(Q34020128)

30 July 2017

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title

Lyophilization and development of solid protein pharmaceuticals (English)

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30 July 2017

Wang W

1

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30 July 2017

language of work or name

English

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publication date

1 August 2000

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International Journal of Pharmaceutics

30 July 2017

published in

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30 July 2017

volume

203

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30 July 2017

issue

1-2

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30 July 2017

page(s)

1-60

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Optimizing the lyophilization cycle and the consequences of collapse on the pharmaceutical acceptability of Erwinia L-asparaginase

30 July 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Stability and surface activity of lactate dehydrogenase in spray-dried trehalose.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Glycine crystallization during freezing: the effects of salt form, pH, and ionic strength

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Effect of temperature history on the freeze-thawing process and activity of LDH formulations

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Counteracting effects of thiocyanate and sucrose on chymotrypsinogen secondary structure and aggregation during freezing, drying, and rehydration

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Effects of drying methods and additives on structure and function of actin: mechanisms of dehydration-induced damage and its inhibition

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Hydrogen bonding between sugar and protein is responsible for inhibition of dehydration-induced protein unfolding.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Polymers protect lactate dehydrogenase during freeze-drying by inhibiting dissociation in the frozen state

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

The effect of formulation excipients on protein stability and aerosol performance of spray-dried powders of a recombinant humanized anti-IgE monoclonal antibody

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Formation of glasses from liquids and biopolymers

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Protein--solvent interactions in pharmaceutical formulations

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Stability of protein formulations: investigation of surfactant effects by a novel EPR spectroscopic technique

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Thermally induced denaturation of lyophilized bovine somatotropin and lysozyme as impacted by moisture and excipients

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

IR and Raman spectroscopic studies of the interaction of trehalose with hen egg white lysozyme

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Chemical stability of insulin. 2. Formation of higher molecular weight transformation products during storage of pharmaceutical preparations

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Chemical stability of insulin. 1. Hydrolytic degradation during storage of pharmaceutical preparations

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Nonenzymatic Browning in Liquid Model Systems of High Water Activity: Kinetics of Color Changes due to Maillard's Reaction Between Different Single Sugars and Glycine and Comparison with Caramelization Browning

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Glass transition in poly(vinylpyrrolidone): effect of molecular weight and diluents

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Characterization of the glycation of albumin in freeze-dried and frozen human serum

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Lysozyme film hydration events: An IR and gravimetric study

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

An infrared spectroscopic study of the interactions of carbohydrates with dried proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Cryoprotection of phosphofructokinase with organic solutes: characterization of enhanced protection in the presence of divalent cations

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Stabilization of phosphofructokinase with sugars during freeze-drying: characterization of enhanced protection in the presence of divalent cations

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Separation of freezing- and drying-induced denaturation of lyophilized proteins using stress-specific stabilization. I. Enzyme activity and calorimetric studies

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Rational design of stable lyophilized protein formulations: some practical advice

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Application of infrared spectroscopy to development of stable lyophilized protein formulations

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Solid state characterization of spray-dried powders of recombinant human deoxyribonuclease (rhDNase).

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Development of a mathematical model for the water distribution in freeze-dried solids.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Stabilization of lyophilized porcine pancreatic elastase

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Development of an efficient single-step freeze-drying cycle for protein formulations.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Physical factors affecting the storage stability of freeze-dried interleukin-1 receptor antagonist: glass transition and protein conformation

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Surface-induced denaturation of proteins during freezing and its inhibition by surfactants

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Development of a stable freeze-dried formulation of recombinant human interleukin-1 receptor antagonist

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Influence of calcium ions on the structure and stability of recombinant human deoxyribonuclease I in the aqueous and lyophilized states

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Maillard reaction and food processing. Application aspects

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Extraordinary stability of enzymes dried in trehalose: simplified molecular biology

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Solid-phase aggregation of proteins under pharmaceutically relevant conditions

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Moisture-induced aggregation of lyophilized insulin

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Fourier-transform infrared spectroscopic investigation of protein stability in the lyophilized form

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Aggregation of a lyophilized pharmaceutical protein, recombinant human albumin: effect of moisture and stabilization by excipients

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

The secondary structure and aggregation of lyophilized tetanus toxoid

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Effect of mannitol crystallization on the stability and aerosol performance of a spray-dried pharmaceutical protein, recombinant humanized anti-IgE monoclonal antibody

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Effect of excipients on the stability and structure of lyophilized recombinant human growth hormone

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

1 reference

7 January 2021

Is trehalose special for preserving dry biomaterials?

