(Q33186287)

23 July 2017

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title

Cell growth and metastasis in pancreatic cancer: is Vav the Rho'd to activation? (English)

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23 July 2017

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Daniel D Billadeau

1

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23 July 2017

publication date

1 January 2002

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International Journal of Gastrointestinal Cancer

23 July 2017

published in

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23 July 2017

volume

31

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23 July 2017

issue

1-3

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23 July 2017

page(s)

5-13

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Reduced membranous and ectopic cytoplasmic expression of beta -catenin correlate with cyclin D1 overexpression and poor prognosis in pancreatic cancer

23 July 2017

cites work

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12 December 2020

Integration of Rac-dependent regulation of cyclin D1 transcription through a nuclear factor-kappaB-dependent pathway

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12 December 2020

Overexpression of RhoA mRNA is associated with advanced stage in testicular germ cell tumour

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12 December 2020

Activation of the small GTPase Rac is sufficient to disrupt cadherin-dependent cell-cell adhesion in normal human keratinocytes

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12 December 2020

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12 December 2020

Rho GTPases are over-expressed in human tumors.

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12 December 2020

Role of integrins in cell invasion and migration

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12 December 2020

Rac affects invasion of human renal cell carcinomas by up-regulating tissue inhibitor of metalloproteinases (TIMP)-1 and TIMP-2 expression

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12 December 2020

Rac1 mediates type I collagen-dependent MMP-2 activation. role in cell invasion across collagen barrier

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12 December 2020

A family outing: small GTPases cyclin' through G1

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12 December 2020

Regulatable Expression of p21-activated Kinase-1 Promotes Anchorage-independent Growth and Abnormal Organization of Mitotic Spindles in Human Epithelial Breast Cancer Cells

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12 December 2020

Dbl family guanine nucleotide exchange factors

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12 December 2020

Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

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12 December 2020

Characterization of RhoC expression in benign and malignant breast disease: a potential new marker for small breast carcinomas with metastatic ability

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12 December 2020

Tyrosine phosphorylation mediates both activation and downmodulation of the biological activity of Vav

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12 December 2020

Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1.

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12 December 2020

Expression of ROCK-1 in human pancreatic cancer: its down-regulation by morpholino oligo antisense can reduce the migration of pancreatic cancer cells in vitro

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12 December 2020

Regulation of G protein-linked guanine nucleotide exchange factors for Rho, PDZ-RhoGEF, and LARG by tyrosine phosphorylation: evidence of a role for focal adhesion kinase

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12 December 2020

Gene expression profiles of pancreatic cancer and stromal desmoplasia

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12 December 2020

How Vav proteins discriminate the GTPases Rac1 and RhoA from Cdc42.

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12 December 2020

Specific subdomains of Vav differentially affect T cell and NK cell activation

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12 December 2020

A novel Cdc42Hs mutant induces cellular transformation

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12 December 2020

Transformation mediated by RhoA requires activity of ROCK kinases

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12 December 2020

Cadherin engagement regulates Rho family GTPases

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12 December 2020

Vav family proteins couple to diverse cell surface receptors

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12 December 2020

Immunohistochemical analysis of IQGAP1 expression in human colorectal carcinomas: its overexpression in carcinomas and association with invasion fronts

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12 December 2020

vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells

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12 December 2020

Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism

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12 December 2020

Overexpression of the rhoC gene correlates with progression of ductal adenocarcinoma of the pancreas

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12 December 2020

Regulation of c-myc expression by PDGF through Rho GTPases.

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12 December 2020

Ras and Rho regulation of the cell cycle and oncogenesis

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12 December 2020

Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav

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12 December 2020

Regulatory and signaling properties of the Vav family

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12 December 2020

Identification of a gene at 11q23 encoding a guanine nucleotide exchange factor: evidence for its fusion with MLL in acute myeloid leukemia

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12 December 2020

Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation

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12 December 2020

Endogenous, hyperactive Rac3 controls proliferation of breast cancer cells by a p21-activated kinase-dependent pathway

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12 December 2020

The Small GTPases Rho and Rac Are Required for the Establishment of Cadherin-dependent Cell–Cell Contacts

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12 December 2020

Rac1 in human breast cancer: overexpression, mutation analysis, and characterization of a new isoform, Rac1b

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12 December 2020

Regulation of Vav proteins by intramolecular events

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12 December 2020

Transforming growth factor-beta-induced mobilization of actin cytoskeleton requires signaling by small GTPases Cdc42 and RhoA

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12 December 2020

RHO-GTPases and cancer

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12 December 2020

Rac1 and RhoG promote cell survival by the activation of PI3K and Akt, independently of their ability to stimulate JNK and NF-kappaB

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12 December 2020

Timing of cyclin D1 expression within G1 phase is controlled by Rho.

