(Q30540027)

16 August 2017

Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease (English)

1 reference

16 August 2017

1 reference

0 references

1 reference

31

0 references

Markus Zweckstetter

20

0 references

Manfred Uhr

24

Manfred Uhr

0 references

Johannes Levin

4

Johannes Levin

1 reference

16 August 2017

Matthias Samwer

27

0 references

Martin Eiden

Martin Eiden

12

0 references

Armin Giese

Armin Giese

32

0 references

Henning Urlaub

25

Henning Urlaub

1 reference

16 August 2017

Jens Wagner

1

1 reference

16 August 2017

Sergey Ryazanov

2

1 reference

16 August 2017

Andrei Leonov

3

1 reference

16 August 2017

Song Shi

5

1 reference

16 August 2017

Felix Schmidt

6

1 reference

16 August 2017

Catharina Prix

7

1 reference

16 August 2017

Francisco Pan-Montojo

8

1 reference

16 August 2017

Uwe Bertsch

9

1 reference

16 August 2017

Gerda Mitteregger-Kretzschmar

10

1 reference

16 August 2017

Markus Geissen

11

1 reference

16 August 2017

Fabienne Leidel

13

1 reference

16 August 2017

Thomas Hirschberger

14

1 reference

16 August 2017

Andreas A Deeg

15

1 reference

16 August 2017

Julian J Krauth

16

1 reference

16 August 2017

Wolfgang Zinth

17

1 reference

16 August 2017

Paul Tavan

18

1 reference

16 August 2017

Jens Pilger

19

1 reference

16 August 2017

Tobias Frank

21

1 reference

16 August 2017

Mathias Bähr

22

1 reference

16 August 2017

Jochen H Weishaupt

23

1 reference

16 August 2017

Ulrike Teichmann

26

1 reference

16 August 2017

Kai Bötzel

28

1 reference

16 August 2017

Martin Groschup

29

1 reference

16 August 2017

Hans Kretzschmar

30

1 reference

16 August 2017

19 April 2013

1 reference

16 August 2017

Acta Neuropathologica

1 reference

16 August 2017

125

1 reference

16 August 2017

6

1 reference

16 August 2017

795-813

1 reference

Creative Commons Attribution 2.0 Generic

16 August 2017

start time

19 April 2013

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661926

Single-channel electrophysiology reveals a distinct and uniform pore complex formed by α-synuclein oligomers in lipid membranes

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661926

Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661926

Prerequisites to launch neuroprotective trials in Parkinson's disease: an industry perspective

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661926

Two different binding modes of α-synuclein to lipid vesicles depending on its aggregation state

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661926

Small-molecule conversion of toxic oligomers to nontoxic β-sheet-rich amyloid fibrils

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661926

Resolving controversies on the path to Alzheimer's therapeutics

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661926

From high-throughput cell culture screening to mouse model: identification of new inhibitor classes against prion disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661926

Diphenylpyrazole-derived compounds increase survival time of mice after prion infection.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661926

Discovery of 6-substituted indole-3-glyoxylamides as lead antiprion agents with enhanced cell line activity, improved microsomal stability and low toxicity.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661926

Targeting oligomers in neurodegenerative disorders: lessons from α-synuclein, tau, and amyloid-β peptide

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661926

2-Aminothiazoles as therapeutic leads for prion diseases

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661926

Are synucleinopathies prion-like disorders?

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661926

Structure-based design of kinetic stabilizers that ameliorate the transthyretin amyloidoses

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661926

Progression of Parkinson's disease pathology is reproduced by intragastric administration of rotenone in mice

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661926

Discovery of 2-aminothiazoles as potent antiprion compounds

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661926

Structural and mechanistic basis behind the inhibitory interaction of PcTS on alpha-synuclein amyloid fibril formation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661926

Genome-wide association study reveals genetic risk underlying Parkinson's disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661926

Pre-fibrillar alpha-synuclein variants with impaired beta-structure increase neurotoxicity in Parkinson's disease models

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661926

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661926

A highly reproducible rotenone model of Parkinson's disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661926

Safety and efficacy of quinacrine in human prion disease (PRION-1 study): a patient-preference trial