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

The role of vitrification in anhydrobiosis

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Aggregation and denaturation of apomyoglobin in aqueous urea solutions

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Thermal stabilities of globular proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Dominant forces in protein folding

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Infrared Spectroscopic Studies of Lyophilization‐ and Temperature‐Induced Protein Aggregation

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Effect of glass transition temperature on the stability of lyophilized formulations containing a chimeric therapeutic monoclonal antibody

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

The relationship between protein aggregation and molecular mobility below the glass transition temperature of lyophilized formulations containing a monoclonal antibody.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Effect of freezing on aggregation of human growth hormone

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Water vapor sorption studies on the physical stability of a series of spray-dried protein/sugar powders for inhalation

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Effect of type of container, storage temperature and humidity on the biological activity of freeze-dried alkaline phosphatase

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Biopreservation. Putting proteins under glass

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Long-term stabilization of biologicals

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Oxidation of human insulin-like growth factor I in formulation studies: kinetics of methionine oxidation in aqueous solution and in solid state

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Determination of soluble and membrane protein structure by Fourier transform infrared spectroscopy. II. Experimental aspects, side chain structure, and H/D exchange

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Conformational states of beta-lactamase: molten-globule states at acidic and alkaline pH with high salt

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

A reassessment of the molecular origin of cold denaturation

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Lyophilization-induced reversible changes in the secondary structure of proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Stability of interleukin 1 beta (IL-1 beta) in aqueous solution: analytical methods, kinetics, products, and solution formulation implications

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Protein reaction kinetics in a room-temperature glass

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

The relationship between the glass transition temperature and the water content of amorphous pharmaceutical solids

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Characteristics and significance of the amorphous state in pharmaceutical systems

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Molecular mobility of amorphous pharmaceutical solids below their glass transition temperatures

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Estimating the critical molecular mobility temperature (T(K)) of amorphous pharmaceuticals

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Where should the cooling rate be determined in an extended freezing sample?

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Glass fragility and the stability of pharmaceutical preparations--excipient selection

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Degradation of lyophilized and reconstituted MACROSCINT (DTPA-IgG): precipitation vs. glucosylation

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Investigation of secondary and tertiary structural changes of cytochrome c in complexes with anionic lipids using amide hydrogen exchange measurements: an FTIR study.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Manipulation of lyophilization-induced phase separation: implications for pharmaceutical proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Protein formulation and lyophilization cycle design: prevention of damage due to freeze-concentration induced phase separation

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Conformational stability of lyophilized PEGylated proteins in a phase-separating system

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Application of a thermodynamic model to the prediction of phase separations in freeze-concentrated formulations for protein lyophilization

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Measurement of glass transition temperatures of freeze-concentrated solutes by differential scanning calorimetry

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Lyophilized formulations of recombinant tumor necrosis factor

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Surface denaturation at solid-void interface--a possible pathway by which opalescent particulates form during the storage of lyophilized tissue-type plasminogen activator at high temperatures

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Design and application of a low-temperature Peltier-cooling microscope stage

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Decreased protein-stabilizing effects of cryoprotectants due to crystallization

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Physical stability and protein stability of freeze-dried cakes during storage at elevated temperatures

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Effect of mannitol crystallinity on the stabilization of enzymes during freeze-drying.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Increased stabilizing effects of amphiphilic excipients on freeze-drying of lactate dehydrogenase (LDH) by dispersion into sugar matrices

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Effects of sugars and polymers on crystallization of poly(ethylene glycol) in frozen solutions: phase separation between incompatible polymers

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Protein structure and function at low temperatures.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

The aggregation of bovine serum albumin in solution and in the solid state

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Characterization of the sucrose/glycine/water system by differential scanning calorimetry and freeze-drying microscopy

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Acute renal toxicity of doxorubicin (adriamycin)-loaded cyanoacrylate nanoparticles

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Quantitation of the area of overlap between second-derivative amide I infrared spectra to determine the structural similarity of a protein in different states

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Effects of Tween 80 and sucrose on acute short-term stability and long-term storage at -20 degrees C of a recombinant hemoglobin

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

The physical state of mannitol after freeze-drying: effects of mannitol concentration, freezing rate, and a noncrystallizing cosolute.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Freezing denaturation of ovalbumin at acid pH.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Effects of additives on the stability of recombinant human factor XIII during freeze-drying and storage in the dried solid