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12 December 2020

p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis

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12 December 2020

Involvement of IQGAP1, an effector of Rac1 and Cdc42 GTPases, in cell-cell dissociation during cell scattering

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12 December 2020

Rho GTPases and their effector proteins

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12 December 2020

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12 December 2020

Biological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteins

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12 December 2020

Identification of VAV2 on 9q34 and its exclusion as the tuberous sclerosis gene TSC1

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12 December 2020

NF-kappaB function in growth control: regulation of cyclin D1 expression and G0/G1-to-S-phase transition

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12 December 2020

Vav2 is required for cell spreading

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12 December 2020

Rho-family GTPases in cadherin-mediated cell-cell adhesion

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12 December 2020

Activation of cdc42, rac, PAK, and rho-kinase in response to hepatocyte growth factor differentially regulates epithelial cell colony spreading and dissociation

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12 December 2020

Tiam1 overexpression potentiates heregulin-induced lymphoid enhancer factor-1/beta -catenin nuclear signaling in breast cancer cells by modulating the intercellular stability

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12 December 2020

Phenotypical characteristics of undifferentiated carcinoma of the pancreas: a comparison with pancreatic ductal adenocarcinoma and relevance of E-cadherin, alpha catenin and beta catenin expression

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12 December 2020

p21(WAF1/CIP1) is upregulated by the geranylgeranyltransferase I inhibitor GGTI-298 through a transforming growth factor beta- and Sp1-responsive element: involvement of the small GTPase rhoA.

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12 December 2020

Integrin-Specific Activation of Rac Controls Progression through the G1 Phase of the Cell Cycle

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12 December 2020

Phosphorylation-dependent and constitutive activation of Rho proteins by wild-type and oncogenic Vav-2

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12 December 2020

Epidermal growth factor stimulation of the ACK1/Dbl pathway in a Cdc42 and Grb2-dependent manner

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12 December 2020

NF-kappaB and cell-cycle regulation: the cyclin connection

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12 December 2020

Small GTP-binding protein, Rho, both increased and decreased cellular motility, activation of matrix metalloproteinase 2 and invasion of human osteosarcoma cells

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12 December 2020

IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling

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12 December 2020

Vav proteins, adaptors and cell signaling.

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12 December 2020

VAV proteins as signal integrators for multi-subunit immune-recognition receptors

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12 December 2020

Cloning of a novel human Rac1b splice variant with increased expression in colorectal tumors

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12 December 2020

Vav2 activates Rac1, Cdc42, and RhoA downstream from growth factor receptors but not beta1 integrins

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12 December 2020

Small GTP-binding proteins

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12 December 2020

Differential requirement for Rho family GTPases in an oncogenic insulin-like growth factor-I receptor-induced cell transformation

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12 December 2020

Isolation and characterization of murine vav2, a member of the vav family of proto-oncogenes

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12 December 2020

IQGAP1, a negative regulator of cell-cell adhesion, is upregulated by gene amplification at 15q26 in gastric cancer cell lines HSC39 and 40A

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12 December 2020

Regulation of Rho GTPases by p120-catenin

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12 December 2020

Rho regulates p21(CIP1), cyclin D1, and checkpoint control in mammary epithelial cells

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12 December 2020

RhoC GTPase, a novel transforming oncogene for human mammary epithelial cells that partially recapitulates the inflammatory breast cancer phenotype.

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12 December 2020

Hyaluronan promotes CD44v3-Vav2 interaction with Grb2-p185(HER2) and induces Rac1 and Ras signaling during ovarian tumor cell migration and growth

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12 December 2020

Nonrandom 4p13 rearrangements of the RhoH/TTF gene, encoding a GTP-binding protein, in non-Hodgkin's lymphoma and multiple myeloma

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12 December 2020

Rho-kinase phosphorylates COOH-terminal threonines of ezrin/radixin/moesin (ERM) proteins and regulates their head-to-tail association

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12 December 2020

RhoC GTPase overexpression modulates induction of angiogenic factors in breast cells

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12 December 2020

Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation

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12 December 2020

High levels of ezrin expressed by human pancreatic adenocarcinoma cell lines with high metastatic potential

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12 December 2020

Rho family proteins: coordinating cell responses

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12 December 2020

Identifiers

DOI

10.1385/IJGC:31:1-3:5

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23 July 2017

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