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661926

Cell-free propagation of prion strains.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661926

Protein aggregation in the brain: the molecular basis for Alzheimer's and Parkinson's diseases

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661926

Amyloid fibrils of the HET-s(218-289) prion form a beta solenoid with a triangular hydrophobic core

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661926

Protein misfolding and neurodegeneration

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661926

Orally administered amyloidophilic compound is effective in prolonging the incubation periods of animals cerebrally infected with prion diseases in a prion strain-dependent manner

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661926

Lentivector-mediated RNAi efficiently suppresses prion protein and prolongs survival of scrapie-infected mice

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661926

Cell-free formation of misfolded prion protein with authentic prion infectivity

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661926

A systematic review of prion therapeutics in experimental models

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661926

Common structure and toxic function of amyloid oligomers implies a common mechanism of pathogenesis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661926

The diagnosis of Parkinson's disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661926

Nosology of Parkinson's disease: looking for the way out of a quagmire

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661926

Systematic identification of antiprion drugs by high-throughput screening based on scanning for intensely fluorescent targets

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661926

Parkinson-like syndrome induced by continuous MPTP infusion: convergent roles of the ubiquitin-proteasome system and alpha-synuclein

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661926

A possible pharmacological explanation for quinacrine failure to treat prion diseases: pharmacokinetic investigations in a ovine model of scrapie

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661926

Neurodegenerative diseases: a decade of discoveries paves the way for therapeutic breakthroughs

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661926

Autocatalytic self-propagation of misfolded prion protein

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661926

In silico prediction of blood–brain barrier permeation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661926

Reconstitution of Cell Membrane Structure in vitro and its Transformation into an Excitable System

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661926

Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661926

Misfolded proteinase K-resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha-synucleinopathies

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661926

Protease-sensitive scrapie prion protein in aggregates of heterogeneous sizes

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661926

Molecular properties that influence the oral bioavailability of drug candidates

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661926

Acridine and phenothiazine derivatives as pharmacotherapeutics for prion disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661926

Sensitive detection of pathological prion protein by cyclic amplification of protein misfolding

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661926

Scrapie strains maintain biological phenotypes on propagation in a cell line in culture

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661926

Prion diseases of humans and animals: their causes and molecular basis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661926

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661926

Ultrasensitive detection of pathological prion protein aggregates by dual-color scanning for intensely fluorescent targets

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661926

Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661926

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661926

Eight prion strains have PrP(Sc) molecules with different conformations

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661926

Late treatment with polyene antibiotics can prolong the survival time of scrapie-infected animals

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661926

Models of amyloid seeding in Alzheimer's disease and scrapie: mechanistic truths and physiological consequences of the time-dependent solubility of amyloid proteins

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661926

Neuronal cell death in scrapie-infected mice is due to apoptosis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661926

Experimental scrapie in the mouse: electrophoretic and sedimentation properties of the partially purified agent

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661926

A simple and effective method for inactivating virus infectivity in formalin‐fixed tissue samples from patients with Creutzfeldt‐Jakob disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661926

Neurotoxic protein oligomers--what you see is not always what you get.

20 June 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1114-9

ST1859 reduces prion infectivity and increase survival in experimental scrapie.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1114-9

AMPA-receptor-mediated excitatory synaptic transmission is enhanced by iron-induced α-synuclein oligomers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1114-9

Single particle characterization of iron-induced pore-forming alpha-synuclein oligomers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1114-9

Neurodegenerative disease: amyloid pores from pathogenic mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1114-9

Targeting cellular prion protein reverses early cognitive deficits and neurophysiological dysfunction in prion-infected mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1114-9

Tissue distribution of protease resistant prion protein in variant Creutzfeldt-Jakob disease using a highly sensitive immunoblotting assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1114-9

Antigenic features of prion proteins of sheep and of other mammalian species

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23604588

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Single particle detection and characterization of synuclein co-aggregation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23604588

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1007/S00401-013-1114-9

1 reference

Dimensions Publication ID

16 August 2017

0 references

1 reference

16 August 2017

PubMed publication ID

23604588

1 reference