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Effect of Tween 20 on freeze-thawing- and agitation-induced aggregation of recombinant human factor XIII

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Effects of additives on the stability of Humicola lanuginosa lipase during freeze-drying and storage in the dried solid

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

An exceptionally stable helix from the ribosomal protein L9: implications for protein folding and stability

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Solid-state chemical stability of proteins and peptides

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Aggregation and precipitation of human relaxin induced by metal-catalyzed oxidation

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Chemical instability of protein pharmaceuticals: Mechanisms of oxidation and strategies for stabilization

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Effects of reducing sugars on the chemical stability of human relaxin in the lyophilized state

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Dehydration and crystallization of trehalose and sucrose glasses containing carbonmonoxy-myoglobin

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

On the role of surface tension in the stabilization of globular proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Efficient oligomerization of negatively-charged beta-amino acids at -20 degrees C.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Moisture-induced aggregation of lyophilized proteins in the solid state

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

In vitro methionine oxidation of recombinant human leptin

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Properties of citric acid at the glass transition

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Formulations of sugars with amino acids or mannitol--influence of concentration ratio on the properties of the freeze-concentrate and the lyophilizate

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Effects of formulation and process variables on the aggregation of freeze-dried interleukin-6 (IL-6) after lyophilization and on storage

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Stability of protein pharmaceuticals

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Formulation of proteins in vacuum-dried glasses. II. Process and storage stability in sugar-free amino acid systems

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Glass Transition and Thermal Stability of Lactase in Low-Moisture Amorphous Polymeric Matrices

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Freeze-drying: in situ observations using cryoenvironmental scanning electron microscopy and differential scanning calorimetry.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Thermophysical properties of trehalose and its concentrated aqueous solutions

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Role of water in plasticity, stability, and action of proteins: the crystal structures of lysozyme at very low levels of hydration

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Physicochemical stability of crystalline sugars and their spray-dried forms: dependence upon relative humidity and suitability for use in powder inhalers

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

The kinetics of relaxin oxidation by hydrogen peroxide

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

The relationship between the glass transition temperature and water vapor absorption by poly(vinylpyrrolidone)

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Molecular mobility in mixtures of absorbed water and solid poly(vinylpyrrolidone).

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Physical state of L-histidine after freeze-drying and long-term storage

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Development of freeze-dried albumin-free formulation of recombinant factor VIII SQ

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Preparation of excipient-free recombinant human tissue-type plasminogen activator by lyophilization from ammonium bicarbonate solution: an investigation of the two-stage sublimation phenomenon

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Lyophilization of protein formulations in vials: investigation of the relationship between resistance to vapor flow during primary drying and small-scale product collapse

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

The stability of insulin in crystalline and amorphous solids: observation of greater stability for the amorphous form

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

The effects of formulation variables on the stability of freeze-dried human growth hormone

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Separation of freezing- and drying-induced denaturation of lyophilized proteins using stress-specific stabilization. II. Structural studies using infrared spectroscopy.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Dehydration-induced conformational transitions in proteins and their inhibition by stabilizers

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Optimization of lyophilization conditions for recombinant human interleukin-2 by dried-state conformational analysis using Fourier-transform infrared spectroscopy

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Stabilization of Enzymes against Thermal Stress and Freeze-Drying by Mannosylglycerate

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Real-time in situ monitoring of lysozyme during lyophilization using infrared spectroscopy: dehydration stress in the presence of sucrose

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

The influence of sucrose, dextran, and hydroxypropyl-beta-cyclodextrin as lyoprotectants for a freeze-dried mouse IgG2a monoclonal antibody (MN12)

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Stabilization of the Restriction Enzyme EcoRI Dried with Trehalose and Other Selected Glass-Forming Solutes

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Assisted protein folding

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Trehalose-mediated protection of the plasma membrane H+-ATPase from Kluyveromyces lactis during freeze-drying and rehydration

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Effects of bovine somatotropin (rbSt) concentration at different moisture levels on the physical stability of sucrose in freeze-dried rbSt/sucrose mixtures

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Deamidation at asparagine-88 in recombinant human interleukin 2

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Calorimetric studies of the kinetic unfreezing of molecular motions in hydrated lysozyme, hemoglobin, and myoglobin

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Trehalose prevents myoglobin collapse and preserves its internal mobility

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Determination of adequate moisture content for efficient dry-heat viral inactivation in lyophilized factor VIII by loss on drying and by near infrared spectroscopy.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Glassy State and Thermal Inactivation of Invertase and Lactase in Dried Amorphous Matrices

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Nucleation and crystallization kinetics of hydrated amorphous lactose above the glass transition temperature

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Stabilization of tetanus and diphtheria toxoids against moisture-induced aggregation

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

A solid-state NMR study of protein hydration and stability

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

How does residual water affect the solid-state degradation of drugs in the amorphous state?

