation by PLA/PLGA coacervation in the light of thermodynamics. 1. Overview and theoretical considerations

21 January 2018

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https://api.crossref.org/works/10.1211%2F0022357021778448

Development and scale-up of a microsphere protein delivery system

21 January 2018

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https://api.crossref.org/works/10.1211%2F0022357021778448

Activity-stability considerations of trypsinogen during spray drying: effects of sucrose

21 January 2018

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https://api.crossref.org/works/10.1211%2F0022357021778448

Protein instability in poly(lactic-co-glycolic acid) microparticles.

21 January 2018

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https://api.crossref.org/works/10.1211%2F0022357021778448

Enzyme thermoinactivation in anhydrous organic solvents

21 January 2018

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https://api.crossref.org/works/10.1211%2F0022357021778448

Instability, stabilization, and formulation of liquid protein pharmaceuticals

21 January 2018

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https://api.crossref.org/works/10.1211%2F0022357021778448

Lyophilization and development of solid protein pharmaceuticals

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778448

Towards a molecular level understanding of protein stabilization: the interaction between lysozyme and sorbitol

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778448

Use of infrared spectroscopy to assess secondary structure of human growth hormone within biodegradable microspheres

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778448

Effect of zinc binding and precipitation on structures of recombinant human growth hormone and nerve growth factor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778448

Stabilization of proteins encapsulated in injectable poly (lactide- co-glycolide)

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778448

Stability of BSA encapsulated into PLGA microspheres using PAGE and capillary electrophoresis

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778448

Fabrication of microspheres using blends of poly(ethylene adipate) and poly(ethylene adipate)/poly(hydroxybutyrate-hydroxyvalerate) with poly(caprolactone): incorporation and release of bovine serum albumin

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778448

Sustained delivery of proteins for novel therapeutic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778448

Moisture-induced aggregation of lyophilized insulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778448

Release of tetanus toxoid from adjuvants and PLGA microspheres: how experimental set-up and surface adsorption fool the pattern

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778448

Development and in vitro characterization of vascular endothelial growth factor (VEGF)-loaded poly(DL-lactic-co-glycolic acid)/poly(ethylene glycol) microspheres using a solid encapsulation/single emulsion/solvent extraction technique

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778448

Microencapsulation of human growth hormone within biodegradable polyester microspheres: protein aggregation stability and incomplete release mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778448

Stabilizing insulin-like growth factor-I in poly(D,L-lactide-co-glycolide) microspheres

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778448

Protein loaded biodegradable microspheres based on PLGA-protein bioconjugates

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778448

Development of a poly(ortho ester) prototype with a latent acid in the polymer backbone for 5-fluorouracil delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778448

The preparation and evaluation of poly(epsilon-caprolactone) microparticles containing both a lipophilic and a hydrophilic drug

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778448

Effects of salt addition on the microencapsulation of proteins using W/O/W double emulsion technique

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778448

Protein behavior at the water/methylene chloride interface

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778448

Stabilization of proteins against methylene chloride/water interface-induced denaturation and aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778448

Effects of bovine somatotropin (rbSt) concentration at different moisture levels on the physical stability of sucrose in freeze-dried rbSt/sucrose mixtures

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778448

The acidic microclimate in poly(lactide-co-glycolide) microspheres stabilizes camptothecins

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778448

Controlled release of recombinant insulin-like growth factor from a novel formulation of polylactide-co-glycolide microparticles

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778448

Improved immunogenicity of a core-coated tetanus toxoid delivery system

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778448

A novel system based on a poloxamer/PLGA blend as a tetanus toxoid delivery vehicle

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778448

The effect of a water/organic solvent interface on the structural stability of lysozyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778448

Improving protein delivery from microparticles using blends of poly(DL lactide co-glycolide) and poly(ethylene oxide)-poly(propylene oxide) copolymers

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778448

Enzymatic catalysis in organic media at 100 degrees C

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778448

Stabilization of proteins encapsulated in cylindrical poly(lactide-co-glycolide) implants: mechanism of stabilization by basic additives

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778448

21 January 2018

Identifiers

DOI

10.1211/0022357021778448

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18 June 2017

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