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

The effects of absorbed water on the properties of amorphous mixtures containing sucrose

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Water vapor sorption by peptides, proteins and their formulations

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Modeling of the primary and secondary drying stages of the freeze drying of pharmaceutical products in vials: numerical results obtained from the solution of a dynamic and spatially multi-dimensional lyophilization model for different operational po

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Denaturation of Catalase by Freezing and Thawing

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

The denatured state (the other half of the folding equation) and its role in protein stability.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Stabilization against thermal inactivation promoted by sugars on enzyme structure and function: why is trehalose more effective than other sugars?

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Proteins in frozen solutions: evidence of ice-induced partial unfolding

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Solid-state stability of human insulin. I. Mechanism and the effect of water on the kinetics of degradation in lyophiles from pH 2-5 solutions

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Solid-state stability of human insulin. II. Effect of water on reactive intermediate partitioning in lyophiles from pH 2-5 solutions: stabilization against covalent dimer formation

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Protein inactivation in amorphous sucrose and trehalose matrices: effects of phase separation and crystallization

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Protein stability in the amorphous carbohydrate matrix: relevance to anhydrobiosis

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Resolution-enhanced Fourier transform infrared spectroscopy of enzymes

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Recombinant human albumin as a stabilizer for biological materials and for the preparation of international reference reagents

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

The quantitative analysis of crystallinity using FT-Raman spectroscopy.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Sugar-polymer hydrogen bond interactions in lyophilized amorphous mixtures

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Evaluation of the physical stability of freeze-dried sucrose-containing formulations by differential scanning calorimetry

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

The control of protein stability and association by weak interactions with water: how do solvents affect these processes?

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Moisture content in proteins: its effects and measurement.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Stability of ribonuclease A in solution and the freeze-dried state

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

I. Study of protein aggregation due to heat denaturation: A structural approach using circular dichroism spectroscopy, nuclear magnetic resonance, and static light scattering.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Activity-stability considerations of trypsinogen during spray drying: effects of sucrose

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Moisture effects on protein-excipient interactions in spray-dried powders. Nature of destabilizing effects of sucrose

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Protective Effect of Disaccharides on Restriction Endonucleases during Drying under Vacuum1

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Thermal stability of low molecular weight urokinase during heat treatment. II. Effect of polymeric additives

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Oral protein drug delivery

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Instability, stabilization, and formulation of liquid protein pharmaceuticals

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Protection of the enzyme L-asparaginase during lyophilisation--a molecular modelling approach to predict required level of lyoprotectant.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

A Fourier transform infrared microspectroscopy study of sugar glasses: application to anhydrobiotic higher plant cells

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Dehydration-induced conformational changes of poly-L-lysine as influenced by drying rate and carbohydrates

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Use of infrared spectroscopy to assess secondary structure of human growth hormone within biodegradable microspheres

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Secondary structure characterization of microparticulate insulin powders

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Stability of beta-galactosidase, a model protein drug, is related to water mobility as measured by 17O nuclear magnetic resonance (NMR).

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Application of accelerated testing to shelf-life prediction of commercial protein preparations

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Dependence of the molecular mobility and protein stability of freeze-dried gamma-globulin formulations on the molecular weight of dextran

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Effect of high molecular mobility of poly(vinyl alcohol) on protein stability of lyophilized gamma-globulin formulations

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

The effect of excipients on the molecular mobility of lyophilized formulations, as measured by glass transition temperature and NMR relaxation-based critical mobility temperature

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

Existence of a mannitol hydrate during freeze-drying and practical implications

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

A new strategy for enhancing the stability of lyophilized protein: the effect of the reconstitution medium on keratinocyte growth factor.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

The effect of the reconstitution medium on aggregation of lyophilized recombinant interleukin-2 and ribonuclease A.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2800%2900423-3

7 January 2021

10.1016/S0378-5173(00)00423-3

Identifiers

DOI

1 reference

30 July 2017

1 reference